An alignment of 237 P450 sequences

This file last modified April 19, 1996

193 Ce 13A10 Z46934 -------------------------MTQSLAHKNAWQC-- 13 194 Ce 13A8 Z48717 T10B9.4 ---------------------------------------- 0 195 Ce 13A7 Z48717 T10B9.10-------------------------MSFSI---------- 5 196 Ce 13A6 Z48717 T10B9.3 -------------------------MIFVL---------- 5 197 Ce 13A5 Z48717 T10B9.2 -------------------------MSLSI---------- 5 198 Ce 13A4 Z48717 T10B9.1 -------------------------MSLSL---------- 5 199 Ce 13A3 Z48717 T10B9.5 -------------------------MSLSI---------- 5 200 Ce 13A2 Z48717 T10B9.7 -------------------------MSLGF---------- 5 201 Ce 13A1 Z48717 T10B9.8 -------------------------MGYF----------- 4 202 Ce 25A1 Z66495 C36A4.1 -------------------------MAL------------ 0 203 Ce 25A2 Z66495 C36A4.2 -------------------------MAL------------ 0 204 Ce 25A3 Z66495 C36A4.3 -------------------------MAF------------ 0 205 Ce 25A4 Z66495 C36A4.6 -------------------------MAI------------ 0 206 Ce 14A1 Z50742 K09A11.2---------------------------------------- 0 207 Ce 14A2 Z50742 K09A11.3---------------------------------------- 0 208 Ce 14A3 Z50742 K09A11.4---------------------------------------- 0 209 Ce 14A4 Z50742 + R04D3 ---------------------------------------- 0 210 Ce 16A1 Z54269 ---------------------------------------- 0 Ce U55365 C12D5.7 ---------------------------------------- 0 Ce U50311 C25E10.2---------------------------------------- 0 211 Ce 22A1 U39648 T13C5.1 SSWIKCRDWMAFALSHHIIMGIYLLILRNFLPQVVPDFEW 0 212 Ce 23A1 U39472 B0304.3 -------------MPIAYFLPSQVNSGVCCLICRHWYLIG 0 213 C.eleg. CEL10E1 ---------------------------------------- 0 214 3A1 pcn1 rat -------------------------MDLLSALTLE----- 10 215 3A2 pcn2 rat -------------------------MDLLSALTLE----- 10 216 3a11 mouse -------------------------MDLVSALSLE----- 10 217 3a16 mouse -------------------------MNLFSALSLD----- 10 218 3A6 3c rabbit -------------------------MDLI--FSLE----- 8 219 3A9 olf2 rat -------------------------MDLIPNFSME----- 10 220 3a13 mouse -------------------------MDLIPNFSME----- 10 221 3A4 nf-25 human -------------------------MALIPDLAME----- 10 222 3A3 HLp human -------------------------MALIPDLAME----- 10 223 3A8 MKnf2 monkey -------------------------MDLIPDLAVE----- 10 224 3A7 HFL33 human -------------------------MDLIPNLAVE----- 10 225 3A5 PCN3 human -------------------------MDLIPNLAVE----- 10 226 3A12 dog -------------------------MDLIPSFSTE----- 10 227 3A14 guinea pig -------------------------MDLVPSFSLE----- 10 228 3A15 guinea pig -------------------------MDLIPSFSLE----- 10 229 3A10 hamster -------------------------MELIPNLSIE----- 10 230 3A18 rat -------------------------MEIIPNLSIE----- 10 231 3A19 goat ---------------------------------------- 0 232 5A1 TXS human -------------------MEALGFLKLEVNGPMV----- 16 233 5A1 TXS rat -------------------MEVLGLLKFEVSGTVV----- 16 234 5A1 TXS mouse -------------------MEVLGLLKFEVSGTMV----- 16 235 5A1 TXS pig -------------------MEVLGFLSPELNGPMV----- 16 236 6A1 Musca domestica -------------------------MDFGSFLLYA----- 10 237 6A2 Drosophila melanog.----------------------------MFVLIYL----- 7 238 6A3 Musca domestica ---------------------------MCCPLVVL----- 8 239 6A4 Musca domestica ----------------------------MFALLLL----- 7 240 6A5 Musca domestica ----------------------------MLSLVQT----- 7 241 6A6 Musca domestica ---------------------------------------- 0 242 6B1 Papilio polyxenes ----------------------------MLYLLAL----- 7 243 6B2 cotton bollworm ----------------------------MWIFYFP----- 7 244 6B3 Papilio polyxenes ----------------------------MLYVITL----- 7 245 6C1 Musca domestica ----------------------------MEAITIS----- 7 246 6C2 Musca domestica ----------------------------MIPIPLAI---- 8 247 6D1 lpr insect J.Scott ------------------------------MLLLL----- 5 248 9A1 tobacco budworm ----------------------------------M----- 1 249 9B1 Dro-G6 ---------------------------------------- 0 250 9B2 DroH6-17 25Jul95 ---------------------------------------- 0 251 9C1 DroG6-25 25Jul95 ---------------------------------------- 0 252 4A3 LAw2 rat IVA3 --------------------------MGFSVFTPTRSLDG 14 253 4A2 IVA2 rat --------------------------MGFSVFSPTRSLDG 14 254 4A5 KDB3 rabbit --------------------------MSVSALSPTRLPGS 14 255 4A6 ka1 rabbit --------------------------MSVSALNPTRLPGS 14 256 4A4 p-2 rabbit ------------------------------ALSPTRLPGS 10 257 4A7 ka2 rabbit --------------------------MSVSALSSTRLPGS 14 258 4A1 LAw1 rat IVA1 --------------------------MSVSALSSTRFTGS 14 259 4A10 mouse --------------------------MSVSALSPTRFADS 14 260 4A8 KP1 rat --------------------------MSGSALSFTIFPGS 14 261 4A12 mouse ---------------------------------------- 0 262 4A11 human --------------------------MSVSVLSPSRLLGD 14 263 new human R51129 ---------------------------------------- 0 264 4A13 guinea pig ---------------------------------------- 0 265 4B1 IVB1 human --------------------------MSGTATMVPSFLSL 14 266 4B1 IVB rabbit ---------------------------------MLGFLS- 6 267 4B1 IVB rat --------------------------------MVLNFLSP 8 268 4F1 rat --------------------------MSQLSLSWLGLGPE 14 269 4F2 human --------------------------MSQLSLSWLGLWPV 14 270 4F3 human --------------------------MPQLSLSSLGLWPM 14 271 4F4 rat --------------------------MPQLDLSWLGLRLE 14 272 4F5 rat --------------------------MPWLTVSGLDLGSV 14 273 4F6 rat --------------------------MLQLSLSRLGMGSL 14 274 CYP4wEST 8B12 C.elegans---------------------------------------- 0 275 4C1 cockroach -------------------------------------MEF 3 276 4G1 Drosophila ---------------------------------------- 0 277 4D1 Drosophila ------------------------------------MFLV 4 278 4D2 Drosophila ---------------------------------------- 0 279 4E1 Drosophila ---------------------------------------- 0 280 4E2 Drosophila ---------------------------------------- 0 281 4E3 DroG4-2 Drosophila ---------------------------------------- 0 282 4E4 Drosophila ---------------------------------------- 0 283 4D8 Dro-G453 ---------------------------------------- 0 284 4J1 Cpan-13 ---------------------------------------- 0 285 4J2 Pan-4 ---------------------------------------- 0 286 4J3 Loox5 ---------------------------------------- 0 287 4M1 Mg1 ---------------------------------------- 0 288 4M2 Mg4 ---------------------------------------- 0 289 4M3 Mg3 ---------------------------------------- 0 290 4C3 Dro-G451 ---------------------------------------- 0 291 4C2 Hiox3 ---------------------------------------- 0 292 4L1 Fb2 ---------------------------------------- 0 293 4L2 Mg2 ---------------------------------------- 0 294 4H1 Chi-H9 ---------------------------------------- 0 295 4H2 Pan-1 ---------------------------------------- 0 296 4H3 Cpan-2 ---------------------------------------- 0 297 4H4 Cpan-5 ---------------------------------------- 0 298 4H5 Clo-A3 ---------------------------------------- 0 299 4H6 Cpan-3 ---------------------------------------- 0 300 4H7 Chi-H3 ---------------------------------------- 0 301 4H8 Loox1 ---------------------------------------- 0 302 4H9 Cpan-4 ---------------------------------------- 0 303 4D5 Clo-A1 ---------------------------------------- 0 304 4D6 Cpan-28 ---------------------------------------- 0 305 4D7 Cpan-30 ---------------------------------------- 0 306 new human R07010 ---------------------------------------- 0 307 CYP4wEST00713 C.elegans---------------------------------------- 0 308 4K1 Chi-Hi4 ---------------------------------------- 0 309 4P1 Dro-R5 ---------------------------------------- 0 310 hum.est H06539/H51951 ---------------------------------------- 0 311 102 BM3 B. megaterium ---------------------------------------- 0 312 118 Mycoplasma leprae ---------------------------------------- 0 313 110 Anabaena cyanobact.---------------------------------------- 0 314 72A1 Catharanthus ros. ------------MEMDMDTIRKAIAATIFALVMAWAWRV- 27 315 72A Arabidopsis T13009---------------MEISVASVTVSVAVVVVSWWVWRT- 24 316 74 Allene ox.syn. flax ----------------------------------SAFR-- 4 317 74 AOS guayule ---------------------------------------- 0 318 74 AOS Arabidopsis ----------------------------------QKML-- 4 319 52A1 alk1 C. trop.------MSSSPSIAQEFLATITPYVEYCQ-ENYTKWYYFI 33 320 52A4 Cm2, ALK3 C. malt.--------MSVSFVHNVLEVVTPYVEYYQ-ENLTKWYILI 31 321 52A2 alk2 C. trop.---------------MSIQDI---VETYS----TKWYVVV 18 322 52A5 ALK2-A C. malt.--------------MTSDSTIHELIQSYI----TKWYVIV 22 323 52A9 ALK5-A C. malt ----------------MIDEI---LPKLV----QYWYIVL 17 324 52A10 ALK7-A C. malt.-----------------MIFTAFIL--------DYWYFTL 15 325 52A11 ALK8-A C. malt.-----------------MVFTAFIL--------EYWYFTL 15 326 52A7 alk4 C. trop.----------------MIEQVL-----------HYWYYVL 13 327 52A8 alk5 C. trop.----------------MYEQVV-----------EYWYVVL 13 328 52A3 ALK1-A C. malt.---------------MAIEQIIEEVLPYL----TKWYTIL 21 329 52A3 Cm1,ALK1-B C.malt.---------------MAIEQIIEEVLPYL----TKWYTII 21 330 52A6 alk3 C. trop.---------------MATQEIIDSALPYL----TKWYTVI 21 331 52D1 ALK4-A C. malt.---------------MAIF---------------TPELWL 10 332 52B1 alk6 C. trop.-------------MSLTETTATFIY--------NYWYIIF 19 333 52C1 alk7 C. trop.--------------------------------MYQLFCFL 8 334 52C2 ALK6-A C. malt.--------------------------------MIDALYIL 8 335 52E1 C.apicola-----------------------MIIGLS-DAFALGGIAL 16 336 52E2 C.apicola-----------------------MNINFS-DALMLGGISL 16 337 10 pond snail --MAIMKKFIHHSLKQLIKPNLTSTKRVVSTSPRKEQGVA 38 338 11A1 scc bovine --------------------------MLARGLPLRSALVK 14 339 11A1 scc goat --------------------------MLARGLPLRSALVK 14 340 11A1 scc sheep --------------------------MLARGLPFRSALVK 14 341 11A1 scc pig --------------------------MLARGLALRSVLVK 14 342 11A1 scc human --------------------------MLAKGLPPRSVLVK 14 343 11A1 scc rat --------------------------MLAKGLCLRSVLVK 14 344 11A1 scc chicken ---------------------------------------- 0 345 11A1 scc trout --------------------------MMVSWSVCRSSLAL 14 346 11B1 11B rat -----------------------------------MALRV 5 347 11B1 11B mouse -----------------------------------MALRV 5 348 11B2 11B aldo mouse -----------------------------------MALRV 5 349 11B2 11B aldo rat -----------------------------------MALRV 5 350 11B3 11B rat -----------------------------------MALRV 5 351 11B1 11B bovine -----------------------------------MALWA 5 352 11B1 11B sheep -----------------------------------MALWA 5 353 11B1 11B1 human -----------------------------------MALRA 5 354 11B2 11B2 human -----------------------------------MALRA 5 355 11B2 bullfrog --------------MLEKTAARQIGSCLMRCRTLDTTSPL 26 356 27 26OH rabbit ---------------MAALGCARLRWALLGPRVAGCGLCP 25 357 27 vitamin D3OH rat ---------------MAVLSRMRLRWALLDTRVMGHGLCP 25 358 27 27OH human ---------------MAALGCARLRWAL---RGAGRGLCP 22 359 trout EST T23107 ---------------------------------------- 0 360 24 25OH D3 24hyd rat ---------------MSCPIDKRRTLIAFLRRLRDLGQPP 25 361 24 25OH D3 24hyd hum. ---------------MSSPISKSRSLAAFLQQLRSPRQPP 25 362 56 DIT2 S. cerevisiae -------------------------MELL--------K-L 6 363 53 bphA Asp. niger -------------------------MLAL------LLS-P 8 364 57A1v1 N. haematococca-------------------------MLVDTGLG--LIS-E 12 365 57A2 N. haematococca-------------------------MLVDTGLG--LIS-E 12 366 58 Fusarium sporotri.-------------------------MVDQDWIKALVNI-P 14 367 59 Asperg.nidulans-4 ---------------------------------------- 0 368 60A2 Asperg.nidulans-2 ---------------------------------------- 0 369 60B1 Asperg.nidulans-3 ---------------------------------------- 0 370 60A1 Asperg.parasiticus---------------------------------------- 0 371 61 S.cerevisiae Z49211---------------------------------------- 0 372 62 Asperg.nidulans-1 ---------------------------------------- 0 373 51 14DM S. cerevisiae ------MSATKSIVGEALEYVNIGLSHFL-ALPLAQ---- 29 374 51 14DM rat -------------------MVLLGLLQSG-GSVLGQ---- 16 375 51 14DM human -------------MAAAAGMLLLGLLQAG-GSVLGQ---- 22 376 51 14DM Issatchenkia ---------------------------------------- 0 377 51 14DM S. pombe ---------------------------------------- 0 378 51 14DM Ustilago maydis---------------------MVASSSSA-TASLLD---- 14 379 51 14DM P. italicum ----------MDLVPLVTG----QILGIA----------- 15 380 51 14DM C. tropicalis ----------MAIVDTAID----GINYFL-SLSLTQ---- 21 381 51 14DM C. albicans ----------MAIVETVID----GINYFL-SLSVTQ---- 21 382 51 14DM C. glabrata ---------------------------------------- 0 383 19 arom human --------------------------MVLE---------- 4 384 19 arom bovine --------------------------MLLE---------- 4 385 19 arom pig ---------------------------------------- 0 386 19 arom rat --------------------------MFLE---------- 4 387 19 arom mouse --------------------------MFLE---------- 4 388 19 arom chick --------------------------MIPE---------- 4 389 19 arom trout -------MDLLSPVCGRVMAVVCLDTVIAD---------- 23 390 19 arom Oryzias latipes-------MDLI-PACDRTMSSSCL----AE---------- 18 391 CYP8 bovine -------------------------MSW------------ 3 392 CYP8 human -------------------------MAW------------ 3 393 CYP7B mouse G.Stapleton--------------------------MQGATTLDAASPGP 14 394 7A1 Chol7a rat --------------------------MMTISLI---WGIA 11 395 7A1 Chol7a mouse --------------------------MMSISLI---WGIA 11 396 7A1 Chol7a hamster --------------------------MMTISLI---WGIA 11 397 7A1 Chol7a rabbit --------------------------MITIFWI---WGIC 11 398 7A1 Chol7a human --------------------------MMTTSLI---WGIA 11 399 105A1 SU1 Str.griseolus---------------------------------------T 1 400 105D P450soy St.griseus------------------------------MTESTTDPAR 10 401 105B SU2 Str. griseolus---------------------------------------T 1 402 105A2 Amycolata autotr.--------------------------------------MT 2 403 105C Streptomyces sp. ---------------------------------------M 1 404 107G Str.hygroscopicus ---------------------------------------M 1 405 105E Rhodococ.fascians ---------------------------------------- 0 406 107D Str.antibioticus -------------------------------------MTD 3 407 55A1 Fusarium oxysporum---------------------------------------M 1 408 55A2 Cylindrocarpon ton---------------------------------------M 1 409 55A3 Cylin. tonkinense ---------------------------------MHATEDE 7 410 107A1 eryF Sacc.eryth. ---------------------------------------M 1 411 107B1 Sacc.eryth. ---------------------------------------M 1 412 107C1 Strepto. thermo. ---------------------------------------M 1 413 113A1 eryK Sacc.eryth. -----------------------------VCADVETTCCA 11 414 113B1 Strepto. fradiae ----------------------------MTTQTLEAEKPP 12 415 112 BJ-1 Bradyrhiz.jap.---------------------------------------- 0 416 114 BJ-3 Bradyrhiz.jap.---------------------------------------- 0 417 106A1 BM1 B.megaterium ---------------------------------------M 1 418 106A2 B.megaterium ---------------------------------------- 0 419 107E Micromososp. gris.---------------------------------------- 0 420 107F Strepto. griseus ---------------------------------------M 1 421 109 Bacillus subtilis ---------------------------------------M 1 422 119 Sulfolobus solfat. ---------------------------------------- 0 423 111 Pseudomonas sp. ---------------------------------------- 0 424 108 terp -------------------------------------MDA 3 425 101 cam P. putida ---------------------------------------T 1 426 103 pinF1 A.tumefaciens---------------------------------------M 1 427 104 pinF2 A.tumefaciens---------------------------------------M 1 428 116 Rhodococcus sp. ---------------------------------------M 1 429 117 Bradyrhizobium jap.---------------------------------------- 0

