An alignment of 125 plant P450 sequences

This file last modified October 21, 1997


  1 71A1     avocado       -------------------------MAIL-----------    4
  2 71A2     eggplant F154 -------------------------MDVPCPWYS------    9
  3 71AlikeAraZ35213/Z35017----------------------------------------    0
  4 71A3     eggplant F151 ----------------------------------------    0
  5 71A4     eggplant E138 -------------------------MDVPCLWYS------    9
  6 71A-like ArabEST T22148----------------------------------------    0
  7 71A-like ArabEST N38590----------------------------------------    0
  8 71A-like ArabEST T45449----------------------------------------    0
  9 71A7 Cathar.CR7  X69779----------------------------------------    0
 10 71A-like ArabEST H76866----------------------------------------    0
 11 71A8 Mentha piperita   -------------MYSIAFMLVLRKMDEIISHTLA-----   22
 12 71D3 Arabidopsis Z27299----------------------------------------    0
 13 71B/D-like Arab. Z34126----------------------------------------    0
 14      Arab. EST F14190  ----------------------------------------    0
 15 71B1 Thlaspi arv.L24438-------------------------MDLL-----------    4
 16 71B-like  Z33677/Z33963----------------------------------------    0
 17 71B2  Arab. P450-48    -------------------------MTI------------    3
 18 71-like Arab.EST R30233----------------------------------------    0
 19         Arab.EST T04417----------------------------------------    0
 20         Arab.EST W43443----------------------------------------    0
 21       Arab. EST T42861 ----------------------------------------    0
 22       Arab. EST N97058 ----------------------------------------    0
 23       Arab. EST T45663 -------------------------MEIT-----------    0
 24 71B-like ArabEST T76255----------------------------------------    0
 25 71B-like ArabEST T14112-------------------------MSVF-----------    4
 26 71BlikeAraT04186/T04714----------------------------------------    0
 27 AraT46392/T44621/N65907----------------------------------------    0
 28 71B Arab.T44855/T44224 ----------------------------------------    0
 29 71B-like  Arab.  T20987----------------------------------------    0
 30 71B-like  Arab.  H76241----------------------------------------    0
 31 AraZ34037/Z33952/Z34791----------------------------------------    0
 32 Arab. T43253 EST       ----------------------------------------    0
 33 92A2 tobacco X95342    -------------------------MEGTN----------    0
 34 83  Arabidopsis pCC19  -------------------------MED------------    3
 35 85  tomato             -------------------------MAFFLIF--------    7
 36 85-like Arab.EST N65267----------------------------------------    0
 37 87-like Arab.EST T45729----------------------------------------    0
 38 87-likeAr.H77048/N37614----------------------------------------    0
 39 88   Zea mays          --------------------MLGVGMAAEAVLVGAVA---   17
 40 88-like Arab.EST T43711----------------------------------------    0
 41 90   Arabidopsis Z17988-------------------------MAFTA----------    5
 42 Arab. EST Z34056       ----------------------------------------    0
 43 71C1 Zea mays maize1   -------------MALEAGYD-YLHVAVVQCTPTQAAAVL   26
 44 71C2 Zea mays maize2   -------------MALGAAYHHYLQLAGDHGTATH-ALLL   26
 45 71C2v2  Zea mays b     ----------------------------------------    0
 46 71C3 Zea mays maize3   --------------ALQAAYE-YLQQAVGHGAWSSTQTLT   25
 47 71C4 Zea mays maize4   -------------MAAQLHHALYELLHEAAAAQR--ALLL   25
 48 71C5 Zea mays a        ----------------------------------------    0
 49 76A1     eggplant F94  ----------------------------------------    0
 50 76A2     eggplant G17  -------------------------MEWEWSY--------    7
 51 76A3 Cathar.CR12 X69784----------------------------------------    0
 52 Arab. EST T43806       ----------------------------------------    0
 53 75A2     eggplant      -------------------------MVILPSELI------    9
 54 75A1     petunia       -------------------------MMLLTELG-------    8
 55 75A3     petunia       -------------------------MVLLSELA-------    8
 56 75-like Bras.campL33505----------------------------------------    0
 57 86A1 CYPIRE Arabidopsis-------------------------MEALN----------    5
 58 86A2 Arabidopsis T04172----------------------------------------    0
 59 86A3 Brass.camp. L35832----------------------------------------    0
 60 86A-like ArabEST T46373-------------------------MDVSN----------    0
 61 86A-like ArabEST Z25705----------------------------------------    0
 62 86A-like ArabEST T20562----------------------------------------    0
 63  Arab. Z26058/Z26059   -------------------------MSLIDR---------    0
 64 94A-like ArabEST H76099----------------------------------------    0
 65 78A1 Zea mays(J.Larkin)----------------------------------------    0
 66 78A2 Phalaenopsis      ----------------------------------------    0
 67 78A-like ArabEST T45256----------------------------------------    0
 68 73A1     Jer.artichoke -------------------------MDLLLI---------    6
 69 73A2     mung bean     -------------------------MDLLLL---------    6
 70 73A3     alfalfa       -------------------------MDLLLL---------    6
 71 73A4 Cathar.CR16 X69788-------------------------MDLLLL---------    6
 72 73A5 Arabidopsis       -------------------------MDLLLL---------    6
 73 73A9  Pea              ---------------------------LLLL---------    4
 74 76C-likeArT04013/T04016----------------------------------------    0
 75 76C-likeArT04014/T04015----------------------------------------    0
 76 Arab. EST H37250       ----------------------------------------    0
 77 91A-like ArabEST Z26103----------------------------------------    0
 78 91A-like ArabEST H76015----------------------------------------    0
 79 91A-like ArabEST T88150----------------------------------------    0
 80 91A-like ArabEST F13573----------------------------------------    0
 81 EST Arab. T14177       ----------------------------------------    0
 82 EST Arab. T41670/T43640-------------------------MD-NQI---------    0
 83 EST Arab. T46441       ----------------------------------------    0
 84 93A-like ArabEST T43276----------------------------------------    0
 85 93A-like ArabEST T88278----------------------------------------    0
 86 93A-like ArabEST F19864----------------------------------------    0
 87 93A-like ArabEST T04613----------------------------------------    0
 88         ArabEST W43241 ----------------------------------------    0
 89 77A1  eggplant H1      ----------------------------------------    0
 90 77A2  eggplant H2      -------------------------MDFFSTSSLSSYYHL   15
 91 Arab. Z30775/Z33076    ----------------------------------------    0
 92 89A-like ArabEST T44110----------------------------------------    0
 93 89A-like ArabEST T14186----------------------------------------    0
 94 89A-like ArabEST T42576----------------------------------------    0
 95 89A-like ArabEST H77059----------------------------------------    0
 96 89A-like CathR15 X69787----------------------------------------    0
 97 79    Sorghum bicolor  MATMEVEAAAATVLAAPLLSSSAILKLLLFVVTLSYLARA   40
 98 80    Berberis stoloni.-------------------------MDYI-----------    4
 99 82    Pea cDNA50       ----------------------------FVLNYL------    6
100 72A1 Catharanthus ros. ------------MEMDMDTIRKAIAATIFALVMAWAWRV-   27
101 72A  Arabidopsis       ---------------MEISVASVTVSVAVVVVSWWVWRT-   24
102 72 variant Arab. N96036----------------------------------------    0
103 72 variant Arab. N96740-----------------------------------VWRT-    0
104 72 variant Arab. H36956---------------MEISVSSVTFSLAVVVVSWWVWRT-    0
105 72 variant Arab. R90024---------------MSF-VVAALPVLVAVVV-LWTWRI-    0
106 72-like EST Arab.N38616----------------------------------------    0
107 74A Allene ox.syn. flax----------------------------------SAFR--    4
108 74A AOS guayule        ----------------------------------------    0
109 74A AOS Arabidopsis    ----------------------------------QKML--    4
110 74B FAhydroperoxidelyas----------------------------------------    0
111 51 14DM Arab. N65031   ----------------------------------------    0
112 51 14DM Z.mays T12664  ----------------------------------------    0
113      Arabidopsis Z24511----------------------------------------    0
114      Arab.T21057/T76384----------------------------------------    0
115      Cathar.CR1  X69789----------------------------------------    0
116      Cathar.CR2  X69790----------------------------------------    0
117      Cathar.CR4  X69776----------------------------------------    0
118      Cathar.CR5  X69777----------------------------------------    0
119      Cathar.CR6  X69778----------------------------------------    0
120      Cathar.CR8  X69780----------------------------------------    0
121      Cathar.CR9  X69781----------------------------------------    0
122      Cathar.CR10 X69782----------------------------------------    0
123      Cathar.CR11 X69783----------------------------------------    0
124      Cathar.CR13 X69785----------------------------------------    0
125      Cathar.CR14 X69786----------------------------------------    0


