An alignment of 192 P450 sequences

This file last modified on April 19, 1996


  1 2C1  PBc1 rabbit       -------------------------MDP------------    3
  2 2C2  PBc2 rabbit       -------------------------MDL------------    3
  3 2C14 pHP3 rabbit       -------------------------MDP------------    3
  4 2C24 rat prostate      -------------------------MDP------------    3
  5 2C32      pig          ----------------------------------------    0
  6 2C33v1    pig          ----------------------------------------    0
  7 2C34v1    pig          ----------------------------------------    0
  8 2C35      pig          ----------------------------------------    0
  9 2C36      pig          ----------------------------------------    0
 10 2C4  1-88 rabbit       -------------------------MDP------------    3
 11 2C5  1    rabbit       -------------------------MDP------------    3
 12 2C16 IIC16 rabbit      -------------------------MDP------------    3
 13 2C15 b32-3 rabbit      ----------------------------------------    0
 14 2C9  mp4  human        -------------------------MDS------------    3
 15 2C31 goat              ----------------------------------------    0
 16 2C30      rabbit       -------------------------MDL------------    3
 17 2C19 11a  human        -------------------------MDP------------    3
 18 2C18 29c  human        -------------------------MVP------------    3
 19 2C8  IIC2 human        -------------------------MEP------------    3
 20 2C20 MKmp13 monkey     -------------------------MDP------------    3
 21 2C11 h    rat          -------------------------MDP------------    3
 22 2C7  f    rat          -------------------------MDL------------    3
 23 2C29      mouse        -------------------------MDL------------    3
 24 2C6  PB1  rat          -------------------------MDL------------    3
 25 2C13 g plus rat        -------------------------MDP------------    3
 26 2C12 i    rat          -------------------------MDP------------    3
 27 2C21 DM 1-1 dog        ----------------------------------------    0
 28 2C3  3b   rabbit       -------------------------MDL------------    3
 29 2C22 Md   rat          -------------------------MAL------------    3
 30 2C23      rat          -------------------------MELLGFT--------    7
 31 2C25 hsm1 hamster      -------------------------MDA------------    3
 32 2C26 hsm2 hamster      -------------------------MDA------------    3
 33 2C27 hsm3 hamster      -------------------------MDA------------    3
 34 2C28 hsm4 hamster      -------------------------MDP------------    3
 35 2E1  3a   rabbit       -------------------------MAVLGI---------    6
 36 2E2       rabbit       -------------------------MAVLGI---------    6
 37 2E1  j    rat          -------------------------MAVLGI---------    6
 38 2E1       mouse        -------------------------MAVLGI---------    6
 39 2E1       hamster      -------------------------MAVFGV---------    6
 40 2E1  j    human        -------------------------MFALGV---------    6
 41 2E1  MKj1 monkey       ----------------------------------------    0
 42 2H1  CHP3 chicken      -------------------------MDFLGLP--------    7
 43 2H2  CHP7 chicken      -------------------------MDFLGLP--------    7
 44 2F1  IIF1 human        -------------------------MDSI-----------    4
 45 2F2  Nah2 mouse        -------------------------MDGV-----------    4
 46 2B4  LM2  rabbit       -------------------------MEFS-----------    4
 47 2B5  HP1  rabbit       -------------------------MEFS-----------    4
 48 2B11 IIB  dog          -------------------------MELS-----------    4
 49 2B6  LM2  human        -------------------------MELS-----------    4
 50 2B17 macaque           -------------------------MELS-----------    4
 51 2B16P     rat          -------------------------MEPS-----------    4
 52 2B2  e    rat          -------------------------MEPS-----------    4
 53 2B1  b    rat          -------------------------MEPS-----------    4
 54 2B10 pf3/46 mouse      -------------------------MEPS-----------    4
 55 2B12 gen4 rat          -------------------------MEFG-----------    4
 56 2B15      rat          -------------------------MELG-----------    4
 57 2B9  pf26   mouse      -------------------------MDPS-----------    4
 58 2B13 16aOH-b mouse     -------------------------MDPS-----------    4
 59 2B3  IIB3 rat          -------------------------MDTS-----------    4
 60 2G1  olf1 rat          -------------------------MALGGAF--------    7
 61 2G1  NMb  rabbit       -------------------------MELGGAF--------    7
 62 NEW HUMAN T84852 EST   ----------------------------------------    0
 63 NEW HUMAN t91507       ----------------------------------------    0
 64 2A6  IIA3 human        -------------------------MLASGML--------    7
 65 2A7  IIA4 human        -------------------------MLASGLL--------    7
 66 2A4  15aOH-1 mouse     -------------------------MLTSGLL--------    7
 67 2A5  15aOH-2 mouse     -------------------------MLTSGLL--------    7
 68 2A3  a3   rat          -------------------------MLASGLL--------    7
 69 2A8  AFB  hamster      -------------------------MLVSGML--------    7
 70 2A1  a1   rat          -------------------------MLDTGLL--------    7
 71 2A12      mouse        -------------------------MLGSGLL--------    7
 72 2A2  a2   rat          -------------------------MLDTGLL--------    7
 73 2A9  MC1-81 hamster    ----------------------------------------    0
 74 2A10      rabbit       -------------------------MLASGLL--------    7
 75 2A11      rabbit       -------------------------MLASGLL--------    7
 76 2Q1      Xenopus laevis-------------------------MDTSWLW--------    7
 77 CYP2 14F12 C. elegans  ----------------------------------------    0
 78 2K1  cons trout        -----------------MSLIEDILQTSSTVT--------   15
 79 2M1       trout        ------------------MDVLHILQTNFVSI--------   14
 80 2J1  ib rabbit intest. ------------------MVAALSSLAAALGAGLH-----   17
 81 2D1  db1  rat          -------------------------MELLNGTGLW-----   10
 82 2D5  db5  rat          -------------------------MELLNGTGLW-----   10
 83 2D9  ca   mouse        -------------------------MELLTGTDLW-----   10
 84 2D10 cb   mouse        -------------------------MELLTGAGLW-----   10