193 --IFLY-FLKAKYIYL--S-YYLWI-------------WTYWRRRGIPGPLGY-PLVGSF--FPK-TLKS 60 194 ---------------------------------------------------------------------- 0 195 ----LI-AIAIFVGII--S-YYLWI-------------WSFWIRKGVKGPRGL-PFLGVI--HKF-TNYE 50 196 ----LS-AVLL--GVF--T-YSVWI-------------WSYFIRKGIKGPRGF-PGIGML--IQT-IDHE 48 197 ----LI-AGASFIGLL--T-YYIWI-------------WSFWIRKGVKGPRGF-PFFGVI--HEF-QDYE 50 198 ----LI-AGALFIGFL--T-YYIWI-------------WSFWIRKGVKGPRGF-PFFGVI--LKF-HDYE 50 199 ----LI-AIALFIGVF--T-YYLWI-------------WSFWMRKGIKGPRGL-PFFGII--NAF-QSYE 50 200 --VLAV-TFSIFLGIL--T-YYLWI-------------WTYWMRKGVKGPRGR-PFVGVL--DVE-LLEH 52 201 --WFPW-FSAIFVAVF--S-YYIWQ-------------WTFWRRRGVVGPMGF-PVLGVF--LNS-LDNN 51 202 ----LI-LSSLVISIF--T-FFIYI------ILARRERFKLREKIGLSGPEPH-WFLGNL--KQT-AERK 0 203 ----LI-LTSILILLV--S-FIIYI------LFARREQFKLREKIGLTGPEPH-WFMGNL--KQI-VDRK 0 204 ----LI-LTSILVSLV--S-FIIYV------ILARKERFRLRGKIGLSGPEPH-WLMGNL--KQI-IERK 0 205 ----LI-ISTIFFTII--T-FISYS------IWRRHAIFKLRSSIGIPGPPVH-WLWGNL--NII-KDRV 0 206 ---MSV-FILAFVIFI--I-FYVFH-------------FYWKVSKYPKGPLPL-PFIGNI--HQF-PPDN 46 207 ---MSI-LIVAFVS-I--T-VYIAY-------------FYWKVSKYPKGPFPL-PFIGNI--LQI-PSEN 45 208 ---MSV-FIIAFFTFI--T-TYVAY-------------FYWKVSKYPKGPLPL-PFFGNL--LQF-PAEN 46 209 ---------------------------------------------------------------------- 0 210 ---------------------------------------------------------------------- 0 ---MIF-FLLLTAFVL----YLFNE-------------FYWKRRGLPPGPIPL-PIIGNM--IEL-FSYP 0 ---MIL-IFFALCTLF----FLIHQ-------------YLWRRRGLPPGPTPI-PIFGNL--FQL-SGSE 0 211 ---QHY-FMRVFIVHI--I-YIIIS-------------YFIRITRYPPGPPPM-AVFGNS--PFV-NILT 0 212 ---QAT-YIYFLTCIT--L-YAIYE-------------LNYKRRRLPNGPVPW-LVAGNM--PSF-INVN 0 213 ----MI-ILLVFTAFL--A-FLFHE-------------LYWKRRNLPPGPIPL-PFMGNI--LTM-LLNK 45 214 --TWVL-LAVVLVLLY--G-FGTRT-------------HGLFKKQGIPGPKPL-PFFGTV--LNY-YMGL 57 215 --TWVL-LAVILVLLY--R-LGTHR-------------HGIFKKQGIPGPKPL-PFLGTV--LNY-YKGL 57 216 --TWVL-LAISLVLLY--R-YGTRK-------------HELFKKQGIPGPKPL-PFLGTV--LNY-YKGL 57 217 --TLVL-LAIILVLLY--R-YGTYT-------------HGLFKKQGIPGPKPL-PFLGTV--LNY-YKGL 57 218 --TWVL-LAASLVLLY--L-YGTST-------------HGLFKKMGIPGPTPL-PFIGTI--LEY-RKVI 55 219 --TWLL-LVISLVLLY--L-YGTHS-------------HGIFKKLGIPGPKPL-PFLGTI--LAY-RKGF 57 220 --TWML-LATSLVLLY--L-YGTHS-------------HGIFKKLGIPGPKPL-PFLGTI--LAY-QKGF 57 221 --TWLL-LAVSLVLLY--L-YGTHS-------------HGLFKKLGIPGPTPL-PFLGNI--LSY-HKGF 57 222 --TWLL-LAVSLVLLY--L-YGTHS-------------HGLFKKLGIPGPTPL-PFLGNI--LSY-HKGF 57 223 --TWLL-LAVTLVLLY--L-YGTHS-------------HGLFKKLGIPGPTPL-PLLGNI--LSY-RKGF 57 224 --TWLL-LAVSLILLY--L-YGTRT-------------HGLFKKLGIPGPTPL-PFLGNA--LSF-RKGY 57 225 --TWLL-LAVSLVLLY--L-YGTRT-------------HGLFKRLGIPGPTPL-PLLGNV--LSY-RQGL 57 226 --TWLL-LAISLVLLY--L-YGTYT-------------HGIFRKLGIPGPTPL-PFVGTA--LGY-RNGF 57 227 --TWVL-LALSLVLLY--R-YATYS-------------HGFFKKLGIPGPKPL-PLFGNV--LSY-RKGM 57 228 --TWVL-LALSLVLLY--Q-YATYS-------------HGFFKKLGIPGPKPL-PLFGNV--LSY-RKGM 57 229 --TWVL-LAISLVLIY--I-YGTYS-------------HGTFKKLGIPGPKPL-PFFGTI--LGY-HDGT 57 230 --TWVL-LATSLMLFY--I-YGTYS-------------HGLFKKLGIPGPKPV-PLFGTI--FNY-GDGM 57 231 ---------------------------------------------------------------------- 0 232 --TVAL-SVALLALLK--W-YSTSA-------------FSRLFKLGLRHPKPS-PFIGNL--TFF-RQGF 63 233 --TVTL-SVVLLALLK--W-YSTSA-------------FSRLRKLGIRHPEPS-PFVGNL--MFF-RQGF 63 234 --TVTL-LVALLALLK--W-YSMSA-------------FSSLEKLGISHPKPS-PFVGNL--MFF-RQGF 63 235 --TMAL-AVVLLALLK--W-YSTSA-------------FSRLEKLGIRHPKPS-PFIGNL--TFF-RQGF 63 236 --LGVL----ASLALY--F-VRWNF-------------GYWKRR-GIPHEEPH-LVMGNV--KGL-RSKY 53 237 --LIAI----SSLLAY--L-YHRNF-------------NYWNRR-GLPHDAPH-PLYGNM--VGF-RKNR 50 238 --LLGS----LTLFVV--Y-LYRLY-------------TYWQRR-GILQETPL-PLLGNF--KGL-GTSH 51 239 ----FC----ICLLVG--Y-LLNLY-------------T-WERQ-GVPHETPI-PLLGNF--KG---SKY 45 240 --ILLA----FVAVLI--G-LYNIY-------------TYWKRR-GVVYERPW-PLFGNF--WGI-GTKY 50 241 ---------------------------------------------------------------------- 0 242 --VTVL----AGLLHY--Y-FTRTF-------------NYWKKR-NVAGPKPV-PFFGNL--KDS-VLRR 50 243 --ISVL----IVTLYF--Y-FTRTF-------------NYWKKR-NVRGPEPV-VFFGNL--KDS-ALRK 50 244 --VTVL----AGLLHY--Y-FTRNF-------------DYWKKR-NVAGPKPI-PFFGNL--KDS-ALRR 50 245 -----------EPIFI--W-ADISH-------------LVHNEH-DIRIKLYM-VATSKS--DSI-RERE 45 246 --FTLI----IFLAII--W-LHYQL-------------TYWRRR-KAPTV----PTTGLY--KL--RNRE 47 247 --LLIV----VTTLYI--F-AKLHY-------------TKWERLGFESDKATI-PLGSMA--KVF-HKER 49 248 --AGGD----HHSGPA--V-LPKRV-------------QPTVQA-GGEPPPHD-PSLGNL--MWMVMKQE 45 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 VSGFFQ-GAFLLSLFLVL----FKAVQFYLRRQ-----WLLKALEKFPSTPSH-WLWGH--DLK-D-REF 69 253 VSGFFQ-GAFLLSLFLVL----FKAVQFYLRRQ-----WLLKALEKFPSTPSH-WLWGH--NLK-D-REF 69 254 LSGLLQ-VAALLGLLLLL----LKAAQLYLRRQ-----WLLRALQQFPCPPFH-WLLGHSREFQMN-QEL 72 255 LSGLLQ-VAGLLGLLLLL----LKAAQLYLHRQ-----WLLRALQQFPCPPFH-WLLGHSREFQNG-HEL 72 256 LSGLLQ-VAALLGLLLLL----LKAAQLYLHRQ-----WLLRALQQFPCPPFH-WLLGHSREFQND-QEL 68 257 FSGFLQ-AAALLGLLLLL----LKAAQLYLRRQ-----WLLRALQQFPCPPSH-WLLGHSREFPID-SEL 72 258 ISGFLQ-VASVLGLLLLL----VKAVQFYLQRQ-----WLLKAFQQFPSPPFH-WFFGH-KQFQGD-KEL 71 259 LSGPLQ-VASVLGLLLLL----VKAVQFYLHRQ-----WLLKAFQQFPSPPFH-WFFGL-EKFKGD-QEL 71 260 ILGFLQ-IATVLTVLLLL----LKTAQFYLHRR-----WLLRATQQFPSPPSH-WFFGH-KIPK-D-QDF 70 261 ---------------------------------------------------------------------- 0 262 VSGILQ-AASLLILLLLL----IKAVQLYLHRQ-----WLLKALQQFPCPPSH-WLFGHIQELQQD-QEL 72 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 SFSSLG-LWASGLILVLGF---LKLIHLLLRRR-----TLAKAMDKFPGPPTH-WLFGHALEIQET-GSL 73 266 ---RLG-LWASGLILILGF---LKLLRLLLRRQ-----RLARAMDSFPGPPTH-WLFGHALEIGKT-GSL 62 267 SLSRLG-LWASVVILMVIV---LKLFSLLLRRQ-----KLARAMDSFPGPPTH-WLFGHALEIGKL-GSL 67 268 VAFPWQ-TLLLFGASWIL----AQILTQIYAAY-----RNFRRLRGFPQPPKRNWLMGHVGMVTPTEQGL 74 269 AASPWL-LLLLVGASWLL----AHVLAWTYAFY-----DNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGM 74 270 AASPWL-LLLLVGASWLL----ARILAWTYTFY-----DNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGL 74 271 TSLPWL-LLLLIGASWLL----VRVLTQTYIFY-----RTYQHLCDFPQPPKWNWFLGHLGMITPTEQGL 74 272 VTSTWH-LLLLGAASWIL----ARILAWTYSFC-----ENCSRLRCFPQSPKRNWFLGHLGTIQSNEEGM 74 273 TASPWH-LLLLGGASWIL----ARILAWIYTFY-----DNCCRLRCFPQPPKPSWFWGHLTLMKNNEEGM 74 274 ---------------------------------------------------------------------- 0 275 ITILLS-TALFHSHLPVPV-------PSGAKRA-----RFVYLVNKLPGPTAY-PVVGNAIEAIVPRNKL 59 276 ---------------------------------------------------------------------- 0 277 IGAILA-SALFVGLLL-----------YHLKFK-----RLIDLISYMPGPPVL-PLVGHGHHFIGKPPHE 56 278 ---------------------------------------------ALPGPRPL-PFLGNLLMYRGLD--P 22 279 ---------------------------------------------------------------------- 0 280 --------------------------------------------------------MGNAHQ-MGKNPSE 13 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 ---------------------------------------------------------------------- 0 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 -----------------------------------------MTIKEMPQPKTF-GELKNL-PLLNTDK-P 26 312 ---------------------------------------------------------------------- 0 313 ------------------------------------------MLTQLPNPISV-PSWWQL-INWIAD--P 24 314 LDWAWF-TPKRIEKRLR---QQGFRGNPYRFLV-----GDVKESGKMMQEALS-KPMEF-NNDIVPR--L 84 315 LQWVWF-KPKMLESYLR---RQGLAGTPYTPLV-----GDLKKNFSMRAEARS-KPINL-TDDITPR--I 81 316 PIKASL-FGDSPIKIPGIT-SQPPP-----SSD-----ETTLPIRQIPGDYGL-PGIGPIQDRLDYFYNQ 61 317 -------------------------------MD-----PSSKPLREIPGSYGI-PFFQPIKDRLEYFYGT 33 318 LRTMAA-TSPRPPPSTSLT-SQQPP------SP-----PSQLPLRTMPGSYGW-PLVGPLSDRLDYFWF- 59 319 PLVILS-LNLISMLHTKYL-ERKFKA----KPL-----AVYVQDYTFGLITPL------V--LIY-YKSK 83 320 PTILLT-LPFLSILHTKYL-EYKFNA----KPL-----TNFAQDYSFGVITPL------M--LMY-FKWH 81 321 LVALIV-YKVFDFFYARYL-MYKLGA----KPF-----LQSQTDGYLGFRVPF------E--LMG-KKSE 68 322 PLAIII-YKVFDYFYVLSL-RKRLGA----AVP-----TNEETDGYFGFHLPF------V--LMS-KKKD 72 323 PTLLII-KHVVSYINTQRL-MRKFRA----KPV-----TNVLNDGFFGIPNGI------K--AIK-EKNK 67 324 LFLIAA-YFIGKHVYTNYL-MRKHHA----EPI-----LDVVDDGAFGFKFGF------Q--SLK-AKKI 65 325 LSLAAG-HFIGKHVYTNYL-MRKHHA----EPI-----LDVVDDGAFGFKFGF------Q--ALK-AKKI 65 326 PAFIIF-HWIVSAIHTNSL-RRKLGA----KPF-----THTQLDGFYGFKFGR------D--FLK-AKRI 63 327 PLVFIL-HKVFDMWHTRRL-MKQLGA----APV-----TNQLHDNFFGIINGW------K--HLS-SRKK 63 328 FGAAFT-YFLSIALRNKYY-EYKLKC----ENP-----PYFKTAGFVGIPGLI------D--VIK-AKNA 71 329 FGAAVT-YFLSIALRNKFY-EYKLKC----ENP-----VYFQDAGLFGIPALI------D--IIK-VRKA 71 330 TLAALV-FLISSNIKNYVK-AKKLKC----RDP-----PYFKGAGWTGISPLI------E--IIK-VKGN 71 331 ICFAVT-VYIFDYIYTKYL-MYKLGA----KPI-----THVIDDGFFGFRLPF------L--ITL-ANNQ 60 332 HLYFYTTSKIIKYHHTTYL-MIKFKA----SPP-----LNYINKGFFGIQATF------T--ELK-HLIC 70 333 AGIIVV-YKAAQYYKRRTL-VTKFHC----KPA-----RISPNKSWLEYLGIA------S--VVH-ADEM 58 334 IVALVI-YKTAQFVHRKSL-EKKHHC----QPV-----KQIPLVSILSGLGFD------M-FFKD-TAEM 59 335 SFLVAY-QFIYFYFIYSPR-AKKLGC----APP-----VIVFSFP-LGLPAAL------Y--KFA-TAML 65 336 SFLLAS-QAIYFYFIYSPR-AKKLGC----APP-----PIFFSFP-LGIPDLI------R---LV-NAWF 64 337 AISLEP-SEMAQCPFRKSIDTFTETTNA-VKAPGMTEVQPFERIPG-PKGLPIVGTLFDY-FKKDGPKFS 104 338 ACPPIL-STVGEGWGHHRVGTGEGAGIS-TKTP-----RPYSEIPS-PGDNGW-LNLYHF-WREKGSQRI 74 339 ACPPLL-NTGREGWGHHRVGTGEGAGIS-TRTP-----RPYSEIPS-PGDNGW-INLYHF-WRKKSSQRI 74 340 ACPPLL-NTGREGWGHHRVGTGEGAGIS-TRTP-----RPYSEIPS-PGDNGW-INLYHF-WRKKGSQRI 74 341 GCQPFL-SAPRECPGHPRVGTGEGACIS-TKTP-----RPFSEIPS-PGDNGW-INLYRF-WKEKGTQKI 74 342 GCQTFL-SAPREGLGRLRVPTGEGAGIS-TRSP-----RPFNEIPS-PGDNGW-LNLYHF-WRETGTHKV 74 343 SCQPFL-SPVWQGPGLA---TGNGAGISSTNSP-----RSFNEIPS-PGDNGW-INLYHF-LRENGTHRI 72 344 ---------------------------------------------------------------------- 0 345 P-ACGL-PSARHNSSMPVVRQALSPDN--SSTV-----QNFSEIPG-LWRNGL-ANLYSF-WKLEGFRNI 72 346 TADVWL-ARPWQCLHRTRALGTTAKVA--PKTL-----KPFEAIPQ-YSRNKW-LKMIQI-LREQGQENL 64 347 TTDVWL-ARPWQCLHRTRALGTTATLA--PKTL-----QPFEAIPQ-YSRNKW-LKMIQI-LREQGQENL 64 348 TADVWL-ARPWQCLHRTRALGTTATLA--PKTL-----QPFEAIPQ-YSRNKW-LKMIQI-LREQGQENL 64 349 TADVWL-ARPWQCLHRTRALGTTATLA--PKTL-----KPFEAIPQ-YSRNKW-LKMIQI-LREQGQENL 64 350 TADVW--ARPWQCLHRTRALGSTATQA--PKTL-----KPFEAIPQ-YSRNKW-LKMIQI-LREQGQENL 63 351 KARVRM-AGPWLSLHEARLLGTRGAAA--PKAV-----LPFEAMPR-CPGNKW-MRMLQI-WKEQGSENM 64 352 KARVWM-AGPWLSLHRARPLGTRASAA--PKAV-----LPFEAMPR-CPGNKW-MRVLQI-WKEQGSENM 64 353 KAEVCM-AVPWLSLQRAQALGTRAARV--PRTV-----LPFEAMPR-RPGNRW-LRLLQI-WREQGYEDL 64 354 KAEVCV-AAPWLCLQRARALGTRAARA--PRTV-----LPFEAMPQ-HPGNRW-LRLLQM-WREQGYEHL 64 355 WTGFSR-LSTAPLIHEAREDGSLASQT-----------LPYEAIPT-TGRSAW-FNLFQF-WRKNSFQHM 81 356 QGARAK-AAIPTALPADEAAQAPGAGPGDRRRR-----RSLEELPR-LGQ----LRFFYQ-AFVQGYLL- 82 357 QGARAK-AAIPAALRDHESTEGPGTG-QDRPRL-----RSLAELPG-PGT----LRFLFQ-LFLRGYVL- 81 358 HGARAK-AAIPAALPSDKATGAPGAGPGVRRRQ-----RSLEEIPR-LGQ----LRFFFQ-LFVQGYAL- 79 359 ---------------------------------------------------------------------- 0 360 RSVTSK-AS-ASRAPKEVPLCPLMTD-GETRN------VTSLPGPT-NWPLLG-SLLEIF-WKGGLK--- 80 361 RLVTST-AY-TSPQPREVPVCPLTAG-GETQN------AAALPGPT-SWPLLA-SLLQIL-WKGGLK--- 80 362 LCLILF-LTLSYV-AFAII-V--------PPLN-------FPKN-IP-TIPFYVVFLPVI--FPI-DQTE 53 363 YGAYLG-LAL-LV-LYYLL-P--------YLKR-----AHLRDIPAP-GLAAF-TNFWLL--LQT-RRGH 56 364 LQAKLG-WAV-LL-QIVPI-TIVAYNLLWFIYASFF--SSLRKIPGP-FLARI-SRVWEM--KKT-ATGN 71 365 LRARLG-WAA-LL-QIVPV-TVVAYNLLWFIYTSFF--ASLRKIPGPGFLARI-SRVWEI--KKA-ATGN 72 366 -----I-SHA-VG-VVAAS-TVIYFLSSCFYNLYL---HPLRKIPGP-KLAAIGPYLEFYHEVIR-DGQY 70 367 --------------------------------------------MPSFSLLTGHFGALKQTIDGM-PPNA 25 368 -----------------MILPLILVLYLLSTAAYRLWLHPVRNYPGPCWWAVWRVPYLKGTIRGT---IV 50 369 ------MVLQDGFPIPSYPNSARRVVYVLFQLVYNLYFHPLRDYPGPLLWRASSLPWKLTLLRGT---MH 61 370 ---------------------------------------------------------------------- 0 371 -MSYLK-IFATLICIL----LVWDQ----------VAYQIKKGSIAGPKFKFW-PIIGPF--LES-LDPK 50 372 -MLSIS-SGPEATGAD----VSQAIR---------IAYFTPLKHIPGPWYASL-TGLRLS--WSV-FANN 51 373 -RISLI-III-PFI----Y-NIVWQ-----LLY-----SLRK--DRPPLVFYWIPWVGSA--VVYGMKP- 76 374 --AMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYIYSPIPFLGHA--IAFGKSP- 81 375 --AMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHA--IAFGKSP- 87 376 -----------------------------------------------------MPWVGSA--VVYGMQP- 14 377 --------------MAFSLVSILLSIALAWYVGYIINQLTSRNSKRPPIVFHWIPFVGSA--VAYGMDP- 53 378 -QLFALTPLADSSAWIKTITVLVLLPLLAVVLNVASQLLLATPKNHPPVVFHFVPVIGSA--IYYGIDP- 80 379 -YYTTG-LFL-VSI----V-LNVIK-----QLI-----FYNR--KEPPVVFHWIPFIGST--IAYGMDP- 62 380 -QITIL-VVF-PFI----Y-NIAWQ-----LLY-----SLRK--DRVPMVFYWIPWFGSA--ASYGMQP- 68 381 -QISIL-LGV-PFV----Y-NLVWQ-----YLY-----SLRK--DRAPLVFYWIPWFGSA--ASYGQQP- 68 382 -------------------------------------------------VFYWMPWVGSA--IPYGTKP- 18 383 ---MLN-PIHYNITSIVPEAMPAATMSVLLLTG----LFLLLWN-YEGTSSIPGPGYCMGIGPLISHGRF 65 384 ---VLN-PRHYNVTSMVSEVVPIASIAILLLTG----FLLLVWN-YEDTSSIPGPSYFLGIGPLISHCRF 65 385 ---------------------------------------------------------------------- 0 386 ---MLN-PMHYNVTIMVPETVPVSAMPLLLIMG----LLLLIRN-CESSSSIPGPGYCLGIGPLISHGRF 65 387 ---MLN-PMQYNVTIMVPETVTVSAMPLLLIMG----LLLLIWN-CESSSSIPGPGYCLGIGPLISHGRF 65 388 ---TLN-PLNY-FTSLVPDLMPVATVPIIILIC----FLFLIWN-HEETSSIPGPGYCMGIGPLISHGRF 64 389 ---LLV-SESRNATATRSEGISLATGSLLLLLC----LLLAAW-RHTDNNSVPGPFFCLGVGPLLSYLRF 84 390 ----LV-SIAPNTTVGLPSGIPMATRSLILLVC----LLLMVW-SHSEKKTIPGPSFCLGLGPLMSYLRF 78 391 --AVVF-GLLAALLLLL----------LLTRRR-------TRRPGEPPLDLGSIPWLGHA--LEFGKDA- 50 392 --AALL-GLLAALLLLL----------LLSRRR-------TRRPGEPPLDLGSIPWLGYA--LDFGKDA- 50 393 --LALL-GLLFAATLLLSALF------LLTRR--------TRRPREPPLIKGWLPYLGMA--LKFFKDP- 64 394 VLVSCC-IWFIV----------------GIRRR---------KAGEPPLENGLIPYLGCA--LKFGSNP- 52 395 VVVSCC-IWFII----------------GIRRR---------KVGEPPLDNGLIPYLGCA--LKFGSNP- 52 396 MVVCCC-IWVIF----------------DRRRR---------KAGEPPLENGLIPYLGCA--LKFGSNP- 52 397 LSVCCC-LWLIL----------------GLRRR---------RMGEPPLEKGWIPYLGCA--LQFGANP- 52 398 IAACCC-LWLIL----------------GIRRR---------QTGEPPLENGLIPYLGCA--LQFGANP- 52 399 DTATTP-QTTDAPAFPS---------------------NRS-CPYQLPDGYAQLRD--------TPGPLH 40 400 QNLDPT-SPAPATSFP----------------------QDRGCPYHPPAGYAPLRE---------GRPLS 48 401 TAERTA-PPDALTVPAS---------------------RAPGCPFDPAPDVTEAAR---------TEPVT 40 402 TDATDP-RTTDAAPFPS----------------------NRSAPYRFSDGYAQLRD--------PPGPLR 41 403 TQA--------APVTFS---------------------TVRENYFGPPAEMQALRH---------KAPVT 33 404 STTDQG-ETGKACPYP----------------------FAEMERLEIHPEYNRLRD---------AGELG 0 405 --------MAGTADLPL---------------------EMRRNGLNPTEELAQVRD---------RDGVI 32 406 THTGPT-PADAVPAYP----------------------FSLPHALDLDPHYAELRR---------DEPVS 41 407 ASGAP--------SFP----------------------FSRASGPEPPAEFAKLRA---------TNPVS 32 408 ASEPP--------SFP----------------------FQRASGMEPPAEFSALRA---------TDPVS 32 409 TTTIP--------RFP----------------------FQRASAFEPPAEFARLRA---------NEPIS 38 410 -TT--V-PDLESD--------------------------DSFHV-DWYRTYAELRE---------TAPVT 31 411 -TTGEV-PDLLAFD-------------------------DAFAQ-DRHNRYARMRE----------EPVQ 33 412 TALNL---------------------------------MDPEVLRDPFGAYAEIRA---------QAPLV 29 413 -RRTLT-TIDEVPG-------------------------MADET-ALLDWLGTMRE-------------K 40 414 EPERTA-NSVHPLAQPAGA-------------------GARGLL-EWFRARARAEA-------------- 47 415 ----MS-EQQPLPTLP----------------------MWRVDHIEPSPEMLALRA-------------N 30 416 ---------------------------------------------------------------------- 0 417 NKE-------VIPVTE----------------------IPKFQSRAEEFFPIQWYK--------EMLNNS 34 418 MKE-------VIAVKE----------------------ITRFKTRATEFSPYAWCK--------RMLEND 33 419 -----M-TSAEPRAYP----------------------FNDVHGLTLAGRYGELQE---------TEPVS 33 420 ENTQVQ-NKETVRNCP----------------------FDYAHELEFDPQLRQLLT---------EEPVS 39 421 TNQTAR-SSKKERYANLIPMEEL---------------HSEKDRLFPFPIYDKLRR------------ES 43 422 -------------------------------------------------MYDWFSE---------MRKKD 0 423 ---MER-PDLKNP--------------------------DLYTQQVPHDIFARLRR---------EEPVY 31 424 RATIPE-HIARTVILPQ---------------------GYAD-DEVIYPAFKWLRD---------EQPLA 41 425 TETIQS-NANLAPL-PPHVPEHLVFDFDMY--------NPSNLSAGVQEAWAVLQE---------SNVPD 52 426 IANSST-DVSVADQKFLNVAKSNQIDPDAV--------PISRLDSEGHSIFAEWRP------------KR 50 427 -EERRV-SISSITW---RFPMLFAPVDDVT--------TIDDLTLDPYPIYRRMRV------------QN 46 428 TVDHAP-EGVKSPTGCPVSGMAAD--------------FDPFRGAYQVDPSSSLRQ---------ARKDE 47 429 ---------------------------------------------------------------------- 0

193 EYPQYLQIRDWTK--LYG------PIYGYTEGTIKTLI-VSDIDIVRQI-FV--EQYDN----------- 107 194 ---------------------------------------------------------------------- 0 195 -NPGALKFSEWTK--KYG------PVYGITEGVEKTLV-ISDPEFVHEV-FV--KQFDN----------- 96 196 -NPPFLKYRDWTK--QYG------PVYGFTEGPQQTMI-ISEPEMVNEI-FK--KQFDN----------- 94 197 -NPGLLKLGEWTK--EYG------PIYGITEGVEKTLI-VSNPEFVHEV-FV--KQFDN----------- 96 198 -NPGLLKLGEWTK--KYG------SIYGITEGVEKTLV-VSNPEFVHEV-FV--KQFDN----------- 96 199 -KPWILRLGDWTK--EYG------PMYGFTDGVEKTLV-VSDPEFVHEV-FV--KQFDN----------- 96 200 ETPGLIKLGEWTK--KYG------KVYGYTDGTQRTLV-VADPAMVHEI-FV--KQFDN----------- 99 201 --PFPLQCREWTK--KFG------KIYGFTEGTLKTLV-ISDPELVHEV-FV--TQYDN----------- 96 202 --DANRWFNELHE--QYG------ETFGIYYGSQMNIV-ISNEKDIKEV-FI--KNFSN----------- 0 203 --DSNKWFNELHK--QYG------ETFGIYFGAQMNIV-LSNEEDIKEV-FI--KNFSN----------- 0 204 --DSYDWYNKLHK--QFG------ETFGIYFGTQLNIN-ITNEEDIKEV-FI--KNFSN----------- 0 205 --DTTQWHPTLHT--KYG------PIFGLYCGTQLHIT-VSEEEDIKEI-FI--QNFSN----------- 0 206 ---VQKYFDVLSK--TYG------PCFTIWIPF-PAIVLTDYEHIKD-A-FV--NQGDT----------- 89 207 ---IQEYLDDLSK--TYG------PCFTLWTPL-PAIVLTDYEHVKE-A-FV--TQGDA----------- 88 208 ---IHLYFDELSQ--TYG------PCFTLWTPL-PAVVLTDYDHVKE-A-FV--TQGDA----------- 89 209 ---------------------------------------------------------------------- 0 210 ---------------------------------------------------------------------- 0 --PPTAAYDAWTK--KFG------KIYTVWMGTDPAVIITGYKELKD-T-FV--NDGHS----------- 0 -APGISIFQKWKD--QYG------PIFTFYMGIATIEKKNDYKKFSGPVPFVVLTDYQDIKETVIKDGDT 0 211 ---PEQTFLEYRE--IYG------PIFTLHLSQPTIIL-AEYKTIQE-A-LV--KNGQQ----------- 0 212 --NVDVLFQSWKQ--QYG------GIFTVWIGPIPLVM-VSDLPTIKKY-FI--QHADS----------- 0 213 --PGYECFRNCTK--KYG------RCVHFLGWERPHFV-ISSYDLLK-T-FV--RDGDT----------- 89 214 ----WKFDVECHK--KYG------KIWGLFDGQMPLFAITDTEMIKNVL-VK--ECFSV----------- 101 215 ----GRFDMECYK--KYG------KIWGLFDGQTPVFAIMDTEMIKNVL-VK--ECFSV----------- 101 216 ----WKFDMECYK--KYG------KTWGLFDGQTPLLAVTDPETIKNVL-VK--ECFSV----------- 101 217 ----WKFDMECYE--KYG------KTWGLFDGQIPLFVITDPETIKNVL-VK--ECFSV----------- 101 218 ---NWDFDIECRK--KYG------KMWGLFDGRQPLMVITDPDMIKTVL-VK--ECYSV----------- 100 219 ----WEFDKYCHK--KYG------KLWGLYDGRQPVLAITDPDIIKTVL-VK--ECYST----------- 101 220 ----WECDIQCHK--KYG------KMWGLYDGRQPVLAITDPDIIKTVL-VK--ECYST----------- 101 221 ----CMFDMECHK--KYG------KVWGFYDGQQPVLAITDPDMIKTVL-VK--ECYSV----------- 101 222 ----CMFDMECHK--KYG------KVWGFYDGQQPVLAITDPDMIKLVL-VK--ECYSV----------- 101 223 ----WTFDMECYK--KYG------KVWGFYDGRQPVLAITDPNMIKTVL-VK--ECYSV----------- 101 224 ----WTFDMECYK--KYR------KVWGIYDCQQPMLAITDPDMIKTVL-VK--ECYSV----------- 101 225 ----WKFDTECYK--KYG------KMWGTYEGQLPVLAITDPDVIRTVL-VK--ECYSV----------- 101 226 ----YVFDMKCFS--KYG------RMWGFYDGRQPVLAITDPDMIKTVL-VK--ECYSV----------- 101 227 ----WSFDIECRK--KYG------NMWGLYDGPQPVLAITEPDMIKAVL-VK--ECYSV----------- 101 228 ----WSFDIECRK--KYG------NMWGLYDGPQPVLAITEPDMIKAVL-VK--ECYSV----------- 101 229 ----WKFDETCYK--KYG------KIWGFYDGRVPVLAIADPEIIKTVL-VK--ECYSN----------- 101 230 ----WKFDDDCYK--KYG------KIWGFYEGPQPFLAIMDPEIIKMVL-VK--ECYSV----------- 101 231 ---------------------------------------------------------------------- 0 232 ----WESQMELRK--LYG------PLCGYYLGRRMFIVISEPDMIKQVL-V---ENFSN----------- 106 233 ----WESHLELRE--RYG------PLCGYYLGRRMYIVISDPDMIKEVL-V---ENFSN----------- 106 234 ----WESQLELRE--RYG------PSVWVLSWPAIDVVISEPDMIKQVL-V---ENFSN----------- 106 235 ----WESHMELRK--QYG------PLSGYYLGRRMIVVISDPDMIKQVL-A---EKFSN----------- 106 236 --HIGEIIADYYR--KFK---GSDPLPGIFLGHKPAAVVLDKELRKRVL-IKDFSNFAN----------- 104 237 --VMHDFFYDYYN--KYR--KSGFPFVGFYFLHKPAAFIVDTQLAKNIL-IKDFSNFAD----------- 102 238 --HLRDIYQRLYG--EFK---GKAQMVGSYMFMQRSALLLDLDLIKNVL-IKDFAYFQN----------- 102 239 --HVRDINQRLYR--RFK---GKAPFAGVYMFVRRAALVIDLNLIKNIM-VKDFANFHD----------- 96 240 --HIREINQRLYR--KFK---GQAPFVGTYMFVRRASLIIDLDLIKNIL-IKDFANFHD----------- 101 241 ---------------------------------------------------------------------- 0 242 ---KPQVMVYKSI--YDE--FPNEKVVGIYRMTTPSVLLRDLDIIKHVL-IKDFESFAD----------- 101 243 ---KNMGVVMEEL--YNM--FPEEKVIGIYRMTSLCLLVRDLEVIKHIM-IKDFEVFSD----------- 101 244 ---KPQVMVYKSI--YDE--FPNEKVVGIYRMTTPSVLLRDLDIIKHVP-TKDFEPFAD----------- 101 245 --HVAFVYERIYK--QLR--EEQRPYAGFLTMLTPTLLVADLDLLKLVY-ISEFDSFPD----------- 97 246 --HIAYSYQRAYH--QMK--RENKGYAGIYTLITPTLLIADLEILKLIL-VTEFEVFPD----------- 99 247 --CFGLVMSDIYD--KCH-----EKVVGIYLFFKPALLVRDAELARQIL-TTDFNSFHD----------- 98 248 --HFVDTLGRCVK--AFP----DDKIVGHYDMVSPILVVLDVDTVKRIT-VKDFEHFVD----------- 95 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 ----QQVLTWVEK--FPG------ACLQWLSGSKTRVLLYDPDYVKVVL-GR--SDPKA----------- 113 253 ----QQVLTWVEK--FPG------ACLQWLSGSTARVLLYDPDYVKVVL-GR--SDPKP----------- 113 254 ----QQILKWVEK--FPR------ACPHWIGGNKVRVQLYDPDYMKVIL-GR--SDPKS----------- 116 255 ----QVMLKWVEK--FPS------ACPRWLWGSRAHLLIYDPDYMKVIL-GR--SDPKA----------- 116 256 ----ERIQKWVEK--FPG------ACPWWLSGNKARLLVYDPDYLKVIL-GR--SDPKA----------- 112 257 ----QQVLKWVEK--FPS------ACPRWLWGSELFLIVYDPDYMKTIL-GR--SDPKA----------- 116 258 ----QQIMTCVEN--FPS------AFPRWFWGSKAYLIVYDPDYMKVIL-GR--SDPKA----------- 115 259 ----QEIVSCIEN--FPS------AFPRWFWGSKAYLTVYDPDYMKVIL-GR--SDPKA----------- 115 260 ----QDILTRVKN--FPS------ACPQWLWGSNVRIQVYDPEYMKLIL-GR--SDPKA----------- 114 261 ---------------------------------------------------------------------- 0 262 ----QRIQKWVET--FPS------ACPHWLWGGKVRVQLYDPDYMKVIL-GR--SDPKS----------- 116 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 ----DKVVSWAHQ--FPY------AHPLWFGQFIGFLNIYEPDYAKAVY-SR--GDPKA----------- 117 266 ----DKVVTWTQQ--FPY------AHPLWVGQFIGFLNIYEPDYAKAVY-SR--GDPKA----------- 106 267 ----DKVVSWAQQ--FPH------AHPLWFGQFVGFLNIYEPDYAKAVY-SR--GDPKA----------- 111 268 ----KELTRLVGT--YPQ------GFLMWIGPMVPVITLCHSDIVRSIL-NA--SAAVALKD-------- 121 269 ----RVLTQLVAT--YPQ------GFKVWMGPISPLLSLCHPDIIRSVI-NA--SAAIAPKD-------- 121 270 ----LYTQSLACT--FGD------MCCWWVGPWHAIVRIFHPTYIKPVL-FA--PAAIVPKD-------- 121 271 ----KQVTKLVAT--YPQ------GFMTWLGPILPIITLCHPDVIRSVL-SA--SASVALKE-------- 121 272 ----RLVTEMGQT--FRD------IHLCWLGPVIPVLRLVDPAFVAPLL-QA--PALVAPKD-------- 121 273 ----QFIAHLGRN--FRD------IHLSWVGPVYPILRLVHPNVIAPLL-QA--SAAVAPKE-------- 121 274 ---------------------------------------------------------------------- 0 275 ----FQVFDRRAK--LYG------PLYRIWAGPIAQVGLTRPEHVELIL-RD--TKHIDK---------- 104 276 ---------------------------------------------------------------------- 0 277 -MVKKIFEFMETI--SKD------QVLKVWLGPELNVLMGNPKDVEVVL-GT--LRFNDK---------- 104 278 -EQIMDFVKKNQR--KYG------RLYRVWILHQLAVFSTDPRDIEFVL-SS--QQHITK---------- 70 279 ---------------------------------------------------------------------- 0 280 ---ILDTVFSWWH--QYG-----KDNFVFWIGTYSNVLVTSSKYLEFIL-SS--QTLITK---------- 60 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 ---------------------------------------------------------------------- 0 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 ----VQALMKIAD--ELG------EIFKFEAPGRVTRYLSSQRLIKEAC-DESRFDKNL----------- 72 312 ---------------RLGS-----GIVEQRISVLSIIALADP--------DETVWENI------------ 30 313 ----IGFQKKYSK--KYG------NIFSMQLAGIGSFVILEPQALQEIFTQDSRFDVG------------ 70 314 ----MPHINHTIN--TYG------RNSFTWMGRIPRIHVMEPELIKEVL-THSSKYQKN----------- 130 315 ----VPY--------------------------------------------------------------- 84 316 --GREEFFKSRLQ--KYKS-----TVYRANMPPGPFIASNPRVIVLLDA-KSFPVL-------------- 107 317 -GGRDEYFRSRMQ--KYQS-----TVFRANMPPGPFVSSNPKVIVLLDA-KSFPIL-------------- 80 318 -QGPDKFFRTRAE--KYKS-----TVFRTNIPPTPFFGNNPNIVAVLDV-KSFSHL-------------- 106 319 GTVMQFACDLWDKVSDPKA-----KTIGLKILGIPLIETKDPENVKAIL-ATQFNDFSL----------- 136 320 GTVMEFACNVWNNVLNGNV-----RTVGLRIMGLNIIETTDPENVKAIL-ATQFNDFSL----------- 134 321 GTLIDFTYQRTLELDNPDI-----PTFTFPIFSVLIISTLEPDNIKAIL-ATQFNDFSL----------- 121 322 GTIIDFSIERYPELKHPET-----PTFEFPIFTVKLISTIDPENIKAIL-ATQFSDFSL----------- 125 323 GRAQEYNDEKFAAGPKPKV-----GTYLFKLFTKDVLVTKDPENIKAIL-ATQFEDFSL----------- 120 324 GNQIDLLFLKFNEAKHPSI-----GTFVTRSFGMQFIATKDPENIKAML-ATQFNEYTL----------- 118 325 GKQIDLLFKKFNEAKHPSI-----GTFVTRSFGMQFIATKDPENIKAML-ATQFNDFTL----------- 118 326 GRQVDLINSRFPD----DI-----DTFSSYTFGNHVIFTRDPENIKALL-ATQFNDFSL----------- 112 327 VELKNIMIINLPIRKFQVW-----VHMLVPSLEQSSSSQKIRRNIKALL-ATQFSDFSL----------- 116 328 GKLADYADQTFD--EYPHH-----SFYMTVAGMLKIVLTVDPENIKAVL-ATQFNDFAL----------- 122 329 GQLADYTDTTFD--KYPNL-----SSYMTVAGVLKIVFTVDPENIKAVL-ATQFNDFAL----------- 122 330 GRLARFWPITKFD-DYPNH-----TFYMSIIGALKIVLTVIQENIKAVL-ATQFTDFSL----------- 123 331 GRLIEFSVKRF---LSSPH-----QTFMNRAFGIPIILTRDPVNIKAML-AVQFDEFSL----------- 110 332 HTSIDYAIDQFNNVPFPHV-----HTFVTKVLGNELIMTKDPENIKVLL-RFPVFDKFD----------- 123 333 IRKGGLYSEIDGRFKSLDV-----STFKSITLGKTTYVTKDIENIRHILSATEMNSWNL----------- 112 334 TKNGGLHKKLQQMLESLQT-----TTFRSRMLTGSQIVTMEPENERTMCSSAHMKDWTI----------- 113 335 --HDNLLEYISIRIADMKV-----RTGFQTLAGQRWLVTLEPENIKTVL-ATSPKDYSL----------- 116 336 --HDDLLEWFTHRFEEFGR-----RTAFQSVAGQLWIGTIEPENIKTML-ATSFKDYSL----------- 115 337 --KMFEVYRQRAL--EFG------NIYYEKVGHFHCVVISSPGEYSR-L-VHAERQ-------------- 148 338 ----HFRHIENFQ--KYG------PIYREKLGNLESVYIIHPEDVAH-L-FKFEGS-------------- 116 339 ----HFRHIENFQ--KYG------PIYREKLGNLESVYIIHPEDVAH-L-FKFEGS-------------- 116 340 ----HFHHIENFQ--KYG------PIYREKLGNLESVYIIHPEGVAH-L-FKFEGS-------------- 116 341 ----HYHHVQNFQ--KYG------PIYREKLGNLESVYIIDPEDVAL-L-FKFEGP-------------- 116 342 ----HLHHVQNFQ--KYG------PIYREKLGNVESVYVIDPEDVAL-L-FKSEGP-------------- 116 343 ----HYHHMQNFQ--KYG------PIYREKLGNMESVYILDPKDAAT-L-FSCEGP-------------- 114 344 ---------------------------------------------------------------------- 0 345 ----HRVMVHNFN--TFG------PIYREKIGYYDSVNIIKPEMPAI-L-FKAEGH-------------- 114 346 ----HLEMHQAFQ--ELG------PIFRHSAEGAQIVSVMLPEDAEK-L-HQVESI-------------- 106 347 ----HLEMHQVFR--ELG------PIFRHSVGKTQIVFVTLPEDVEK-L-TQVEST-------------- 106 348 ----HLEMHQVFR--ELG------PIFRHSVGKTQIVSVMLPEDAEK-L-HQVESM-------------- 106 349 ----HLEMHQAFQ--ELG------PIFRHSAGGAQIVSVMLPEDAEK-L-HQVESI-------------- 106 350 ----HLEMHQAFQ--ELG------PIFRHSAGGAQIVSVMLPEDAEK-L-HQVESI-------------- 105 351 ----HLDMHQTFQ--ELG------PIFRYDVGGRHMVFVMLPEDVER-L-QQADSH-------------- 106 352 ----HLDMHQTFQ--ELG------PIFRYDVGGRHMVFVMLPEDVER-L-QQAESL-------------- 106 353 ----HLEVHQTFQ--ELG------PIFRYDLGGAGMVCVMLPEDVEK-L-QQVDSL-------------- 106 354 ----HLEMHQTFQ--ELG------PIFRYNLGGPRMVCVMLPEDVEK-L-QQVDSL-------------- 106 355 ----HLAMEENFQ--NLG------PIYREKLGTHNSVNIMLPQDVAR-L-FQSEGI-------------- 123 356 ----HLHKLQVLNKARYG------PMWVSYLGPQLFVNLASAPLVET-V-MRQEGK-------------- 126 357 ----HLHELQALNKAKYG------PMWTTTFGTRTNVNLASAPLLEQ-V-MRQEGK-------------- 125 358 ----QLHQLQVLYKAKYG------PMWMSYLGPQMHVNLASAPLLEQ-V-MRQEGK-------------- 123 359 ---------------------------------------------------------------------- 0 360 ----KQHDTLAEYHKKYG------QIFRMKLGSFDSVHLGSPSLLEA-L-YRTESA-------------- 124 361 ----KQHDTLVEYHKKYG------KIFRMKLGSFESVHLGSPCLLEA-L-YRTESV-------------- 124 362 L--YDLYIRESME--KYG------AVKFFFGSRWNILVSRSEYLAQIFKDEDTFAK-------------- 99 363 R---FVVVDNAHK--KYG------KLVRIAPRHTSIADDGAIQAVYGHGNG------------------- 96 364 I---HEIMMDLHR--RHG------AIVRIGPRRYDFDTMEALKII-----YRIGNA-------------- 111 365 