1 -VSLLF-LAIALTFFL----LKLNE-------------KREKKPNLPPSPPN-LPIIGNL--HQLGN-LP 5 2 -LLIPL-FVFIFLLIH--H-CFFTT-------------SKKQNMLLLPSPRK-LPIIGNL--HQLGS-LP 57 3 -MSWFL-IAVATIAAV----VSYKL-------------IQRLRYKFPPGPSP-KPIVGNL--YDIKP-VR 0 4 --LVPL-FVFILFLHK----CFFTT--------------SNNNKKLPPSPRK-LPIIGNL--HQLGL-HP 45 5 -LLILL-LLFIFLLIH--H-CF-TT-------------SKTQNMFLPPSPRK-LPIIGNL--HQLGS-HP 56 6 --------------------LFLKK------------QLSGKKGKTPPSPPG-LPLIGNL--HQLGR-HT 0 7 MIRIIL-LSLIIFITI----LFFIK------------QKKGKKSNTPASPPR-LPLIGNL--HQLGR-HP 0 8 -------------------------------------------WNLPPSPPK-FPVIGNL--HQIGE--P 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 -FQALV-SLILLISIT----KWLSN-------------SPKNKNSSPPSPRK-LPILGNL--LQLGS-LP 69 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 --LSMA-SITLLGRIL----SRPTK-------------TKDRSCQL-PGPPG-WPILGNL--PELFM-TR 0 15 -L-YIV-AALVIFASL----LIAKS-------------KRKPKKNLPPGPPR-LPIIGNL--HQLGE-KP 50 16 ---------------------------------------------------------------------- 0 17 -LLCFF-VLSLLTIVS--S-IFLKQ-------------NKTSKFNLPPSPSS-LPIIGNL--HHLAG-LP 51 18 --------------------------------------DSRVNFDLPPSPPS--P-IGHV--HLLLS-TL 0 19 --------------LT----IFFLQ------------ENKRLTSWLPPSPPS-LPIIGHL--HLILF-VP 36 20 -------------------------------------------CGLPPSPPS-LPIIGHL--HFLLS-VP 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 -TIIFL-IISSLTFSI----FLKLI-------------FFFSTHKLPPGPPR-FPVIGNI--IWLK--NN 0 24 ---------------------------------------------------------------------- 0 25 -LVFLC-LLPLILIFL--------K------------NLKPSKWKLPPGPKK-LPIIGNL--HQRRE-LH 48 26 ---------------------------------------------------------------------- 0 27 -VMLGV-AALLAVVCY----WIQGK------------SKSKNGPPLPPGPWP-L-IVGNL--PFLN-D-L 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 0 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 -LTTYA-AVFLGTLFL----LFLSK------------LLRQRKLNLPPGPKP-WPIIGNL--NLIGN-LP 0 34 -IIIGV-VALAAVLLF----FLYQK-------------PKTKRYKLPPGPSP-LPVIGNL--LQLQK-LN 50 35 -LSSFF-GLCIFCTAL----LRWNQ-------------VKYNQKNLPPGTM--WPLFGET--TEFLK-LG 53 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 -LVVVD-AAARRAHGW----REAAL-------------GAARRARLPPGEMG-WPLVGGM--WAFLR-AF 64 40 ---------------------------------------------------------------------- 0 41 -FLLLL-SSIAAGFLL----LLRR--------------TRYRRMGLPPGSLG-LPLIGET--FQLIG-AY 51 42 ---------------------------------------------LPPGCMG-FPIIGET--LDFFK-AL 0 43 -GVLLL-LAIRLAAAA----R--SSSAT---------SPKWKQHRLPPTPPGKLPIIGHL--HLIGS-HP 76 44 -GVLIF-LVIRLVSAR----RTGTTSANK--------RKQQQRLPLPPWPPGKLPIIGHL--HLIGA-ET 79 45 ---------------------------------------------------------------------- 0 46 -LLLIA-VPTVLLLLA----SLAKSTSSS----------GRGKPPLPPSPPGTLPIVGHL--HHIGP-QT 76 47 -AIPFS-LLLLPLLLR--YLAASASASATKNDGAAPASDPDKLLSLLPSPPMKLPIIGHL--HLMGD-IP 88 48 ---------------------------------------------------------------------- 0 49 --------------------------------------------------------FGNM-FDLAGS-AP 12 50 -VFFSA-IIILPAFIL--F-FSQKN-------------TTKSSYKFPPGPPG-LPIFGNM-FEL-GT-EP 55 51 ---------------------------------------------------------------------- 0 52 ---------------------------------------------------------------------- 0 53 -GATII-YIIVYIIIQ----KLIAT-------------GSWRRRRLPPGPEG-WPVIGAL--PLLGG-MP 56 54 -AATSI-FLIAHIIIS----TLI---------------SKTTGRHLPPGPRG-WPVIGAL--PLLGA-MP 53 55 -AATLI-FLTTHIFIS----TLL---------------SITNGRRLPPGPRG-WPVIGAL--PLLGA-MP 53 56 ---------------------------------------------------------------------- 0 57 -SILTG-YAVAALSVY----ALW--------------FYFL-SRRL-TGPKV-LPFVGSL--PYLIA-NR 49 58 ---------------------------------------------------------------------- 0 59 ---------------------------------------------------------------------- 0 60 ----TM-LLVAVVAAY----WLW--------------FQRI-SRWL-KGPRV-WPVLGSL--PGLIE-QR 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ----IS-GHLCLQDVS--I-ALLGLFLF----------GCLQAKTNKGGPVQ-WPVFGIT-PEFFLHVHD 0 64 ---------------------------------------------------------------------- 0 65 -ALLAW-ATSPGGPAW--T-NGRGA-------------SASLLSWDPVVCPC-SAASSRC--PGAAAPRP 49 66 ---------------------------------------------------------------------- 0 67 ---------------------------------------------------------------------- 0 68 -EKTLV-ALFAAIIGA----ILISK-------------LRGKKFKLPPGPIP-VPIFGNW--LQVGDDLN 54 69 -EKTLL-GLFLAAVVA----IVVSK-------------LRGKRFKLPPGPLP-VPIFGNW--LQVGDDLN 54 70 -EKTLL-ALFIAATIA----VTISK-------------LRGKRFKLPPGPIP-VPIFGYW--LQVGDDLN 54 71 -EKTLL-GLFAAIIVA----SIVSK-------------LRGKKFKLPPGPIP-VPVFGNW--LQVGDDLN 54 72 -EKSLI-AVFVAVILA----TVISK-------------LRGKKLKLPPGPIP-IPIFGNW--LQVGDDLN 54 73 -EKTLL-ALFLAAITA----ITISK-------------LRGKPFKLPPGPFP-VPVFGNW--LQVGDDLN 52 74 ---------------------------------------------------------------------- 0 75 --------------------------------------------NLPPFNKR-S----NI--HLVGRNP- 0 76 ---------------------------------------------------------------------- 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 ---------------------------------------------------------------------- 0 81 -----L-FFFFIFLSL----K-L-G-------------PRPRKLNLPPSPSRPFPIIGH---H-LKLP-- 0 82 -LI-SF-LSLFTLAIF----LLTR---------------SKRKLNLPPSPAISLPVIGHL--HLLKPPL- 0 83 ---------------------------------------------LPPSPS-SLPILGHH--LLIKPPV- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 ---------------------------------------------------------------------- 0 88 ---------------------------------------------------------------------- 0 89 -IFTAF-SLLFSLFIF----LLTRK-------------PKSKTPNLPPGPPG-WPIVGNL-FQVAGSGKQ 49 90 -IFTIL-AFVISSIIY--F-LLSKK-------------AESKKLKLPPGPPG-WPVVGNL-LQVARSGKP 65 91 ---------------------------------------------------------------------- 0 92 ---------------------------------------------------------------------- 0 93 ---------------------------------------------------------------------- 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 LRRPRK-STTKCSSTT----CASPP-------------AGVGNPPLPPGPVP-WPVVGNL--PEMLLNKP 89 98 -IVGFV-SISLVALLY----FLL---------------FKPKHTNLPPSPPA-WPIVGHL--PDLIS-KN 49 99 -NTTTI-AFISLISLL--F-FLFRF-------------SKVSHTKEPPIISGSWPLLGSI-PLMRNTQTP 57 100 LDWAWF-TPKRIEKRLR---QQGFRGNPYRFLV-----GDVKESGKMMQEALS-KPMEF-NNDIVPR--L 84 101 LQWVWF-KPKMLESYLR---RQGLAGTPYTPLV-----GDLKKNFSMRAEARS-KPINL-TDDITPR--I 81 102 ---------------------------------------------------------------------- 0 103 LQAVWL-KPKMLESYLR---RQGLAGTPYTPLV-----GDLKRNFSMLAEARS-KPINL-TDDITPR--I 0 104 LKWVWF-TPKMLERSLR---RQGLSGTSYTPLI-----GDFKKMISMFIEATS-KPIKP-TDDITPR--V 0 105 VKWVWI-KPKML-SSLK---RQGLTGTPYTPLV-----GDIKRNVDMMMEARS-KPINV-TDDITPR--- 0 106 ---------------------------------------------------------------------- 0 107 PIKASL-FGDSPIKIPGIT-SQPPP-----SSD-----ETTLPIRQIPGDYGL-PGIGPIQDRLDYFYNQ 61 108 -------------------------------MD-----PSSKPLREIPGSYGI-PFFQPIKDRLEYFYGT 33 109 LRTMAA-TSPRPPPSTSLT-SQQPP------SP-----PSQLPLRTMPGSYGW-PLVGPLSDRLDYFWF- 59 110 -------------MIPIMS-SAPLS-----TAT-----PISLPVRKIPGSYGF-PLLGPLWDRLDYNWFQ 0 111 --------------------------------------------KRLPPTLKAWPLVGSL--IKFLKGP- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 ----HRSLRSLAN--ELG------PLILLHLGHIPTLIVSTAEIAEEIL-KTHDLIFAS----------- 97 2 ----HRSLHKLSQ--KYG------PVMLLHFGSKPVIVASSVDAARDIM-KTHDVVWAS----------- 103 3 ----FRCYYEWAQ--SYG------PIISVWIGSILNVVVSSAELAKEVL-K------------------- 0 4 ----HRSLHKLSK--KYG------PVMLLHLGSKPVIVASSVEAVRDIM-KTNDLVWSN----------- 91 5 ----HRSLRKLSQ--KYG------PVMLLHLGSKPVIVASSVDAARDIL-KTHDHVWAT----------- 102 6 ----HRSLCDLSR--RYG------PLMLLHLGRVPVLIVSSADMAQEIL-KT------------------ 0 7 ---------------------------------------------------------------------- 0 8 ----HRSLQHLAE--RYG------PVMLLHFGFVPVTVVSSREAAEEVL-RTH-L--------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 ----HHNLRSMAR--KHG------PIMLLHLGSVRP--VSSRRRPRGNH-ENSRSRLR------------ 112 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 ----HRAMVELSK--TYG------PLMSLKLGSVTTVVATSVETVRDVL-KTYDLECCS----------- 96 16 ---------------------------------------------------------------------- 0 17 ----HRCFHKLSI--KYG------PLVFLRLGSVPVVVISSSEAAEAVL-KTNDLECCS----------- 97 18 ----HKSLQKLSS--R------------------------------------------------------ 0 19 ---IHQSFKNISS--KYG------PLLHLRFFNFPIVLVSSASTAYEIF-KAQDVNVSS----------- 83 20 ---CYKSFQKLSS--KYG------PFLHLRAFNIPIVLVSSGSMANEVL-RIQDLNFAS----------- 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 FSDFQGVLRDLAS--RHG------PIITLHVGFKPFIWVT------------------------------ 0 24 ---------------------------------------------------------------------- 0 25 ----PRNSRNLSE--KYG------PIVFLRYGFVPVVVISSKEAAEEVL-KTHDLECCS----------- 94 26 ---------------------------------------------------------------------- 0 27 ---------------KHG------PLMKIHLGSKLAIVVSSPDMAREVL-KTHDITFAN----------- 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 0 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 ----YRSIHELSL--KYG------PVMQLQFGSFPVVVGSSVEMAKIFL-KSMDINFVG----------- 0 34 ----PQRFFAGWA--KYG------PILSYRIGSRTMVVISSAELAKELL-KTQDVNFAD----------- 96 35 ----PSFMKNQRA--RYG------SFFKSHILGCPTIVSMDSELNRYIL-VNEAKGLVP----------- 99 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 KSGKPDAFIASFVR-RFG----RTGVYRSFMFSSPTVLVTTAEGCKQVL-MDDDAFVTG----------- 117 40 ---------------------------------------------------------------------- 0 41 KTENPEPFIDERVA-RYG------SVFMTHLFGEPTIFSADPETNRFVL-QNEGKLFEC----------- 102 42 ----IPTFVKKRMI-RYG------PLFRTNIFGSKTVVSTDPDVIHQIF-R------------------- 0 43 ----HVSFRDLHA--KYG----HNGLMLVQVGAVPTIVVSTPQAAEAVL-RTHDHVLAS----------- 124 44 ----HISIRDLDA--KHG----RNGLLLLRIGAVPTLFVSSPSAADAVL-RTQDHIFAS----------- 127 45 ---------------------------------------------------------------------- 0 46 ----HISLQELVA--KYG----HNGFLFLRAGAVPTLIVSSPSAAEAVM-RTHDHICAS----------- 124 47 ----YVSLAALAT--RYG-----PDLMLLRLGAVPTVVVSSPRVAEAVL-RTYDHVFSS----------- 135 48 ----------------------------------------------------------G----------- 1 49 ----YKKIACLKE--KYG------PILWLKIGSMNTMVIQTANSASELF-RNHDVSFSD----------- 58 50 ----YKKMAVLRQ--KYG------PVLWLKLGSTYTMVVQTAQASEELF-KNHDISFAN----------- 101 51 ---------------------------------------------------------------------- 0 52 ---------------------------------------------------------------------- 0 53 ----HVALAKMAK--KYG------PIMYLKVGTCGMVVASTPNAAKAFL-KTLDINFSN----------- 102 54 ----HVSLAKMAK--KYG------AIMYLKVGTCGMAVASTPDAAKAFL-KTLDINFSN----------- 99 55 ----HVSLAKMAK--KYG------AIMYLKVGTCGMVVASTPDAAKAFL-KTLDLNFSN----------- 99 56 ---------------------------------------------------------------------- 0 57 ----SRIHDWIADNLRATGGTYQTCTMVIPFVAKAQGFYTVTCHPKNVE-HILKTRFDNYP--------- 105 58 --------------------------------------------------HMLKTRFDNYP--------- 0 59 ---------------------------------------------------------------------- 0 60 ----DRMHDW-TENLRACGGTYQTCICGVPFLGKKQGLVTVTCDPKTI--HM-KTRFDNYP--------- 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ----MFGWVTRCL--TKS-----RGTFPYQGIWFSGSYGAMTSVPANIE-YMLKTNFKNFL--------- 0 64 ---------------------------------------------------------------------- 0 65 ----RRDGPRRRP--RAK------ELMAFSVGDTPAVVSSCPATAREVL---AHPSFAD----------- 93 66 --------------------------MAFSVGLTRFIVSSHPKTAKEIL---SSPAFAD----------- 30 67 ---------------------------------------------------------------------- 0 68 ----HRNLTDLAK--RFG------EILLLRMGQRNLVVVSSPELAKEVL-HTQGVEFGS----------- 100 69 ----HRNLTQLAK--RFG------DIFLLRMGQRNLVVVSSPDLAKEVL-HTQGVEFGS----------- 100 70 ----HRNLTDYAK--RFG------EIFLLRMGQRNLVVVSSPELAKEVL-HTQCVEFGS----------- 100 71 ----HRNLSDYAK--KFG------EIFLLRMGQRNLVVVSSPELAKEVL-HTQCVEFGS----------- 100 72 ----HRNLVDYAK--KFG------DLFLLRMGQRNLVVVSSPDLTKEVL-LTQGVEFGS----------- 100 73 ----HRNLTDLAK--RFA------EILLLRMEQRNLVVISSPELAKEVL-HTQGVEFGS----------- 98 74 ---------------------------------------------------------------------- 0 75 ----HHSFADLSK--TYG------PIMSLKFGSLNTVVVTSPEAAREVL-RTYDQILSS----------- 0 76 ---------------------------------------------------------------------- 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 ---------------------------------------------------------------------- 0 81 ----HRR--------------------------------------------------------------- 0 82 ----HRTFLSLSK--SIGNA----PVFHLRLGNRLVYVISSRSIAEELF--KNDVVLAN----------- 0 83 ----HRLFHRLSN--IHG------PIFYLRLGSRRAVVISSSSLARECF-GQNDVIVSN----------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 ---------------------------------------------------------------------- 0 88 ---------------------------------------------------------------------- 0 89 ---FFEYIRDLKP--KYG------SIFTLKMGSRTMIIVASAELAHEAL-IQKGQIFAS----------- 96 90 ---FFQIMRELRQ--KYG------PIFTLRMGTRTMIILSNADLVHEAL-ILKGQVFAT----------- 112 91 ---------------------------------------------------------------------- 0 92 ---------------------------------------------------------------------- 0 93 ---------------------------------------------------------------------- 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 ---AFRWIHQMMR--EMG-----TDIACVKLGGVHVVSITCPEIAREVL-RKQDANFIS----------- 137 98 SPPFLDYMSNIAQ--KYG------PLIHLKFGLHSSIFASTKEAAMEVL-QTNDKVLSG----------- 99 99 ----HKTLGALVD--KYG------PIFTIKLGATNALVLSNWELAKECF-TKNDIVVSS----------- 103 100 ----MPHINHTIN--TYG------RNSFTWMGRIPRIHVMEPELIKEVL-THSSKYQKN----------- 130 101 ----VPYPLQMLK--THG------RTFFTWFWAIPTITIMDPEQIKEVF-NKVYDFQKA----------- 84 102 ---------------------------------------------------------------------- 0 103 ----VPYPLQMLK--THG------RTFFTWFGPIPTITIMDPEQIKEVF-NKVNDFQKA----------- 84 104 ----MPHPLQMLK--AHG------RPTLTWFGPIPT---------------------------------- 84 105 ----LPLALKMLN--SHG------KTFFIWIGPL-TI-IT-PEQIKEVF-NKVN---------------- 0 106 ---------------------------------------------------------------------- 0 107 --GREEFFKSRLQ--KYKS-----TVYRANMPPGPFIASNPRVIVLLDA-KSFPVL-------------- 107 108 -GGRDEYFRSRMQ--KYQS-----TVFRANMPPGPFVSSNPKVIVLLDA-KSFPIL-------------- 80 109 -QGPDKFFRTRAE--KYKS-----TVFRTNIPPTPFFGNNPNIVAVLDV-KSFSHL-------------- 106 110 --KLPDFFSKRVE--KYNS-----TVFRTNVPPCPFLGVNPNVVAVLDV-KSFAHL-------------- 0 111 ----I-MLREEYP--KLG------SVFTVNLVHKKIT-LIGPEVSAHF--KASESDLSQ----------- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 -----RPS-TTAARRIFYD------CTDVAFS-PYGEYWRQVRKICVLELLSIKRVN---------SYRS 145 2 -----RPK-SSIVDRLSYG------SKDVGFS-PFGEYWRRAKSITVLHLLSNTRVQ---------SYRN 151 3 ---------------------------------------------------------------------- 0 4 -----RPK-SKMADRLIYG------SKDVSFS-PHGEYWRQIRSITVLHLLSNKRVQ---------SYRA 139 5 -----RPK-YSIADSLLYG------SKDVGFS-PFGEYWWQVRSIVVLHLLSNKRVQ---------SYRD 150 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 -----RPR-GSRSAALQLQ-------GRVG---GYGEYWRQLKTICVVQLLSNKRVQ---------SFRS 157 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 -----RPY-MTYPARITYN------LKDLVFS-PYDKYWRQVRKLTVVELYTAKRVQ---------SFRH 144 16 ---------------------------------------------------------------------- 0 17 -----RPK-TVGSGKLSYG------FKDITFA-PYGEYWREVRKLAVIELFSSKKVQ---------SFRY 145 18 ---------------------------------------------------------------------- 0 19 -----RPP-PPIEESLILG------SSSFINT-PYGDYSKFMKEFMGQKLLGPQ-LQ---------RSRN 130 20 --RDSGQT-PIMEKSLLFG------SFGFVSV-PYGDTWRFMKKLLVKKLLGAHSLE---------QTRV 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 ---------------------------------------------------------------------- 0 25 -----RPE-TVGTRAISYN------FK-SGFA-PCG---------------------------------- 116 26 --------------------------------------WKARRKFALREVF-LKK-Q---------SFRH 21 27 -----HDL-PEVGKINTYG------GEDDILWSPYGTHWRRLRKLCVMKMFTTPT-E--------ASYST 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 0 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 -----RPK-TAAGKYTTYN------YSDITWS-PYGPYWRQARRMCLTELFSTKCLD---------SYEY 0 34 -----RPP-HRGHEFISYG------RRDMALN-HYTPYYREIRKMGMNHLFSPTRVA---------TFKH 144 35 -----GYP-QSMIDILGKC---------NIAA-VNGSAHKYMRGALLSLISPTMIRD---------QLLP 144 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 -----WPK-ATVALVGPRS---------FVAM-PYD-EHRRIRKLTAAPINGFDALT---------GYLP 161 40 ---------------------------------------------------------------------- 0 41 -----SYP-ASICNLLGKH---------SLLL-MKGSLHKRMHSLTMSFANSSIIKD---------HLML 147 42 ---------------------------------------------------------------------- 0 43 -----RPR-NPVADIIRYN------STDVAFA-PYGVYWRTARKVVNTHLLSAKMVF---------SKRR 172 44 -----RPP-WMAAEIIRYG------PSDVAFV-PYGEYGRQGRKLLTTHMLSTKKVQ---------SFRH 175 45 -----RPP-SMAAEIIRYG------PSDVAFV-PYGEYWRQGRKLLTTHMLSTKKVQ---------SFRH 48 46 -----RPW-SMASHILRYN------TCDVAFS-PLGEYWQQTRKLMNTHLLSNKKVY---------SFRH 172 47 -----RPR-SLVSDIIMYG------ATDSCFA-PYGDHFRKARKLVTVHLLNASKVR---------SQRP 183 48 ----------------------------------YGEHWRQARKLVTAHLFTVKRVH---------SYRR 28 49 -----RPI-VDVNLAHNYY------KGSMALA-PYGNYWRFSRRICTVEMFVHKRIN---------ETTN 106 50 -----RVI-PDVNQAHSYY------QGSLAIA-PYGPFWRFQRRICTIEMFVHKKIS---------ETEP 149 51 ---------------------------------------------------------------------- 0 52 ---------------------------------------------------------------------- 0 53 -----RPP-NAGATHMAYN------AQDMVFA-PYGPRWKLLRKLSNLHMLGGKALE---------NWAN 150 54 -----RPP-NAGATHLAYN------AQDMVFA-HYGPRWKLLRKLSNLHMLGGKALE---------NWAN 147 55 -----RPP-NAGATHLAYG------AQDMVFA-HYGPRWKLLRKLSNLHMLGGKALE---------NWAN 147 56 ---------------------------------------------------------------------- 0 57 -----KGP-MWRAAFHDLL------GQG-IFN-SDGDTWLMQRKTAALEFTTRTLRQ---------AMAR 152 58 -----KGP-TWQAVFHDFL------GQG-IFN-SDGDTWLFQRKTAALEFTTRTLRQ---------AMGR 23 59 -----------------------------------------------LEFTTRTLRQ---------AMGR 0 60 -----KGP-TWE-VFHDFF------GQ----N-S------------------------------------ 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 -----KE--SFYK---DLL------EDG-IFN-ADDESWKRQRRISSYE--------------------- 0 64 ---------------------------------------------------------------------- 0 65 -----RPV-KRSARELMF-------ARAIGFA-PNGEYWRRLRRVASTHLFSPRRVA---------SHEP 140 66 -----RPI-KESAYELLF-------NRAMGFA-PFGDYWRNLRRISSTYLFSPRRVS---------SFEK 77 67 ---------------------------------------------------------------------- 0 68 -----RTR-NVVFDIFTCK------CQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 69 -----RTR-NVVFDIFTGE------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRH 148 70 -----RTR-NVVFDIFTGK------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 71 -----RTR-NVVFDIFTGK------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 72 -----RTR-NVVFDIFTGK------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QNRE 148 73 -----RTR-NVVFDIFTGK------GQDIVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRF 146 74 ---------------------------------------------------------------------- 0 75 -----RTP-TNSIRSINHD------KVSVVWLPPSSSRWRLLRKLSATQLFSPQRIE---------ATKT 23 76 ---------------------------------------------------------------------- 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 ------------GKYVAYD------YNSMVTA-PYGDHWRNLRRIT-LEVFSTIDST---------LHGK 0 81 ---------------------------------------------------------------------- 0 82 -----RPK-FTISKHLGYN------ATYLLSA-SY-DHW------------------------------- 0 83 -----RPW-FLTAKYI-YN--------------------------------------------------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 ---------------------------------------------------------------------- 0 88 ---------------------------------------------------------------------- 0 89 -----RPR-ENPTRTIFSC------NKFSVNAAVYGPVWRSLRRNMVQNMLSPSRLK---------EFRE 145 90 -----RPR-ENPTRTVFSC------DKFTVNAAVYGPVWRSLRKNMVQNGLSSIRLK---------EFRA 161 91 ---------------------------------------------------------------------- 0 92 ---------------------------------------------------------------------- 0 93 -----RSL-ALPTTKVITS------NQHDIH-SVYGSLWRTLRRNLTSEILQPSRVK---------AH-P 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 -----RPL-TFASETFSGG------YRNAVLS-PYGDQWKKMRRVLTSEIICCPSRH---------AWLH 185 98 -----RQP-LPCFRIKPHI------DYSILWS-DSNSYWKKGRKILHTEIFSQKMLQ---------AQEK 147 99 -----RPK-PVAVELMSYN------QAFIGWA-PYGEYWRQLRKIVTLEILSNRRIE---------LLSH 151 100 -----FDV-HNPLVKFL--------LTGVGSF--EGAKWSKHRRIISPAFTLEKLKS-----------ML 173 101 -------H-TFPLGRLI--------AAGLVSY--DGDKWTKHRRIINPAFHLE-IKN-----------MV 84 102 ------------------------------------------------AFHLEKIKN-----------MV 0 103 -------H-TFPLGRLNS-------GLGLVS---DGDKWPNTR-IINPAF-------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------RPEVFILF--------GKGLSFI--QGDDWIRHRRILNPAFSM-RLKA-----------MT 0 107 -----FDM-SKVEKKDL--------FTGTYM---PSTELTGGYRILSYLDPSEPNHT-----------KL 149 108 -----FDV-SKVEKKDL--------FTGTYM---PSTKLTGAYRVLSYLDPSEPRHA-----------QL 122 109 -----FDM--LVDKK------------------------------------------------------- 114 110 -----FDM-EIVEKANV--------LVGDFM---PSVVYTGDMRVCAYLDTSEPKHT-----------QI 0 111 -----QEV-Y-QFNVPTF-------GPGVVFDV-DYSVRQEQFRFFTEGLRS-----------NKLK-YV 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 IREEEVGLMMERISQS-CSTGEA-------VNLSELLLLLSSGTITRVAF-------GKKYEGEEERKNK 200 2 VRAEETANMIGKIRQG-CDSSV--------INLGEHLCSLTNNIISRVAL-------GRTYDEKESGIEH 205 3 ---------------------------------------------------------------------- 0 4 AREEETSNMIEKLKQM-SNSSSSA------TDLRDLFCWLAYNIINRVAL-------GKKYNDE---IDA 192 5 VREEETANMIEKIRQG-CDASV--------INLGEHLCFLTNNITSRVAL-------GRTYDERESGIDA 204 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 VREEETELLMKKIGDS-SGN----------VNLSHMFTQLTNDVVCRSAI-------GRKYGAGDENGEK 209 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 IREEEVASFVRFNKQA-ASSEET-------VNLSQKILKMSGSVICRIGF-------GINL-EGSKLENT 198 16 ---------------------------------------------------------------------- 0 17 IREEEVDFVVKKVSESALKQSP--------VDLSKTFFSLTASIICRVAL----GQNFNESGFVIDQDRI 203 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 ---------------------------------------------------------------------- 0 25 ---------------------------------------------------------------------- 116 26 IREEECNFLVKQLSESAVNRSP--------VDLSKSLFWLTASIFFRVAL----GQNFHESNF-IDKEK- 77 27 RREETRQT-IVHMSEMAREGSP--------VNL------------------------------------- 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 0 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 IRAEELHSLLHNLNKI-SGKP---------IVLKDYLTTLSLNVISRMVL-------GKRYLDESENSFV 0 34 