 85 2D11 cc   mouse        -------------------------MELLTGAGLW-----   10
 86 2D3  db3  rat          -------------------------MELLAGTGLW-----   10
 87 2D2  db2  rat          -------------------------MGLLIGDDLW-----   10
 88 2D4  db4  rat          -------------------------MRMPTGSELW-----   10
 89 2D6  db1  human        -------------------------MGL---EALV-----    7
 90 2D14      bovine       -------------------------MGLLSGDTLG-----   10
 91 2D15      dog          -------------------------MGLLTGDTLG-----   10
 92 1A        trout        -----------------MVLMILPIIGSVSASEGL-----   18
 93 1A        trout        -----------------MVLMILPIIGSVSVSEGL-----   18
 94 1A        scup         -----------------MVLMILPVIGSVSVSEGL-----   18
 95 1A        toadfish     -----------------MALIILPFIGSLSVSESL-----   18
 96 1A        plaice (fish)-----------------MMLMMLPFIGSVSVSESL-----   18
 97 1A Microgadus tomcod   -----------------MALMILPLIGSVSVSETL-----   18
 98 1A Chaetodon capistr.  -----------------MALMILPFIGSVSVSESL-----   18
 99 1A1  c    rat          ------------------MPSVYGFPAFTSATELL-----   17
100 1A1  P1   mouse        ------------------MPSMYGLPAFVSATELL-----   17
101 1A1  P1   hamster      ------------------MSSIYGLLNFMSATELL-----   17
102 1A1       guinea pig   --------------------------MSTSAMELL-----    9
103 1A1  dah1 dog          ------------------MMSMFRLSIPISASELL-----   17
104 1A1  P1   human        ----------------------MLFPISMSATEFL-----   13
105 1A1  MKah1 monkey      ----------------------MLFRISMSATEFL-----   13
106 1A1  6    rabbit       ------------------MVSDFGLPTFISATELL-----   17
107 1A2  d    rat          --------------------MAFSQYISL-APELL-----   14
108 1A2  P3   mouse        --------------------MAFSQYISL-APELL-----   14
109 1A2  MC4  hamster      --------------------MALSQYTSL-STELV-----   14
110 1A2  Dah2 dog          ----------------------------------L-----    1
111 1A2  4    human        --------------------MALSQSVPFSATELL-----   15
112 1A2       guinea pig   --------------------MPLSWLVPFSAMELL-----   15
113 1A2  LM4  rabbit       --------------------MAMSPAAPLSVTELL-----   15
114 1A2       chicken      ----------------------------------------    0
115 1b1 C3H 10T1/2 cell mou-------------------MATSLSADSPQQLSSL-----   16
116 1B1 norway rat         -------------------MATSLSADSPQQLSSL-----   16
117 1B1       human        -------------------MGTSLSPNDPWPLNPL-----   16
118 17   17a  bovine       ----------------------------------------    0
119 17   17a  porcine      ----------------------------------------    0
120 17   17a  human        ----------------------------------------    0
121 17   17a  mouse        ----------------------------------------    0
122 17   17a  rat          ----------------------------------------    0
123 17   17a  chicken      ----------------------------------------    0
124 17   17a  trout        ----------------------------------MAWFLC    6
125 17   17a  dogfish      -------------------------------------MSL    3
126 21   C21  bovine       ----------------------------------------    0
127 21   C21  sheep        ----------------------------------------    0
128 21   C21  porcine      ----------------------------------------    0
129 21   C21  human        ----------------------------------------    0
130 21   C21  mouse        ----------------------------------------    0
131 71A1     avocado       -------------------------MAIL-----------    4
132 71A2     eggplant F154 -------------------------MDVPCPWYS------    9
133 71A3     eggplant F151 ----------------------------------------    0
134 71A4     eggplant E138 -------------------------MDVPCLWYS------    9
135 71A7 Cathar.CR7  X69779----------------------------------------    0
136 71A8 Mentha piperita   -------------MYSIAFMLVLRKMDEIISHTLA-----   22
137 71B1 Thlaspi arv.L24438-------------------------MDLL-----------    4
138 71B-like  Z33677/Z33963----------------------------------------    0
139 71B-like Arabido T20987----------------------------------------    0
140 92A2 tobacco X95342    -------------------------MEGTN----------    0
141 83  Arabidopsis pCC19  -------------------------MED------------    3
142 88   Zea mays          --------------------MLGVGMAAEAVLVGAVA---   17
143 90   Arabidopsis Z17988-------------------------MAFTA----------    5
144 71C1 Zea mays maize1   -------------MALEAGYD-YLHVAVVQCTPTQAAAVL   26
145 71C2 Zea mays maize2   -------------MALGAAYHHYLQLAGDHGTATH-ALLL   26
146 71C3 Zea mays maize3   --------------ALQAAYE-YLQQAVGHGAWSSTQTLT   25
147 71C4 Zea mays maize4   -------------MAAQLHHALYELLHEAAAAQR--ALLL   25
148 71C5 Zea mays a        ----------------------------------------    0
149 71C-like  Z.mays T12664----------------------------------------    0
150 76A1     eggplant F94  ----------------------------------------    0
151 76A2     eggplant G17  -------------------------MEWEWSY--------    7
152 76A3 Cathar.CR12 X69784----------------------------------------    0
153 75A2     eggplant      -------------------------MVILPSELI------    9
154 75A1     petunia       -------------------------MMLLTELG-------    8
155 75A3     petunia       -------------------------MVLLSELA-------    8
156 86A2 Arabidopsis T04172----------------------------------------    0
157 78A1 Zea mays(J.Larkin)----------------------------------------    0
158 78A2 Phalaenopsis      ----------------------------------------    0
159 73A1     Jer.artichoke -------------------------MDLLLI---------    6
160 73A2     mung bean     -------------------------MDLLLL---------    6
161 73A3     alfalfa       -------------------------MDLLLL---------    6
162 73A4 Cathar.CR16 X69788-------------------------MDLLLL---------    6
163 73A5 Arabidopsis T04086----------------------------------------    0
164 73A9  Pea              ---------------------------LLLL---------    4
165 77A1  eggplant H1      ----------------------------------------    0
166 77A2  eggplant H2      -------------------------MDFFSTSSLSSYYHL   15
167 79    Sorghum bicolor  MATMEVEAAAATVLAAPLLSSSAILKLLLFVVTLSYLARA   40
168 80    Berberis stoloni.-------------------------MDYI-----------    4
169 82    Pea cDNA50       ----------------------------FVLNYL------    6
170     Brassica campestris----------------------------------------    0