I---HEIMVDLHR--CHG------PIVRICPNRYDFDTMEALKII-----YRIGDA-------------- 112 366 L---WEIA-KMHD--KYG------PIVRVNDKEVHIRDPSYYSTIYTAGARKTNK--------------- 113 367 TLHSIMLKLSQKF--RSG------MFYINMWPFSGTWLVVATPSGAAQIQSLNLSKP------------- 74 368 ----RDIQ-RLHN--QYG------PVVRIAPDELSYITPEAAKPIYTSSPE------------------- 88 369 ----HDLMHRHHQ--TYG------DTVRIKPDEISYANGQAWRDIHAHVPGRPE---------------- 103 370 ------------------------------------------SPIYTSNPE------------------- 9 371 -----FEEYKAKW--ASG------PLSCVSIFHKFVVI-ASTRDLARKI-LQ--SSKFV----------- 92 372 ---RIHYVHSLHQ--KYG------PIVRIGPQEIDVADPVAGREI-----HRMGSG-------------- 91 373 ----YEFFEECQK--KYG------DIFSFVLLGRVMTVYLGPKGHEFVF-NAKLADVSA----------- 122 374 ----IEFLENAYE--KYG------PVFSFTMVGKTFTYLLGSDAAALLF-NSKNEDLNA----------- 127 375 ----IEFLENAYE--KYG------PVFSFTMVGKTFTYLLGSDAAALLF-NSKNEDLNA----------- 133 376 ----YEFFENCRK--QHG------DVFSFLLLGKVMTVYLGPKGHEFVL-NAKLSDVSA----------- 60 377 ----YVFFRECRA--KYG------DVFTFVCMGRKMTAFLGVQGNDFLF-NGKLADLNA----------- 99 378 ----YKFFFECRE--KYG------DVFTFVLLGRKITVALGPKGSNLVF-NAKHQQVTA----------- 126 379 ----YQFFFASRA--KYG------DIFTFILLGKKTTVYLGVEGNEFIL-NGKLKDVNA----------- 108 380 ----YEFFEKCRL--KYG------DVFSFMLLGKVMTVYLGPKGHEFIY-NAKLSDVSA----------- 114 381 ----YEFFESCRQ--KYG------DVFSFMLLGKIMTVYLGPKGHEFVF-NAKLSDVSA----------- 114 382 ----YEFFEDCQK--KYG------DIFSFMLLGRIMTVYLGPKGHEFIF-NAKLADVSA----------- 64 383 L-WMGSRSACNYYNRVYGE-----FMRVWISGEETLIISKSSSMFHIMK-HNHYSSRFG----------- 117 384 L-WMGIGSACNYYNKMYGE-----FMRVWVCGEETLIISKSSSMFHVMK-HSHYISRFG----------- 117 385 ---------------------------------------------------------------------- 0 386 L-WMGSRSACNYYNKMYGE-----FMRVWISGEETLIISKSSSMVHVMK-HSNYISRFG----------- 117 387 L-WMGIGSACNYYNKMYGE-----FMRVWISGEETLIISKSSRLFHVMK-HSHYISRFG----------- 117 388 L-WMGVGNACNYYNKTYGE-----FVRVWISGEETFIISKSSSVFHVMK-HWNYVSRFG----------- 116 389 I-WMGIGTASNYYNSKYGD-----IVRVWINGEETFILSSSSAVHHVLR-QGRYTSRFG----------- 136 390 I-WTGIGTASNYYNNKYGD-----IVRVWINGEETLILSRASAVHHVLK-NRKYTSRFG----------- 130 391 ----AGFLTRMKE--KHG------DIFTVLVGGRHVTVLLDPHSYDAVV-WEPRSRL------------- 94 392 ----ASFLTRMKE--KHG------DIFTILVGGRYVTVLLDPHSYDAVV-WEPRTRL------------- 94 393 ----LTFLKTLQR--QHG------DTFTVFLVGKYITFVLNPFQYQYVT-KNPKQLS------------- 108 394 ----LEFLRANQR--KHG------HVFTCKLMGKYVHFITNSLSYHKVL-CHGKYFD------------- 96 395 ----LEFLRAKQR--KHG------HVFTCKLMGKYVHFITNSLSYHKVL-CHGKYFD------------- 96 396 ----LEFLRANQR--KHG------HVFTCKLMGKYVHFITNSLSYHKVL-CHGKYFD------------- 96 397 ----LDFLRANQR--KYG------HVFTCKLMGKYVHFITNSLSYHKVL-CHGKYFD------------- 96 398 ----LEFLRANQR--KHG------HVFTCKLMGKYVHFITNPLSYHKVL-CHGKYFD------------- 96 399 --------------------------RVTLYDGRQAWVVTKHEAARKLL-GDPR---LSSNRTD------ 74 400 --------------------------RVTLFDGRPVWAVTGHALARRLL-ADPR---LSTDRSHP----- 83 401 --------------------------RATLWDGSSCWLVTRHQDVRAVL-GDPR---FSADAHR------ 74 402 --------------------------LGTRYDGRQAWVVVIHEAARKLL-ASRF---ESADAHR------ 75 403 --------------------------RTAFADGRPGWLVTGYSAARAVL-SDSR---FTARGER------ 67 404 --------------------------RVLMLDGREAWLAASWEDVAKVF-VDPR---FSRSAT------- 0 405 --------------------------PVGELYGAPAFLVCRYEDVRRIL-ADSN---RFSNAHTPMFA-- 70 406 -------------------------RVRLPYGEGTAWLVTRMSDARIVL-GDSR---FSTAAATDPATP- 81 407 --------------------------QVKLFDGSLAWLVTKHKDVCFVA-TSEK---LSKVRTR------ 66 408 --------------------------KVKLFDGSLAWLVTKYKDVTFVA-TDER---LSKVRTR------ 66 409 --------------------------QVELFDGSLAWLVVKHEDVCRVA-TDER---LSKERTR------ 72 410 --------------------------PVRFL-GQDAWLVTGYDEAKAAL-SDLR---LSSDPKKKYPGVE 70 411 -------------------------RIRTVNGL-DAWLITRYEDVKQAL-LDPR---IAKDFGRTQQIIE 73 412 --------------------------RASYPWGAVQWLATRYSDVKAVL-TDPR---LVNNPANVPEMHL 69 413 --------------------------QPVWQDRYGVWHVFRHADVQTVL-RDTA--TFSSDPTR------ 75 414 --------------------------PVFWDESRQAWQVFRYDDYLTVS-TNPQ---LFSSDFSPV---- 83 415 -------------------------RVRFPSGH-EGWWVTGYDEAKAVL-SDAA---FRPAGMP------ 64 416 --------------------------------------LSRHADIFWAF-KATG---DAFRGPAPGE--- 25 417 --------------------------PVYFHEETNTWNVFQYEHVKQVL-SNYD--FFSSDGQR------ 69 418 --------------------------PVSYHEGTDTWNVFKYEDVKRVL-SDYK--HFSSVRKR------ 68 419 -------------------------RVRPPYGE-EAWLVTRYEDVRAVL-GDGR--FVRGPSMT------ 68 420 -------------------------RIRMAYGEGEAWLVTRYEDVRTVT-TDRR--FSRSAVLG------ 75 421 --------------------------PVRYDPLRDCWDVFKYDDVQFVL-KNPK--LFSSKRG------- 77 422 --------------------------PVYYDGN--IWQVFSYRYTKEVL-NNFS--KFSSDLTGYHERL- 0 423 --------------------------WNPESDGSGFWAVLRHKDIIEVS-RQPL--LFSSAYENGGHRI- 71 424 --------------------------MAHIEGYDPMWIATKHADVMQIG-KQPG--LFSNAEGSEILYDQ 82 425 --------------------------LVWTRCNGGHWIATRGQLIREAY-EDYR--HFSS---------- 83 426 --------------------------PFLRREDG-IFLVLRADHIFLLG-TDPR--TRQI---------- 80 427 --------------------------PVVHVASVRRTFLTKAFDTKMVK-DDPS--RFSSDDPS------ 81 428 --------------------------PVFFSPLLDYWVVTRYEDIKQIF-KTPS--VFSPSIDEALQILG 88 429 ---------------------------------------LFGGTLVAQD-GIAH---RQARDAI------ 21

193 -----FYG-RKLNPIQGDP--EKDERTNLFSA--QGFRWKRLRAISSPTFSNNSLRK-----------IN 156 194 ---------------------------------------------------------------------- 0 195 -----FYG-RKLTAIQGDP--NKNKRVPLVAA--QGHRWKRLRTLASPTFSNKSLRK-----------IM 145 196 -----FYG-RKLRPIIGDP--EKDKRVNIFST--QGKRWKRLRTLSSPSFSNNSLRK-----------VR 143 197 -----FYG-RKTNPIQGDP--NKNKRAHLVSA--QGHRWKRLRTLSSPTFSNKNLRK-----------IM 145 198 -----FYG-RKTNPIQGDP--NKNKRAHLVLA--QGHRWKRLRTLASPTFSNKSLRK-----------IM 145 199 -----FYA-RKQNPLQGDP--DKDPRIHLVTS--QGHRWKRLRTLASPTFSNKSLRK-----------IF 145 200 -----FYG-RKLNPIQGNP--EKEQRVHLLAA--QGYRWKRLRTISSQSFSNASLKK-----------MK 148 201 -----FYG-RKRNPIQGDS--EKEKRTNLFAA--QGFRWKRLRAISSPTFSNSSLRK-----------LY 145 202 -----FSD-RSVPSIYEAN--QLTASLLMNS---YSSGWKHTRSAIAPIFSTGKMKA-----------MQ 0 203 -----FSD-RIVPPIFDSN--QLNQSLLQNT---YATGWKHTRSAIAPIFSTGKMKA-----------MQ 0 204 -----FSD-RTPPPIIEDN--KLKESLLQNT---YESGWKHTRSAIAPIFSTGKMKA-----------MH 0 205 -----FSD-RMTPDIFGMN--QLNQSLLQNT---YATGWKHTRSAIAPIFSTGKMKA-----------MH 0 206 -----FTY-RAHRSPETLL--PVHDHTGILAS--DGDHWRLQRRTSLKILRDFGLGR-----------NL 138 207 -----FIY-RADRPPETLL--QPHLNTGVLFS--NGDNWRFQRRTALKILRDFGLGR-----------NL 137 208 -----FIN-RANRPPETLL--QPHLNTGVLGS--SGDNWRLQRRTALKILRDFGLGR-----------NL 138 209 ---------------------------------------------------------------------- 0 210 ---------------------------------------------------------------------- 0 -----YLD-KMIYSKLNTS--LRGGDYGVIDT--NGNTWKEHRKFALHTLRDFGMGK-----------EA 0 -----YAD-KYLSPEFNKY--FREMQFTKLL---SGDRWKEHRKFAVLQLRELGVGK-----------PL 0 211 -----TSG-RSSAESFVLFTGDRLNGDGVILA--MRQKWKDMRHEISRFMNKWYGAP-----------MD 0 212 -----FSN-RWRNFVTDSI---MEGSNGIVQI--DGNKWREQRRFALHTLRDFGVGK-----------PL 0 213 -----YKG-KYPQAFNQKF------V-GI-GS--RGK-AFV----------------------------- 113 214 -----FTN-RRDFGPVGIM------GKAVSVA--KDEEWKRYRALLSPTFTSGRLKE-----------MF 146 215 -----FTN-RRDFGPVGIM------GKAVSVA--KDEEWKRYRALLSPTFTSGRLKE-----------MF 146 216 -----FTN-RRDFGPVGIM------SKAISIS--KDDEWKRYRALLSPTFTSGKLKE-----------MF 146 217 -----FTN-RQDFFPVGIM------SKSISLA--KDEEWKRYRALLSPTFTSGNLKE-----------MF 146 218 -----FTN-RRSFGPVGFM------KKAVSIS--EDEDWKRVRTLLSPTFTSGKLKE-----------ML 145 219 -----FTN-RRNFGPVGIL------KKAISIS--EDEEWKRIRALLSPTFTSGKLKE-----------MF 146 220 -----FTN-RRRFGPVGIL------KKAISIS--ENEEWKRIRALLSPTFTSGRLKE-----------MF 146 221 -----FTN-RRPFGPVGFM------KSAISIA--EDEEWKRLRSLLSPTFTSGKLKE-----------MV 146 222 -----FTN-REPFGPVGFM------KSAISIA--EDEEWKRLRSLLSPTFTSGKLKE-----------MV 146 223 -----FTN-RRPFGPVGFM------KNAISIA--EDEEWKRIRSLLSPTFTSGKLKE-----------MV 146 224 -----FTN-RRPFGPVGFM------KNAISIA--EDEEWKRIRSLLSPTFTSGKLKE-----------MV 146 225 -----FTN-RRSLGPVGFM------KSAISLA--EDEEWKRIRSLLSPTFTSGKLKE-----------MF 146 226 -----FTN-RRTLGPVGFM------KSAISLS--EDEEWKRMRTLLSPTFTTGKLKE-----------MF 146 227 -----FTN-RRSLVPVGFM------KKAVSLP--EDEEWKRIRTQLSPNFTSGKLKE-----------MF 146 228 -----FTN-RRSLVPVGFM------KKSVSLS--EDEEWKRIRTQLSPNFTSGKLKE-----------MF 146 229 -----FTN-RRSFGPVGFM------KKSITIS--KDEEWKRLRTLLSPAFTSGKLKE-----------MF 146 230 -----FTN-RRCFGPMGFM------KKAITMS--EDEEWKRLRTILSPTFTSGKLKE-----------MF 146 231 ---------------------------------------------------------------------- 0 232 -----FTN-RMASGLEFKSV-----ADSVLFL--RDKRWEEVRGALMSAFSPEKLNE-----------MV 152 233 -----FSN-RMASGLEPKLI-----ADSVLML--RDRRWEEVRGALMSAFSPEKLNE-----------MT 152 234 -----FSN-SMASGLEPKMV-----ADSVLLL--RDSSWEEVSGALMSSFSPEKLDE-----------MT 152 235 -----FTN-RMATGLESKPV-----ADSILFL--RDKRWEEVRSVLTSAFSPKKLNK-----------LT 152 236 -----RGL-YYNEKDDPLT------GHLVMV---EGEKWRSLRTKLSPTFTAGKMKY-----------MY 148 237 -----RGQ-FHNGRDDPLT------QHLFNL---DGKKWKDMRQRLTPTFTSGKMKF-----------MF 146 238 -----RGG-FHNVEDDPLT------GHLSNL---EGEQWRALRAKLTPVFTSARMKY-----------MF 146 239 -----RGG-LSNVEDDPLT------GHLVSL---EGEQWRAMRTKLTPVFTSARMKY-----------MF 140 240 -----RGV-FNNVEDDPLT------GHLVAL---EGEQWRAMRTKLSPVFTSARMKY-----------MF 145 241 ---------------------------------------------------------------------- 0 242 -----RGV-EFSL--DGLG------ANIFHA---DGDRWRSLRNRFTPLFTSGKLKS-----------ML 143 243 -----RGV-EFSK--EGLG------SNLFHA---DGDTWRTLRNRFTPIFTSGKLKN-----------MF 143 244 -----RGV-EFSL--DGLG------ANIFHA---DGDRWRSLRNRFTPLFTSGKLKT-----------ML 143 245 -----RGF-YANFKDDPLS------KNLVRL---HGDLWRKVRTKLTPTFTSGRMRQ-----------MF 141 246 -----RGF-FVNYKSDPLS------RNMARL---HGEMWRKIRTKITPTFTAAPMRQ-----------MF 143 247 -----RGL-YVDEKNDPMS------ANLFVM---EGQSWRTLRMKLAPSFSSGKLKG-----------MF 142 248 -----RRT-FTSSFDPIF-------GRGLLLL--HGDEWKAMRSTMSPAFTSSKMRL-----------MV 139 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 -----SGI-YQFLAPWI--------GYGLLLL--NGKKWFQHRRMLTPAFHYGILKP-----------YV 156 253 ---------YQSLAPWI--------GYGLLLL--NGKKWFQHRRMLTPAFHYDILKP-----------YV 153 254 -----RGS-YTFVAPWI--------GYGLLLL--NGQPWFQHRRMLTPAFHYDILKP-----------YV 159 255 -----QGS-YRFLAPWI--------GYGLLLL--NGQTWFQHRRMLTPAFHYDILKP-----------YV 159 256 -----PRN-YKLMTPWI--------GYGLLLL--DGQTWFQHRRMLTPAFHYDILKP-----------YV 155 257 -----RVS-YSFLAPWI--------GYGLLLL--EGQTWFQHRRMLTPASHYDILKP-----------YV 159 258 -----NGV-YRLLAPWI--------GYGLLLL--NGQPWFQHRRMLTPAFHYDILKP-----------YV 158 259 -----NGA-YRLLAPWI--------GYGLLLL--NGQPWFQHRRMLTPAFHYDILKP-----------YV 158 260 -----HGS-YRFLAPWI--------GYGLLLL--NGQTWFQHRRMLTPAFHYDTLKP-----------YV 157 261 ---------------------------------------------------------------------- 0 262 -----HGS-YRFLAPWI--------GYGLLLL--NGQTWFQHRRMLTPAFHYDILKP-----------YV 159 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 -----PDV-YDFFLQWI--------GRGLLVL--EGPKWLQHRKLLTPGFHYDVLKP-----------YV 160 266 -----PDV-YDFFLQWI--------GKGLLVL--DGPKWFQHRKLLTPGFHYDVLKP-----------YV 149 267 -----ADV-YDFFLQWI--------GKGLLVL--DGPKWFQHRKLLTPGFHYDVLKP-----------YV 154 268 -----VIF-YTILKPWL--------GDGLLVS--AGDKWSRHRRMLTPAFHFNILKP-----------YV 164 269 -----KFF-YSFLEPWL--------GDGLLLS--AGDKWSRHRRMLTPAFHFNILKP-----------YM 164 270 -----KVF-YSFLKPWL--------GDGLLLS--AGEKWSRHRRMLTPAFHFNILKP-----------YM 164 271 -----VIF-YSFLKPWL--------GDGLLLS--DGDKWSCHRRMLTPAFHFNILKP-----------YV 164 272 -----TTF-LRFLKPWL--------GDGLFLS--SGDKWSRHRRLLTPAFHFDILKP-----------YV 164 273 -----MTL-YGFLKPWL--------GDGLLMS--AGEKWNHHRRLLTPAFHFDILKS-----------YV 164 274 ---------------------------------------------------------------------- 0 275 -----SLV-YSFIRPWL--------GEGLLTG--TGAKWHSHRKMITPTFHFKILDI-----------FV 147 276 ---------------------------------------------------------------------- 0 277 -----AGE-YKALEPWL--------KEGLLVS--RGRKWHKRRKIITPAFHFKILDQ-----------FV 147 278 -----NNL-YKLLNCWL--------GDGLLMS--TGRKWHGRRKIITPTFHFKILEQ-----------FV 113 279 ---------------------------------------------------------------------- 0 280 -----SDI-YQLTHPWL--------GLGLLTS--TGSKWHKHRKMITPAFHNILQDF-----------HE 104 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 -----SPPYYFLKNWL---------RDGLLLS--KGPKWQSRRKILTPTFHFNILRQ-----------FC 43 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 -----SQALKFVRDFA---------GDGLFTSWTHEKNWKKAHNILLPSFSQQAMKG-----------YH 117 312 ------------RLLM---------GDELFT----ESNWGKAHN-------------------------- 49 313 ----------------------------------DGDRHRRERKLLMPPFHGERLQA-----------YA 95 314 -----FDV-HNPLVKFL--------LTGVGSF--EGAKWSKHRRIISPAFTLEKLKS-----------ML 173 315 ---------------------------------------------------------------------- 84 316 -----FDM-SKVEKKDL--------FTGTYM---PSTELTGGYRILSYLDPSEPNHT-----------KL 149 317 -----FDV-SKVEKKDL--------FTGTYM---PSTKLTGAYRVLSYLDPSEPRHA-----------QL 122 318 -----FDM--LVDKK------------------------------------------------------- 114 319 -----GTR-HDFLYSLL--------GDGIFTL--DGAGWKHSRTMLRPQFAREQVSH--------VKLLE 182 320 -----GTR-HDFLYSLL--------GDGIFTL--DGAGWKHSRAMLRPQFAREQVAH--------VKLLE 180 321 -----GTR-HSHFAPLL--------GDGIFTL--DGAGWKHSRSMLTPQFAREQVSH--------VKLLE 167 322 -----GTR-HAHFAPLI--------GDGIFTL--DGAGWKHSRAMLRPQFAREQVGH--------VKLLE 171 323 -----GKR-LDFFKPLL--------GYGIFTL--DGEGWKHSRAMLRPQFAREQVGH--------VKLIE 166 324 -----GQR-LNFLAPLL--------GKGIFTL--DGNGWKHSRAMLRPQFSRDQIGH--------VKMLE 164 325 -----GQR-LSYFAPLL--------GKGIFTL--DGEGWKHSRAMLRPQFSRDQVGH--------VKMLE 164 326 -----GGR-IKFFKPLL--------GYGIFTL--DGEGWKHSRAMLRPQFAREQLPM--------SPSLE 158 327 -----GKR-HTLFKPLL--------GDGIFTL--DGQGWKHSRAMLRPQFAREQVAH--------VTSLE 162 328 -----GAR-HAHFDPLL--------GDGIFTL--DGEGWKHSRAMLRPQFAREQIAH--------VKALE 168 329 -----GAR-HAHFDPLL--------GDGIFTL--DGEGWKHSRAMLRPQFAREQIAH--------VKALE 168 330 -----GTR-HAHFYPLL--------GDGIFTL--DGEGWKHSRAMLRPQFARDQIGH--------VKALE 169 331 -----GLR-YNQFEPLL--------GNGIFTS--DGEPWKHSRIMLRPQFIKSQVSH--------VNRLE 156 332 ----YGTR-SSAVQPSL--------GMGIFTL--EGENWKATRSVLRNMFDRKSIDK--------VHDFE 170 333 -----GAR-PIALRPFI--------GDGIFAS--EGQSWKHSRIMLRPVFAKEHVKQ--------ITSME 158 334 -----GYR-PFALKPLL--------GDGIFSS--EGESWKHSRIMLRPIFAKEHIKQ--------ITAME 159 335 -----GFR-YDIMYGLL--------GNGIFTL--SGDGWKHSRALLRPQFSREQVSH--------LESMR 162 336 -----GFR-YNAMYGLL--------GNGIFTL--SGDGWKNSRALLRPQFSREQVSH--------LESMR 161 337 -----YPN-RREMVPIAYYRKQKGFDLGVVNS--QGEEWYRQRTVVSKKMLKLAEVS-------NFSTQM 203 338 -----YPE-RYDIPPWLAYHRYYQKPIGVLFK--KSGTWKKDRVVLNTEVMAPEAIK-------NFIPLL 171 339 -----YPQ-RYDIPPWLAYHQYYQKPIGVLFK--KSGAWKKDRVVLNTEVMAPEAIK-------NFIPLL 171 340 -----YPQ-RYDIPPWLAYHRYYQKPIGVLFK--KSGAWKKDRVVLNTEVMAPEAIK-------NFIPLL 171 341 -----NPE-RYNIPPWVAYHQHYHKPVGVLLK--KSGAWKKDRLVLNTEVMAPEAIK-------NFIPLL 171 342 -----NPE-RFLIPPWVAYHQYYQRPIGVLLK--KSAAWKKDRVALNQEVMAPEATK-------NFLPLL 171 343 -----NPE-RYLVPPWVAYHQYYQRPIGVLFK--SSDAWRKDRIVLNQEVMAPDSIK-------NFVPLL 169 344 ---------------------------------------------------------------------- 0 345 -----YPK-RLTVEAWTSYRDYRNRKYGVLLK--NGEDWRSNRVILNREVISPKVLG-------NFVPLL 169 346 -----LPH-RMPLEPWVAHRELRGLRRGVFLL--NGADWRFNRLQLNPNMLSPKAIQ-------SFVPFV 161 347 -----HPC-RMPLESWIVHRELRGLGRGVFLL--NGPEWYFDRLQLNPNVLSPKAVQ-------KFVPLV 161 348 -----LPR-RMHLEPWVAHRELRGLRRGVFLL--NGPEWRLNRLRLNRNVLSPKAVQ-------KFVPMV 161 349 -----LPR-RMHLEPWVAHRELRGLRRGVFLL--NGAEWRFNRLKLNPNVLSPKAVQ-------NFVPMV 161 350 -----LPR-RMTLESWVAHRELRGLRRGVFLL--NGADWRFNRLQLNPNMLSPKAVQ-------SFVPFV 160 351 -----HPQ-RMILEPWLAYRQARGHKCGVFLL--NGPQWRLDRLRLNPDVLSLPALQ-------KYTPLV 161 352 -----HPQ-RMLLEPWLAYRQARGHKCGVFLL--NGPQWRLDRLRLNPDVLSLPALQ-------KYTPLV 161 353 -----HPH-RMSLEPWVAYRQHRGHKCGVFLL--NGPEWRFNRLRLNPEVLSPNAVQ-------RFLPMV 161 354 -----HPH-RMILEPWVAIRQHRGHKCGVFLL--NGPEWRFNRLRLNPDVLSPKAVQ-------RFLPMV 161 355 -----FPR-RMTMEAWSKHRELRNHKQGVFLL--NGEAWRSDRIILNKEVLSLAGVK-------KFLPFL 178 356 -----YPV-RNDMQLWKEHRDHQDLAYGVFTT--DGHDWYQLRQALNQRLLKPAEAA-------LYTDAL 181 357 -----YPI-RDSMEQWKEHRDHKGLSYGIFIT--QGQQWYHLRHSLNQRMLKPAEAA-------LYTDAL 180 358 -----YPV-RNDMELWKEHRDQHDLTYGPFTT--EGHHWYQLRQALNQRLLKPAEAA-------LYTDAF 178 359 ---------------------------------------------------------------------- 0 360 -----HPQ-RLEIKPWKAYRDHRNEAYGLMIL--RGQEWQRVRSAFQKKLMKPVEIM-------KLDKKI 179 361 ------PQ-RLEIKPWKAYRDYRKEGYGLLIL--EGEDWQRVRSAFQKKLMKPGEVM-------KLDNKI 178 362 -----SGN-QKKIPYSALAAYT---GDNVISA--YGAVWRNYRNAVTNGLQHFDDAP------------I 146 363 -----FLK-SDFYDAFVSI------HRGLFNTR-DRAEHTRKRKTVSHTFSMKSIGQ-----------FE 142 364 -----LPK-ADYYKPFGLPS-----FPNLFDEQ-NPARHSAIKKQVASLYTMTALLS-----------YE 158 365 -----LPK-ADYYIPFGLPS-----SPNLFDVQ-NPARHYAMKKQVASLYTMTALLS-----------YE 159 366 -----DPA-TVGAFDVPTAT-----AATVDH------DHHRARRGYLNPYFSKRSIT----------NLE 156 367 -----NIL-RRPLETITG-------GPSLMSM--HGETWKRWRALFNPGFNPNYLIG-----------LA 118 368 -----FPK-DPMLLPPFHN------GAPGILAA-DYAHHRRYRRLLASAFSEKGLRA-----------QQ 134 369 -----FLK-DPVRLPLAPN------GVMSILVS-DTRNHARFRSLFGHAFSDKGLRA-----------QE 149 370 -----FPK-DPMHLPPFHN------GTPGILAA-DHAHHRRYRRLLAFSFSDKGLRH-----------ER 55 371 -----KPC-VVDVAVKILR-------PCNWVFL-DGKAHTDYRKSLNGLFTKQALAQ---------YLPS 139 372 -----FMK-APFYELLSP-------GPVDNIFR-DPKLHAARRKLYARGFTLQSLRN----------EWE 137 373 -----EAA-YAHLTTPVF-------GKGVIYDC-PNSRLMEQKKFVKGALTK-----------EAFKSYV 167 374 -----EEV-YGRLTTPVF-------GKGVAYDV-PNAVFLEQKKILKSGLNI-----------AHFKQYV 172 375 -----EDV-YSRLTTPVF-------GKGVAYDV-PNPVFLEQKKMLKSGLNI-----------AHFKQHV 178 376 -----EDA-YTHLTTPVF-------GKGVIYDC-PNWKLMEQKKFAKVALTK-----------ESFIRYV 105 377 -----EEA-YSHLTTPVF-------GKDVVYDI-PNHVFMEHKKFIKSGLGF-----------SQFRSYV 144 378 -----EDA-YTHLTTPVF-------GKEVVYDV-PNAVFMEQKKFVKVGLSI-----------ENFRVYV 171 379 -----EEV-YGKLTTPVF-------GSDVVYDC-PNSKLMEQKKFIKYGLSQ-----------EALESYV 153 380 -----EEA-YTHLTTPVF-------GKGVIYDC-PNSRLMEQKKFAKFALTT-----------DSFKTYV 159 381 -----EDA-YKHLTTPVF-------GKGVIYDC-PNSRLMEQKKFAKFALTT-----------DSFKRYV 159 382 -----EAA-YSHLTTPVF-------GKGVIYDC-PNHRLMEQKKFVKGALTK-----------EAFVRYV 109 383 -----SKL-GLQ--CIGMH------EKGIIFN-NNPELWKTTRPFFMKALSGPGLVR-----------MV 161 384 -----SKL-GLQ--FIGMH------EKGIIFN-NNPALWKAVRPFFTKALSGPGLVR-----------MV 161 385 ---------------------------------------------------------------------- 0 386 -----SKR-GLQ--CIGMH------ENGIIFN-NNPSLWRTVRPFFMKALTGPGLIR-----------MV 161 387 -----SKR-GLQ--CIGMH------ENGIIFN-NNPSLWRTIRPFFMKALTGPGLVR-----------MV 161 388 -----SKL-GLQ--CIGMY------ENGIIFN-NNPAHWKEIRPFFTKALSGPGLVR-----------MI 160 389 -----SKQ-GLS--CIGMD------ERGIIFN-SNMALWKKTRTYFAKALTGPGLQK-----------TV 180 390 -----SKQ-GLS--CIGMN------EKGIIFN-NNVALWKKIRTYFTKALTGPNLQQ-----------TV 174 391 -------D-FHAYAVFLMERIF---DVQ-----LPHYNPGDEKSKMKPTLLHKELQA-----------LT 137 392 -------D-FHAYAIFLMERIF---DVQ-----LPHYSPSDEKARMKLTLLHRELQA-----------LT 137 393 -----FQK-FSSRLSAKAFSVK-----KLLTD--DDLNEDVHRAYLL--LQGKPLDA-----------LL 152 394 -----WKK-FHYTTSAKAFGHR-----SIDPN--DGNTTENINNTFTKTLQGDALCS-----------LS 142 395 -----WKK-FHYTTSAKAFGHR-----SIDPS--DGNTTENINKTFNKTLQGDALCS-----------LS 142 396 -----WKK-FHYTTSAKAFGHR-----SIDPN--DGNTTENINNTFTKTLQGDALHS-----------LS 142 397 -----WKK-FHFTTSAKAFGHR-----SIDPR--DGNTTENINNTFNKTLQGDALIS-----------LT 142 398 -----WKK-FHFATSAKAFGHR-----SIDPM--DGNTTENINDTFIKTLQGHALNS-----------LT 142 399 DNFPATSP-RFEAVRESPQA-FI-----GL----DPPEHGTRRRMTISEFTVKRIKG-----------MR 122 400 -DFPVPAE-RFAGAQRRRVA-LL-----GV----DDPEHNTQRRMLIPTFSVKRIGA-----------LR 130 401 TGFPFLTA-GGREIIGTNPT-FL-----RM----DDPEHARLRRMLTADFIVKKVEA-----------MR 122 402 TGFPFLTA-GGRDMIGTNPT-LF-----RM----DDPEHARLRRMTISHYTVKRIKT-----------IS 123 403 -EHPAVPR-AATLEDERCRR-LI-------------AGQFTARRMRQLTGRTERIVR-----------EH 110 404 -LGKDVPR-PAIQDQPVIM---------LM----DPPEHTRLRRVATKALTSRRMEA-----------LR 0 405 IPSGGDVI-EDELAAMRAGN-LI-----GL----DPPDHTRLRHILAAEFSVHRLSR-----------LQ 118 406 RMFPTPPE-PDGVLAQ------------------DPPDHTRLRRLVGKAFTARRVEE-----------MR 121 407 QGFPELSA-SGKQAAKAKPT-FV-----DM----DPPEHMHQRSMVEPTFTPEAVKN-----------LQ 114 408 PGFPELNA-GGKQAAKAKPT-FV-----DM----DAPDHMNQRGMVESLFTLEHVKK-----------LQ 114 409 LGFPELSA-GGKAAAKNKPT-FV-----DM----DAPAHMNQRSMVEPFFTEDHVEN-----------LR 120 410 VEFPAYLG-FPEDVRNYFAT-NM----GTS----DPPTHTRLRKLVSQEFTVRRVEA-----------MR 119 411 -KRLADAE-RRPGFSPDLGP-HM----LNT----DPPDHTRLRKLVVKAFTARRVEG-----------LR 121 412 PHPYEQAL-GDGGIPDEYVR-YLAGSILSQ----DGPGHLRLRRLSSRAFTVRRVNA-----------LR 122 413 -FSSDPTR-VIEGASPTPGM-IH-----EI----DPPEHRALRKVVSSAFTPRTISD-----------LE 122 414 --FPVPEE-LAILMG--PGT-FG-----GI----DPPRHGPLRKLVSQAFTPRRIAT-----------LE 127 415 ---PAAFT-PDSVILGSPGW-LV-----SH----EGREHARLRAIVAPAFSDRRVKL-----------LV 109 416 -LARYFSR-AATSPSLNLLA-ST----LAMK---DPPTHTRLRRLISRDFTMGQIDN-----------LR 74 417 TTIFVGDN-SKKKSTSPITN-LT-----NL----DPPDHRKARSLLAAAFTPRSLKN-----------WE 117 418 TTISVGTD-SEEGSVPEKIQ-I------ES----DPPDHRKRRSLLAAAFTPRSLQN-----------WE 115 419 RDEPRTRP-EMVKGGLLSM---------------DPPEHSRLRRLVVKAFTARRAES-----------LR 111 420 RDFPRMTP-EPIVQAESIN--LM-----------DPPASSRLRGLVAKSFTPRRVEQ-----------MR 120 421 ------------IQTESIL--TM-----------DPPKHTKLRALVSRAFTPKAVKQ-----------LE 111 422 ------------PTRYTML--TS-----------DPPLHDELRSMSADIFSPQKLQT-----------LE 0 423 FNENEVGL-TNAGEAAVGVP-FI-----SL----DPPVHTQYRKVIMPALSPARLGD-----------IE 119 424 NNEAFMRS-ISGGCPHVIDS-LT-----SM----DPPTHTAYRGLTLNWFQPASIRK-----------LE 130 425 -ECPFIPR---EAGEAYDFI-PT-----SM----DPPEQRQFRALANQVVGMPVVDK-----------LE 128 426 ETELMLNR-GVKAGAVFDFI-DH-----SMLF-SNGETHGKRRSGLSKAFSFRMVEA-----------LR 131 427 TPMKPAFQ-AHTLMRK------------------DGTEHARERMAMARAFAPKAIAD-----------HW 121 428 SYQFAAGR-MLVNE--------------------DEPIHTERRRLLMQPFEADNVAT-----------LE 126 429 QAALLPKG-LTLAGIGELFA-PV-----IR----ARVQRWKKRGDVTILRETGDLML-----------KL 69

193 VTVEDSAMELLRHIEEQ-TSEGQQID------MLQFYQEFTMDTIGRIAM-------GQTD----SQMFK 208 194 ---------------------------------------------------------------------- 0 195 GTVEESVTELVRSLEKA-SAEGKTLD------MLEYYQEFTMDIIGKMAM-------GQEK----SLMFR 197 196 NSVQECGTEILWNIEQK-VRKNEDID------MLIVYQEYTLGVISRIAL-------GQSE----SNMFK 195 197 STVEETVVELMRHLDDA-SAKGKAVD------LLDYYQEFTLDIIGRIAM-------GQTE----SLMFR 197 198 STVEETVVELMRHLDEA-SAKGKAVD------LLDYYQEFTLDIIGRIAM-------GQTE----SLMFR 197 199 STVEESVAEMMRHLEKG-TAGGKTID------ILEYYQEFTMDIIGKIAM-------GQSG----SMMFE 197 200 RTVEDSALELLRHIEKQ-TAGGEQID------MLRFYQEYTMDVIGRFAM-------GQTD----SMMFK 200 201 QTVEDSALELLRHIEKQ-SAGGKQID------MLKFYQEFTLDVIGRIAM-------GQTD--SQMFKNP 199 202 ETINSKVDLFLDILREK-ASSGQKWD------IYDDFQGLTLDVIGKCAF-------AIDS--NCQRDRN 0 203 ETIHSKVDLFLDILREK-ASSGQKWD------IYEDFQGLTLDVIGKCAF-------AIDS--NCQRDRN 0 204 ETIHSKVDLFLEILKEK-ASSGQKWD------IYDDFQGLTLDVIGKCAF-------AIDS--NCQRDRN 0 205 ETLVSKIDIFLEVLKEK-SSSGQKWD------IFENFQSLSLDIIGKCAF-------AIDS--NCQRDRT 0 206 MEEQVIRSVHEMLIQLENINDKKNVD------VFWPIQLCVGNVINETLF-------GFHY--KYEDSEK 193 207 MEEQVMRSVHEMLAQLERIADKKNVD------MFWPIQLCVGNVINESLF-------SYHY--KYEDSKK 192 208 MEEQVMRSVQEMLAQLDHIPDKQNVD------MYWPIQLCVGNVINESLF-------GYHY--KYEDSDK 193 209 ---------------------------------------------------------------------- 0 210 ---------------------------------------------------------------------- 0 MEASIQLEVDKIDEELK-KVEGKEVN------IQEHFDLAIGNIINQFLF-------GNRF--KDSSKFN 0 MESKILIEAEELIKKLK-TAEILNED----FLLQSELDVAVGSVINQFLF-------GYRF--DRSKLFE 0 211 ELVLHHTRCLEQELAKI-AETKSLID------LRDPLAGAIANVIQQITI-------GRNY--MYQDQEF 0 212 MEQMITLEVTSLMNHMEKSCGLDGKE----LHLCPSIAVCVGNIINNMLF-------GLRF--NQDNSYM 0 213 ---------------------------------------------------------------------- 113 214 PIIEQYGDILVKYLKQE-AETGKPVT------MKKVFGAYSMDVITSTSF-------GVNV--DSLNNPK 200 215 PIIEQYGDILVKYLKQE-AETGKPVT------MKKVFGAYSMDVITSTSF-------GVNV--DSLNNPK 200 216 PVIEQYGDILVKYLRQK-AKKGKPVT------MKDVLGAYSMDVITSTSF-------GVNV--DSLNNPE 200 217 PVIEQYGDILVKYLRQE-AEKGKPVA------VKDVLGAYSMDVIISTTF-------GVNI--DSLNNPE 200 218 PIIAQYGDVLVKNLRQE-AEKASPST------LKEIFGAYSMDVITGTSF-------GVNI--DSLRNPQ 199 219 PIINQYTDMLVRNMRQG-SEEGKPTS------MKDIFGAYSMDVITATSF-------GVNV--DSLNNPQ 200 220 PIINQFTDVLVRNMRQG-LGEGKPTS------MKDIFGAYSMDVITATSF-------GVNI--DSLNNPQ 200 221 PIIAQYGDVLVRNLRRE-AETGKPVT------LKDVFGAYSMDVITSTSF-------GVNI--DSLNNPQ 200 222 PIIAQYGDVLVRNLRRE-RETGKPVT------LKDVFGAYSMDVITSSSF-------GVNV--DSLNNPQ 200 223 PIIAKYGDVLVRNLRRE-AETGKPVT------LKDVFGAYSMDVITSTSF-------GVNI--DSLNNPQ 200 224 PIIAQYGDVLVRNLRRE-AETGKPVT------LKHVFGAYSMDVITSTSF-------GVSI--DSLNNPQ 200 225 PIIAQYGDVLVRNLRRE-AEKGKPVT------LKDIFGAYSMDVITGTSF-------GVNI--DSLNNPQ 200 226 PIIGQYGDVLVNNLRKE-AEKGKAIN------LKDVFGAYSMDVITSTSF-------GVNI--DSLNHPQ 200 227 PIIKQYGDVLVKNLRQE-AEKGKPVQ------LKEIFGAYSMDIIVATAF-------GVNV--DSLNNPH 200 228 PIIKQYGDVLVKNLRQE-AEKGKPVQ------LKEIFGAYGMDIIIATAF-------GVNV--DSLNNPH 200 229 PIIGQYGDTLVKNLRRE-EEKGKPVN------MKEILGAYSMDVITGTSF-------GVNV--DSLNNPE 200 230 PLMRQYGDTLLKNLRRE-EAKGEPIN------MKDIFGAYSMDVITGTSF-------GVNV--DSLNNPQ 200 231 ---------------------------------------------------------------------- 0 232 PLISQACDLLLAHLKRY-AESGDAFD------IQRCYCNYTTDVVASVPF-------GTPV--DSWQAPE 206 233 PLISQACELLLSHLKHS-AASGDAFD------IQRCYCCFTTNVVASVAF-------GIEV--NSQDAPE 206 234 PLISQACELLVAHLKPY-AASSDAFN------IQSCYCCYTMDVVASVAF-------GTQV--DSQNSPE 206 235 PLISQACDLLLAHLERY-AESGDAFD------IQRCYCCYTTDVVASVAF-------GTQV--NSSEEPE 206 236 NTVLEVGQRLLEVMYEK-LEVSSELD------MRDILARFNTDVIGSVAF-------GIEC--NSLRNPH 202 237 PTVIKVSEEFVKVITEQ-VPAAQNGA---VLEIKELMARFTTDVIGTCRF-------GIEC--NTLRTPV 203 238 PTVVRVGEILSDTIRGE-ISRESPKD-VQVLEIKDFCSRYTTDVIANCAF-------AIEC--SILTDPR 205 239 PTVVKVGENFARTVGEM-LEEGSG---TQILEIRDLCARFTTDVIGNCAF-------GIEC--NSLKDPN 197 240 STVVRVGENLHRVMGEM-LSERSD----QILEIKDVCARFTTDVIGTCLC--------IEC--NSLRDPD 200 241 ---------------------------------------------------------------------- 0 242 PLMSQVGDRFINSIDEV-SQTQPEQS------IHNLVQKFTMTNIAACVF-------GLNL----DEGML 195 243 YLMNEGADNFIDHVSKE-CEKHQEFE------IHTLLQTYTMSTISSCAF-------GVSY--DTISDKL 197 244 PLMSQVGDKFINTSDEV-SQTKSEQS------IHDLVQIFTITNIAACAF-------GLNL----DENML 195 245 GTVQAIGENFIQVMAGQ-VEELNN-----ELEVRDLCARFTTDVIGNVAF-------GLEC--NSLQEPQ 196 246 GNVEAIGRHFMQVMEKQ-AEPKRN-----VVEVRDLCARFTTDVIGNVAF-------GLDC--NSLEDPN 198 247 ETVDDVADKLINHLNERLKDGQTHVLE-----IKSILTTYAVDIIGSVIF-------GLEI--DSFTHPD 198 248 PFMEEIALEMIRVLRGKIKDSGKPYID---VEAKSMMTRYANDVIASCAF-------GLKV--NSQASDH 197 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 KIMADSVNIMLDKWEKLDDQDHP-------LEIFHYVSLMTLDTVMKCAFSHQ----GSVQLD-VNSRSY 214 253 KIMADSVSIMLDKWEKLDDQDHP-------LEIFHYVSLMTLDTVMKCAFSHQ----GSVQLD-VNSRSY 211 254 GLMVDSVQIMLDKWEQLVSQDSS-------LEVFQDISLMTLDTIMKCAFSYQ----GSVQLDSRNSQSY 218 255 GLMADSVQIMLDKWEQLVSQDSS-------LEVFQDISLMTLDTIMKCAFSHQ----GSVQLD-RNSQSY 217 256 GLMVDSVQIMLDRWEQLISQDSS-------LEIFQHVSLMTLDTIMKCAFSYQ----GSVQLD-RNSHSY 213 257 GLMVDSVQVMLDKLEKLARKDAP-------LEIYEHVSLMTLETIMKCAFSHQ----GSVQLESRTSKSY 218 258 KNMADSIRLMLDKWEQLAGQDSS-------IEIFQHISLMTLDTVMKCAFSHN----GSVQVD-GNYKSY 216 259 KNMADSIRLMLDKWERLADQDSS-------IEIFQHISLMTLDTVMKCAFSHK----GSVQVD-GNYRTY 216 260 GIMADSVRIMLDKWEQIVGQDST-------LEIFQHITLMTLDTIMKCAFSQE----GSVQLD-RKYKSY 215 261 ---------------------------------------------------------------------- 0 262 GLMADSVRVMLDKWEELLGQDSP-------LEVFQHVSLMTLDTIMKCAFSHQ----GSIQVD-RNSQSY 217 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 AVFTESTRIMLDKWEEKAREGKS-------FDIFCDVGHMALNTLMKCTFGRG----DTG-LG-HRDSSY 217 266 AIFADSTRIMLEKWEKKACEGKS-------FDIFSDVGHMALDTLMKCTFGKG----DSG-LN-HRDSSY 206 267 AIFAESTRMMLDKWEKKASENKS-------FDIFCDVGHMALDTLMKCTFGKG----DSG-LG-HRDNSY 211 268 KIFNDSTNIMHAKWKRLISEGSSR------LDMFEHVSLMTLDSLQKCVFSFD----SNCQ---EKSSEY 221 269 KIFNESVNIMHAKWQLLASEGSAC------LDMFEHISLMTLDSLQKCVFSFD----SHCQ---EKPSEY 221 270 KIFNESVNIMHAKWQLLASEGSAR------LDMFEHISLMTLDSLQKCVFSFD----SHCQ---EKPSEY 221 271 KIFNDSTNIMHAKWQDLASGGSAR------LDMFKNISLMTLDSLQKCVFSFD----SNCQ---EKPSEY 221 272 KIFNQSVNIMHAKWKHLCLEGSAR------LEMFENISLMTLDSLQKCLFGFD----SNCQ---ESPSEY 221 273 KIFNKSVNTMHAKWQRLTAKGSAR------LDMFEHISLMTLDSLQKCIFSFD----SNCQ---ESNSEY 221 274 ---------------------------------------------------------------------- 0 275 DVFVEKSEILVKKLQSKVG-GKD-------FDIYPFITHCALDIICETAMGIQ----MNAQ-E-ESESEY 203 276 ---------------------------------------------------------------------- 0 277 EVFEKGSRDLLRNMEQDRLKHGDSG-----FSLYDWINLCTMDTICETAMGVS----INAQ-S-NADSEY 206 278 EIFDQQSAVMVEQLQSRRDGMTP-------INIFPVICLTALDIIAETAMGTK----INAQ-K-NPNLPY 170 279 ---------------------------------------------------------------------- 0 280 VMNENSTKFIKHLKTVAAGDNI--------FDFQEQAHYLTLDVICDTAMGVS----INAM-E-NRSSSI 160 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 GILEDNSERLVQNVGKSLGKPV--------NIIPTISEYTLYSICETAMGSRL----GEES-K-ESQKSY 99 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 AMMVDIAVQLVQKWERLNADEH--------IEVPEDMTRLTLDTIGLCGFNYR----FNSF---YRDQPH 172 312 ---------------------------------------------------------------------- 49 313 MEKGIQAYAQQICLITNQIASEWQIGQP--VFARSAMQKLSLEVIIQIVFGLAD---GERY---QQIKPL 157 314 PAFAICYHDMLTKWEKIAEKQGSHE-----VDIFPTFDVLTSDVISKVAFG------STYEEGGKIF-RL 