Universities of Leicester and Dundee

Post-Doctoral Research Opportunities

NMR, modelling and mutagenesis studies of cytochrome P450

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Two post-doctoral positions are available in a major collaborative programme involving the groups of Profs. Gordon Roberts (Leicester) and Roland Wolf (Dundee) which is aimed at developing structural models of human cytochromes P450 and elucidating their catalytic mechanism. The positions are funded by an industrial consortium and by the Medical Research Council; they provide an excellent opportunity to work in an active team involving enzymologists, molecular biologists, NMR spectroscopists and molecular modellers, and in collaboration with pharmaceutical companies.

Applications are invited from individuals with expertise in protein NMR and an interest in enzyme structure and mechanism. Experience of protein purification, of paramagnetic relaxation experiments and/or of structure determination would be an advantage. Most important, applicants should have an enthusiasm for contributing to the work of this interdisciplinary team.

The positions are available immediately, for three years in the first instance; strating salaries will be in the range £17,570-20,860 according toexperience.

Informal enquiries are welcome and can be addressed to Prof. Gordon Roberts (Centre for Mechanisms of Human Toxicity, University of Leicester, Hodgkin Building, PO Box 138, Leicester Lei 9HN, UK; phone +44-(0)116-252-5533; e-mail gcr@le.ac.uk or Dr. Thomas Friedberg (Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK; phone +44-(0)1382-660111; e-mail t.h.friedburg@dundee.ac.uk).

For details see also http://www.le.ac.uk/bi/p450/index.html or http://www.dundee.ac.uk/BioMedRes/

Applications, including CV (2 copies) and the names and e-mail addresses of 2-3 referees, should be sent to Prof. Gordon Roberts, Centre for Mechanisms of Human Toxicity, University of Leicester, Hodgkin Building, PO Box 138, Leicester Lei 9HN, UK.

Closing date: October 31st 1998.