171 71D3 Arabidopsis Z27299----------------------------------------    0
172      Arabidopsis T14112-------------------------MSVF-----------    4
173      Arabidopsis T04417----------------------------------------    0
174      Arabidopsis T04186----------------------------------------    0
175      Arabidopsis Z24511----------------------------------------    0
176      Arab.T04013/T04016----------------------------------------    0
177      Arab.T04714/T04452----------------------------------------    0
178      Arabidopsis Z26103----------------------------------------    0
179      Arabidopsis T04613----------------------------------------    0
180      Arab.T04014/T04015----------------------------------------    0
181      Cathar.CR1  X69789----------------------------------------    0
182      Cathar.CR2  X69790----------------------------------------    0
183      Cathar.CR4  X69776----------------------------------------    0
184      Cathar.CR5  X69777----------------------------------------    0
185      Cathar.CR6  X69778----------------------------------------    0
186      Cathar.CR8  X69780----------------------------------------    0
187      Cathar.CR9  X69781----------------------------------------    0
188      Cathar.CR10 X69782----------------------------------------    0
189      Cathar.CR11 X69783----------------------------------------    0
190      Cathar.CR13 X69785----------------------------------------    0
191      Cathar.CR14 X69786----------------------------------------    0
192      Cathar.CR15 X69787----------------------------------------    0


1 ---VVV-LGLCLSCLL--L-LSLWK-------------QSYGGGKLPPGPTPF-PILGNI--LQIGIKDI 50 2 ---VVV-LGLCLSCLL--L-LSLWK-------------QSHGGGKLPPGPTPF-PILGNV--LQLDFKDL 50 3 ---VVV-LVLCLSCLL--L-LSLWK-------------QSHGGGKLPPGPTPL-PILGNI--LQIDFKDI 50 4 ---VLV-LVLTLSCLL--L-LSLWR-------------QSSGRGKLPPGPTPL-PIIGNI--LQIDVKDI 50 5 ---------------------------------------------------------------------- 0 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ---VAG-LVLGLCCLL--L-LSLWK-------------QNSGRGKLPPGPTPF-PIIGNI--LQIDVKDI 50 11 ---VVV-LVLGLCCLL--L-LSIWK-------------QNSGRGKLPPGPTPF-PIIGNI--LQIDAKDI 50 12 ---VVV-LVLGLCCLL--L-LSHWK-------------QNSGRGKLPPGPTPF-PIIGNI--LQIDAKDI 50 13 ---------------------------------------------------------------------- 0 14 ---LVV-LVLCLSCLL--L-LSLWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIGIKDI 50 15 ---------------------------------------------------------------------- 0 16 ---FIV-LVICLSCLL--L-VSLLK-------------QSYARRKLPPGPTAF-PLVGNV--LQLDRKNI 50 17 ---FVV-LVLCLSCLL--L-LSIWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIDIKDV 50 18 ---AVA-LVLCLSCLF--L-LSLWR-------------QSSGRGRLPSGPTPL-PIIGNI--LQLDVKDM 50 19 ---FVV-LVLCLSFML--L-FSLWR-------------QSCRRRKLPPGPTPL-PIIGNM--LQIDVKDI 50 20 ---FVV-LVLCLSFVL--L-FSLWR-------------QSSGRRKLPPGPTPL-PIIGNI--LQIDVKDI 50 21 ---VLV-LVLTLSSLL--L-LSLWR-------------QSFGRGKLPPGPTPL-PIIGNT--LQIYMKDI 50 22 ---VTF-LVLTLSSLI--L-LSLWR-------------QSSRRRKLPPGPTPL-PIIGNF--LQIDVKNI 50 23 ---VVF-LALTLSCLI--L-LSLWR-------------QSSGRGKLPPGPTPL-PIIGNF--LQIDVKNI 50 24 ---VML-LVLTLTCLI--L-LSIWR-------------QSSGRGKLPPGPIPL-PIIGNI--FQLNVKNI 50 25 ---VVV-LLLSLFFLL--F-LSLWR-------------PSSGRGKLPPGPTPL-PIIGNF--FQVDMKDI 50 26 ---FVV-LVLSLSFLL--L-LYLWR-------------PSPGRGKLPPGPTPL-PIFGNF--LQIDMKDI 50 27 --------------------------------------------KLPPGPTPL-PIIGNI--LQINTKNV 23 28 ---LII-LGICLSCVV--L-LSLWK-------------KTHGKGKLPPGPTPL-PVVGNL--LQLETKDI 50 29 ---FIF-LGIWLSCLV--F-LFLWN-------------QHHVRRKLPPGPTPL-PIFGNI--LQVGVKNI 50 30 ---TLA-LVVSVTCLS--L-LSVWT-------------KLRTRGRLPPGPHPP-SHYWES--TATEPQGH 54 31 ---VLV-LVFILSSLV--F-LSLWR-------------QSSERRKLPPGPTPL-PIIGNF--LQIDVKNI 50 32 ---FVV-LVFILSCLF--L-LSLWR-------------QSSERGKLPPGPTPL-PIIGNF--LQIDVKDI 50 33 ---FVV-LVFILSCLF--L-LSLWR-------------QSSERGKLPPGPTPL-PLIGNF--FQIDVKDI 50 34 ---VLV-LVLTLSCLL--L-FSVWR-------------QSSGRGRLPPGPTPL-PLIGNI--LQIDIKDI 50 35 ---TVA-LLGWMVILL--F-ISVWK-------------QIHSSWNLPPGPFPL-PIIGNL--LQLDLKDI 53 36 ---TVA-LLGWMAILL--F-ISVWK-------------QIHSSWNLPPGPFPL-PIIGNL--LQLDFKDI 53 37 ---TIA-LLVWVATLL--V-ISIWK-------------QIYNSWNLPPGPFPL-PILGNI--FQLDLKDI 53 38 ---TVA-LLVWIATLL--L-VSIWK-------------QIYRSWNLPPGPFPI-PFFGNI--FQLDLKDI 53 39 ---TIA-LLVWVATLL--I-VSIWK-------------QIYSSWNLPPGPFPL-PILGNI--FQLDLKNI 53 40 ---TVA-LLVWAAFLL--L-VSMWR-------------QVHSSWNLPPGPFPL-PIIGNL--FQLELKNI 53 41 -----------------------------------------------------------L--FQLELKNI 9 42 ---TIL-LLVCISCL---L-IAAWR-------------STSQRGKEPPGPTPI-PIIGNV--FQLNPWDL 53 43 ---TIL-LLVCISCF---L-IAAWR-------------STSQRGKEPPGPTPI-PIIGNV--FQLNPWDL 53 44 ---STA-ILLLLLALV--C-LLLTL-------------SSRDKGKLPPGPRPL-SILGNL--LLLCSQDM 51 45 ---STA-ILLLLLAVI--S-LSLTF-------------SSRGKGQLPPGPKPL-PILGNL--LQLRSQDL 51 46 ---LLL-LLAFLAGLL--L-LLFRG-------------HPKAHGRLPPGPSPL-PVLGNL--LQMDRKGL 51 47 ---LLL-LLAFLAGLL--L-LLLRG-------------HPKAHGRLPPGPPPL-PVLGNL--LQMDRKGL 51 48 ---VLL-LLALLTGLL--L-LMARG-------------HPKAYGHLPPGPRPL-PILGNF--LQMDRKGL 51 49 ---VLL-FLALLTGLL--L-LLVQR-------------HPNTHDRLPPGPRPL-PLLGNL--LQMDRRGL 51 50 ---VLL-FLALLTGLL--L-LLVQR-------------HPNAHGRLPPGPCPL-PLLGNL--LQMDRRGL 51 51 ---VLL-LLAVLLSFL--L-LLVRG-------------HAKIHGRLPPGPCPV-PLLGNL--LQMDRGGL 51 52 ---ILL-LLALLVGFL--L-LLVRG-------------HPKSRGNFPPGPRPL-PLLGNL--LQLDRGGL 51 53 ---ILL-LLALLVGFL--L-LLVRG-------------HPKSRGNFPPGPRPL-PLLGNL--LQLDRGGL 51 54 ---VLL-LLALLVGFL--L-LLARG-------------HPKSRGNFPPGPRPL-PLLGNL--LQMDRGGL 51 55 ---VLL-LLTLTVGFL--L-FLVSQS------------QPKTRGHLPPGPRPL-PFLGNL--LQMNRRGF 52 56 ---VLL-LLTFTVGFL--L-LLASQN------------RPKTHGHLPPGPRPL-PFLGNL--LQMNRRGL 52 57 ---VLL-LLAVLLSLF--L-LLVRG-------------HAKIHGHLPPGPHPL-PLLGNL--LQMDRGGL 51 58 ---VLL-LLAVLLSLF--L-LLVRG-------------HAKIHGHLPPGPRPL-PLLGNL--LQMDRGGL 51 59 ---VLL-LLAVLLSFL--L-FLVRG-------------HAKVHGHLPPGPRPL-PLLGNL--LQMDRGGF 51 60 ---SIF-MTLCLSCLL--I-LIAWK-------------RTSRGGKLPPGPTPI-PFLGNL--LQVRIDAT 54 61 ---TIF-LALCFSCLL--I-LIAWK-------------RVQKPGRLPPGPTPI-PFLGNL--LQVRTDAT 54 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ---LVA-LLVCLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEQM 54 65 ---LVA-LLACLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEHI 54 66 ---LVA-AVAFLSVLV--L-MSVWK-------------QRKLSGKLPPGPTPL-PFVGNF--LQLNTEQM 54 67 ---LVA-AVAFLSVLV--L-MSVWK-------------QRKLSGKLPPGPTPL-PFIGNF--LQLNTEQM 54 68 ---LVA-SVAFLSVLV--L-MSVWK-------------QRKLSGKLPPGPTPL-PFIGNY--LQLNTEKM 54 69 ---LVV-VLTCLSVMI--I-MSVWR-------------QRRLLRKMPPGPTPL-PFIGNF--LELDTEKF 54 70 ---LVV-ILASLSVML--L-VSLWQ-------------Q-KIRGRLPPGPTPL-PFIGNY--LQLNTKDV 53 71 ---LLA-ILAFLSVMV--L-VSVWQ-------------Q-KIRGKLPPGPIPL-PFIGNY--LQLNRKDV 53 72 ---LVV-ILASLSVMF--L-VSLWQ-------------Q-KIRERLPPGPTPL-PFIGNY--LQLNMKDV 53 73 ---------------------------------------------------------------------- 0 74 ---LAA-LLACLTVMI--L-LSVWR-------------QRKLWGKLPPGPTPL-PFIGNY--LQLNTEQM 54 75 ---LAA-LLACLTVMI--L-LSVWR-------------QRKLWGKLPPGPTPL-PFIGNY--LQLNTEQM 54 76 ---TLL-LSLLISCIL--I-YSTWN-------------KMYRKRNLPPGPTPI-PLFGNV--LQIKRGEM 54 77 ---------------------------------------------------------------------- 0 78 ---LLG-TVLFLLVLY--L-RSSGS-------------SSEEQGKEPPGPRPL-PLLGNM--LQLDLKKP 62 79 ---IIG-FVVIILLWM--N-RGKQS-------------NS----RLPPGPAPI-PLLGNL--LRMDVKAP 57 80 ---PKT-LLLGAVAFL--F-FAYFL-------------KTRRPKNYPPGPWRL-PFLGNL--FTLDMEKS 64 81 ---SMA-IFTVIFILL--V-DLMHR-------------RHRWTSRYPPGPVPW-PVLGNL--LQVDLSNM 57 82 ---PMA-IFTVIFILL--V-DLMHR-------------HQRWTSRYPPGPVPW-PVLGNL--LQVDPSNM 57 83 ---PVA-IFTVIFILL--V-DLTHQ-------------RQRWTSRYPPGPVPW-PVLGNL--LQVDLGNM 57 84 ---SVA-IFTVIFILL--V-DLMHR-------------HQRWTSRYPPGPVPW-PVLGNL--LQVDLDNM 57 85 ---SVA-IFTVIFILL--V-DLMHR-------------HQHWTSRCPPGPVPW-PVLGNL--LQVDLDNM 57 86 ---PMA-IFTVIFILL--V-DLMHR-------------RQRWTSRYPPGPVPW-PVLGNL--LQVDLCNM 57 87 ---AVV-IFTAIFLLL--V-DLVHR-------------HKFWTAHYPPGPVPL-PGLGNL--LQVDFENM 57 88 ---PIA-IFTIIFLLL--V-DLMHR-------------RQRWTSRYPPGPVPW-PVLGNL--LQIDFQNM 57 89 ---PLA-VIVAIFLLL--V-DLMHR-------------RQRWAARYPPGPLPL-PGLGNL--LHVDFQNT 54 90 ---PLA-VALLIFLLL--L-DLMHR-------------RSRWAPRYPPGPTPL-PVLGNL--LQVDFEDP 57 91 ---PLA-VAVAIFLLL--V-DLMHR-------------RRRWATRYPPGPTPV-PMVGNL--LQMDFQEP 57 92 ---VAM-VTLCLVYMI--M-KYMHT-------------EIPEGLKRLPGPKPL-PIIGNV--LEVH-NNP 64 93 ---VAI-VTLCLVYML--M-KYKHT-------------EIPEGLKRLPGPKPL-PIIGNV--LEVY-NNP 64 94 ---VAM-ITMCLAYLI--L-RLFRT-------------EIPEGLLQLPGPKPL-PIIGNV--LEVG-RNP 64 95 ---VAL-ITICVVYLI--L-TYSHT-------------KIPAGLQRLPGPKPL-PIIGNV--LEIG-RKP 64 96 ---VAM-TTMCLVYLI--L-KFFQT-------------EIPEGLRRLPGPKPL-PIIGNV--LGLG-SKP 64 97 ---VAM-ITVCMIYML--M-KFLHP-------------DVPEA-PPAPGPQAL-PIIGNV--WSWE-NGL 63 98 ---VAL-TAVCLVYLI--L-KFFRT-------------EIPAGLRQLPGPKPL-PIIGNV--LEVG-SKP 64 99 ---LAV-TTFCLGFWV--V-RVTRT-------------WVPKGLKSPPGPWGL-PFIGHV--LTLG-KNP 63 100 ---LAV-TVFCLGFWV--V-RATRT-------------WVPKGLKTPPGPWGL-PFIGHM--LTVG-KNP 63 101 ---VAI-TVFCLGFWV--V-RALRT-------------QVPKGLKTPPGPWGL-PILGHV--LTLG-KNP 63 102 ---LTA-TIFCLVLWV--V-RIFRP-------------QVPKGLKSPPGPWGW-PLIGHM--LTLG-KNP 55 103 ---LAS-TVFCLVLWV--V-KAWQP-------------RLPKGLKSPPGPWGW-PVLGNV--LTLG-KSP 63 104 ---LAS-VIFCLVFWV--I-RASRP-------------QVPKGLKNPPGPWGW-PLIGHM--LTLG-KNP 59 105 ---LAS-LIFCLVFWV--I-RASRP-------------RVPKGLKNPPGPWGW-PLIGHI--LTLG-KNP 59 106 ---LAS-AVFCLVFWV--A-GASKP-------------RVPKGLKRLPGPWGW-PLLGHV--LTLG-KNP 63 107 ---LAT-AIFCLVFWV--L-RGTRT-------------QVPKGLKSPPGPWGL-PFIGHM--LTLG-KNP 60 108 ---LAT-AIFCLVFWM--V-RASRT-------------QVPKGLKNPPGPWGL-PFIGHM--LTVG-KNP 60 109 ---LAT-AIFCIVFWV--A-RALRT-------------QVPKGLKTPPGPWGL-PILGHV--LTLG-KNP 60 110 ---LAS-TIFCLILWV--V-KAWQP-------------RLPKGLKSPPGPWGW-PLLGNV--LTLG-KSP 47 111 ---LAS-AIFCLVFWV--L-KGLRP-------------RVPKGLKSPPEPWGW-PLLGHV--LTLG-KNP 61 112 ---LTA-TIFYLVLWV--V-KAFRL-------------QVPKGLKSPPGAWGW-ALIGHV--LTLG-KNP 61 113 ---LVS-AVFCLVFWA--V-RASRP-------------KVPKGLKRLPGPWGW-PLLGHL--LTLG-KNP 61 114 ---------------------------------------------------------------------- 0 115 --STQQ-TTLLLLFSV--L-AAVHLGQWLLRQ------WQRKPWSSPPGPFPW-PLIGNA--AAVG-QAS 70 116 --STQQ-TILLLLVSV--L-AIVHLGQWLLRQ------WRRKPWSSPPGPFPW-PLIGNA--ASVG-RAS 70 117 --SIQQ-TTLLLLLSV--L-ATVHVGQRLLRQ------RRRQLRSAPPGPFAW-PLIGNA--AAVG-QAA 70 118 --MWLL-LAVFLLTLA--Y-LFWPK-------------TKHSGAKYPRSLPSL-PLVGSL-PFLPRRGQQ 49 119 --MWVL-LVFFLLTLT--Y-LFWPK-------------TKGSGAKYPRSLPVL-PVVGSL-PFLPRRGHQ 49 120 --MWEL-VALLLLTLA--Y-LFWPK-------------RRCPGAKYPKSLLSL-PLVGSL-PFLPRHGHM 49 121 --MWEL-VGLLLLILA--Y-FFWPK-------------SKTPNAKFPRSLPFL-PLVGSL-PFLPRRGHM 49 122 --MWEL-VGLLLLILA--Y-FFWVK-------------SKTPGAKLPRSLPSL-PLVGSL-PFLPRRGHM 49 123 ---MPP-LAVLLLALA--L-LCAWRLSYSQG-------PTGTGTGRPRSLPAL-PLVGSL-LQLAGHPQL 54 124 MCVFSV-VGLGLLLLQ--V-KLRRS-------------LETRGG--PPSLPVF-PLIGSL-LSLRSNQAP 55 125 MLAALI-LTVAFVICS--L-TGFTQRK-----------LSGGRL--PKCLPSF-PLIGSL-LSLRSDLPP 54 126 -----M-VLAGLLLLL--T-LLAGA------------HLLWGRWKLRNLHLP-PLVPGFL--HLLQPNL- 45 127 -----M-VLAGLLLLLL-T-LLAGA------------HLLWGRWKLRNLHLP-PLVPGFL--HLLQPNL- 46 128 -----M-VLVWLLLLT--T-LKAGA------------RLLWGQWKLRNLHLP-PLVPGFL--HLLQPNL- 45 129 -----M-LLLGLLLL---P-LLAGA------------RLLWNWWKLRSLHLP-PLAPGFL--HLLQPDL- 44 130 -----M-LLPGLLLLL--L-LLAGT------------RWLWGQWKLRKLHLP-RLAPGFL--HFLQPNL- 45 131 -VSLLF-LAIALTFFL----LKLNE-------------KREKKPNLPPSPPN-LPIIGNL--HQLGN-LP 51 132 -LLIPL-FVFIFLLIH--H-CFFTT-------------SKKQNMLLLPSPRK-LPIIGNL--HQLGS-LP 57 133 --LVPL-FVFILFLHK----CFFTT--------------SNNNKKLPPSPRK-LPIIGNL--HQLGL-HP 45 134 -LLILL-LLFIFLLIH--H-CF-TT-------------SKTQNMFLPPSPRK-LPIIGNL--HQLGS-HP 56 135 ---------------------------------------------------------------------- 0 136 -FQALV-SLILLISIT----KWLSN-------------SPKNKNSSPPSPRK-LPILGNL--LQLGS-LP 69 137 -L-YIV-AALVIFASL----LIAKS-------------KRKPKKNLPPGPPR-LPIIGNL--HQLGE-KP 50 138 ---------------------------------------------------------------------- 0 139 ---------------------------------------------------------------------- 0 140 -LTTYA-AVFLGTLFL----LFLSK------------LLRQRKLNLPPGPKP-WPIIGNL--NLIGN-LP 0 141 -IIIGV-VALAAVLLF----FLYQK-------------PKTKRYKLPPGPSP-LPVIGNL--LQLQK-LN 50 142 -LVVVD-AAARRAHGW----REAAL-------------GAARRARLPPGEMG-WPLVGGM--WAFLR-AF 64 143 -FLLLL-SSIAAGFLL----LLRR--------------TRYRRMGLPPGSLG-LPLIGET--FQLIG-AY 51 144 -GVLLL-LAIRLAAAA----R--SSSAT---------SPKWKQHRLPPTPPGKLPIIGHL--HLIGS-HP 76 145 -GVLIF-LVIRLVSAR----RTGTTSANK--------RKQQQRLPLPPWPPGKLPIIGHL--HLIGA-ET 