231 315 ---------------------------------------------------------------------- 84 316 KQLLFNLIKNRRDYVIP-------------EFSSSFTDLCEVVEYDLATKG------KAAFNDPAEQAAF 200 317 KNLLFFMLKNSSNRVIP-------------QFETTYYELFEGLEAELAKNG------KAAFNDVGEQAAF 173 318 ---------------------------------------------------------------------- 114 319 PHMQVLFKHIRKHHGQT-------------F-IQELFFRLTVDSATEFLLG------ESAESLRDESVGL 232 320 PHVQVLFKHVRKSQGKT-------------FDIQELFFRLTVDSSTEFLFG------GSVESLRDASIGM 231 321 PHMQVFFKHIRKHHGQT-------------FDIQELFFRLTVDSATEFLFG------ESVESLRDESIGM 218 322 PHVQVLFKHIRKNKGRE-------------FDLQELFFRFTVDSATEFLFG------ESVESLRDASIGM 222 323 PHFQSLKKHIIKNKGQF-------------FDIQELFFRFTVDSATEFLFG------ESVESLKDESIGY 217 324 PHFQLLKKHIIKNKGTF-------------FDIQELFFRFTVDSATEFLFG------ESVSSLKDESIGY 215 325 PHFQLLKKHIIKNKGSF-------------FDIQELFFRFTVDSATEFLFG------ESVSSLKDESIGY 215 326 PHFNVKAYPQEQRWV---------------FDIQELFFRFTVDSATEFLFG------ESVNSLKSASIGC 207 327 PHFQLLKKHMVKNKGGF-------------FDIQELFFRFTVDSATEFLFG------ESVHSLKDETIGS 213 328 PHVQVLAKQIKLNKGET-------------FDLQELFFRFTVDTATEFLFG------ESVHSLYDEKLGV 219 329 PHVQILAKQIKLNKGKT-------------FDLQELFFRFTVDTATEFLFG------ESVHSLYDEKSGI 219 330 PHIQILAKQIKLNKGKT-------------FDIQELFFRFTVDTATEFLFG------ESVHSLYDEKLGI 220 331 PHFNLLQKNITAQTDNY-------------FDIQTLFFRFTLDTATEFLFG------QSVHSL------- 200 332 PHFKTLQKRIDG-KVGY-------------FDIQQEFLKLGLELSIEFIFG------QVV---------- 210 333 PYVQLLIKIIKNHEGEP-------------LEFQTLAHLFTIDYSTDFLLG------ESCDSLKDFLGEE 209 334 PYMLLLIEIIKSSSANEGP-----------VDLQPLFHAFTIDYASDFLFG------ESCDVLKENLGGK 212 335 THINL-MINNHFKGGQV-------------VDAQALYHNLTIDTATEFLFG------ESTNTLDPDLAQQ 212 336 THINI-IINNHFKGGQV-------------VDAQVLYHNLTIDTATEFLFG------ESTNTLDPALAQQ 211 337 GEVSDDFVKRLSHVRDSHG-EIPA-------LERELFKW-AMESIGTFLF-------EERI---GCLGQE 254 338 NPVSQDFVSLLHKRIKQQGSGKFV------GDIKEDLFHFAFESITNVMF-------GERL---GMLEET 225 339 NPVSQDFVSLLRKRIQQQGSGKFA------GDIKEDLFHFAFESITNVMF-------GERL---GMLEDT 225 340 NPVSQDFVSLLHKRIKQQGSGKFV------GDIKEDLFRFAFESITNVMF-------GERL---GMLEDT 225 341 DTVSQDFVGVLHRRIKQQGSGKFS------GDIREDLFRFAFESITNVIF-------GERL---GMLEEI 225 342 DAVSRDFVSVLHRRIKKAGSGNYS------GDISDDLFRFAFESITNVIF-------GERQ---GMLEEV 225 343 EGVAQDFIKVLHRRIKQQNSGKFS------GDISDDLFRFAFESITSVVF-------GERL---GMLEEI 223 344 ------------------------------------------------------------------LQDF 4 345 DEVGQDFVARVHKKIERSGQDKWT------TDLSQELFKYALESVGSVLY-------GERL---GLMLDY 223 346 DVVARDFVENLKKRMLENVHGSMS------INIQSNMFNYTMEASHFVIS-------GERL---GLTGHD 215 347 DGIARDFVDNLKKKMLESVHGSFS------MDFQSSVFNYTIEASHFVLF-------GERL---GLIGRD 215 348 DMVARDFLETLKEKVLQNARGSLT------MDVQQSLFNYTIEASNFALF-------GERL---GLLGHD 215 349 DEVARDFLEALKKKVRQNARGSLT------MDVQQSLFNYTIEASNFALF-------GERL---GLLGHD 215 350 DVVARDFVENLKKRMLENVHGSMS------MDIQSNVFNYTMEASHFVIS-------GERL---GLTGHD 214 351 DGVARDFSQTLKARVLQNARGSLT------LDIAPRLFRYTIEASTLVLY-------GERL---GLLTQQ 215 352 DGVARDFSQTLKARVLQNARGSLT------LDIGPSVFRYTIEASTLVLY-------GERL---GLLTQQ 215 353 DAVARDFSQALKKKVLQNARGSLT------LDVQPSIFHYTIEASNLALF-------GERL---GLVGHS 215 354 DAVARDFSQALRKKVLQNARGSLT------LDVQPSIFHYTIEASNLALF-------GERL---GLVGHS 215 355 DEAAADFVTFMKKRMSKNTRGSLT------VDLYADLFRFTLEASSYVLY-------GQRL---GLLEEH 232 356 NEVIDSFVVRLDQLRAESASGDQV------PDMADLLYHFALEAICYILF-------EKRI---GCLEAS 235 357 NEVISDFIARLDQVRTESASGDQV------PDVAHLLYHLALEAICYILF-------EKRV---GCLEPS 234 358 NEVIDDFMTRLDQLRAESASGNQV------SDMAQLFYYFALEAICYILF-------EKRI---GCLQRS 232 359 ---------------------------------------------------------------------- 0 360 NEVLADFLERMDELCDERGRI---------PDLYSELNKWSFESICLVLY-------EKRF---GLLQKE 230 361 NEVLADFMGRIDELCDERGHV---------EDLYSELNKWSFESICLVLY-------EKRF---GLLQKN 229 362 FKNAKILCTLIKNRLLEGQTSI--------PMGPLSQ-RMALDNISQVAL-------GFDF--GALTHEK 198 363 QYIHGNIELFVKWWNRMADTQRNPKTGFASLDALNWFNYLAFDIIGDLAF-------GAPF--GMLDKGK 203 364 EGVDGQTAILKEQLQRFCDQKQV-------IDLPRFLQYYAFDVIGVITV-------GKSM--GMMESNS 212 365 AGVDGQTIILKEQLQSFCDQK----------DLPQFLQYYAFDVIGVITQVIV----GKSM--GMMETNS 213 366 PFIHERVTKLLSRFQEHLDNDQV-------LSLDGAFCALTADVITSRFY-------GKHY--NYLDLPD 210 367 PLIADEVVVFCEQLRQKARTGTV-------FQLEPLTLRLTVDTICSVTL-------YVVT--PVGRWPF 172 368 GMIQSHIDRLMTRLQGNCSSGS--------LDMTVWFNWATFDIIGDLAF-------GEPF--GCLERME 187 369 PTIARYADLLVEVLREVADTGK-------SVEMVRYFNMAIFDSIGALSF-------GESF--DSLRNRE 203 370 SLIERSIDLLITQLHENCGQGS---------GLALWFNWATFDIIGDLAF-------GDSF--GCLENVQ 107 371 -LEQIMDKYMDKFVRL-SKEN---------NYEPQVFFHEMREILCALSL-------NSFCGNYITED-- 189 372 PKVRDIIKLTVEKIKCDAVKGE--------AEIMGWWTLMANEIVCQLTF-------GGGA--GIVAKGV 190 373 PLIAEEVYKYFRDSKNFRLNERTTGT----IDVMVTQPEMTIFTASRSLL-------GKEM--------- 217 374 SIIEKEAKEYFKSW--GESGE---------RNVFEALSELIILTASHCLH-------GKEI--------- 215 375 SIIEKETKEYFESW--GESGE---------KNVFEALSELIILTASHCLH-------GKEI--------- 221 376 PLIKDEMLKYFNANFRGDSGK---------TDVLKSQSEMTLFTASRSLF-------GDAL--------- 150 377 PLILNEMDAFLSTSPDFGPGKEGV------ADLLKTMPVMTIYTASRTLQ-------GAEV--------- 192 378 PQIVDEVREYIKSDARFSALKTRKTIT---VDIFQAMSELIILTASRTLQ-------GKEV--------- 222 379 PLIADETNAYIKSSPNFKGQSGT-------IDLAAAMAEITIFTAARTLQ-------GEEV--------- 200 380 PKIREEVLNYFVNDVSFKTKERDHGV----ASVMKTQPEITIFTASRCLF-------GDEM--------- 209 381 PKIREEILNYFVTDESFKLKEKTHGV----ANVMKTQPEITIFTASRSLF-------GDEM--------- 209 382 PLIAEEIYKYFRNSKNFKINENNSGI----VDVMVSQPEMTIFTASRSLL-------GKEM--------- 159 383 TVCAESLKTHLDRLEEVTNESG----------YVDVLTLL-RRVMLDTS----------NT--LFLRIPL 208 384 TICADSITKHLDRLEEVCNDLG----------YVDVLTLM-RRIMLDTS----------NM--LFLGIPL 208 385 ---------------------------------------------------------------------- 0 386 EVCVESIKQHLDRLGDVTDNSG----------YVDVVTLM-RHIMLDTS----------NT--LFLGIPL 208 387 EVCVESIKQHLDRLGEVTDTSG----------YVDVLTLM-RHIMLDTS----------NM--LFLGIPL 208 388 AICVESTIVHLDKLEEVTTEVG----------NVNVLNLM-RRIMLDTS----------NK--LFLGVPL 207 389 DVCVSSTQTHLDALQGPDGLMGG---------QVDVLSLL-RCTVVDIS----------NR--LFLGVPL 228 390 EVCVTSTQTHLDNL-----SSLS---------YVDVLGFL-RCTVVDIS----------NR--LFLGVPV 217 391 DA----TNLRTVLLGDTVEAGS----------GWHEMGLL-EFSYGFLL----------RA--GYLTQYG 180 392 EAM--YTNLHAVLLGDATEAGS----------GWHEMGLL-DFSYSFLL----------RA--GYLTLYG 182 393 ETMIQEVKELFESQLL---KIT----------DWNTERIF-AFCGSLVF----------EI--TFATLYG 196 394 EAMMQNLQSVMRPPGLPKSKSN----------AWVTEGMY-AFCYRVMF----------EA--GYLTLFG 189 395 EAMMQNLQSVMRPPGLPKSKSA----------VWVTEGMY-AFCYRVMF----------EA--GYLTLFG 189 396 EAMMQNLQFVLRPPDLPKSKSD----------AWVTEGMY-AFCYRVMF----------EA--GYLTLFG 189 397 DAMMENLQLTLRRPE-PKSR------------AWVTEGMY-SFCYRVMF----------EA--GYLTLFG 186 398 ESMMENLQRIMRPPVSSNSKTA----------AWVTEGMY-SFCYRVMF----------EA--GYLTIFG 189 399 PEVEEVVHGFLDEMLA-AGPT------------ADLVSQF-ALPVPSMV----------IC--RLLGVP- 165 400 PRIQETVDRLLDAMER-QGPP------------AELVSAF-ALPVPSMV----------IC--ALLGVP- 173 401 PEVQRLADDLVDRMTT-GRTS------------ADLVTEF-ALPLPSLV----------IC--LLLGVP- 165 402 EFVEEVVLVFLRRMTI-SGPT------------ADLVSQF-LIGAGHMV----------IC--RLLGVP- 166 403 ----------LDAMEH-MGSP------------ADLVEHF-ALPVPSLV----------IA--ELLGVP- 143 404 PRTQEVADDLIDKMLA-KGAP------------ADLMEDF-ALPLPIIM----------IC--ELLGVP- 0 405 PRIAEIVDSALDGLEQ-AGQP------------ADLMDRY-ALPVSLLV----------LC--ELLGVP- 161 406 PRVRSLVDSLLDDMVA-HGSP------------ADLVEFL-AVPFPVAV----------IC--ELLGVP- 164 407 PYIQRTVDDLLEQMKQ-KGCANGP---------VDLVKEF-ALPVPSYI----------IY--TLLGVP- 160 408 PYIQKTVDDLLAAMKK-KGCANGP---------VDLVKEF-ALPVPSYI----------IY--TILGVP- 160 409 PYIKETVQGLLNDMVA-NGC-EEP---------VDIEKEF-ALPVPSYI----------IY--TILGVP- 165 410 PRVEQITAELLDEVGD-SGV-------------VDIVDRF-AHPLPIKV----------IC--ELLGVD- 161 411 PRIEQITDDLLDRLAG--RSE------------VDLIDEF-AFPLPTTV----------IS--ELMGVE- 163 412 PRVTELAHRLLASLPD-RAQDGV----------IDVLEDF-SYPLSIDV----------IC--EIVGIP- 167 413 PRIRDVTRSLLAD-AG--ES-------------FDLVDVL-AFPLPVTI----------VA--ELLGLP- 162 414 PRIAEITRGLLDGLRE-KGQ-------------IDVVDSL-AYPLPVIV----------IA--ELLGIP- 169 415 QQVEAIAAHLFETLAA-QPQP------------ADLRRHL-SFPLPAMV----------IS--ALMGVL- 152 416 RIVAARLDGITPALER--GEA------------VDLHREF-ALALPMLV----------FA--ELFGMP- 116 417 PRIKQIAADLVEAIQK--NST------------INIVDDL-SSPFPSLV----------IA--DLFGVP- 159 418 PRIQEIADELIGQMDG--GTE------------IDIVASL-ASPLPIIV----------MA--DLMGVP- 157 419 PRAREIAHELVDQMAA-TGQP------------ADLVAMF-ARQLPVRV----------IC--ELLGVP- 154 420 GGTQRVVDRLLDEMEE--EGS------------PGLRRPG-LRALPLIT----------MC--EALDIP- 162 421 TRIKDVTAFLLQEARQ--KST------------IDIIEDF-AGPLPVII----------IA--EMLGAP- 153 422 TFIRETTRSLLDSIDP--RE-------------DDIVKKL-AVPLPIIV----------IS--KILGLP- 0 423 QRIRVRAEALIERIPL--GEE------------VDLVPLL-SAPLPLLT----------LA--ELLGLD- 161 424 ENIRRIAQASVQRLLD-FDGE------------CDFMTDC-ALYYPLHV----------VM--TALGVP- 173 425 NRIQELACSLIESLRP-QGQ-------------CNFTEDY-AEPFPIRI----------FM--LLAGLP- 170 426 PEIAKITECLWDDLQK-VDD-------------FNFTEMY-ASQLPALT----------IA--SVLGLP- 173 427 APIYRDIVNEYLDRLP-RGDT------------VDLFAEI-CGPVAARI----------LA--HILGIC- 164 428 PKIREV-VNTYLDRVI-KDGR------------ADLIGDL-LYEVPCIV----------AL--IFLGVP- 168 429 IFSLMGIPAQDLPGWH-RKYR------------QLLQLIV-APPV------------------DLPGLP- 106

193 NPLLKFVRAIFG-----------DNRKHIPLIGGVFPT-L------AQVF-------------------- 240 194 ---------------------------------------------------------------------- 0 195 NPMLDKVKTIFK-----------EGRNNVFMISGIFPF-V------GIAL-------------------- 229 196 NPLLPKVQAIFN-----------GSWHVFLITGIFPPL-A------GVFR-------------------- 227 197 NPMLPKVKGIFK-----------DGRKLPFLVSGIFPI-A------GTMF-------------------- 229 198 NPMLPKVKEIFK-----------KGGKMPFLIAGVFPI-A------GTLM-------------------- 229 199 NPWLDKIRAIFN-----------TRGNIIFIICGIVPF-T------GSIF-------------------- 229 200 NPIVNVVREIFC-----------GSRKNLMLICQVFPP-I------GQFI-------------------- 232 201 NPIMPIVSKLFQ-----------GNFAKLFLIGGIFPT-F------LVEII------------------- 232 202 DVFYHPVTVKKI-----------TINNFTYFHSSSPGT-F------HFLESTLQIHTTGRC--------- 0 203 DVFYVNARKFIA-----------NIDIRHSKVIAASFI-L------PELAPL------------------ 0 204 DVFYVNARKFIT-----------NIDIRHSKIISTSFL-F------PELSKL------------------ 0 205 DLFYVQARKFVG-----------AVDLKKSWILPVSLI-L------PELSWL------------------ 0 206 FKTFVKIVDKHL---------RHLQGKMPLLVSA-FPW-L------KHVPI------------------- 227 207 FETFVKVLDKHL---------KTVQGKTIFLMSA-FPW-L------KHFPV------------------- 226 208 FETFVKVINKHL---------KIAQGKPQLLVSA-FPW-L------RYVPI------------------- 227 209 ---------------------------------------------------------------------- 0 210 ---------------------------------------------------------------------- 0 ELKKLLDLFFEV---------QGSLRVYFAYTVDFLPQ-W------MVELL------------------- 0 FTRIKTLVNNFM---------EEVGKPLGVLAFTCHGI-P------SFLVK------------------- 0 211 QTQLRDINAVVK----------EIMTAEVFFVNC-YPW-L------RYLPE------------------- 0 212 HRLHQLLDDQSH----------TVMQPIMGAYIA-FPV-T------SKIPI------------------- 0 213 ---------------------------------------------------------------------- 113 214 DPFVEKTKKLLR----------FDFFDPLFLSVVLFPF-L------TPIYE------------------- 234 215 DPFVEKTKKLLR----------FDFFDPLFLSVVLFPF-L------TPIYE------------------- 234 216 DPFVEKAKKLLR----------FDFFDPLLFSVVLFPF-L------TPVYE------------------- 234 217 DPFVENAKKVLR----------FDYFDPLSLSVALFPF-L------TPIYE------------------- 234 218 DPFVKNVRRLLK----------FSFFDPLLLSITLFPF-L------TPIFE------------------- 233 219 DPFVEKVKKLLK----------FDIFDPLFLSVTLFPF-L------TPLFE------------------- 234 220 DPFVEKIKKLLK----------FDIFDPLFLSVTLFPF-L------TPVFD------------------- 234 221 DPFVENTKKLLR----------FDFLDPFFLSITVFPF-L------IPILE------------------- 234 222 DPLVENTKKLLR----------FDFLDPFFLSITVFPF-L------IPILE------------------- 234 223 DPFVENTKKLLR----------FDFLDPFFLSITIFPF-I------IPILE------------------- 234 224 DPFVENTKKLLR----------FNPLDPFVLSIKVFPF-L------TPILE------------------- 234 225 DPFVESTKKFLK----------FGFLDPLFLSIILFPF-L------TPVFE------------------- 234 226 DPFVENTKKLLK----------FDFLDPFFFSILLFPF-L------TPVFE------------------- 234 227 DPFVSKARKLFR----------FDFLSPFLLSIVMFPF-L------TQLYE------------------- 234 228 DPFVSKANKLFR----------FDFLSPFLLSTVMFPF-L------TQLYE------------------- 234 229 DPFVQKARKILK----------FNFFDPFILSIILFPF-L------TTIYD------------------- 234 230 DPFVQKAKKILK----------FQIFDPFLLSVVLFPF-L------TPIYE------------------- 234 231 ---------------------------------------------------------------------- 0 232 DPFVKHCKRFFE----------FCIPRPILVLLLSFPS-I------MVPLA------------------- 240 233 DPFVQHCQRVFA----------FSTPRPLLALILSFPS-I------MVPLA------------------- 240 234 DPFVQHCRRAST----------FCIPSPLLVLILSFPS-M------MVPLA------------------- 240 235 HPFVKHCRRFFA----------FSVPRLILVLILSFPS-I------MVPLA------------------- 240 236 DRFLAMGRKSIEV---------PRHNALIMAFIDSFPE-L---------SR------------------- 234 237 SDFRTMGQKVFTD---------MRHGKLLTMFVFSFPK-L---------AS------------------- 235 238 AEFRQRGIDIFTK---------PRHHPLLLLLIITNPK-V---------AQ------------------- 237 239 SEFRLKGKEIFSR---------PRNGPLLHLFAITNDK-L---------AS------------------- 229 240 AEFRQKGKDIFGK---------PRHSPLVQISTITNSN-L---------AK------------------- 232 241 ---------------------------------------------------------------------- 0 242 KTLEDLDKHIFTV---------NYSAELDMM----YPG-I---------LK------------------- 223 243 DTLAIVDKIISEP---------SYAIELDMM----YPG-L---------LP------------------- 225 244 KTLQDLDKYIFTV---------NYSGEFDML----YPG-I---------LK------------------- 223 245 AEFRVKGDKAFY-----------TIHPFMEMIASTYPK-L---------FH------------------- 226 246 TEFRLKGDRTFS-----------DVNPFWDMLASHFPK-L---------FT------------------- 228 247 NEFRVLSDRLFNPKKS------TMLERIRNLSTFMCPP-L---------AK------------------- 233 248 -EFYVNSQAITKF---------KFSAFLKVLFFRCLPS-V---------AQ------------------- 228 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 YKAVEDLNNLTFFRV-------RSAFYGNSIIYNMSSD-GRL----SRRA-------------------- 252 253 YKAVEDLNNLIFFRV-------RSAFYGNSIIYNMSSD-GRL----SRRA-------------------- 249 254 IQAVGDLNNLVFARV-------RNIFHQSDTIYRLSPE-GRL----SHRA-------------------- 256 255 IQAVGDLNNLFFSRV-------RNVFHQSDTIYRLSPE-GRL----SHRA-------------------- 255 256 IQAINDLNNLVFYRA-------RNVFHQSDFLYRLSPE-GRL----FHRA-------------------- 251 257 IQAVRELSDLALQRV-------RNVFHQSDFLYRLSPE-GRL----SHRA-------------------- 256 258 IQAIGNLNDLFHSRV-------RNIFHQNDTIYNFSSN-GHL----FNRA-------------------- 254 259 LQAIGDLNNLFHSRV-------RNNFHQNDTIYKLSSN-GRL----AKQA-------------------- 