VREEEARRMMDKINKA-ADKSEV-------VDISELMLTFTNSVVCRQAF-------GKKYNEDGEEMKR 199 35 KIDEFMRSHLTNWDNK-V------------IDIQEKTNKMAFLSSLKQIA-------GIESTSLA----- 189 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 FIDRTVTSSLRAWADH-GGS----------VEFLTELRRMTFKIIVQIFL-------GGADQA-TTRALE 212 40 ---------------------------------------------------------------------- 0 41 DIDRLVRFNLDSWSSR--------------VLLMEEAKKITFELTVKQLM-------SFDPGE-WSESLR 195 42 ---------------------------------------------------------------------- 0 43 EREEEVRLVVARIRDA-AEASPG-TA----LDMTELLGGYASDFVCRAVL-------GESHRK-QGRNKL 228 44 GRQEEVRLVMDKIRAA-ATAAPA--A----VDLSDLLSGYTNDVVSRAVL-------GASHRN-QGRNRL 230 45 GRQEEVRLVMDKIRAA-ATAAPA--A----VDLSDLLSGYTNDVVCRAVL-------GASHRN-QGRNRL 103 46 GREEEVCLVVDNLREA-AAKSPS-TA----VDMSEVLAAYTNDVVSRSVL-------GSTHRK-KGRNTL 228 47 AREEEVRGALDRVRRA-AAAREP-------VDMSELLHSFVNNLVCRAVS-------GKFSME-EGRNRL 237 48 ARKEEVRLVVAKVREA-AVAGTA-------TDMSLAMNTFANDIISRAVS-------GKFFRA-EGRNKL 82 49 IRQESVDKMLRLDEEKASSSGGGGEG----IEVTRYMFLASFNMVGNMIF------SKDLTDPESKQGSE 166 50 VRRKCVDNMLKWIEKEANSAEK-GSG----IEVTRFVFLASFNMLGNLIL------SKDLADLESEEASE 208 51 ---------------------------------------------------------------------- 0 52 ---------------------------------------------------------------------- 0 53 VRANELGHMLKSMFDA-SHVGER-------IVVADMLTFAMANMIGQVML------SKRVFVEKGKEVNE 206 54 VRANELGHMLKSMSDM-SREGQR-------VVVAEMLTFAMANMIGQVML------SKRVFVDKGVEVNE 203 55 VRANELGHMLKSMFDM-SREGER-------VVVAEMLTFAMANMIGQVIL------SKRVFVNKGVEVNE 203 56 ---------------------------------------------------------------------- 0 57 WVNGTIKNRLWLILDRAVQNNKP-------VDLQDLFLRLTFDNICGLTF-------GKDP--ETLSLDL 206 58 WVNRGIKLRFCPILETAQNNYEP-------VDLQDLILRLTFDNICGLAF-------GK----------- 68 59 WVNNGIKLRFCPILESAQAKAEP-------IDLQDLILRLTFDNICGLAF-------GKDTKTCAPGLPE 68 60 ---------------------------------------------------------------------- 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ---------------------------------------------------------------------- 0 65 GRQGDAEAMLRSIAAE-QSASGA-------VALRPHLQAAALNNIMGSVF-------GTRYDVTSGAGAA 195 66 QRSEIGEGMVRDMKRM-MERNGV-------VEVRRMLHYGSLNNIMLTVF-------GKKFD-FAKD--- 128 67 ---------------------------------------------------------------------- 0 68 GWEAEAAAVVDDVKKNPAAATEG-------IVIRRRLQLMMYNNMFRIMF-------DRRF--ESEDDPL 202 69 GWEAEAAAVVDDVRKNPDAAVSG-------LVIRRRLQLMMYNNMYRIMF-------DRRF--ESEEDPL 202 70 GWESEAESVVNDVKNNAEASVGG-------IVIRKRLQLMMYNIMYRIMF-------DRRF--ESEEDPL 202 71 GWEEEAARVVEDVKKNPESATNG-------IVLRRRLQLMMYNNMYRIMF-------DRRF--ESEDDPL 202 72 GWEFEAASVVEDVKKNPDSATKG-------IVLRKRLQLMMYTNMFRIMF-------DRRF--ESEDDPL 202 73 GWESEAASVVDDVKKNSKASVNG-------IVIRRRLQLMMYNIMYRIMF-------DRRF--ESEEDPL 200 74 ---------------------------------------------------------------------- 0 75 LRENKVLELVSFMSES-SEREEA-------VDISRATFITALNIISNILF--------VDL--GNY---- 61 76 ---------------------------------------------------------------------- 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 IRHDELKMLLQKLHDL-SVERPAK------VELRQLLTGLTLNVIMRMMT-------GKRFFEEDDGGKA 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------- 0 83 ---------------------------------------------------------------------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 ---------YKTLLDK-AMKKQT-------VEIRNEAMKLTNNTICKMIM-------GRSCSEENGEAET 46 88 ---------------------------------------------------------------------- 0 89 FREIAMDKLIERIRVD-AKENND-------VVWALKNARFAVFYILVAMC------FGVEMDNEEMIERV 201 90 VRKSAMDKMIEKIRAE-ADANEG-------VVWVLKNARFAVFCILLAMC------FGVEM-DEKTIEKI 216 91 IRSWAMQNHMKRIKTE-NVEKGF-------VE-VMSQCRLTICSILICLC------FGAKI-SEEKIKNI 0 92 ---------------------------------------------------------------------- 0 93 SRKWSLEILVDLFETE-QR----------------IILRHAMFYLLALM-------FGEK---------- 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 DKRTDEADNLTRYVYNLATKAAT-GD--VAVDVRHVARHYCGNVIRRLMF-------NRRY--FGEPQAD 243 98 NRERVAGNLVNFIMTK-VGDV---------VELRSWLFGCALNVLGHVVF------SKDVFEYSDQSDEV 201 99 IRVSEVQTSIKELVNV-WSNQIS-SQ---YGLLDDTKSSSTNDEPSTTDY-------VVPELKKWFAQLT 209 100 PAFAICYHDMLTKWEKI-AEKQGSHE----VDIFPTFDVLTSDVISKVAFG------STYEEGGKIF-RL 231 101 PAFHQSCREVVGEWDQLVSDKGSSCE----VDVWPGLVSMTADVISRT-FG------SSYKEGQRIF-EL 84 102 PAFHQSCSEIVGEWDKLVTDKQSSCE----VDIWPWLVSMTADVISRT-FG------SSYKEGQRIF-EL 84 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 KQLLFNLIKNRRDYVIP-------------EFSSSFTDLCEVVEYDLATKG------KAAFNDPAEQAAF 200 108 KNLLFFMLKNSSNRVIP-------------QFETTYYELFEGLEAELAKNG------KAAFNDVGEQAAF 173 109 ---------------------------------------------------------------------- 114 110 KNFSLDILKRSSKTWVP-------------TLVKELDTLFGTFESDLSKSK------SASLLPALQKFLF 0 111 ---------------------------------------------------------------------- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 FADLATELTTLM----------GAFFVGDYFPSFAWVD-VLT-------GM------------------- 233 2 ---IIEQFVELL----------GIFNVGDYIPRLEWVN-KFT-------GL------------------- 235 3 ---------------------------------------------------------------------- 0 4 -KATLDKFVELL----------GTFNVGDYIPCLEWVN-KIT-------GF------------------- 224 5 -KDILEQFLQLL----------DTFNVGDYIPWLKWVN-KIT-------GL------------------- 236 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 FLIELREFLELL----------GAISIGDFVPSLWWIN-RIN-------GF------------------- 242 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 YQEIIVQAFEVL----------GSLAAVDYFPVIGTIIDRIT-------GL------------------- 232 16 ---------------------------------------------------------------------- 0 17 EELVTE-SAEAL----------GTFTFSDFFPGGLGRF-VDW-----LFQR------------------- 237 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 ---------------------------------------------------------------------- 0 25 ---------------------------------------------------------------------- 116 26 EELVF-EAETAL----------ASFTC-DFFP-------------------------------------- 97 27 ---------------------------------------------------------------------- 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 0 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 NPEEFKK------MLDELFLLNGVLNIGDSIPWIDFMDLQ---------GY------------------- 0 34 FIKILYGTQSVL----------GKIFFSDFFPYCGFLDDLS--------GL------------------- 232 35 QEFMSEFFNLVL----------GTLSLPINLPNTNYHR-----------GF------------------- 219 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 RSYTELNYGMRA----------MAINLPGFAYRGALRARRRLVAVLQ--GV------------------- 251 40 ---------------------------------------------------------------------- 0 41 KEYLLVIEGFFS----------LPLPLFSTTYRKAIQARRKVAEALT--VV------------------- 234 42 ---------------------------------------------------------------------- 0 43 FRELTETSAALL----------GGFNVEDYFP-KLADVDLFLRII------------------------- 262 44 FSELTEINVSLL----------AGFNLEDYFPPNMAMADVLLRLV------------------------- 265 45 FS--ELTEINVSLL--------GGFNLEDYFPPNMAMADVLLRLV------------------------- 138 46 FREMTMTNVDLL----------VGFNLEYYIP-RWPLTDLLFRLV------------------------- 262 47 FRELTDINAGLL----------GGFHIQDYFP-RLGRIELVRKVA------------------------- 271 48 FR--ELVEANSALF--------GGFNPGDYFP-GLARALGFLSRRLLFLRS------------------- 122 49 FFNAMIGIMEWA----------GVPNISDIFPCLKMFD-VQ--------GL------------------- 198 50 FFIAMKRINEWS----------GIANVSDIFPFLKKFD-LQ--------SL------------------- 240 51 ---------------------------------------------------------------------- 0 52 -------FLDAV----------GLSPVGEY-PSLAWIG-KIT-------GS------------------- 0 53 FKNMVVELMTVA----------GYFNIGDFIPQIAWMD-LQ--------GI------------------- 238 54 FKDMVVELMTIA----------GYFNIGDFIPCLAWMD-LQ--------GI------------------- 235 55 FKDMVVELMTTA----------GYFNIGDFIPCLAWMD-LQ--------GI------------------- 235 56 ---------------------------------------------------------------------- 0 57 PDNPFSVAFDTA----------TEATLKRLLYTGFLWR-IQ--------KLW------------------ 239 58 ---------------------------------------------------------------------- 68 59 --NSFATAFDRA----------TEASLQRFILPEFMWK-LK--------KWL------------------ 0 60 ---------------------------------------------------------------------- 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ---------------------------------------------------------------------- 0 65 EAEHLKSMVREGFELL------GAFNWSDHLPWLAHLY-DP--------SN------------------- 231 66 EGLELELILKEGYELL------GIFNWGDHLPLLGWLD-LQ--------GV------------------- 164 67 --------------------------------FLRWFD-FQ--------GV------------------- 0 68 FLKLKALNCERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 69 FQRLKALNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 70 FVKLKALNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 71 FVKLKALNGERS-----RLAQGFEYNYGDFIPILRPFL-------------------------------- 235 72 FLRLKALNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 73 FVKLKRLNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 233 74 ---------------------------------------------------------------------- 0 75 ---------------------------------------------------------------------- 61 76 ---------------------------------------------------------------------- 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 ---------------------------------------------------------------------- 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------- 0 83 ---------------------------------------------------------------------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 VRGLVTESIFLT----------KKHFLGAMFHKPLKKL-GI--------SL------------------- 78 88 ---------------------------------------------------------------------- 0 89 --DQMMKDVLIV----------LDPRIDDFLPILRLFV-GY--------KQ------------------- 231 90 --DQMMKSVLIA----------LDPRLDDYLPILSPFF-S---------KQ------------------- 245 91 --ENVLKDVMLI----------TSPTLPDFLPVFTPLF-S------------------------------ 0 92 ---------------------------------------------------------------------- 0 93 ---------------------------------------------------------------------- 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 GGPGPMEVLHMD-AVFTSLGLLYAFCVSDYLPWLRGLD-LD--------GHEK----------------- 286 98 GM--DKLIHGMLMT-------GGDFDVASYFPVLARFD-LH--------GL------------------- 234 99 FL--ENIRDFMRLI--------GTFTVGDGVPFLKWLDLGGHEK-------------------------- 243 100 LKELMDLTIDCM----------RDVYIPGWSYLPTKRN-KRM----KEIN-------------------- 266 101 QAELAQLIIQAF----------RKAFIPGYSYLPTKSN-RR-----KAKA-------------------- 84 102 QAELAQLIIQAF----------RKAIIPGYRYFPTKGN-RR-----IEKA-------------------- 84 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 NFLSRAFFGVKPIDT-------PLGKDAPSLISKWVLF-NLA----PILS-------------------- 