79 146 -LLLIA-VPTVLLLLA----SLAKSTSSS----------GRGKPPLPPSPPGTLPIVGHL--HHIGP-QT 76 147 -AIPFS-LLLLPLLLR--YLAASASASATKNDGAAPASDPDKLLSLLPSPPMKLPIIGHL--HLMGD-IP 88 148 ---------------------------------------------------------------------- 0 149 ---------------------------------------------------------------------- 0 150 --------------------------------------------------------FGNM-FDLAGS-AP 12 151 -VFFSA-IIILPAFIL--F-FSQKN-------------TTKSSYKFPPGPPG-LPIFGNM-FEL-GT-EP 55 152 ---------------------------------------------------------------------- 0 153 -GATII-YIIVYIIIQ----KLIAT-------------GSWRRRRLPPGPEG-WPVIGAL--PLLGG-MP 56 154 -AATSI-FLIAHIIIS----TLI---------------SKTTGRHLPPGPRG-WPVIGAL--PLLGA-MP 53 155 -AATLI-FLTTHIFIS----TLL---------------SITNGRRLPPGPRG-WPVIGAL--PLLGA-MP 53 156 ---------------------------------------------------------------------- 0 157 -ALLAW-ATSPGGPAW--T-NGRGA-------------SASLLSWDPVVCPC-SAASSRC--PGAAAPRP 49 158 ---------------------------------------------------------------------- 0 159 -EKTLV-ALFAAIIGA----ILISK-------------LRGKKFKLPPGPIP-VPIFGNW--LQVGDDLN 54 160 -EKTLL-GLFLAAVVA----IVVSK-------------LRGKRFKLPPGPLP-VPIFGNW--LQVGDDLN 54 161 -EKTLL-ALFIAATIA----VTISK-------------LRGKRFKLPPGPIP-VPIFGYW--LQVGDDLN 54 162 -EKTLL-GLFAAIIVA----SIVSK-------------LRGKKFKLPPGPIP-VPVFGNW--LQVGDDLN 54 163 ---------------------------------------------------------------------- 0 164 -EKTLL-ALFLAAITA----ITISK-------------LRGKPFKLPPGPFP-VPVFGNW--LQVGDDLN 52 165 -IFTAF-SLLFSLFIF----LLTRK-------------PKSKTPNLPPGPPG-WPIVGNL-FQVAGSGKQ 49 166 -IFTIL-AFVISSIIY--F-LLSKK-------------AESKKLKLPPGPPG-WPVVGNL-LQVARSGKP 65 167 LRRPRK-STTKCSSTT----CASPP-------------AGVGNPPLPPGPVP-WPVVGNL--PEMLLNKP 89 168 -IVGFV-SISLVALLY----FLL---------------FKPKHTNLPPSPPA-WPIVGHL--PDLIS-KN 49 169 -NTTTI-AFISLISLL--F-FLFRF-------------SKVSHTKEPPIISGSWPLLGSI-PLMRNTQTP 57 170 ---------------------------------------------------------------------- 0 171 ---------------------------------------------------------------------- 0 172 -LVFLC-LLPLILIFL--------K------------NLKPSKWKLPPGPKK-LPIIGNL--HQRRE-LH 48 173 --------------LT----IFFLQ------------ENKRLTSWLPPSPPS-LPIIGHL--HLILF-VP 36 174 ---------------------------------------------------------------------- 0 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 ---------------------------------------------------------------------- 0 180 ---------------------------------------------------------------------- 0 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 ----SKSFTKLSE--VYG------PVFTVYLGMKPTVVIHGYDAVKEAL-VDLGEEFSG----------- 96 2 ----SKSLTNLSK--VYG------PVFTVYLGMKPTVVVHGYEAVKEAL-VDLGHELSG----------- 96 3 ----SKSLQNLSK--VYG------NVFTVYMGMKPTVVMYGYEAVKEAL-VDLGEEFSG----------- 96 4 ----SKSFTNFSK--IYG------PVFTLYFGPKPTVVVHGYEAVKEAL-DDLGEEFSG----------- 96 5 ---------------------------------------------------------------------- 0 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 ----SKSLTKFSE--RYG------PVFTVYLGMKPTVVLHGYKAVKEAL-VDLGEEFAG----------- 96 11 ----SKSLTKFSE--CYG------PVFTVYLGMKPTVVLHGYEAVKEAL-VDLGEEFAG----------- 96 12 ----SKSLTKFSE--RYG------PVFTVYLGMKPAVVLHGYQAVKEAL-VDLGEEFAG----------- 96 13 ---------------------------------------------------------------------- 0 14 ----SKSLTNLSK--VYG------PVFTLYFGLKPIVVLHGYEAVKEAL-IDLGEEFSG----------- 96 15 ---------------------------------------------------------------------- 0 16 ----SKSISMLAK--EYG------PVFTVYFGTKPSVVLHGYEAVKEAL-VDHGEEFSG----------- 96 17 ----SKSLTNLSK--IYG------PVFTLYFGLERMVVLHGYEVVKEAL-IDLGEEFSG----------- 96 18 ----SKSLTNFSK--VYG------PVFTVYFGLKPIVVLHGYEAVKEAL-IDHGEEFSG----------- 96 19 ----CKSFTNFSK--VYG------PVFTVYFGMNPIVVFHGYEAVKEAL-IDNGEEFSG----------- 96 20 ----CKSFSNFSK--VYG------PVFTVYFGMNPVVVLHGYETVKEAL-IDNAEEFSG----------- 96 21 ----GQSIKKFSK--VYG------PIFTLYLGMKPFVVLHGYEAVKEAL-VDLGEEFSG----------- 96 22 ----SQSLTKFSK--TYG------PVFTLYLGSQPTVILHGYEAIKEAL-IDNGEKFSG----------- 96 23 ----SQSFTNFSK--AYG------PVFTLYLGSKPTVILHGYEAVKEAL-INRGEEFAG----------- 96 24 ----TQSLTSFSK--VYG------PVFTLYFGTKPTVILHGYEAVKEAL-IDHGEEFAE----------- 96 25 ----RQSLTNFSK--TYG------PVYTLYVGSQPTVVLHGYEALKEAL-VDHGEEFSG----------- 96 26 ----RQSISNFSK--TYG------PVFTLYFGSQPTVVLHGYEAVKEAL-IDYGEEFSG----------- 96 27 ----SKSLSKLAE--NYG------PVFTVYFGMKPTVVLYGYEAVKEAL-IDRSEEFSG----------- 69 28 ----NKSLSMLAK--EYG------SIFTLYFGMKPAVVLYGYEGVIEAL-IDRGEEFSG----------- 96 29 ----SKSMCMLAK--EYG------PVFTMYLGMKPTVVLYGYEVLKEAL-IDRGEEFSD----------- 96 30 ----PASLSKLAK--EYG------PVYTLYFGTSPTVVLHGYDVVKEAL-LQQGDEFLG----------- 100 31 ----SGSLTNFSK--VYG------PVFTLYLGMKPTVVLHGYETVKEAL-IDHGEEFAG----------- 96 32 ----SGSLTNFSK--VYG------PVFTLYLGMKPTVVLHGYEAVKEAL-IDHGEEFAG----------- 96 33 ----SGSLTNFSK--VYG------PVFTLYLGRKPAVVLHGYEAVKEAL-IDHGEEFAG----------- 96 34 ----SKSLANFSK--VYG------PVFTLYFGTKPTVVVHGYEAVKEAL-EDLGEEFSG----------- 96 35 ----PKSFGRLAE--RFG------PVFTVYLGSRRVVVLHGYKAVREML-LNHKNEFSG----------- 99 36 ----PKSFGRLAE--RFG------PVFTLYLGSRRVVVLHGYKAVREML-LNHKNEFSG----------- 99 37 ----PKSFTKLAK--RFG------PVFTLHLGSRRIVVLHGYKAVKEVL-LNHKNEFSG----------- 99 38 ----PKSLTKLAK--RFG------PVFTLHLGQRRIVVLHGYKAVKEVL-LNHKNEFSG----------- 99 39 ----PKSLTKLAE--RFG------PVFTLHLGSKRIVVLHGYKAVKEVL-LNHKNEFSG----------- 99 40 ----PKSFTRLAQ--RFG------PVFTLYVGSQRMVVMHGYKAVKEAL-LDYKDEFSG----------- 99 41 ----PKSFTRLAQ--RFG------PVFTLYVGSRRVVVVHGIKAVKEVL-LDHKDEFSG----------- 55 42 ----MGSFKELSK--KYG------PIFTIHLGPKKIVVLYGYDIVKEAL-IDNGEAFSG----------- 99 43 ----MESFKELSK--KYG------PIFTIHLGPKKVVVLYGYDVVKEAL-IDNGEAFSG----------- 99 44 ----LTSLTKLSK--EYG------SMYTVHLGPRRVVVLSGYQAVKEAL-VDQGEEFSG----------- 97 45 ----LTSLTKLSK--EYG------SVFTVYLGSRPVIVLSGYQTVKEAL-VDKGEEFSG----------- 97 46 ----LRSFLRLRE--KYG------DVFTVYLGSRPVVVLCGTDAIREAL-VDQAEAFSG----------- 97 47 ----LHSFLQLRE--KYG------DVFTVYLGSRPVVVLCGTDAIREAL-VDQAEAFSG----------- 97 48 ----LKSFLRLQE--KYG------DVFTVYLGPRRTVMLCGIDAIREAL-VDNAEAFSG----------- 97 49 ----LKSFLRFRE--KYG------DVFTVHLGPRPVVMLCGVEAIREAL-VDKAEAFSG----------- 97 50 ----LRTFLRFRE--KYG------DVFTVYLGPRPVVLLCGVEAIREAL-VDNAEAFSG----------- 97 51 ----LKSFIQLQE--KYG------DVFTVHLGLRPVVVLCGTQTIREAL-VDHAEAFSG----------- 97 52 ----LNSFMQLRE--KYG------DVFTVHLGPRPVVMLCGTDTIKEAL-VGQAEDFSG----------- 97 53 ----LNSFMQLRE--KYG------DVFTVHLGPRPVVMLCGTDTIKEAL-VGQAEDFSG----------- 97 54 ----LKSFIQLRE--KYG------DVFTVHLGPRPVVMLCGTDTIREAL-VGQAEAFSG----------- 97 55 ----LNSFMQLQE--KYG------DVFTVHLGPRPVVILCGTGTIREAL-VDQAEAFSG----------- 98 56 ----LRSFMQLQE--KYG------DVFTVHLGPRPVVILCGTDTIREAL-VDQAEAFSG----------- 98 57 ----LKCFIQLQE--KHG------DVFTVHLGPRPVVVLCGTQTIREAL-VDHAEAFSG----------- 97 58 ----LKCFIHLQE--KHG------DVFTVHLGPRPVVVLCGTQTIREAL-VNNAEAFSG----------- 97 59 ----RKSFIQLQE--KHG------DVFTVYFGPRPVVMLCGTQTIREAL-VDHAEAFSG----------- 97 60 ----FQSFLKLQK--KYG------SVFTVYFGPRPVVILCGHEAVKEAL-VDQADDFSG----------- 100 61 ----FQSFLKLRE--KYG------PVFTVYMGPRPVVILCGHEAVKEAL-VDRADEFSG----------- 100 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ----YNSLMKISE--RYG------PVFTIHLGPRRVVVLCGHDAVREAL-VDQAEEFSG----------- 100 65 ----CNSIMKFSE--CYG------PVFTIHLGPRRVVVLCGHDAVREAL-VDQAEEFSG----------- 100 66 ----YNSLMKISQ--RYG------PVFTIYLGSRRIVVLCGQEAVKEAL-VDQAEEFSG----------- 100 67 ----YNSLMKISQ--RYG------PVFTIYLGPRRIVVLCGQEAVKEAL-VDQAEEFSG----------- 100 68 ----YSSLMKISQ--RYG------PVFTIHLGPRRVVVLCGQEAVKEAL-VDQAEEFSG----------- 100 69 ----YDCLSKMRE--RYG------PVFTIHLGPRPAVMLWGYDAVKEAL-IDQAEELSD----------- 100 70 ----YSSITQLSE--RYG------PVFTIHLGPRRVVVLYGYDAVKEAL-VDQAEEFSG----------- 99 71 ----YSSITQLQE--HYG------PVFTIHLGPRRVVVLYGYDAVKEAL-VDHAEEFSG----------- 99 72 ----YSSITQLSE--RYG------PVFTIHLGPRRIVVLYGYDAVKEAL-VDQAEEFSG----------- 99 73 ---------------------------------------------------------------------- 0 74 ----YDSLMKISE--RYG------PVFTIHLGPRRIVVLCGQEAVKEAL-VDQAEDFSG----------- 100 75 ----YDSLMKIRD--RYG------PVFTIHLGPRRIVVLCGQEAVKEAL-VDQAEDFSG----------- 100 76 ----VKSLIEYGK--KYG------DTYTLYFGPSPVIILCSYRATKEAL-IDQAEDFSG----------- 100 77 ------------K--RYG------NIFTLWVGPVPHVSIADYETSYEVF-VKQGNKL-D----------- 37 78 ----YCTLCELSK--KYG------SIFTVHFGPKKVVVLAGYKTVKQAL-VNQAEDFGD----------- 108 79 ----YKLYMELSK--KYG------SVFTVWLGSKPVVVISGYQAIKDAF-VTQGEEFSG----------- 103 80 ----HLQLQQFVK--KYG------NLFCLDLAGKSIVIVTGLPLIKEVL-VHMDQNFIN----------- 110 81 ----PYSLYKLQH--RYG------DVFSLQKGWKPMVIVNRLKAVQEVL-VTHGEDTAD----------- 103 82 ----PYSMYKLQH--RYG------DVFSLQMGWKPMVIVNRLKAVQEVL-VTHGEDTAD----------- 103 83 ----PYSLYKLQN--RYG------DVFSLQMAWKPMVVINGLKAMKEML-LTCGEDTAD----------- 103 84 ----PYSLYKLQN--RYG------DVFSLQMGWKPMVVINGLKAMKEVL-LTCGEDTAD----------- 103 85 ----PYSLYKLQN--RYG------DVFSLQMAWKPMVVINGLKAMKEML-LTCGEDTAD----------- 103 86 ----PYSMYKLQN--RYG------DVFSLQMGWKPVVVINGLKAVQELL-VTCGEDTAD----------- 103 87 ----PYSLYKLRS--RYG------DVFSLQIAWKPVVVINGLKAVRELL-VTYGEDTAD----------- 103 88 ----PAGFQKLRC--RFG------DLFSLQLAFESVVVLNGLPALREAL-VKYSEDTAD----------- 103 89 ----PYCFDQLRR--RFG------DVFSLQLAWTPVVVLNGLAAVREAL-VTHGEDTAD----------- 100 90 ----RPSFNQLRR--RFG------NVFSLQQVWTPVVVLNGLAAVREAL-VYRSQDTAD----------- 103 91 ----ICYFSQLQG--RFG------NVFSLELAWTPVVVLNGLEAVREAL-VHRSEDTAD----------- 103 92 ----HLSLTAMSE--RYG------SVFQIQIGMRPVVVLSGSETVRQAL-IKQGEDFAG----------- 110 93 ----HLSLTAMSE--RYG------SVFQIQIGMRPVVVLSGNETVRQAL-IKQGEDFAG----------- 110 94 ----YLSLTAMSK--RYG------DVFQIQIGMRPVVVLSGSETVRQAL-IKQGEDFAG----------- 110 95 ----YQTLTALSK--RYG------PVFQIQIGMRPVVVLSGSETVRQAL-IKQGEDFSG----------- 110 96 ----YLSLTAMSK--RYG------HVFQIQIGMRPVVVLSGTGTVRQAL-IKQGDEFAG----------- 110 97 ----PEPHGHGQ---RYG------DILQIQIGMRSVVVLSGHETVRQAL-IKQGHDLRP----------- 108 98 ----HLSLTAMSK--RYG------DVFQIQIGMRPVVVLSGSETVRQAL-IKQGDEFSG----------- 110 99 ----HLSLTKLSQ--QYG------DVLQIRIGSTPVVVLSGLNTIKQAL-VKQGDDFKG----------- 109 100 ----HLSLTRLSQ--QYG------DVLQIRIGSTPVVVLSGLNTIKQAL-VRQGDDFKG----------- 109 101 ----HLSLTKLSK--QYG------DVLQIRIGSTPVVVLSGLDTIRQAL-VRQGDDFKG----------- 109 102 ----HLALTRLSA--RYG------DVLQIRIGSTPVVVLSGLDTIRQAL-VRQGDDFKG----------- 101 103 ----HLALSRLSQ--RYG------DVLQIRIGSTPVLVLSGLDTIRQAL-VRQGDDFKG----------- 109 104 ----HLALSRMSQ--QYG------DVLQIRIGSTPVVVLSGLDTIRQAL-VRQGDDFKG----------- 105 105 ----HLALSRMSQ--RYG------DVLQIRIGSTPVLVLSGLDTIRQAL-VQQGDDFKG----------- 105 106 ----HVALARLSR--RYG------DVFQIRLGSTPVVVLSGLDTIKQAL-VRQGDDFKG----------- 109 107 ----HLSLTKLSQ--QYG------DVLQIRIGSTPVVVLSGLNTIKQAL-VKQGDDFKG----------- 106 108 ----HLSLTRLSQ--QYG------DVLQIRIGSTPVVVLSGLNTIKQAL-VRQGDDFKG----------- 106 109 ----HLSLTKLSK--QYG------DVLQIRIGSTPVVVLSGLDTIRQAL-VRQGDDFKG----------- 106 110 ----HLALSRLSQ--RYG------DVLQIRIGSTPVLVLSGLDTIRQAL-VRQGDDFKG----------- 93 111 ----HLALSRMSQ--RYG------DVLQIRIGSTPVLVLSRLDTIRQAL-VRQGDDFKG----------- 107 112 ----HLALTRLSA--RYG------DVLQIRIGSTPVVVLSGLDTIRQAL-VRQSDDFKG----------- 107 113 ----HVALARLSQ--RYG------DVFQIRLGSTPVVVLSGLDTIKQAL-VRQGDDFKG----------- 107 114 ---------------------------------------------------------------------- 0 115 ----HLYFARLAR--RYG------DVFQIRLGSCPVVVLNGESAIHQAL-VQQGSIFAD----------- 116 116 ----HLYFARLAR--RYG------DVFQIRLGSCPVVVLNGESAIHQAL-VQQGGVFAD----------- 116 117 ----HLSFARLAR--RYG------DVFQIRLGSCPIVVLNGERAIHQAL-VQQGSAFAD----------- 116 118 ----HKNFFKLQE--KYG------PIYSFRLGSKTTVMIGHHQLAREVL-LKKGKEFSG----------- 95 119 ----HMNFFKLQD--KYG------PIFSFRLGSKTTVVIGDHQLAKEVL-LKKGKEFSG----------- 95 120 ----HNNFFKLQK--KYG------PIYSVRMGTKTTVIVGHHQLAKEVL-IKKGKDFSG----------- 95 121 ----HANFFKLQE--KYG------PIYSLRLGTTTAVIVGHYQLAREVL-VKKGKEFSG----------- 95 122 ----HVNFFKLQE--KYG------PIYSLRLGTTTTVIIGHYQLAREVL-IKKGKEFSG----------- 95 123 ----HLRLWRLQG--RYG------SLYGLWMGSHYVVVVNSYQHAREVL-LKKGKAFAG----------- 100 124 ----HVLFQKLQQ--KYG------HTYSLMMGPHTVILVNHHQHAKEVL-LKKGKIFAG----------- 101 125 ----HLLFQKLQK--TYG------NLFSLMMGPHYAVVINNHQHAKEVL-LKKGKIFAG----------- 100 126 ----PIHLLSLTQ--KLG------PVYRLRLGLQEVVVLNSKRTIEEAM-IRKWVDFAG----------- 91 127 ----PIHLLSLTQ--KLG------PVYRLRLGLQEVVVLNSKRTIEEAM-IRKWVDFAG----------- 92 128 ----PIYLLGLTQ--KLG------PIYRLRLGLQDVVVLNSKRTIEEAL-VRKWVDFAG----------- 91 129 ----PIYLLGLTQ--KFG------PIYRLHLGLQDVVVLNSKRTIEEAM-VKKWADFAG----------- 90 130 ----PIYLLGLTQ--KLG------PIYRIHLGMQDVVVLNSNRTIEEAL-IQKWVDFAG----------- 91 131 ----HRSLRSLAN--ELG------PLILLHLGHIPTLIVSTAEIAEEIL-KTHDLIFAS----------- 97 132 ----HRSLHKLSQ--KYG------PVMLLHFGSKPVIVASSVDAARDIM-KTHDVVWAS----------- 103 133 ----HRSLHKLSK--KYG------PVMLLHLGSKPVIVASSVEAVRDIM-KTNDLVWSN----------- 