254 260 IKAVEDLNNLFFFRV-------QNMFHQNDFIYSLSSN-GRN----RDNA-------------------- 253 261 ---------------------------------------------------------------------- 0 262 IQAISDLNNLVFSRV-------RNAFHQNDTIYSLTSA-GRW----THRA-------------------- 255 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 YLAVSDLTLLMQQRL-------VSFQYHNDFIYWLTPH-GRR----FLRA-------------------- 255 266 YVAVSELTLLMQQRI-------DSFQYHNDFIYWLTPH-GRR----FLRA-------------------- 244 267 YLAVSDLTLLMQQRI-------DSFQYHNDFIYWLTPH-GRR----FLRA-------------------- 249 268 IAAILELSALVAKRH-------QQPLLFMDLLYNLTPD-GMR----FHKACNL----------------- 262 269 IAAILELSALVSKRH-------HEILLHIDFLYYLTPD-GQR----FRRACRL----------------- 262 270 IAAILELSALVTKRH-------QQILLYIDFLYYLTPD-GQR----FRRACRL----------------- 262 271 ISAILELSALVAKRY-------QQLLLHTDSLYQLTHN-GRR----FHKACKL----------------- 262 272 ISAILELSSLIIKRS-------QQLFLYLDFLYYRTAD-GRR----FRKACDL----------------- 262 273 IAAILELSSLIVKRQ-------RQPFLYLDFLYYLTAD-GRR----FRKACDV----------------- 262 274 ---------------------------------------------------------------------- 0 275 VKAVYEISELTMQRS-------VRPWLHPKVIFDLTTM-GKR----YAECLRILHGFT------------ 249 276 -----------IPQE-------VKLLYRLDSIYKFTKL-REK----GDRMMNIILGMT------------ 35 277 VQAVKTISMVLHKRM-------FNILYRFDLTYMLTPL-ARA----EKKALNVVHQF------------- 251 278 VQAVNDVTNILIKRF-------IHAWQRVDWIFRLTQP-TEAKR--QDKAIKVMHDF------------- 217 279 ---------------------------------------------------------------------- 0 280 VQAFKDMCYNINMRA-------FHPLKRNELLYRLAPD-YPA----YSRTLKTLQDF------------- 205 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 KQSICALGRQFVYRI-------TRIYLHSDFIYNLITF-GKV-----KKDLDVVHNFT------------ 144 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 PFITSM----------------VRALDEAMNKLQRANP--------DDPAY------------------- 199 312 ---------------------------------------------------------------------- 49 313 FTDWLN----------------MTDSPLRSSMLFLKSL-QKD----WG---------------------- 184 314 LKELMDLTIDCM----------RDVYIPGWSYLPTKRN-KRM----KEIN-------------------- 266 315 ---------------------------------------------------------------------- 84 316 NFLSRAFFGVKPIDT-------PLGKDAPSLISKWVLF-NLA----PILS-------------------- 238 317 RFLGRAYFNSNPEET-------KLGTSAPTLISSWVLF-NLA----PTLD-------------------- 211 318 ---------------------------------------------------------------------- 114 319 TPTTKDFDGRNEFAD-------AFNYSQTNQAYRFLLQ-QMY----WILN-------------------- 270 320 VPSTKNIAGREEFAD-------AFNYSQDYNAYRFLLQ-QFY----WILN-------------------- 269 321 LNDALDFDGKAGFAD-------AFNYSQNYLASRALMQ-QMY----WILN-------------------- 256 322 TSKSKDVDGIEDFTG-------AFNYSQNYLASRSIMQ-QFY----WILN-------------------- 260 323 DQQDFDFDGRKNFAE-------AFNKAQEYLGTRAILQ-LFY----WLVN-------------------- 255 324 DQEEIDFAGRKDFAE-------AFNKSQVYLSTRTLLQ-LLY----WLVN-------------------- 253 325 DQEEIDFAGRKDFAE-------AFNKSQVYLSTRSLLQ-LLY----WLVN-------------------- 253 326 -DEETELEERKKFAE-------AFNKAQEYISTRVALQ-QLY----WFVN-------------------- 244 327 YQDDIDFVGRKDFAE-------SFNKAQEYLAIRTLVQ-DFY----YLVN-------------------- 251 328 -PPPNNIPGRENFAK-------AFNTSQHYLATRTYSQ-MFY----FLTN-------------------- 256 329 -PAPNDIPGRENFAE-------AFNTSQHYLATRTYSQ-IFY----WLTN-------------------- 256 330 -PTPNEIPGRDNFAT-------AFNTSQHYLATRTYSQ-TFY----FLTN-------------------- 257 331 ----NDGENSLQFLE-------AFTKSQAILATRANLH-ELY----FLAD-------------------- 234 332 ---SEDVPHYDDFTQ-------AWDRCQDYMMLRLLLG-DFY----WMAN-------------------- 245 333 SNSTLDTSLRLAFAS-------QFNKTQQQMTIRFMLG-KLA----FLMY-------------------- 247 334 STSGMDAQVKRDFAS-------VFNDVQNYLTKRMMLG-PLA----FLVS-------------------- 250 335 LPGPKGLVTGEQFAE-------AFTSALEILSVRVIVG-AAW----FLIW-------------------- 250 336 LPGPKGLVTGEQFAE-------AFTSALELLSVRVMAG-AAW----FLVW-------------------- 249 337 TSPMAQTFIANL----------EGFFKTLQPLMYNLPT-YKL----WS---------------------- 287 338 VNPEAQKFIDAV----------YKMFHTSVPLLNVPPELYRL----FR---------------------- 259 339 VNTEAQKFIDAV----------YKMFHTSVPLLNLPPELYRL----FR---------------------- 259 340 VDTEAQKFIDAV----------YKMFHTSVPLLNLPPELYRL----FR---------------------- 259 341 VDPEAQKFIDAV----------YQMFHTSVPMLNLPPDLFRL----FR---------------------- 259 342 VNPEAQRFIDAI----------YQMFHTSVPMLNLPPDLFRL----FR---------------------- 259 343 VDPESQRFIDAV----------YQMFHTSVPMLNMPPDLFRL----FR---------------------- 257 344 VDPEAQQFIDAV----------TLMFHTTSPMLYVPPALLRH----LN---------------------- 38 345 INPEAQHFIDCI----------SLMFKTTSPMLYIPPAMLRR----VG---------------------- 257 346 LKPESVTFTHAL----------HSMFKSTTQLMFLPKSLTRW----TS---------------------- 249 347 LSPDSLKFLHTL----------HSMFKTTTQLLYLPRSLTRW----TS---------------------- 249 348 LSPGSLKFIHAL----------HSMFKSTSQLLFLPKSLTRW----TS---------------------- 249 349 LNPGSLKFIHAL----------HSMFKSTTQLLFLPRSLTRW----TS---------------------- 249 350 LNPESLKFIHAL----------HSMFKSTTQLMFLPKNLTRW----TS---------------------- 248 351 PNPDSLNFIHAL----------EAMLKSTVQLMFVPRRLSRW----MS---------------------- 249 352 PNPDSLNFIHAL----------EAMFKSTVQLMFVPRRLSRW----TS---------------------- 249 353 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----TS---------------------- 249 354 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----IS---------------------- 249 355 PNADTLRFISAV----------ETVLKTTLPLLYYPHQILQL----FQ---------------------- 266 356 IPKDTENFIRSV----------GLMFQNSVYVTFLPKWTRPL---------------------------- 267 357 IPEDTATFIRSV----------GLMFKNSVYVTFLPKWSRPL---------------------------- 266 358 IPEDTVTFVRSI----------GLMFQNSLYATFLPKWTRPV---------------------------- 264 359 ---------------------------------------------------------------------- 0 360 TEEEALTFITAI----------KTMMSTFGKMMVTPVELHKR----LN---------------------- 264 361 AGDEAVNFIMAI----------KTMMSTFGRMMVTPVELHKS----LN---------------------- 263 362 NAFHEHLIRIKK----------QIF-HPFFLT---FPF-L------DVLPIP------------------ 229 363 D-FAEMRKTPDSPPSYVQAVEVLNRRGEVSATLGCYPA-L------KPFAKYL----------------- 248 364 D-TNGACSALDGMWHYASMMAYIPNMHAWWLR-------------------------------------- 243 365 D-TNGACGSLDAMWHYSSMMAFIPHMHAWWLR-------------------------------------- 244 366 F-HFVVRDGFLGLTKVYHLARFIPVL-------------------------------------------- 235 367 LTPDLEIHSSTT----------KLRTTPLPQRCNGRSNGPRLE---LP---------------------- 207 368 TNPWIASIQGNV----------KSIPILNALRRYRLDRLIEFL---AP---------------------- 222 369 LHPWVDTIHHKN-------------LKSVAISHVLRSMGVEFL---AP---------------------- 235 370 THPWIASIQGNV----------KLIPILNAFRRYRLDGLLRLL---GS---------------------- 142 371 QVRKIADDYYLV-----------TAALELVNFPIIIPY-T--KTWYGKK--------------------- 224 372 KEPFVLMLERRM----------GDLAHLLKHFAPPGYY--------LGR--------------------- 221 373 RAKLDTDFAYLY----------SDLDKGFTPINFVFPN--------LP---------------------- 247 374 RSQLNEKVAQLY----------ADLDGGFSHAAWLLPGW-------LP---------------------- 246 375 RSQLNEKVAQLY----------ADLDGGFSHAAWLLPGW-------LP---------------------- 252 376 RNRLDASYAEMY----------SDLDKGFTPLNFVFSY--------LP---------------------- 180 377 RKGFDAGFADLY----------HDLDQGFSPVNFVFPW--------LP---------------------- 222 378 RQGLDKSFAQLY----------HDLDSGFTPINFVIPN--------LP---------------------- 252 379 RSKLTSEFADLF----------HDLDLGFSPINFMLPW--------AP---------------------- 230 380 RKSFDRSFAQLY----------ADLDKGFTPINFVFPN--------LP---------------------- 239 381 RRIFDRSFAQLY----------SDLDKGFTPINFVFPN--------LP---------------------- 239 382 RDKLDTDFAYLY----------SDLDKGFTPINFVFPN--------LP---------------------- 189 383 DESAIVVKIQGY----------FDAWQALLIKPDIF---FKI---------------------------- 237 384 DESAIVVNIQGY----------FDAWQALLLKPDIF---FKI---------------------------- 237 385 ---------------------------------------------------------------------- 0 386 DESSIVKKIQGY----------FNAWQALLIKPNIF---FKI---------------------------- 237 387 DESAIVKKIQGY----------FNAWQALLIKPNIF---FKI---------------------------- 237 388 DESAIVLKIQNY----------FDAWQALLLKPDIF---FKI---------------------------- 236 389 NEKELLQKIQKY----------FDTWQTVLIKPDVY---FKL---------------------------- 257 390 DEKELLQKIHKY----------FDTWQTVLIKPDIY---FKF---------------------------- 246 391 VEAPPHTQESQAQDRVH-----SADVFHTFRQLDLL---LPK----LARGSLSA---------------- 222 392 IEALPRTHESQAQDRVH-----SADVFHTFRQLDRL---LPK----LARGSLSV---------------- 224 393 KILAGNKKQII-----------SELRDDFFK-FDDM---FPY----LVSDIP------------------ 229 394 RDISKTDTQKAL----------ILNNLDNFKQFDQV---FPA----LVAGLP------------------ 224 395 KDISKTDTQRAF----------IQNNLDSFKQFDQV---FPA----LVAGVP------------------ 224 396 RDTSKPDTQRVL----------ILNNLNSFKQFDQV---FPA----LVAGLP------------------ 224 397 RELTRQDAQRAF----------ILNSLEDFKQFDKV---FPA----LVAGLP------------------ 221 398 RDLTRRDTQKAH----------ILNNLDNFKQFDKV---FPA----LVAGLP------------------ 224 399 --------------------------------YADHEF-FQDAS----KRLVQ----------------- 181 400 --------------------------------YADHAF-FEERS----QRLLR----------------- 189 401 --------------------------------YEDHAF-FQERS----RVLLTL---------------- 182 402 --------------------------------YEDHAF-FQERS----RVLLTL---------------- 183 403 --------------------------------PADREQ-FQH------DTLRW----------------- 157 404 --------------------------------IEDQTK-FRTWS----DQMLSNG--------------- 0 405 --------------------------------YADRDE-LRDRT----ARLLDL---------------- 178 406 --------------------------------LEDRDL-FRTFS----DAMLSST--------------- 182 407 --------------------------------FNDLEY-LTQ----QNAIRTNG---------------- 177 408 --------------------------------FNDLDH-LTN----QNAIRTNG---------------- 177 409 --------------------------------FEDLEY-LTE----QNAIRSNG---------------- 182 410 --------------------------------EKYRGE-FGRWS--SEILVMD----------------- 179 411 --------------------------------DSRRDD-FRSWT----NVLVD----------------- 179 412 --------------------------------EEAREQ-WHTWG----SAFY------------------ 182 413 --------------------------------PMDHEQ-FGDWSGALVDIQMDDPTDPALA--------- 190 414 --------------------------------AEDRDL-FREWV--DVILNNEGMEYPNLP--------- 195 415 --------------------------------YEDHAF-FAGLS----DEVMTHQHES------------ 173 416 --------------------------------QDDMFE-LAAGI----GTILEGLGPHAS---------- 139 417 --------------------------------VKDRYQ-FKKWV----DILFQ-PYDQERL--------- 182 418 --------------------------------SKDRLL-FKKWV----DTLFL-PFDREKQ--------- 180 419 --------------------------------SADHDR-FTRWS----GAFLSTA--------------- 172 420 --------------------------------EADRPW-LRAHA----MTMMNVG--------------- 180 421 --------------------------------IEDRHL-IKTYS--DVLVAGAKDSSDKAV--------- 179 422 --------------------------------IEDKEK-FKEW--------------------------- 0 423 --------------------------------PDCWYE-LYNWT----NAFVG--EDDPEF--------- 183 424 --------------------------------EDDEPL-MLKLTQDFFGVHEPDEQAVAAPRQSA----- 205 425 --------------------------------EEDIPH-LKYLT----DQMTR----------------- 186 426 --------------------------------SEDTPF-FTRLV----YKVSRCL-SPSWR--------- 196 427 --------------------------------EASDVE-IIRWS----QRLIDGAGNFGWR--------- 188 428 --------------------------------DEDIET-CRQYG----MQQTLFTWGHPT---------- 191 429 ---------------------------------------------------------------------- 106

193 --RFFMLKFVTAVQNRIDQRENDRKNGIEIGEPQD---FIDLFLEARADDVEHFQENNGDFS--LTTQEI 303 194 ------------MSRIAQREADKKHGVE-PGEAAD---YIDMFLNARAEVEHFGESNDEFHK--LTTQEI 52 195 --RNIFAKFPALNKRLEQREADEKAGIEPSGEPQD---FIDLFLDARSTVDFFEGEAEQDFA--LTFDEI 292 196 --KMSKMLPAAVQARIDQRAKDEIKGVE-PGEPQD---FIDLFLDARVPDVKILSGEANEDF--LTFDEI 289 197 --REFFMRFPALNKRLEQRAADEKAGIEPSGEPQD---FIDLFLDARANVDFFEEESALGFA--LTFDEI 292 198 --RQLFMKFPALNKRLEQRAADKKAGIEPSGEPQD---FIDLFLDARANVDFIEEESTLGFA--LTFDEI 292 199 --RWFFSKVPTATKRVEQRAADEKAGIESSGEPQD---FIDLFLDVQADTDFLEDETKNGFA--LTFDEI 292 200 --RDLTFKFQDVVAARIAQRERE--KGAESGEPQD---FIDLFLDARSDDVDFSAEAREDFS--LSADEV 293 201 --RQILLKNLDAIHNRIKQREEDQKNGIEIGEPAD---FIDLFLDAKAEDVEHFGENNGDFS--LTTEEI 295 202 --RNSTCRRTVKCVGFRQDKAKFCSDYERRRGGEG-----SDSVDLLKLLLNREDDKSKP----MTKQEV 0 203 --WRALYKYTPLADAEIPLVEGLSNVYERRRGGEG-----SDSVDLLKLLLNREDDKSKP----MTKQEV 0 204 --WKVLYRFTDLAKAEIPLVEGLADVYERRRGGEG-----SDSVDLLKLLLNREDDKSKP----MTKQEV 0 205 --WRFLYKFSDLSAAELPLVKGLVDLYDRRRAGEG----GNDSTDLLNLLIRRETIGK------MTQREV 0 206 --VGDIGYHNIKNNISSYHTFIEEEVATQVKKYDG-----ESEPENFVHAYMQQMKQTGNPG--LDITNL 288 207 --IGELGYHRIKKNIQSYQEFINDEVTSQIKHYDG-----ESEPENFVHAYMQQMKQSGNPN--LDMNNL 287 208 --IGELGYHKIQRNIQSYQKFIDEEVVSQIKQYDG-----ESEPENFVHAYLQQMKQSGNPN--LDMNNL 288 209 ------------------------------------------------------------------VKNL 4 210 ---------------------------------------------------------------------- 0 --TPDVSRVRDGIYQFFDEQIEEHRQEIDFETSDS------KDYVETFMKEQKKREAEGDFAS-FSNEQL 0 --LMVSGIEEQKRELFRFLRKQIDGAKSQINYEEEHN----EDFVEAYLRKKFQREQKNDFDS-YCDSQL 0 211 --GILRKWTNYKRSGFRLQQWFRTILEEHHVNRHQ-----GDFMSHMIDLQESKQEQ-------FRDLSI 0 212 --INGEWNRLMGIKNELLEFLETQIEGHRMNWKDEMI---EQEPEDLTYAYMIEVEKRKRNG--FDDQQL 0 213 ---------------------------------------------------------------------- 113 214 --MLNICMFPKDSIEFFKKFVYRMKETRLDSVQKH---RVD-FLQLMMNAHNDSKDKESHTA--LSDMEI 296 215 --MLNICMFPKDSIAFFQKFVHRIKETRLDSKHKH---RVD-FLQLMLNAHNNSKDEVSHKA--LSDVEI 296 216 --MLNICMFPKDSIEFFKKFVDRMKESRLDSKQKH---RVD-FLQLMMNSHNNSKDKVSHKA--LSDMEI 296 217 --MLNICMFPKDSIEFFKKFVDRMTENRLDSKQKH---RVD-FIYLMMEAYNKSKDKDSHKA--LSEIEI 296 218 --ALHISMFPKDVMDFLKTSVEKIKDDRLKDKQKR---RVD-FLQLMINSQ-NSKEIDSHKA--LDDIEV 294 219 --ALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQ---RMD-FLQLMINSQ-NSKVKDSHKA--LSDVEI 295 220 --ALNVSLFPRDVISFFTTSVERMKENRMKEKEKQ---RVD-FLQLMINSQ-NYKTKESHKA--LSDVEI 295 221 --VLNICVFPREVTNFLRKSVKRMKESRLEDTQKH---RVD-FLQLMIDSQ-NSKETESHKA--LSDLEL 295 222 --VLNICVFPREVTNFLRKAVKRMKESRLEDTQKH---RVD-FLQLMIDSHKNSKETESHKA--LSDLEL 296 223 --VLNISIFPREVTSFLRKSVKRIKESRLKDTQKH---RVD-FLQLMIDSQ-NSKETESHKA--LSDLEL 295 224 --ALNITVFPRKVISFLTKSVKQIKEGRLKETQKH---RVD-FLQLMIDSQ-NSKDSETHKA--LSDLEL 295 225 --ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKH---RLD-FLQLMIDSQ-NSKETESHKA--LSDLEL 295 226 --ILNIWLFPKKVTDFFRKSVERMKESRLKDKQKH---RVD-FLQLMINSQ-NSKEMDTHKA--LSDLEL 295 227 --MLSISIFPRDSLKFFTKFVKKTKENHLESNKKQ---RVD-FLQMMLNSQ-NFKDTESHKA--LSDVEI 295 228 --MLSISIFPRDSLKFFTKFVKKTKENHLESNKKQ---RVN-FLQMMLNSQ-NFKDTESHKA--LSDVEI 295 229 --LLRFSIFPRQSTNFFKKFITTMKKNRLHSNQKT---RMD-FFQLMMNTQ-NSKGKESQKA--LSDLEM 295 230 --MLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKN---RVD-FLQLMMNTQ-NSKGQESQKA--LSDLEM 