238 108 RFLGRAYFNSNPEET-------KLGTSAPTLISSWVLF-NLA----PTLD-------------------- 211 109 ---AR-F-GTNPA-T-------KLKADAPGLITKW--F-NLH----PLLS-------------------- 114 110 NFFSLTFLGADPSAS------PEIANSGFAYLDAWLAI-QLA----PTVS-------------------- 0 111 ---------------------------------------------------------------------- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 --DARLKRNHGELDAFVDHVIDDHLLSRKANGSDG---VEQKDLVDVLLHLQKDS-SLGVH---LNRNNL 294 2 --DAKVKKVAKELDMFLEIVIEEHIIRKKKEEYTS--TGEAKDFVDVLLEIQNGNETDFP----LQRDSL 297 3 ---------------------------------------------------------------------- 0 4 --DSKVDKVAKDLDTFLEFVIEAHMIRNEKEENNR--AGESKDLVDVLLEIQNGKETGFP----IQRDSL 286 5 --DTKVEKIAKKLDTFLDSVIEEHIIRNKKEEYAI--TDEAKDFVDVLLEIQNGKETDFP----LQRDSL 298 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------------------------------------------------------- 0 11 --DRRVDRIAKEMDEFLEKVIHERLENPAAKAEEN--------FVDILLEIYRNN-SAGVS---IDRDSI 298 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 --HAKCEKVFHGIDSFFDQAIQRHI-------DDP---SIKDDIIDLLLKMERGEGSLGEYE--LTREHT 288 16 --------------------------------------------------------------------NT 0 17 --HKKINKVFKELDAFYQHVIDDHLKPEGRKNQDI--VTLILDMIDKQEDSDSFK----------NMDNL 294 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 -------------------TFFQNILDDHLKPGRESS----DIIDVMIDMMKKQEKEGDSFK--FTTDHL 0 25 ---------------------------------------------------------------------- 116 26 ---------------------------------------------------------------------- 97 27 ---------------------------------------------------------------------- 0 28 ---------------------------------------------------------------------- 0 29 ----------------------------------------------------EDSSLE------LTIDHI 12 30 ----------------------------------------IDSMLDVIHKQGEDSSLE------LTIDHI 0 31 -----------------------------------------------------------------TIDVY 0 32 -------------------------------------------------------TLK-QYD--LSEDTI 0 33 --VKRMKVVSKKFDKFLEHVIDEHNIRR-NGVENY----VAKDMEDVLLQLADDPKLEVK----LERHGV 0 34 --TAYMKECFERQDTYYIQEVVNET-------LDP---KRVKPETESMIDLLMGIYTEQPFASEFTVDNV 290 35 --QARKIIVNLLRTLIEERRASKEIQHDMLGYLMN--EEATRFK--------------------LTDDEM 265 36 ---------------------------------------------------------------------- 0 37 ---------------------------------------------------------------------- 0 38 ---------------------------------------------------------------------- 0 39 --LDERRAARAKGVSGGGVDMMDRLIEAQDERGRH-----------------------------LDDDEI 290 40 ---------------------------------------------------------------------- 0 41 --VMKRREEEEEGAERKKDMLAALLAADDG----------------------------------FSDEEI 268 42 ---------------------------------------------------------------------- 0 43 --CAKAKSVSKRWDSLFNELLSEYALSGGKQGD-----HNSEDFVHLLLSLQKDYG--------LTTDNI 317 44 --SVKARRLNQRWNDVFDELIQEHVQSRPSGES----EESEADFIHVLLSIQQEYG--------LTTDNL 321 45 --SVKARRLTQRWSDVFAELIQEHVQSRPSAES----EESETDFIHVLLSIHQECG--------LTPDNL 194 46 --CWKVTRHLKRWDALLEEVIHEHVEMRKLSGD---KEKESDDFIDIFLSRYEEYG--------FTMDNV 319 47 --CAKTRRVRKRWDDLLDKLIDDHAARMATHQD----EDDDKDFIYVLLSLQKEYG--------LTRDHI 327 48 --RRRVQETHRRWDELLETILSDHEGRRGSVSV-----DGGGDFTDVLLSVQTEYG--------MTRDHL 177 49 --RKKMERDMGKGKEIT-KKFIEERIEERKKGEKN---RSIKDLLDVLIDFEGSGKDEPDK---LSEDEI 259 50 --RKKMARDMGKAVEIM-SMFLKEREEERKKGTEK-----GKDFLDVLLEFQGTGKDEPAK---LSEHEI 299 51 ---------------------------------------------------------------------- 0 52 ---GKLEKITKQFGDFIEKVLQ-HEDTT-DKETP--------DFFDMLLTIQRDETAQCQ----LDKSDL 0 53 --EKGMKKLHKKFDDLLTKMFEEHEATSNERKGKP-------DFLDFIMA-NRDNSEGER----LSITNI 294 54 --EKRMKRLHKKFDALLTKMFDEHKATTYERKGKP-------DFLDVVME-NGDNSEGER----LSTTNI 291 55 --EKGMKRLHKKFDALLTKMFDEHKATSYERKGKP-------DFLDCVME-NRDNSEGER----LSTTNI 291 56 ----------------------------------------------------------------LTDTEI 6 57 --DWIRDKLKKSLEVVETYMNDAIDARKNSPSDDP-----FVTFLEETLNVNGNV---------LPTDVL 293 58 ---------------------------------------------------------------------- 68 59 --DW------------------------------------------------------------------ 0 60 ---------------------------------------------------------------------- 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ---------------------------------------------------------------------- 0 65 --VTRRCAALPRVQTFVRGVIDEHRRRRQ-NSAAL---NDNADFVDVLLSLEGDEK--------LGDDDM 287 66 --RRRCRTLVAKVNVFVKKIIDEHKRRANGVGIDE---GEGEDFVDVLLGLEEKDR--------LSESDM 221 67 --RKRCRALVSEVNTFVGGIIEKHKMKKGNNLN-----GEEN-FVDVLLGLQKDEK--------LSDS-M 0 68 --RNYLKLCKEVKDKRIQLFKDYFVDERKKIGSTK---KMDNNQLKCAIDHILEAKEKGE----INEDNV 296 69 --KGYLKICKEVKETRLKLFKDYFVDERKNIGSTK---STNNEGLKCAIDHILDAEKKGE----INEDNV 296 70 --KGYLKVCKEVKDRRLQLFKDYFVDERKKLESTK--STTSNDGLKCAIDHILDAQKKGE----INDDNV 297 71 --RGYLRICKEVKERRLQLFKDYFVDERKKFGSTK---SMDNNSLKCAIDHILEAQQKGE----INEDNV 296 72 --RGYLKICQDVKDRRIALFKKYFVDERKQIASSK---PTGSEGLKCAIDHILEAEQKGE----INEDNV 296 73 --KGYLKVCKEVKDRRLQLFKDYFVDERKKLGSTK--STY-NEGLKCAIDHILDAQKKGE----INDDNV 294 74 ---------------------------------------------------------------------- 0 75 ---------------------------------------------------------------------- 61 76 ----------------------------------------------------------------LNINDI 0 77 ---------------------------------------------------------------------- 0 78 ---------------------------------------------------------------------- 0 79 ---------------------------------------------------------------------- 0 80 ---------------------------------------------------------------------- 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------I 0 83 ---------------------------------------------------------------------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------SRVVGAYGDENAEYK----ITKNHI 0 86 ------------------------SEEKPDNEH------QDTDMIDALLAAYRDEKAEYK----ITRNQI 0 87 --FAKELMNVSNRFDELLEKILVEHEEKLQEHH------QTSDMLDMLLEAYGDENAEYK----ITR-QI 135 88 ---------------------------------------------------------------------- 0 89 --RKRVNEVRKRQIETL-VPLIEKRRSVVQN-PGSD--KTAASFSYLDTLFDVKVEGRKSG---PTNAEL 292 90 --RKHAMDVRKQQIKTI-VPFIEQRKKKILESPEID--KTAASFSYLDTLFDLKIEGRNST---PTYPEL 307 91 ---------------------------------------------------------------------- 0 92 ---------------------------------------------------------------------- 0 93 ---------------------------------------------------------------------- 0 94 ---------------------------------------------------------------------- 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 --IVKEANVAVNRLHDTVIDDRWRQWKSGERQEME-------DFLDVLIT-LKDAQGNPL----LTIEEV 342 98 --KRKMDEQFKLLIKIWEGEVLARRANRNPEP---------KDMLDVLIAND------------FNEHQI 281 99 ----EMKKCAKKFDVMLNEWLEEHREKKKGLGSEDK--VVPERDFMDRMLLVLKDKPIEG----FDVDTI 303 100 --KEITDMLRFIINKRMKALKAGEPGEDDLLGVL----LES-NIQEIQK--QGNKKDGG-----MSINDV 322 101 --REIQVILRGIVNKRLRAREAGEAPNDDLLGIL----LES-NLGQTKG--NG-----------MSTEDL 84 102 ---------------------------------------------------------------------- 0 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 --VGLPKEVEEATLHSVRLPPLLVQNDYHRLYEF----FTS-AAGSVLD--EAEQSGIS---RDEACHNI 296 108 --LGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDY----FQS-VATPVME--QAEKLGVP---KDEAVHNI 269 109 --IGLPRVIEEPLIHTFSLPPALVKS-YQRLYEF------E-SAGEILV--EADKLGIS---REEATHNL 114 110 --IGVLQPLEEIFVHSFSYPYFLVRGGYEKLIKF----VKS-EAKEVLT--RAQTDFQ--LTEQEAIHNL 0 111 ---------------------------------------------------------------------- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 ---------------------------------------------------------------------- 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 KAVILDMFSGGTDTTAVTLEWAMAELIKH-PDVMEKAQQEVRRVVG----KKA-------KVEEEDLHQL 352 2 KAILLDSFAAGTDTTFATLDWTMAELLRQ-PRALKTLQDEVRGLQG----KSE--------ITEDDLKNM 354 3 ---------------------------------------------------------------------- 0 4 KALLLDPFSAGTDTIYTVLEWTMTELLRH-PRAMEKLQNEVQGLAQ----EKA-------EITEDDLPNM 344 5 KAILLDAFAAGTDTIYTNLDWTMADVLRQ-PRAMKTLQNEVRGLAQ----GKS-------EITEDDLKNM 356 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---------------------TMTELIRS-PKSMKKLQDEIRSTIR----PHG------SYIKEKEVENM 0 11 KAIILDVFAAGTDTTAVVLEWAMTELLRH-PEIMKKLQSEVRQVVK----DKH-------NITDDDIEKM 356 12 ---------------------------------------------------------------------- 0 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 KGILMNILTAGIDTSAQTMTWAMTHLLAN-PRVMKKLQAEIREKIK----NID-------EITDDDVEQL 346 16 KGILFNILNAGIDTSAQVMTWVMTYLISN-PRVMKKAQAEVREVIK----NKD-------DIIEEDIERL 0 17 KAIVMDVFLAGIDTSAVTMIWAMTELIRN-PRVMKKAQGSIRTTLG---LKKE-------RITVEDLGKV 353 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 ---------------------------------------------------------------------- 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 KGMISDIFLAGVGTSSTTLIWAMTELIRN-PRVMKKVQDEIRT-LG----DKK------ER-TEEDL-QL 0 25 ---------------------------------------------------------------------- 116 26 ---------------------------------------------------------------------- 97 27 ---------------------------------------------------------------------- 0 28 KGILTNIF-GGIDTGALTMIWAMTELARN-PEVMKKVQGEIRDRLRR---NKE-------RITEEDNNKV 0 29 KGFLANIFLAGIDTGALTMIWAMTELVKN-PKLIKKVQGEIREQLG---SNKA-------RITEEDIDKV 71 30 KGFLANIFLAGIDTGAITMIWAVTELVKN-PKLIKKVQGDIREQLG---SNKE-------RITEEDIEKV 71 31 YMLLQDVLLAGMDTSAITMTWAMAELAKN-PRVMKKVQSEIRSQIK----NKE-------RISFDDTDKL 0 32 IGLLWD-ITAGMDTTAITAEWAMAE-IKN-PRVQQKVQEEFDR-VG----LDR-------FLTEAD-SRL 0 33 KAFTQDMLAGGTESSAVTVEWAISELSKK-PEIFKKATEELDRVIG----QNR-------WVQEKDIPNL 0 34 KAVILDIVVAGTDTAAAAVVWGMTYLMKY-PQVLKKAQAEVREYMK----EKGST-----FVTEDDVKNL 350 35 IDLIITILYSGYETVSTTSMMAVKYLHDH-PKVLEELRKEHMAIRE----KKKPED----PIDYNDYRSM 326 36 -DQVVTI-YSGYET-STTSMMALKYLHDH-PKALQELRAEHLAFRE----RKRQDE----PLGLEDVKSM 0 37 -------------------------------------K-EH-AILQ----NRNGKGA---GVSWEEYRH- 0 38 --------------------------------------------LR----NREDADS---GLTWEEYKSM 0 39 IDVLVMYLNAGHESSGHITMWATVFLQEN-PDMFARAKAEQEAIMR----SIPSSQR---GLTLRDFRKM 352 40 --------------------------------------------------------------------KM 0 41 VDFLVALLVAGYETTSTIMTLAVKFLTET-PLALAQLKEEHEKIRA----MKSDSY----SLEWSDYKSM 329 42 ---------------------------------------------------------------------- 0 43 KGILVNMFEAAIETSFLVLEYSMSELMNN-RHVLAKLQKEVRT--ATPDGR---------MVMEEDLSRM 375 44 KAILVDMFEAGIETSYLTLEYGMAELINN-RHVMEKLQTEVRTTMGSPDGKKLD------MLAEEDLGSM 384 45 KAILVDMFEAGIETSYLTLEYGMAELINN-RHVMEKLQTEVRTTMRSPDGKKLD------MLAEEDLGSM 257 46 KSLLMNVFEAAIETSYLVLESAMAELMNH-RRVMKKLQAEVRAYGA---EKKLD------MIREDDLSSL 379 47 KAILIDMFEAGTDTSYMTLEFAMTELIRK-PHLMKKLQEEVRRNVPAGQE----------MVTEDNLPGM 386 48 KAILVDMFGAGTDTSSLVLELAMAELMRN-PQQMAKLQAQVRRHTPEGQE----------TVEEENLSDM 236 49 TVIILEMFLAGTETTSSSVEWALTELLRH-PQAMAKVKLEILQVIG----PNK-------KFEECDIDSL 317 50 KIFVLEMFLAGTETTSSSVEWALTELLRH-PEAMAKVKTEISQAIE----PNR-------KFEDSDIENL 357 51 ---------------------------------------------------------------------- 0 52 KVIIFEMFLG-TATTSAVIEWAMTRLM-N-PE-------------------------------------- 0 53 KALLLNLFTAGTDTSSSVIEWALTEMMKN-PTIFKKAQQEMDQIIG----KNR-------RFIESDIPNL 352 54 KALLLNLFTAGTDTSSSAIEWALAEMMKN-PAILKKAQAEMDQVIG----RNR-------RLLESDIPNL 349 55 KALLLNLFTAGTDTSSSAIEWALAEMMKN-PAILKKAQGEMDQVIG----NNR-------RLLESDIPNL 349 56 KALLLNMFTAGTDTSASTVDWAIAELIRH-PEIMRKAQEELDSVVG----RGR-------PINESDLSQL 64 57 QRIALNFVLAGRDTSSVALSWFFWLVMNN-REVETKIVNELSMVLKETRGNDQEKWTEE-PLEFDEADRL 361 58 ---------------------------------------------------------------------- 68 59 ---------------------------------------------------------------------- 68 60 ---------------------------------------------------------------------- 0 61 ---------------------------------------------------------------------- 0 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 RDMVISFIMAGRDTTSAAMTWLFWLLTEN-DDVERKILEEVDPLVSL-------------GLGFEDLKEM 0 65 VAILWEMVFRGTDTTALLTEWCMAELVRH-PAVQARVRAEVDAAVG----AGG-------CPTDADVARM 345 66 VAVLWEMIFRGTDTVAILLEWTLARMVLH-PDIQSKAQVEIDSVVD----SSR-------PVLDSDIQRL 279 67 IAVLWE-IFRGTDTVAILVEWVLAR-VLH-QDIQDKLYREIASATS---N-IR-------SLSDSDIPKL 0 68 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQAKLRHELDTKLG----PGV-------QITEPDVQNL 354 69 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQQKVRDEIDRVLG----VGH-------QVTEPDIQKL 354 70 LYIVENINVAAIETTLWSIEWGIAELVNH-QDIQNKVREEMDRVLG----PGH-------QVTEPDLHKL 355 71 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQKKLRDELETVLG----PGV-------QITEPDTYKL 354 72 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQSKLGNELDTVLG----PGV-------QVTEPDLHKL 354 73 LYIVENINVAAIETTLWSIEWGIAELVNH-QEIQNKLREEMDKVLG----PGH-------QVTEPDLEKL 352 74 ---------------------------------------------------------------------- 0 75 ---------------------------------------------------------------------- 61 76 VHLLLDLFGAGTDTNSSTVEWAMAELLRN-PETMVKAQAEIDCVIG----QKG-------VVEESDISTL 0 77 ---------------------------------------------------------------------- 0 78 ----------------------------------------------------Q-------LMDESDISNL 0 79 KGLMLSMMLAGTDTAAVTLEWAMANLLKK-PEVLKKAKAEIDEKIG----EER-------LVDEPDIANL 0 80 ---------------------------------------------------------------------- 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------- 0 83 ---------------------------------------------------------------------- 0 84 KSL-VELILGGTDTSAQTIEWTMA-IIKK-PNIL-RLRKEIDSFVG----KT--------LIQEKDLP-L 0 85 KAFFVDLFIGATDTS-QTIQWTMAEIMNN-THILERMREEIDSFVG----KSR-------LIQETDLPNL 0 86 KAFLVDIFIAGTDISALTTQGTMAEIINN-PNIFVRIREEIDSVVG----KSR-------LIQETDLPKL 0 87 KSLFVDLFSAGT-ASANTIQWTMAEIIKN-PKIC-RLREEI-S-VG----KT--------FVQETDLPN- 146 88 ------------------IEWGIAQLIVN-PEIQSRLYD-IKSTVG-----DR-------EVEEKDVDKM 0 89 VTLCSEFLNGGTDTTATALEWGIGRLMEN-PTIQNQLYQEIKTIVG-----DK-------KVDENDIEKM 349 90 VTLCSEFLNGGTDTTATAIEWAIGRLIEN-PNIQSQLYEEIKKTVG-----EN-------KIDEKDIEKM 364 91 ---------------------------------------------------------------------- 0 92 ---------------ATSMQWIMAIMVKY-PEIQRKVYEEMKSAFA----GEE---GEREEIREEDLGKL 0 93 ---------------------------------------------------------------------- 0 94 -----------T-TTATALQW-MANLVKN-PDIQKRLYEEIKS-VG-----EE-----ANKVEEEDAQKM 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 KAQSQDITFAAVDNPSNAVEWALAEMVNN-PEVMAKAMEELDRVVG----RER-------LVQESDIPKL 400 98 NAMFMETFGPGSDTNSNIIEWALAQLIKN-PDKLAKLREELDRVVG----RSS-------TVKESHFSEL 339 99 IKAHIELILGGSDTTAGTLTWAMCLLLKH-PHVLEKLKEELNTYIG----KER-------CVNESDINKL 361 100 IEECKLFYFAGQETTGVLLTWTTILLSKH-PEWQERAREEVLQAFG----KN--------KPEFERLNHL 379 101 MEECKLFYFVGQETTSVLLVWTMVLLSQH-QD-QARAREEVKQVF-----DK--------EPDAEGLNQL 84 102 ---------------------------------------------------------------------- 0 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 LFAVCFNSWGGFKILLPSLMKWIGRAGLE-LHTKLAQEIRSAIQST----GGG-------KVTMAAMEQM 354 108 LFAVCFNTFGGVKILFPNTLKWIGVAGEN-LHTQLAEEIRGAIKSY----GDG-------NVTLEAIEQM 327 109 LFATCLTRGGGMKIFFPN-VKRIG---------------------------------------------- 114 110 LFILGFNAFGGFTIFLPTLLGNLGDEKNA-EMQEKLRKEVREKVGT----NQE-------NLSFESVKEM 0 111 ---------------------------------------------------------------------- 0 112 ---------------------------------------------------------------------- 0 113 ---------------------------------------------------------------------- 0 114 -------VLGGVDTSVNAS-FAMAEIVSR-PEVLNKIRLELDQVVG----KDN-------IVEESHLPKL 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 HYLKLIIKETLRLHPVAPLLV--PRESTRDVVIRG--------YHIPAKTRVFINAWAIGRDPKS-WENA 411 2 QYLRAVIKESLRLHPTQSLLV--PRESMEDVNLLG-------YYHIPARTQAIINAWAIGRDPLS-WENP 414 3 ---------------------------------------------------------------------- 0 4 HYLKAVIKETLRLHPPIPLLL--P---------------------------------------------- 366 5 QYLRAVIKESLRLHPPNSLLV--PRESMEDVKLLG-------YYHIPARTQALINVWAIGRDPLS-WENP 416 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 KYLKAVIKEVLRLHPSLPMIL--PRLLSEDVKVKG--------YNIAAGTEVIINAWAIQRDTAI-WGPD 0 11 HYLKAVMKETMRFHTPIPLLV--PRVARNDVEVMG--------YDVPVGTMVMINAWAIGRDPTS-WDEP 415 12 HYLKMVINETWRLHPPAPLLV--PREVMSIFEING--------YTIPAKTRLYVNVWGIGRDPDT-WKDP 59 13 ---------------------------------------------------------------------- 0 14 ---------------------------------------------------------------------- 0 15 DYFKLVLKETFRISPIVPVLV--PRVAAKDLKIAG--------YDVPEKTWIHVNMWAVHMSPSI-WKDP 405 16 EYLKMVVKETFRVLPLVPLLI--PREASKDVKIGG--------YDIPKKTWIHVNIWAIHRNPNV-WKDP 0 17 EYLNHILKETFRLHPALPFVV--PRETMSHIKIQG--------YDIPPKTQIQLNVWTIGRDPKR-WNDP 412 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 --------------------------------------------YVPKNTTLVVNAYAVMGDPDS--EDP 0 22 ---------------------------------------------------------------------- 0 23 ---------------------------------------------------------------------- 0 24 HYF-LMVK-IFRLHP------------------------------------------------------- 0 25 ---------------------------------------------------------------------- 116 26 ---------------------------------------------------------------------- 97 27 ---------------------------------------------------------------------- 0 28 PYLNLVIKETFRLHYPVPLLL--PRETMAHIKVQG--------Y-IP-KRRVL-NVWA-G--PK--WKNP 0 29 PYLKMVVKETFRLHPAAPLIL--P-G-MAYIKVQG----------------------------------- 102 30 PYLKMVIKETFRLHPAAPLIL--PRGTMAHIKVQG--------YDIP-----LVNVSAIGRGPKL-L-NP 102 31 EYLKMVIKETWR---------------------------------------------------------- 0 32 PYLQ-VVKESFRLHPPTALML--PHRSNAD-KIGG--------YDIPKG--------------------- 0 33 PYIEAIVKETMRLHPVAPMKA---TECRENSKVAG--------YDVQKGTRVLVSVWTIGRDPTL-WDEP 0 34 PYFRALVKETLRIEPVIPLLI--PRACIQDTKIAG--------YDIPAGTTVNVNAWAVSRDEKE-WGPN 409 35 RFTRAVILETSRLATIVNGVL---RKTTQDMEING--------YIIPKGWRIYVYTRELNYDPRL-YPDP 384 36 KFTRAVIYETSRLATIVNGVL---RKTTRDLEING--------YLIPKGWRIYVYT-GINYGANL-Y-GP 0 37 -FTNMVIN-ALRMANMAPIMY---RKAVNDVEIKG--------YTIPAGWI-AVIPPAVH-N-AI-Y-NP 0 38 TYTFQFINETARLANIVPAIF---RKALRDIKFKD--------YTIPAGWAVMVCPPAVHLNP-M-YKDP 0 39 EYLSQVIDETLRLVNISFVSF---RQATRDVFVNG--------YLIPKGWKVQLWYRSVHMDPQV-YPDP 410 40 EFLSKVVDETLRVITFSLTAF----EAKTDVEMNG--------YLIPKGWKVLTWFRDVHIDPEV-FPDP 0 41 PFTQCVVNETLRVANIIGGVF---RRAMTDVEIKG--------YKIPKGWKVFSSFRAVHLDPNH-FKDA 387 42 ---------------------------------------------------------------------- 0 43 PYLKATIKESMRIHPPAPFLL--PHFSTHDCEING--------YTIPAGTRVIVNAWALARDPTC-WDKA 434 44 PYLKATIKETLRLHPPAPFLL--PHYSTADSEIDG--------YFVPAGTRVLVHAWALGRDRTT-WEKP 443 45 PYLKATIKETLRLHPPAPFLL--PHYSTADSEIDG--------YFVPAGTRVLVNAWALGRDRTT-WENP 316 46 PYLKASMKEALRLHPPGPLLL--PHYSTADCQIDG--------YHIPANPRVLVNGWAIGRDPAV-WEKP 438 47 TDLKAVIKETLRLHPPVPLLL--PHYSLDACEVAG--------YTIPANTRVVVNAWALGRHSGY-WERE 445 48 PFLRAVVKETLRLHPPAPLLV--PHLSLADCVVDG--------YHVPSGTRVIINAWALGRDPGE-WEKP 295 49 PYMQAVLKEQLRLHPPLPLLI--PRKAIQDTKFMG--------YDIPKGTQVLVNAWAIGRDPEY-WDNP 376 50 PYMQAVLKESLRLHPPLPFLI--PRETIQDTKFMG--------YDVPKDTQVLVNAWAIGRDPEC-WDDP 416 51 ---------------------------------------------------------------------- 0 52 ---------------------------------------------------------------------- 0 53 PYLRAICKEAFRKHPSTPLNL--PRVSSDACTIDG--------YYIPKNTRLSVNIWAIGRDPDV-WENP 411 54 PYLRAICKETFRKHPSTPLNL--PRISNEPCIVDG--------YYIPKNTRLSVNIWAIGRDPQV-WENP 408 55 PYLRAICKETFRKHPSTPLNL--PRISNEPCIVDG--------YYIPKNTRLSVNIWAIGRDPEV-WENP 408 56 PYLQAVIKENFRLHPPTPLSL--PHIASESCEIHG--------YHIPKGSTLLTNIWAIGRD-------- 116 57 VYLKAALAETLRLYPSVPQDF--KYVVDDDVLPDG--------TFVPRGSTVTYSIYSIGRMKTI-WGED 420 58 ---------------------------------------------------------------------- 68 59 ---------------------------------------------------------------------- 68 60 ---------------------------------------------------------------------- 0 61 ---------------------------------------------------------------------- 0 62 ------------------------------VFPDG--------TMLKKGDKVIYAI-AMGRMEAI-WGKD 0 63 ---------------------------------------------------------------------- 0 64 AYTEACLC-AMRLYPPV----------------------------------------------------- 0 65 PYLQAVVKETLRAHPPGPLLSWARLATADVPLCNG--------MVVPAGTTAMVNMWAITHDAAV-WADP 406 66 PYLQSIVKETLRMHPPGPLLSWARLAIHDVPV-DG--------HMIPAGTTAMVNMWAITHDECN-WAEP 339 67 PYLQAI-KE-LR-HPPG-L--WVR---------------------------------------------- 0 68 PYLQAVVKETLRLRMAIPLLV--PHMNLHDAKLGG--------FDIPAESKILVNAWWLANNPDQ-WKKP 413 69 PYLQAVVKETLRLRMAIPLLV--PHMNLHDAKLGG--------YDIPAESKILVNAWWLANNPAH-WKKP 413 70 PYLQAVIKETLRLRMAIPLLV--PHMNLHDPKLNG--------FDIPAESKILVNAWWLPNNPAH-WKKP 414 71 PYLQAVIKETLRLRMAIPLFL--PHMNLHDAKLGG--------YDIPAESKILVNAWFLANNPEH-WKKP 413 72 PYLQAVVKETLRLRMAIPLLV--PHMNLHDAKLAG--------YDIPAESKILVNAWWLANNPNS-WKKP 413 73 PYLQAVIKETLRLRMAIPLLV--PHMNLHDAKLGG--------FDIPAETKILVNAWWLRNNPAL-WKKP 411 74 ---------------------------------------------------------------------- 0 75 ---------------------------------------------------------------------- 61 76 PYLQAVVK-TFRLHPAA-LLV--PRKA-SDVE-LG--------F-V-K-TQ---NVWAFGRAPTV-W--- 0 77 ---------------------------------------------------------------------- 0 78 PYLQNIVSETLRLYPAAPMLL--PHVASEDCKVAG--------YDMPRGTILLTNVWAIHRDPQL-WDDP 0 79 PYLQNIVSETFRL-PAAPLLV--PRSPSEDLKIGG--------YGIPRGTIVLVNAW-IH--PKL-WDEP 0 80 ---------------------------------------------------------------------- 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------- 