295 231 ----------------------------------------------------------------RHEVEL 6 232 --RILPNKNRDELNGFFNKLIRNVIALRDQQAAEE---RRD-FLQMVLDAR-HSASPMGVQDFDLTVDEI 303 233 --RILPNKNRDELNGFFNTLIRNVIALRDKQTAEE--RRGD-FLQMVLDAQ-RSMSSVGVEAFDLTVDEI 304 234 --RILPNKNRDELNGFFNTLISNVIALRDQQAAEE--SRSD-FLQMVLDAQ-HSMNSVGVEGFDFTVDEI 304 235 --RILPNKKRDEVNGFFNKLIRNVIALRDQQAAEE--RRQD-FLQMVLDLR-HSAPSVGVENFDLTVDEV 304 236 --KLGMRVLPEDVHQFFMSSIKETVDYREKNNIR----RND-FLDLVLDLKNNPESISKLGG--LTFNEL 295 237 --RLRMRMMPEDVHQFFMRVLNDTIALRERENFK----RND-FMNLLIELKQKGSSFTLDNGEVMDIGEL 298 238 --RLRLKLFPDELTEFFMSVIRQTVEYRERNQVK----CND-FMDLLMEIRAKEGEEG------LSFEQM 294 239 --KFHMKILPDDITEFFMSLVRQTVEYRVKNEVK----CND-FMDLLIEMRAKDEELARASKGILTLEQM 292 240 --KLHIKLFPDDVADFFMSVIRQTVEYRQKNNVK----CND-FMDLLIEMKAKNEEEAKAGKGILTLEQM 295 241 ---------------------------------------------------------------------- 0 242 --KLNGSLFPKVVSKFFDNLTKNVLEMRKGTPSY----QKD-MIDLIQELREKKTLELSRKHENLTDGVI 286 243 --KLNLSIFPSVVHKFFKNLVNTIVTQRNGKPSG----RND-FMDLILELRQMGEITSNKYGNNITESVM 288 244 --KFNGSIFPKVVKQFFDKLTKDIFEMRKGTSSC----QKD-MIDSIQELRQQKTVDLWRKHDNLTDGVI 286 245 --RFGYKVFTQELITFYSRIVRETVEYREKNGVK----RND-FLDLLIELKNSPLEEAEYQ---LDMEDI 286 246 --WLDYKVATPELISFYSNIVCRTVEYREKNGVR----RND-FLDLLIELKNRPQQEGEYQ---LEMDDL 288 247 --LLSRLGAKDPITYRLRDIVKRTIEFREEKGVV----RKD-LLQLFIQLR-NTGKIS-DDND-MSIDMI 293 248 --KLKMSLVPRECSDYFSNVVLTTMKDREKNKVV----RND-LINILMEVKKGQLTHEKDDAD-WTDSDL 290 249 ---------------------------------------------------------------------- 0 250 ---------------------------------------------------------------------- 0 251 ---------------------------------------------------------------------- 0 252 --CQIAHEHTDGVIKMRKAQLQNEEELQKARKKR----HLD-FLDILLF--AKMEDGKS-----LSDEDL 308 253 --CQIAHEHTDGVIKTRKAQLQNEEELQKARKKR----HLD-FLDILLF--AKMEDGKS-----LSDEDL 305 254 --CQLAHEHTDRVIQQRKAQLQQEGELEKVRRKR----RLD-FLDVLLF--AKMENGSS-----LSDQDL 312 255 --CQLAHEHTDRVIQQRKAQLQQEGELEKVRRKR----RLD-FLDVLLF--AKMENGSS-----LSDQDL 311 256 --CQLAHEHTDRVIQQRKAQLQQEGELEKVRRKR----RLD-FLDVLLF--AKMENGSS-----LSDQDL 307 257 --CQLAHEHTDRVIQQRKAQLQQEGELEKVRRKR----RLD-FLDVLLF--AKMENGSS-----LSDQDL 312 258 --CQLAHDHTDGVIKLRKDQLQNAGELEKVKKKR----RLD-FLDILLL--ARMENGDS-----LSDKDL 310 259 --CQLAHDHTDGVIKLRKDQLQDEGELEKIKKKR----RLD-FLDILLF--ARMENGDS-----MSDKDL 310 260 --WQLAHDYTDQVIKSRKAQLQDEEELQKVKQKR----RLD-FLDILLL--ARIENGSS-----LSDKDL 309 261 ---------------------------------------------------------------------- 0 262 --CQLAHQHTDQVIQLRKAQLQKEGELEKIKRKR----HLD-FLDILLL--AKMENGSI-----LSDKDL 311 263 ---------------------------------------------------------------------- 0 264 ---------------------------------------------------------------------- 0 265 --CQVAHDHTDQVIRERKAALQDEKVRKKIQNRR----HLD-FLDILLG--ARDEDDIK-----LSDADL 311 266 --CRAAHDHTDRVIRQRKAALQDEKEREKIQNRR----HLD-FLDILLD--VRGESGVQ-----LSDTDL 300 267 --CKIAHDHTDEVIRQRKAALQDEKERKKIQQRR----HLD-FLDILLG--VRDESGIK-----LSDAEL 305 268 --VHEFTDAVIRERRRTLPDQGLDEFLKSKAKSK----TLD-FIDVLLL--TKDEDGKE-----LSDEDI 318 269 --VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSK----TLD-FIDVLLL--SKDEDGKK-----LSDEDI 318 270 --VHDFTDDVIQERRRTLPSQGVDDFLQAKAKSK----TLD-FIDVLLL--SKDEDGKK-----LSDEDI 318 271 --VHNFTDAVIQGRRRALPSQHEDDILKAKARSK----TLD-FIDVLLL--TKDEDGKE-----LSDEDI 318 272 --VHNFTDAVIRERRRLLSSQGTDEFLESKTKSK----TLD-FIDVLLL--AKDEHGKE-----LSDEDI 318 273 --VHNFTDAVIRERRSTLNTQGVDEFLKARAKTK----TLD-FIDVLLL--AKDEHGKG-----LSDVDI 318 274 --------------------------------RR----RMA-FLDLMLD----MNSKGE-----LPMEGI 24 275 --NKVIQERKSLRQMTGMKPTISNEEDELLGKKK----RLA-FLDLLLE---ASENGTK-----MSDTDI 304 276 --SKVVKDRKENFQEESRAIVEDDIDENDVGAKR----RLA-LLDAMVE---AKNPDIE-----WNRKDI 90 277 --TEKIIVQRREELIREGSSQESSNDDADVGAKR----KMA-FLDILLQ---STVDERP-----LSNLDI 306 278 --TENIIRERRETLVNNSKETTPEEEVNFLGQKR----RMA-LLDVLLQ---STIDGAP-----LSDEDI 272 279 --------------------------------------KMA-FLDTLLS---SKVDGRP-----LTSQEL 23 280 --TNEIIAKRIKAHKSGAV----STNAGDEFTRK----KMA-FLDTLLS---STIDGRP-----LNSKEL 256 281 ---------------------------------------------------------------------- 0 282 ---------------------------------------------------------------------- 0 283 ---------------------------------------------------------------------- 0 284 ---------------------------------------------------------------------- 0 285 ---------------------------------------------------------------------- 0 286 ---------------------------------------------------------------------- 0 287 ---------------------------------------------------------------------- 0 288 --TKVIKDRKEYVEKYGINMFGVSDIDDNNVYKKNK--KIA-MLDLLIT---AQKEGF------IDDIGI 200 289 ---------------------------------------------------------------------- 0 290 ---------------------------------------------------------------------- 0 291 ---------------------------------------------------------------------- 0 292 ---------------------------------------------------------------------- 0 293 ---------------------------------------------------------------------- 0 294 ---------------------------------------------------------------------- 0 295 ---------------------------------------------------------------------- 0 296 ---------------------------------------------------------------------- 0 297 ---------------------------------------------------------------------- 0 298 ---------------------------------------------------------------------- 0 299 ---------------------------------------------------------------------- 0 300 ---------------------------------------------------------------------- 0 301 ---------------------------------------------------------------------- 0 302 ---------------------------------------------------------------------- 0 303 ---------------------------------------------------------------------- 0 304 ---------------------------------------------------------------------- 0 305 ---------------------------------------------------------------------- 0 306 ---------------------------------------------------------------------- 0 307 ---------------------------------------------------------------------- 0 308 ---------------------------------------------------------------------- 0 309 ---------------------------------------------------------------------- 0 310 ---------------------------------------------------------------------- 0 311 --DENKRQFQEDIKVMNDLVDKIIADRKASG-EQ----SDD-LLTHMLN--GKDETGEP-----LDDENI 254 312 --------------------------------SQ----HDD-ILDIMLYS-ADPSTGEQ-----LDTDNV 76 313 --TWTPWGQKHKQRSIYDLLQAEIEEKRTKENEQ----RGD-VLSLMMA--ARDENGQA-----MTDEEL 240 314 --KEITDMLRFIINKRMKALKAGEPGEDDLLGVL----LES-NIQEIQK--QGNKKDGG-----MSINDV 322 315 ---------------------------------------------------------------------- 84 316 --VGLPKEVEEATLHSVRLPPLLVQNDYHRLYEF----FTS-AAGSVLD--EAEQSGIS---RDEACHNI 296 317 --LGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDY----FQS-VATPVME--QAEKLGVP---KDEAVHNI 269 318 ---------------------------------------------------------------------- 114 319 --GSEFRKSIAIVHKFADHYVQKALELTDEDLEK----KEG-YVFLFEL--AKQT---------RDPKVL 322 320 --GSKFNKSIKTVHKFADFYVQKALSLTDDDLEK----QEG-YVFLYEL--AKQT---------RDPKVL 321 321 --GKKFKECNAKVHKFADYYVEKALELTPDQLEK----QDG-YVFLYEL--VKQT---------RDRQVL 308 322 --GKKFRECNAIVHKFADHYVQKALNLTEADLEK----QAG-YVFLYEL--VKQT---------RDPQVL 312 323 --GADFKKSVAEVHKFTDYYVQKALDATPEELEK----HSG-YIFLYEL--VQQT---------RDPKVL 307 324 --SADFKRCNKIVHKFSDYYIKKALTATPEELEK----HSS-YIFLYEL--AKQT---------RDPIVL 305 325 --SSDFKRCNKIVHKFSDYYIKKALTATPEELEK----HSS-YIFLYEL--AKQT---------RDPIVL 305 326 --NSEFKECNEIVHKFTNYYVQKALDATPEELEK----QSG-YVFLYEL--VKQT---------RDPNVL 296 327 --NQEFRDCNKLVHKFTNYYVQRALDATPEELEK----QSG-YVFLYEL--VKQT---------RGPNVL 303 328 --PKEFRDCNAKVHKLAQYFVNKALDASEDEVAEKS--KGG-YVFLYEL--VKQT---------RDPKVL 310 329 --PKEFRDCNAKVHKLAQYFVNTALNATEKEVEEKS--KGG-YVFLYEL--VKQT---------RDPKVL 310 330 --PKEFRDCNAKVHYLAKYFVNKALNFTPEEIEEKS--KSG-YVFLYEL--VKQT---------RDPKVL 311 331 --GIKFRQYNKMVQDFSQRCVDKVLNMSNSEIDK----LDR-YFFLYEM--VKIT---------RNPQVL 286 332 --DWRYKQSNQIVQAFCDYLVQKSLENTC---------NDK-FVFVHQL--AKHT---------TNKTFI 292 333 --PKSFQYSIQMQKDFVDVYIDRVVGMSEEELNNH---PKS-YVLLYQL--ARQT---------KNRDIL 300 334 --SKDFHDGIKKQHEFVSYFVQKAISMSDEELNDE---SKN-YVFLYQL--AKQT---------KDAKVL 303 335 --TPKFWRSCKVCHNFIDYFVYKALATPMEKDQE----ADR-YVFIREL--TKET---------SDPRVI 302 336 --TPKFWRSCKVCHNFIDYFVYKALATPMEKGQD----ADR-YVFIREL--TKET---------SDPRVI 301 337 --TKLWKQFENYSDNVIDIGRSLVEKKWH--PCKMEV-TQN-LHLISYL--VNNGS--------MSTKEV 341 338 --TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEF-RNY-PGILYCL--LKSEK--------MLLEDV 315 339 --TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRQKTEF-RNY-PGILYHL--LKSEK--------MLLEDV 315 340 --TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRQKTEF-RNY-PGILYHL--LKSEK--------MLLEDV 315 341 --TKTWRDHVAAWDTIFNKAEKYTQNFYWDLRRKREF-NNY-PGILYRL--LGNDK--------LLSEDV 315 342 --TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDY-RGILYRL--LGDSK--------MSFEDI 316 343 --TKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSK-Y-PGVLYSL--LGGNK--------LPFKNI 313 344 --TKTWRASCMAWDAIFTQADKCIQNVYRDIRLQRKSTE-E-HTGIFSL--LVQDK--------QPLDDI 94 345 --AKIWRDHVEAWDCIFNQADRCIQNIYRTMRGDTNTHGKY-PGVLASL--LMLDK--------LSIEDI 314 346 --TRVWKEHFDSWDIISEYVTKCIKNVYRELAE-GRQQS-W-SVI-SEM--VAQST--------LSMDAI 303 347 --TRVWKENLESWDFISEYVTKCIKNVYRELAE-GRPQS-Y-SVITAEL--VAERT--------LSMDAI 304 348 --TRVWKEHFDAWDVISEYANRCIWKVHQELRL-GSSQT-Y-SGIVAEL--ISQGS--------LPLDAI 304 349 --TQVWKEHFDAWDVISEYANRCIWKVHQELRL-GSSQT-Y-SGIVAAL--ITQGA--------LPLDAI 304 350 --TQVWKGHFESWDIISEYVTKCIKNVYRELAE-GRQQS-W-SVI-SEM--VAQST--------LSMDAI 302 351 --TNMWREHFEAWDYIFQYANRAIQRIYQELAL-GHPWH-Y-SGIVAEL--LMRAD--------MTLDTI 304 352 --SSMWREHFEAWDYIFQYANRAIQRIYQELAL-GHPWH-Y-SGIVAEL--LMRAD--------MTLDTI 304 353 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-SRPQQ-Y-TSIVAEL--LLNAE--------LSPDAI 304 354 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-TRPQH-Y-TGIVAEL--LLNAE--------LSLEAI 304 355 --TRLWNEHMHAWDVIFEQADRCIQNIYQEYCL-GQERG-Y-SGIMAEL--LLQAE--------LPLDSI 321 356 --LPFWKRYLDGWDTIFSFGKNLIDQKLQEVVAQLQSAGSD-GVQVSGY--LHSLLTSGQ----LSPREA 328 357 --LPFWKRYMNNWDNIFSFGEKMIHQKVQEIEAQLQAAGPD-GVQVSGY--LHFLLTKEL----LSPQET 327 358 --LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPD-GIQVSGY--LHFLLASGQ----LSPREA 325 359 ---------------------------------------------------------------------- 0 360 --TKVWQAHTLAWDTIFKSVKPCIDNRLQ---------RYS-QQPGADF--LCDIYQQDH----LSKKEL 316 361 --TKVWQGHTLAWDTIFKSVKACIDNRLE---------KYS-QQPSADF--LCDIYHQNR----LSKKEL 315 362 --SRKKAFKDVVSFRELLVKRVQDELVNNYKFEQTTFAASDLIRAHNNE--IIDYKQ-------LTD--- 285 363 --PDSFFRDGIQAVEDLAGIAVARVNERLRPEVMANNTRVD-LLARLMEGKDSNGEK-------LGRAEL 308 364 --LSSLLPIEVPIKGLTEYVERRIIQYRLKAAEFGDDAALKGENNFLAKLLLMEKKGTV-----TPVETQ 306 365 --LSSLLPIEDPIKGLTEYVERQIIQYRLKAAEFGDDDALKGENNFLAKILLMERQGTV-----TSTETQ 307 366 --VTVLKRLPYSCLRLIAPSVSDLLQMRNEIHERGGDEFLSSKTSEAKSSILFGALADTHIPPVERTVER 303 367 --STPLRRYLTVRPLVMWYNNRLMNRFIDQEVDRAYREQSGRQSKSVISLALRDYMKEKDGSLEDFKRRV 275 368 --PRLLEMRRRNAQFTAEKVDRRLKHATTTRGDLWDSVLADPPDGEPF----------------MSRAEM 274 369 --YLMPAELRGKRQENYTYAIEKLKKRMQKTGDQGDFWDRVIVKSADGNQSGDG----------MSYGEM 293 370 --RKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDIWDAVLAQKPDGEPP----------------MTRDEM 194 371 --TADMAMKIFENCAQMAKDHIAAGGKPVCVMDAW---CKLMHDAKNSNDDDSRIYHRE-----FTNKEI 284 372 --ALAWFIPPLQDIFYSQERMFAAGGDAGN----------------------------------LTDTDI 255 373 --LEHYRKRDHAQKAISGTYMSLIKERRKNN-DIQ---DRD-LIDSLM-KNSTYKDGVK-----MTDQEI 304 374 --LPSFRRRDRAHREIKNIFYKAIQKRRLSK-EP----AED-ILQTLL--DSTYKDGRP-----LTDDEI 301 375 --LPSFRRRDRAHREIKDIFYKAIQKRRQSQ-EK----IDD-ILQTLL--DATYKDGRP-----LTDDEV 307 376 --LPNYWKRDAAHKNISNTYLDLINTKRAGG-EIK---NED-LVDALL-KNSVYKDGTR-----MTDEEL 237 377 --LPRNRRRDRAHKIMQKTYLKIIKDRRSST-ENP---GTD-MIWTLM--SCKYRDGRP-----LKEHEI 278 378 --LPSNFKRDRAQKKMSQFYQDIVAKRRAAG-DASG--END-MIAALI--EQKYKNGRA-----LSGVEI 309 379 --LPHNASAIKHTTYARDLSGNYPSATGSWR-DKSK--GTD-MISNLM--RCVYRDGTP-----IPDKEI 287 380 --LPHYWRRDAAQRKISAHYMKEIKRRRESG-DIDP--KRD-LIDSLL-VNSTYKDGVK-----MTDQEI 297 381 --LPHYWRRDAAQKKISATYMKEIKLRRERG-DIDP--NRD-LIDSLL-IHSTYKDGVK-----MTDQEI 297 382 --LEHYRKRDHAQQAISGTYMSLIKERREKN-DIQN---RD-LIDELM-KNSTYKDGTK-----MTDQEI 246 383 --SWLYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGD---------LTRENV 296 384 --SWLCRKYEKSVKDLKDAMEILIAEKRHRISTAEKLEDSIDFATELIFAEKRGE---------LTRENV 296 385 ---------------------------------------------------------------------- 0 386 --SWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGD---------LTKENV 296 387 --SWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGD---------LTKENV 296 388 --SWLCKKYEEAAKDLKGAMEILIEQKRQKLSTVEKLDEHMDFASQLIFAQNRGD---------LTAENV 295 389 --DWIHEKHRRAAQELEDAIESLVDQKRRGLQEADKLD-HINFTADLIFAQSHGE---------LSAENV 315 390 --SWIHQRHKTAAQELQDAIESLVERKRKEMEQAEKLD-NINFTAELIFAQGHGE---------LSAENV 304 391 --GGDKDRVGKVKGRLWKLLSPTRLASRAHRSRW----LESYLLHLEEMG--------------VSEEMQ 272 392 ---GDKDHMCSVKSRLWKLLSPARLARRAHRSKW----LESYLLHLEEMG--------------VSEEMQ 273 393 --IQLLRNEESMQKKIIKCLTSEKVAQMQGQSKI----VQESQDLLKRYYR-------------HDDPEI 280 394 --IHLFKTAHKAREKLAEGLKHKNLCVRDQVSEL----IRLRMFLNDTLST-------------FDDMEK 275 395 --IHLLKTAHKARERLAESLKHKNLYMRDQVSEL----IRLRMFLNDTLST-------------FDDMEK 275 396 --IHLFKAAHKAREQLAEGLKHENLSVRDQVSEL----IRLRMFLNDTLST-------------FDDMEK 275 397 --IHIFMTAHNAREKLAEGLKHDNLRTRDHISEL----IRLRMFLNDTLST-------------FDAMEK 272 398 --IHMFRTAHNAREKLAESLRHENLQKRESISEL----ISLRMFLNDTLST-------------FDDLEK 275 399 --STDAQSALTARNDLAGYLDGLITQFQTEPGAG----LVGALVADQL---ANGE---------IDREEL 233 400 --GPGADDVNRARDELEEYLGALIDRKRAEPGDG----LLDELIHRDH---PDGP---------VDREQL 241 401 --RSTPEEVRAAQDELLEYLARLARTKRERPDDA----IISRLV-------ARGE---------LDDTQI 230 402 --RSTPEEVRAAQDELLQYLARLARTKRERPDDA----IISRLV-------ARGE---------ILREED 231 403 --RST-EEVTEAFVSLGGQLQRLVRLKRTEPGDD----LLSGLIA------ADPA---------LTDEEL 205 404 --AYSQEVVMAAGQSLYLYLSELIAERRKQDTND----LLGSLVR------ARDKDDR------LSETEL 0 405 --SASAEQRAVAQREDRRYMATLVTRAQEQPGDD----LLGILARK-----IGDN---------LSTDEL 228 406 --RLTAAEIQRVQQDFMVYMDGLVAQRRDAPTED----LLGALALATD---NDDH---------LTKGEI 234 407 --SSTAREASAANQELLDYLAILVEQRLVEPKDD----IISKLCTEQV---KPGN---------IDKSDA 229 408 --SSTAREASAANQELLDYLASLVEKRLEEPKDD----LISKLCTEQV---KPGN---------IEKADA 229 409 --SGTAQEAAAANQQLLKYLAKLVDQRLQEPKDD----LIGRLVDQQ