0 83 ---------------------------------------------------------------------- 0 84 P-LQAVIK-------------------------------------------------------------- 0 85 PYLHAVIKEALRLHPPGPLLP--R-FQQG-CKIGG--------FYIPG---------------------- 0 86 PYLQAVVKEGLRLHPPTPLMV--R---------------------------------------------- 0 87 ---------------------------------------------------------------------- 146 88 VFLQAVVKEILRKHPPTYFTL--THSVTEPTTVAG--------YDVPVGINVEFYLPGINEDPKL-WSDP 0 89 PYLNAVVKELLRKHPPTYFTL--THSVTEPVKLAG--------YDIPMDTNVEFFVHGISHDPNV-WSDP 408 90 PYLNAVVKELLRKHPPTYMSL--THAVTEPAKLGG--------YDIPTGVNVEIFLPGISDDPNL-WSEP 423 91 ---------------------------------------------------------------------- 0 92 SYLKAVILE-LRRHPPGHYL---YHKVTHDTVLGG--------F-IPRQGTINFMVGEMGRDPKI-WGDP 0 93 ---------------------------------------------------------------------- 0 94 PYLEAVVMEGLRRHPP-H--L--PHSVT------------------------------------------ 0 95 ---------------------------------------------------------------------- 0 96 ---------------------------------------------------------------------- 0 97 NYVKACIREAFRLHPVAPFNV--PHVALADTTIAG--------YRVPKGSHVILSRTGLGRNPRV-WDEP 459 98 PYLQACVKETMRLYPPISIMI--PHRCMETCQVMG--------YTIPKGMDVHVNAHAIGRDPKD-WKDP 398 99 VYLHAIIKETLRLYPPAPFSS--PREFTEDCTIGG--------YHIKKGTRLMPNLWKIHRDPSV-WPDP 420 100 KYVSMILYEVLRLYPPVIDLT--KIVHKDTKL-GS--------YTIPAGTQVMLPTVMLHREKSI-WGED 437 101 KSMTIILYEVLRLNPPIVPLT--RAIHKEMKL-GD--------LTLPGGVQISLPV-LVHR-TEL-WGND 84 102 ---------------------------------------------------------------------- 0 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 PLMKSVVYETLRIEPPVALQY--GKAKKDFILESHEAA-----YQVKEGEMLFGYQPFATKDPKI-FDRP 416 108 PLTKSVVYESLRIEPPVPPQY--GKAKSNFTIESHDAT-----FEVKKGEMLFGYQPFATKDPKV-FDRP 389 109 ---------------------------------------------------------------------- 114 110 ELVQSFVYESLRLSPPVPSQY--ARARKDFMLSSHDSV-----YEIKKGELLCGYQPLVMKDPKV-FDEP 0 111 ---------------------------------------------------------------------- 0 112 DVLYRCIKEALRLHPPLIMLL--RQSHSDFTVTTKEGKE----YDIPKATSS------------------ 46 113 ---------------------------------------------------------------------- 0 114 PYLQAVMK-TLRLHPTLPLLV--PHRNSETSVVAG--------YTVPKDSKILINVWAI-RDPK--WDEP 0 115 ---------------------------------------------------------------------- 0 116 ---------------------------------------------------------------------- 0 117 ---------------------------------------------------------------------- 0 118 ---------------------------------------------------------------------- 0 119 ---------------------------------------------------------------------- 0 120 ---------------------------------------------------------------------- 0 121 ---------------------------------------------------------------------- 0 122 ---------------------------------------------------------------------- 0 123 ---------------------------------------------------------------------- 0 124 ---------------------------------------------------------------------- 0 125 ---------------------------------------------------------------------- 0


1 -EEFLPERFVNNSVD-------------------FKGQDFQLIPFGAGRRGCPGIAFGISSVEIS-LANL 460 2 -EEYQPERFLNSDAD-------------------VKGLNFKLLPFGAGRRGCPGSSFAIAVIELA-LARL 463 3 ---------------------------------------------------------------------- 0 4 ---------------------------------------------------------------------- 366 5 -EEFCPERFLNNDID-------------------MKGLKFELLPFGSGRRGCPGSSFAIAVIELA-LARL 465 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 --------------------------------------------------ICPGISFALPNVELP-IAQL 19 10 -AEEFKPERHLDSALD------------------YHGKNLELIPFGSG----PGVNL------------- 0 11 -EKFRPERFLNSSVD-------------------FKGLDFELIPFGAGRRGCPGTTFPMATLEFT-LANL 464 12 -EEFLPERFVNSNID-------------------AKGQNFELLPFGSGRRMCPAM------VEFG-LANL 102 13 ----------------------------------------------GG-RMCPAVYMGTTMVEFG-LTNL 0 14 ---------------------------------------------------------------------- 0 15 -ETFNPERFIDNQTD-------------------FKGLNFELLPFGSGRRMCPGMGMGLAVVHLT-LINL 454 16 -EAFIPERFMDNQID-------------------YKGLNFEF-PFGSGRRMCPGIGMGMALVHLT-LINL 0 17 -EEFNPERFANSSVD-------------------FRGQHFDLLPFGSGRRICPGMPMAIASVELA-LMNL 461 18 ---------------------------------------------------------------------- 0 19 ---------------------------------------------------------------------- 130 20 ---------------------------------------------------------------------- 0 21 --EFKP-RFLASSRGKEE----------------EREQELKYIPFGSGRRGCPGVNLGYIF-GTA-IG-M 0 22 ----------------------------------KREDML-YI-FGSGRRACPGSHLAYTVVGSV-IG-M 0 23 ---------------------------------------------------------------------- 0 24 ---------------------------------------------------------------------- 0 25 ---------------------------------------------------------------------- 116 26 -------------------------------------------------RICPGCPMGIAAVELG-LLNL 97 27 ---------------------------------------------------------------------- 0 28 ---------------------------------------------------------------------- 0 29 ---------------------------------------------------------------------- 102 30 ---------------------------------------------------------------------- 0 31 ---------------------------------------------------------------------- 0 32 ---------------------------------------------------------------------- 0 33 -EVFKPERFHEKASID------------------VKGHDYELLPFGVGRRMCPGYSLGLKVIQAS-LANL 0 34 PDEFRPERFLEKEVD-------------------FKGTDYEFIPFGSGRRMCPGMRLGAAMLEVP-YANL 459 35 -YSFNPWRWMDK----------------------SLEHQNSFLVFGGGTRQCPGKELGVAEISTF-LHYF 430 36 -LSFNP---------------------------------------------------------------- 0 37 -LEFNPWRWE-KE--------------------------------------------------------- 0 38 -LVFNPSRW-GSK---------------------VTNAS-HFMAFGGGMRFCVGTDFTKLQMAAF-LHSL 0 39 -TKFDPSRWEG-----------------------HSPRAGTFLAFGLGARLCPGNDLAKLEISVF-LHHF 455 40 -RKFDPARWDNG----------------------FVPKAGAFLPFGAG-HLCPGNDLAKLEISI---HHF 0 41 -RTFNPWRWQSNSV--------------------TTGPSNVFTPFGGGPRLCPGYELARVALSVF-LHRL 435 42 ---------------------------------------------------------------------- 0 43 -EEFFPERFLEQGRDAEVD---------------MYGKDIRFVPFGAGRRICAGATFAIATVEIM-LANL 487 44 -EEFMPERFVQEPGAVDVH---------------MKGKDLRFIPFGSGRRICPGMNFGFATMEVM-LANL 496 45 -EEFMPERFVQEPGAVDVH---------------MKGKDLRFIPFGSGRRICPGMNFGFATMEIM-LANL 369 46 -EEFMPERFMRDGWDKSNS---------------YSGQDFRYLPFGSGRRICPGANFGLATMEIM-LANL 491 47 -NEFVPERFLSGDVAGGVD---------------LKPNEFQFLAFGSGRRMCPGVHSASATIEAM-LSNL 498 48 -EEFLPERFMDGGSAAGVD---------------IKGNHFHLLPFGAGRRICPGLNFGMATVEIM-LANL 348 49 -FEFKPERFLESKVD-------------------VKGQNYELIPFGAGRRMCVGLPLGHRMMHFT-FGSL 425 50 -MSFKPERFLGSKID-------------------VKGQHYGLIPFGAGRRMCVGLPLGHRMMHFA-LGSL 465 51 --------------------------------------------------ICPGLPLAYRTLHTM-LATC 19 52 ---------------------------------------------------------------------- 0 53 -LEFIPERFLSEKNAKIE----------------HRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 463 54 -LEFNPERFLSGRNSKID----------------PRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 460 55 -IEFYPERFLSGRNSKID----------------PRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 460 56 ---------------------------------------------------------------------- 116 57 CLEFRPERWLTADGERFE----------------TPKDGYKFVAFNAGPRTCLGKDLAYNQMKSV-ASAV 473 58 ---------------------------------------------------------------------- 68 59 ---------------------------------------------------------------------- 68 60 ---------------------------------------------------------------------- 0 61 ------W-WISPDDGKF-----------------VNHDQYRFVAFN--PRICLGKDLAYLQMKTI-AAA- 0 62 CLEFRP-RWL--RDGRF-----------------MS-SVYKFTAFNGGPRL--GKDF-Y-QMKST----- 0 63 --------------------------------------------FNAGPRL-LGKAFAYLQ-----AASI 0 64 ---------------------------------------------------------------------- 0 65 -DAFAPERFLPSEGGADVD---------------VRGVDLRLAPFGAGRRVCPGKNLGLTTVGLW-VARL 459 66 -NKFNPDRFIDEDVN-------------------ILGSDLRLAPFGSGKRVCPGKTMALAAVHLW-LAQL 388 67 ---------------------------------------------------------------------- 0 68 -EEFRPERFLEEEAKVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 464 69 -EEFRPERFFEEESHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-LGRL 464 70 -EEFRPERFLEEESHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 465 71 -EEFRPERFLEEESKVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 464 72 -EEFRPERFFEEESHVE-----------------ANGNDFRYVPFGVGRRSCPGIILALPILGIT-IGRM 464 73 -EEFRPERFLEEEAHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIH-IGRL 462 74 ------------DID-------------------LRGRDYELTPFGAGRRICPGFPLAVKTVPLM-LASL 38 75 ---------------------------------------------------------------------- 61 76 ---------------------------------------------------------------------- 0 77 ----------------------------------------KLMPFGIGRRSCPGSGLAQRLVTLA-LGSL 29 78 -MSFKPERF-------------------------KEGEAQKLMPFGLGRRACPGSGLAHR------FGHL 0 79 ---------------------------------------------------------------------- 0 80 -----------------------------------------------------GLSLANRVVGLL-LGSM 0 81 ---------------------------------------------------------------------- 0 82 ---------------------------------------------------------------------- 0 83 ---------------------------------------------------------------------- 0 84 ---------------------------------------------------------------------- 0 85 ---------------------------------------------------------------------- 0 86 ---------------------------------------------------------------------- 0 87 ---------------------------------------------------------------------- 146 88 -KKFNPDRFISGKEEA-I----------------TGVT--KMMP-------------------------- 0 89 -EKFDPDRFLSGREDADI----------------TGVKEVKMMPFGVGRRICPGLGMATVHVNLM-LARM 460 90 -EKFDPDRFYLGKEDADI----------------TGVSGVKMIPFGMGRRICPGLNMATVHVSLM-LARL 475 91 --------------------------------------GV---PFGAGRRICPGL---------M-LARM 0 92 -LTFKPERFLENGEAC-F-M--------------TGTREIK-MPFGAGRRMCPGY-L-LLH-----VAN- 0 93 ---------------------------------------------------------------------- 0 94 ---------------------------------------------------------------------- 0 95 -MAFKP-RFM--EEAVDI----------------TGSRGIKM-PFGAGRRI-PGIGLA-LHLEYY-VANM 96 -------------------------------------------PF--G--ICPGYGLALLHLEYF-VANL 22 97 -LRFYPDRHLATAASDVA----------------LTENDLRFISFSTGRRGCIAASLGTAMSVML-FGRL 511 98 -LKFQPERFLDSDIE-------------------YNGKQFQFIPFGSGRRICPGRPLAVRIIPLV-LASL 447 99 -LEFKPESFLSTHKDVD-----------------VRGQNFELLPFGSGRRMCAGMSLGLHMVHYI-LANF 471 100 AMEFNPMRFVDGVAN-------------------ATKNNVTYLPFSWGPRVCLGQNFALLQAKLG-LAMI 487 101 AGEFKPERFKDGLSK-------------------ATKNQVSFFPFAWGPRICIGQNFTL-EAKMA-MSLI 84 102 ---------------------------------------------------------------------- 0 103 ---------------------------------------------------------------------- 0 104 ---------------------------------------------------------------------- 0 105 ---------------------------------------------------------------------- 0 106 ---------------------------------------------------------------------- 0 107 -EEFVADRFVGEGVKLMEYV--------------MWSNGPETETPSVANKQCAGKDFVVMAARLF-VVEL 470 108 -EEFVPDRFVGDGEALLKYV--------------WWSNGPETESPTVENKQCAGKDFVVLITRLF-VIEL 443 109 ---------------------------------------------------------------------- 114 110 -EKFMLERFTKEKGKELLNYL-------------FWSNGPQTGSPTESNKQCAAKDAVTLTASLI-VAYI 0 111 ---------------------------------------------------------------------- 0 112 ---------------------------------------------------------------------- 46 113 -NEFKPERFLENSLD-------------------FNGGDFKYLPFGSGRRICAAINMAERLV-LF-CSTL 48 114 -NGFKP-RFLEDSL--------------------FNGG-LKYLPFG-GR---PG---------------- 0 115 -------------------------------------------PF--G--VCIGQNFAMLEAKIA-LSMI 22 116 -------------------------------------------PF--G--ICVGQNFAMLEAKLV-MAMI 22 117 -------------------------------------------PF--G--ACPGVNFAIPIAELA-LANL 22 118 -------------------------------------------PF--G--MCPGISFALANVELP-LAQL 22 119 -------------------------------------------PF--G--SCPGMLFGIANIELP-LALL 22 120 -------------------------------------------PF--G--ICPGISYAIANVQLP-LAQL 22 121 -------------------------------------------PF--G--ICPGISYAIANIQLP-LRQL 22 122 -------------------------------------------PF--G--VCPGILFGTTNVELL-LAAF 22 123 -------------------------------------------PF--G--ICPGLPMAARVVPLV-IASF 22 124 -------------------------------------------PF--G--ICPGMSFAIPNVTLP-LAQL 22 125 -------------------------------------------PF--G--MCPGISFGIPNIELP-LALL 22


1 LYWF-NWELPGI---------------------------------*-------------- 471 2 VHKF-DFALPEGIKP--EDLDMTETIGITTRRKLPLLVVATPC*---------------- 503 3 LHHF-VWDTPQGTKP--EEIDMSENPGPVTYMRTPVQTVATPRLPSDLYRKVPYDM*--- 0 4 ---------------------------------------------*-------------- 366 5 VHKF-NFALPKGTKP--EDLDMTECTGIATRRKSPLPVVATPFSG*-------------- 507 6 ---------------------------------------------*-------------- 0 7 ---------------------------------------------*-------------- 0 8 ---------------------------------------------*-------------- 0 9 LYHF-DWKLPNDAKP--EELDMNEKFGLTVGRENDLELIAIPYCHSFLQ*---------- 65 10 ---------------------------------------------*-------------- 0 11 MQKF-DWELPHEC----RELDMSERPGVAIRRVIPLLAIGTKM*---------------- 502 12 LYHF-DW----------------------------------------*------------ 108 13 LYHL-DWKLPEGMKV--DDIDMEEAPGLTVNKKNELILVPTKFLDP*------------- 0 14 ----------------------------------------------*------------- 0 15 LYRF-DWKLPNGMKA--EELSIEENYGLICVKKLPLEAIPVLTQWT*------------- 497 16 LYRF-DWKLPEGMEV--EDVDLEESYGLVCPKKVPLQLIPVL*----------------- 0 17 LYYF-DWSMPDGTKG--EDIDMEEAGNISIVKKIPLQLVPVQRY*--------------- 502 18 --------------------------------------------*--------------- 0 19 --------------------------------------------*--------------- 130 20 --------------------------------------------*--------------- 0 21 VHCF-DWRTNG------DKVNMEET-AGITLNMAHPLRCTPVSRMQLQKSQFVSS*---- 0 22 VQ-F--WIIKG------EK-NMKEG-GT-TLTMAHPL-CTPVPRNLNT*----------- 0 23 -------------------------------------------*---------------- 0 24 ------------------------------------------*----------------- 0 25 ------------------------------------------*----------------- 116 26 LYFL-DWKLPDGMTH--KDIDTEEAGTLTIVKKVPLQLVPVRVQ*--------------- 97 27 ------------------------------------------*----------------- 0 28 ------------------------------------------*----------------- 0 29 ------------------------------------------*----------------- 102 30 ------------------------------------------*----------------- 102 31 --------------------DMEEAPGLTCQQEKRAYTLCQRSF*--------------- 0 32 ------------------------------------------*----------------- 0 33 LHGF-NWSLPDNMTP--EDLNMDEIFGLSTPKKFPLATVIEPRLSPKLYSV*-------- 0 34 LLSF-NFKLPNGMKP--DDINMDVMTGLAMHKSQHLKLVPEKVNKYM*------------ 503 35 VTKY-RWEEIGGDKL--MKFPRVEAPNGLRIRVSAH*----------------------- 463 36 -----------------------------------------*------------------ 102 37 -----------------------------------------*------------------ 102 38 VTKY-RWEEIKGGNI--TRTPGLQFPNGYHVKLHKKRD*--------------------- 102 39 LLGY-KLARTNPRCR--VRYLPHPRPVDNCLAKITRVGS*-------------------- 491 40 LLKY----R-NPEC-------PHTRPPVNCLARI*------------------------- 102 41 VTGF-SWVPAEQDKL--VFFPTTRTQKRYPIFVKRRDFAT*------------------- 472 42 ----------------------------------------*------------------- 0 43 IYHF-DWEMPAEMERTGAKVDMSDQFGMTLRRTQKLYLVPRIPKCVSSS*---------- 535 44 MYHF-DWEVPG----SGAGVSMEESFGLTLRRKEKLLLVPRIAS*--------------- 535 45 MYHF-DWEVPG----SAAGVSMDESFGLTLRRKEKLLLVPRIAS*--------------- 408 46 MYHF-DWEVPNEKEDGCWKVSMDEKFGLMLRRNELLYLVPRAS*---------------- 533 47 MYRF-DWQLPAGMKAED--VDMTEVFGITVSRKEKLLLVPQAA*---------------- 538 48 VYCF-DWQLPMGMEEKD--IDMTEVFGLTVHPKEKLMLVPKVARVLQLLVNNSIVQVAD* 404 49 LHEF-DWELPHNVSPKSINMEESMGITARKKQPL--KVIPKKA*---------------- 465 50 LREF-EWELPDGVSPKSINMDGSMGVTARKRDSL--KVIPKKA*---------------- 505 51 IHNF-DWKLKDGMKPEDIDIEEKYGLTLQLAVPL--NVIPVKL*---------------- 59 52 ----------------------------------------------*------------- 0 53 IHSF-DWKLPNDVVDINMEETFGLALQKAVPLEA--IVTPRLSFDIYQSSEPF*------ 513 54 VHSF-DWKLPSEVIELNMEEAFGLALQKAVPLEA--MVTPRLQLDVYVP*---------- 506 55 VHSF-DWKLPSEVIELNMEEAFGLALQKAVPLEA--MVTPRLPIDVYAPLA*-------- 508 56 ---------------------------------------------------*-------- 116 57 LLRY-RVFPVPGHRVEQKMSLTLFMKNGLRVYLQ-----PRGEVLA*------------- 513 58 --------------------------------------------*--------------- 68 59 --------------------------------------------*--------------- 68 60 -----------------------------------------*------------------ 0 61 LLRH-RLTVAPGHKVEQKMSLTLFMKNGLLVNVH-----KRDLE*--------------- 0 62 --------------------------------------------*--------------- 0 63 LLNY-----------------TLYMKHGLKVRIT-----PRSLEEKQDS*---------- 0 64 ---------------------------------------------*-------------- 0 65 VHAF-QWALPDGAAAVCLDEVLKLSLEMKTPLVA--AAIPRTA*---------------- 499 66 LKSF-KLLPSRNG--VDLSECLKMSLEMKNPLVC--VAVPRFE*---------------- 426 67 ---------------------------------------------*-------------- 0 68 VQNF-ELLPPPGQSKIDTDEKGGQFSLHILKHST-IVAKPRSF*---------------- 505 69 VQNF-ELLPPPGQSQIDTSEKGGQFSLHILKHST-VVAKPRSF*---------------- 505 70 VQNV-ELLPPPGQSKIDTSEKGGQFSLHILKHST-IVAKPRSF*---------------- 506 71 VQNF-ELLPPPGKSKIDTSEKGGQFSLHILKHST-IVLKPRTF*---------------- 505 72 VQNF-ELLPPPGQSKVDTSEKGGQFSLHILNHSI-IVMKPRNC*---------------- 505 73 VQNF-ELLPPPGQSKIDTSEKGGQFSLHILKHST-IVAKPRAF*---------------- 503 74 LYSF-DWKLPNGVGSEDLDMDETFGLTLHKTNPLHAVPVKKRGRN*-------------- 82 75 ---------------------------------------------*-------------- 61 76 ---------------------------------------------*-------------- 0 77 VQCF-EWERVGEKYLDMRSEKGTTMRKRTSLQAM-CKARPIVHKVLDASCP*-------- 78 78 IQ----------------------------------------*----------------- 0 79 ------------------------------------------*----------------- 0 80 IQCF-EWESGSGGQVDMTEGPGLSLPKAEPLVAP-CRTREMASELLFFGSEPSNKNV-I* 0 81 ------------------------------------------*----------------- 0 82 ------------------------------------------*----------------- 0 83 ------------------------------------------*----------------- 0 84 ------------------------------------------*----------------- 0 85 ------------------------------------------*----------------- 0 86 ------------------------------------------*----------------- 0 87 ------------------------------------------*----------------- 146 88 ------------------------------------------*----------------- 0 89 VQEF-EWFAYPGNNKVDFSEKLEFTVVMKNPLRA--KVKLRI*----------------- 499 90 VQEF-EW-ADPENTRVDFTEKLEFTVVMKNTLRA--KIKPRM*----------------- 513 91 ------------------------------------------*----------------- 0 92 ---F--WK----------------------------------*----------------- 0 93 ------------------------------------------*----------------- 0 94 ------------------------------------------*----------------- 0 95 VREF---KEVQGHEVDLTEKLEFTVVMKHPLKAL---AVPRRSH*--------------- 0 96 IWYF-EWTAMDGNDIDLSEKQEFTICMKNPLSAY---ISPRVNTF*-------------- 63 97 LQGF-TWSKPAGVEAVDLSESKSDTFMATPLVLH---AEPRLPAHLYPSISI*------- 559 98 VHAF-GWELPDGVPNEKLDMEELFTLSLCMAKPL--RVIPKVRI*--------------- 488 99 LHSF-EILNPS-PESIDVTEVLEFVTTKATPLEV--LVKPCLSFKCYESM*--------- 517 100 LQRF-KFDV--APSYVHA-PFTI-LTVQPQFGSHVIYKKLES*----------------- 524 101 LQRF--SFE--QPSYVHA-PYDI-ITLYPQFGAHLMLHKL--*----------------- 84 102 ------------------------------------------*----------------- 0 103 ------------------------------------------*----------------- 0 104 ------------------------------------------*----------------- 0 105 ------------------------------------------*----------------- 0 106 ------------------------------------------*----------------- 0 107 FKRY-DSFD--IEVGTSSLGATITLTSLKRSTF*-------------------------- 500 108 FRRY-DSFE--IELGESPLGAAVTLTFLKRASI*-------------------------- 473 109 ---------------------------------*-------------------------- 114 110 FQKY-DSVS--FSSGSLTSVKKAC*----------------------------------- 0 111 --------------------------------------------*--------------- 0 112 --------------------------------------------*--------------- 46 113 LHFF-TLLIGKLLKDRSLRLKRSLVLFLSLKSPLVLFLFQGCPIQTLHSLSKKDVEKRV* 106 114 -----------------------------------------*------------------ 0 115 LQNF-SFELSPSYSHAPHTVITLQPQRGAQLIVRKVQTS*-------------------- 60 116 LQRF-SFELSPSYAHAPTSIVTLQPQHGAHLILRKL*----------------------- 57 117 IHKF-NFSLPDGVTAEDLDPTDVVGFISQKETPLSFIATVA*------------------ 62 118 LYHF-DWKLPGELKLEELDMEESFGLTVRRKKDLLLIPISYACSSVK*------------ 68 119 LYHF-NWSLPDGLTSETLDMSETWGITTPRKYDLHLIPTSYYP*---------------- 64 120 LYHF-EWKLPAGMKPEELDMTEILGTAAQRKENLLLIPNSHSCSSLKQV*---------- 70 121 LYHF-DWKLAGGMKPEELDMAEILGTAAQRKEDLLLIPNSHSCSSLKQQV*--------- 71 122 LFHF-DWELPGGMKPEELDMNELFGAGCIRENPLCLIPSISTVVEGN*------------ 68 123 LHFF-SWSFPNGKDAQQLDMNEKLDAALVKEQPLFVIPQPRTTT*--------------- 65 124 LLHF-DWKSAVGKLEDLDMTEARV*----------------------------------- 45 125 LFHF-NWNLPAGHVLDMEEAMGLTATRKNHLWLVATPIKKCLNLLSKLHNLDNMFSLDS* 80