91 134 ----HRSLRKLSQ--KYG------PVMLLHLGSKPVIVASSVDAARDIL-KTHDHVWAT----------- 102 135 ---------------------------------------------------------------------- 0 136 ----HHNLRSMAR--KHG------PIMLLHLGSVRP--VSSRRRPRGNH-ENSRSRLR------------ 112 137 ----HRAMVELSK--TYG------PLMSLKLGSVTTVVATSVETVRDVL-KTYDLECCS----------- 96 138 ---------------------------------------------------------------------- 0 139 ---------------------------------------------------------------------- 0 140 ----YRSIHELSL--KYG------PVMQLQFGSFPVVVGSSVEMAKIFL-KSMDINFVG----------- 0 141 ----PQRFFAGWA--KYG------PILSYRIGSRTMVVISSAELAKELL-KTQDVNFAD----------- 96 142 KSGKPDAFIASFVR-RFG----RTGVYRSFMFSSPTVLVTTAEGCKQVL-MDDDAFVTG----------- 117 143 KTENPEPFIDERVA-RYG------SVFMTHLFGEPTIFSADPETNRFVL-QNEGKLFEC----------- 102 144 ----HVSFRDLHA--KYG----HNGLMLVQVGAVPTIVVSTPQAAEAVL-RTHDHVLAS----------- 124 145 ----HISIRDLDA--KHG----RNGLLLLRIGAVPTLFVSSPSAADAVL-RTQDHIFAS----------- 127 146 ----HISLQELVA--KYG----HNGFLFLRAGAVPTLIVSSPSAAEAVM-RTHDHICAS----------- 124 147 ----YVSLAALAT--RYG-----PDLMLLRLGAVPTVVVSSPRVAEAVL-RTYDHVFSS----------- 135 148 ----------------------------------------------------------G----------- 1 149 ---------------------------------------------------------------------- 0 150 ----YKKIACLKE--KYG------PILWLKIGSMNTMVIQTANSASELF-RNHDVSFSD----------- 58 151 ----YKKMAVLRQ--KYG------PVLWLKLGSTYTMVVQTAQASEELF-KNHDISFAN----------- 101 152 ---------------------------------------------------------------------- 0 153 ----HVALAKMAK--KYG------PIMYLKVGTCGMVVASTPNAAKAFL-KTLDINFSN----------- 102 154 ----HVSLAKMAK--KYG------AIMYLKVGTCGMAVASTPDAAKAFL-KTLDINFSN----------- 99 155 ----HVSLAKMAK--KYG------AIMYLKVGTCGMVVASTPDAAKAFL-KTLDLNFSN----------- 99 156 ---------------------------------------------------------------------- 0 157 ----RRDGPRRRP--RAK------ELMAFSVGDTPAVVSSCPATAREVL---AHPSFAD----------- 93 158 --------------------------MAFSVGLTRFIVSSHPKTAKEIL---SSPAFAD----------- 30 159 ----HRNLTDLAK--RFG------EILLLRMGQRNLVVVSSPELAKEVL-HTQGVEFGS----------- 100 160 ----HRNLTQLAK--RFG------DIFLLRMGQRNLVVVSSPDLAKEVL-HTQGVEFGS----------- 100 161 ----HRNLTDYAK--RFG------EIFLLRMGQRNLVVVSSPELAKEVL-HTQCVEFGS----------- 100 162 ----HRNLSDYAK--KFG------EIFLLRMGQRNLVVVSSPELAKEVL-HTQCVEFGS----------- 100 163 ---------------------------------------------------------------------- 0 164 ----HRNLTDLAK--RFA------EILLLRMEQRNLVVISSPELAKEVL-HTQGVEFGS----------- 98 165 ---FFEYIRDLKP--KYG------SIFTLKMGSRTMIIVASAELAHEAL-IQKGQIFAS----------- 96 166 ---FFQIMRELRQ--KYG------PIFTLRMGTRTMIILSNADLVHEAL-ILKGQVFAT----------- 112 167 ---AFRWIHQMMR--EMG-----TDIACVKLGGVHVVSITCPEIAREVL-RKQDANFIS----------- 137 168 SPPFLDYMSNIAQ--KYG------PLIHLKFGLHSSIFASTKEAAMEVL-QTNDKVLSG----------- 99 169 ----HKTLGALVD--KYG------PIFTIKLGATNALVLSNWELAKECF-TKNDIVVSS----------- 103 170 ---------------------------------------------------------------------- 0 171 ---------------------------------------------------------------------- 0 172 ----PRNSRNLSE--KYG------PIVFLRYGFVPVVVISSKEAAEEVL-KTHDLECCS----------- 94 173 ---IHQSFKNISS--KYG------PLLHLRFFNFPIVLVSSASTAYEIF-KAQDVNVSS----------- 83 174 ---------------------------------------------------------------------- 0 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 ---------------------------------------------------------------------- 0 180 ---------------------------------------------------------------------- 0 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 -----RIV-FPLTAKINK-------GYGIVFS--NGKRWKETRRFSLMTLRNFGMGK---------RSIE 142 2 -----RSR-FLVTAKLNK-------GFGVIFS--NGKRWTETRRFSLMTLRNFGMGK---------RSIE 142 3 -----RNL-SPINKKVNK-------GLGVIFS--NGKRWKEIRRFSLMTLRNFGMGK---------RSIE 142 4 -----RGS-FPIVERMN--------GLGLIFS--NGTKWKELRRFSLMTLRNFGMGK---------RSIE 141 5 ---------------------------------------------------------------------- 0 6 ---------------------------------------------------------------------- 0 7 ---------------------------------------------------------------------- 0 8 ---------------------------------------------------------------------- 0 9 ---------------------------------------------------------------------- 0 10 -----RGH-FPIAEKVNK-------GLGIVFT--NANTWKEMRRFSLMTLRNFGMGK---------RSIE 142 11 -----TGS-VPILEKVSK-------GLGIAFS--NAKTWKEMRRFSLMTLRNFGMGK---------RSIE 142 12 -----RGS-FPMLDKVSK-------GLGIVFT--NGKRWKEIRRFSLMTLRNFGMGK---------RSIE 142 13 --------------------------LGILFS--NANTWKEMRRFSLMTLRNFGMGK---------RSIE 33 14 -----RGI-FPLAERANR-------GFGIVFS--NGKKWKEIRRFSLMTLRNFGMGK---------RSIE 142 15 ---------------------------------------------------------------------- 0 16 -----RVT-VPVFDRYAQ-------GAGLFAS--QGELWKETRRFTLTVLRNMGMGK---------KTIE 142 17 -----RGH-FPLAERANR-------GFGIVFS--NGKRWKEIRRFSLMTLRNFGMGK---------RSIE 142 18 -----RGS-FPVAEKVNK-------GLGILFS--NGKRWKEIRRFCLMTLRNFGMGK---------RSIE 142 19 -----RGN-SPISQRITK-------GLGIISS--NGKRWKEIRRFSLTTLRNFGMGK---------RSIE 142 20 -----RGI-LPISERITN-------GLGIISS--NGKRWKETRRFSLTTLRNFGMGK---------RSIE 142 21 -----RGS-FPVSERVNK-------GLGVIFS--NGMQWKEIRRFSIMTLRTFGMGK---------RTIE 142 22 -----RGS-YPMIENVTK-------GFGIVFS--NGNRWKEMRRFTIMNFRNLGIGK---------RNIE 142 23 -----RGS-FPMAEKIIK-------GFGVVFS--NGNRWKEMRRFTLMTLRNLGMGK---------RNIE 142 24 -----RGS-FPVAEKINK-------DLGIVFS--HGNRWKEIRRFTLTTLRNLGMGK---------RNIE 142 25 -----RGR-LPICEKVAK-------GQGIAFS--HGNVWKATRHFTVKTLRNLGMGK---------GTIE 142 26 -----RGR-MPVFEKATK-------GLGISFS--RGNVWRATRHFTVNTLRSLGMGK---------RTIE 142 27 -----RGH-FPLLDWTIQ-------GLGIVFS--NGEKWKQTRRFSLTVLRNMGMGK---------KTVE 115 28 -----RGI-FPVFDRVTK-------GLGIVFS--SGEKWKETRRFSLTVLRNLGMGK---------KTIE 142 29 -----KMH-SSMLSKVSQ-------GLGIVFS--NGEIWKQTRRFSLMVLRSMGMGK---------RTIE 142 30 -----RGP-LPIIEDTHK-------GYGLIFS--NGERWKVMRRFSLMTLRNFGMGK---------RSLE 146 31 -----RGD-FPMAERINK-------GLGIVFS--NGNRWKEIRRFSLMTLRNLGMGK---------RNIE 142 32 -----RGS-FPVAERVNK-------GLGIVFS--NGSRWKETRRFSLMTLRNLGMGK---------RSIE 142 33 -----RGS-FPMAERYNK-------GLGIVFS--NGNRWKDIRRFSLMALRSLGMGK---------RSIE 142 34 -----RGN-FPIVERMNS-------GLGIIFS--NGTKWKELRRFSLMTLRNFGMGK---------RSIE 142 35 -----RGE-IPAF-REFK-------DKGIIFN--NGPTWKDTRRFSLTTLRDYGMGK---------QGNE 144 36 -----RGE-IPAL-REFK-------DKGIIFN--NGPTWKDTRRFSLTTLRDYGMGK---------QGNE 144 37 -----RGD-IPVF-QEYK-------NKGIIFN--NGPTWKDVRRFSLSILRDWGMGK---------QGNE 144 38 -----RGD-IPVF-QEYK-------NKGIIFN--NGPTWKDVRRFSLSILRDWGMGK---------QGNE 144 39 -----RGD-IPVF-QEYM-------NKGIIFN--NGPTWKDVRRFSLSILRDYGMGK---------QGNE 144 40 -----RGD-LPAF-HAHR-------DRGIIFN--NGPTWKDIRRFSLTTLRNYGMGK---------QGNE 144 41 -----RGD-IPAF-HAHR-------DRGIIFN--NGPTWKDIRRFSLTTLRNYGMGK---------QGNE 100 42 -----RGI-LPLIEKLFK-------GTGIVTS--NGETWRQLRRFALTTLRDFGMGK---------KGIE 145 43 -----RGN-LPLFEKVFK-------GTGIVTS--NGESWRQMRRFALTTLRDFGMGK---------KSIE 145 44 -----RGD-YPAFFNFTK-------GNGIAFS--SGDRWKVLRQFSIQILRNFGMGK---------RSIE 143 45 -----RGA-YPVFFNFTR-------GNGIAFS--DGERWKILRRFSVQILRNFGMGK---------RSIE 143 46 -----RGK-IAVVDPIFQ-------GYGVIFA--NGERWRALRRFSLATMRDFGMGK---------RSVE 143 47 -----RGK-IAVLDPIFQ-------GYGVTFA--NGERWRALRRFSLATMRDFGMGK---------RSVE 143 48 -----RGK-IAVVEPVFQ-------GYGVVFA--NGERWKTLRRFSLATMRDFGMGK---------RSVE 143 49 -----RGK-IAMVDPFFR-------GYGVIFA--NGNRWKVLRRFSVTTMRDFGMGK---------RSVE 143 50 -----RGK-IAITDPVFQ-------GYGVIFA--NGNRWKVLRRFSLTTMRDFGMGK---------RSVE 143 51 -----RGT-IAGLEPVFQ-------DYGIFFS--SGEQWKTLRRFSMATMRDFGMRK---------KSVE 143 52 -----RGT-IAVIEPIFK-------EYGVIFA--NGERWKALRRFSLATMRDFGMGK---------RSVE 143 53 -----RGT-IAVIEPIFK-------EYGVIFA--NGERWKALRRFSLATMRDFGMGK---------RSVE 143 54 -----RGT-VAVVEPTFK-------EYGVIFA--NGERWKTLRRFSLATMKEFGMGK---------RSVE 143 55 -----RGT-VAVLHPVVQ-------GYGVIFA--TGERWKTLRRFSLVTMKEFGMGK---------RSVD 144 56 -----RGT-VAVLHPVVQ-------GYGVIFA--NGERWKILRRFSLVTMRNFGMGK---------RSVE 144 57 -----RGT-IAAAQLVMQ-------DYGIFFA--SGQRWKTLRRFSLATMKEFGMGK---------RSVE 143 58 -----RGT-IAAAQLVMQ-------DYGIFFS--SGERWKTLRRFSLATMKEFGMGK---------RSVE 143 59 -----RGI-IAVLQPIMQ-------EYGVSFV--NEERWKILRRLFVATMRDFGIGK---------QSVE 143 60 -----RGE-MPTLEKNFQ-------GYGLALS--NGERWKILRRFSLTVLRNFGMGK---------RSIE 146 61 -----RGE-LASVERNFQ-------GHGVALA--NGERWRILRRFSLTILRDFGMGK---------RSIE 146 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 -----RGE-QATFDWVFK-------GYGVVFS--NGERAKQLRRFSIATLRDFGVGK---------RGIE 146 65 -----RGE-QATFDWVFK-------GYGVAFS--NGERAKQLLRFAIATLRDFGVGK---------RGIE 146 66 -----RGE-QATFDWLFK-------GYGIAFS--SGERAKQLRSFSIATLRDFGVGK---------RGIE 146 67 -----RGE-QATFDWLFK-------GYGVVFS--SGERAKQLRRFSIATLRDFGVGK---------RGIE 146 68 -----RGE-QATFDGLFK-------GYGVAFS--SGERAKQLRRFSIATLRDFGVGK---------RGIE 146 69 -----RGE-QAFFDWFFK-------GYGVVFS--SGERAKQLRRFSIATLRDFGFGK---------RGIE 146 70 -----RGE-QATYNTLFK-------GYGVAFS--SGERAKQLRRLSIATLRDFGVGK---------RGVE 145 71 -----RGE-QATFNTLFK-------GYGVAFS--NGERAKQLRRFSIATLRDFGMGK---------RGVE 145 72 -----RGE-LPTFNILFK-------GYGFSLS--NVEQAKRIRRFTIATLRDFGVGK---------RDVQ 145 73 ---------------------------------------------------------------------- 0 74 -----RGE-LATFDWLFK-------GYGVVFS--SWERARPLRRFAISTLRDFGVGK---------RGIE 146 75 -----RGE-QATFDWLFK-------GYGVAFS--TWERARPLRRFAISTLRDFGVGK---------RGIE 146 76 -----RGA-MPSFDQYFQ-------GYGVVFT--NGEEWKQLRRFSLTTLRNFGMGK---------RGIE 146 77 -----VAH-SPVLKEFSR-------GVGLIRC--NGEHWQVMRRFALQTFRNMGFGK---------EPME 83 78 -----RDI-TPVFYDFNQ-------GHGILFA--NGDSWKEMRRFALTNLRDFGMGK---------KGSE 154 79 -----RAN-YPVIMTVSK-------GYGVLVS--SGKRSKDLRRFSLMTLKTFGMGR---------RSIE 149 80 -----RPV-PPIRERSFK-------KNGLIMS--SGQLWKEQRRFALMTLRNFGLGK---------KSLE 156 81 -----RPP-VPIFKCLGVKPR----SQGVILAS-YGPEWREQRRFSVSTLRTFGMGK---------KSLE 153 82 -----RPP-VPIFKCLGVKPR----SQGVVFAS-YGPEWREQRRFSVSTLRTFGMGK---------KSLE 153 83 -----RPP-VPIFEYLGVKPG----SQGVVLAP-YGPEWREQRRFSVSTLRNFGLGK---------KSLE 153 84 -----RPQ-VPIFEYLGVKPG----SQGVVLAP-YGPEWREQRRFSVSTLRNFGLGK---------KSLE 153 85 -----RPP-VPIFEYLGVKPG----SQGVVLAP-YGPEWREQRRFSVSTLRNFGLGK---------KSLE 153 86 -----RPE-MPIFQHIGYGHK----AKGVVLCT-YGPEWREQRRFSVSTLRNFGVGK---------KSLE 153 87 -----RPL-LPIYNHLGYGNK----SKGVVLAP-YGPEWREQRRFSVSTLRDFGVGK---------KSLE 153 88 -----RPP-LHFNDQSGFGPR----SQGVVLAR-YGPAWRQQRRFSVSTFRHFGLGK---------KSLE 153 89 -----RPP-VPITQILGFGPR----SQGVFLAR-YGPAWREQRRFSVSTLRNLGLGK---------KSLE 150 90 -----RPP-PAVYEHLGYGPR----AEGVILAR-YGDAWAEQRRFSLTTLRNFGLGK---------KSLE 153 91 -----RPP-MPIYDHLGLGPE----SQGLFLAR-YGRAWREQRRFSLSTLRNFGLGR---------KSLE 153 92 -----RPD-LYSFKFIND-------GKSLAFSTDKAGVWRARRKLAMSALRSFATLEGTTPEYS--CALE 165 93 -----RPD-LYSFKFIND-------GKSLAFSTDKAGVWRARRKLAMSALRSFATLEGTTPEYS--CALE 165 94 -----RPD-LYSFRFIND-------GKSLAFSTDQAGVWRARRKLAYSALRSFATLEGTTPEYS--CALE 165 95 -----RPD-LYTFQFISD-------GKSLAFSTDKVGVWRARRKLAYSALRSFSSLESTNQEYS--CMLE 165 96 -----RPD-LYSFRFINA-------GKSLAFSTDQAGVWRARRKLAYSALRSFSTLEGTTPEYS--CVLE 165 97 -----PPD-LYSFQFIND-------GKSLAFSTDQAGVWSPPKAGHECPALLFHARGHHAAVLL--HVGG 163 98 -----RPD-LYSFTFIND-------GKSLAFSTDQAGVCGACRKLAYSALRSFSTLDGTTPEYS--CMLE 165 99 -----RPD-LYSFTLIAN-------GQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASS--CYLE 164 100 -----RPD-LYSFTLITN-------GKSMTFNPDSGPVWAARRRLAQNALKSFSIASDPTSASS--CYLE 164 101 -----RPD-FYSFTLITN-------GKSMTFNPDCGPVWAARRRLAQDALKSFSIALDPASASS--CYLE 164 102 -----RPD-LYSFTFISD-------GQSMTFNPDSGPVWAARRRLAQSALKSFSVASDPASVSS--CYLE 156 103 -----RPD-LYSFSLVTD-------GQSLTFSPDSGPVWAARRRLAQNALKSFSIASDPASSCS--CYLE 164 104 -----RPD-LYTFTLISN-------GQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS--CYLE 160 105 -----RPN-LYSFTLISN-------GQSMSFGPDSGPVWAARRRLAQNGLKSFSIASDPASSSS--CYLE 160 106 -----RPD-LYSFSFVTK-------GQSMIFGSDSGPVWAARRRLAQNALNSFSVASDPASSSS--CYLE 164 107 -----RPD-LYSFTLITN-------GKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSVSS--CYLE 161 108 -----RPD-LYSFTLITN-------GKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASS--CYLE 161 109 -----RPD-LYSFTLITN-------GKSMTFNPDCGPVWAARRRLAQDALKSFSIASDPTSASS--CYLE 161 110 -----RPD-LYSLSLITD-------SQSMSFSPDSGPVWAAGRRLAQNALNTFSIASDPASSCS--CYLE 148 111 -----RPD-LYTSTLITD-------GQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS--CYLE 162 112 -----RPD-LYSSTFISD-------GQSMIFNPDSGPVWAARRRLAQSALQSFSLASDPASVSS--CYLE 162 113 -----RPD-LYSSSFITE-------GQSMTFSPDSGPVWAARRRLAQDSLKSFSIASNPASSSS--CYLE 162 114 ---------------------------------------------------------------------- 0 115 -----RPP-FASFRVVSG-------GRSLAFG-HYSEHWKTQRRSAYSTMRAFSTRHPRSR-----GLLE 167 116 -----RPP-FASFRVVSG-------GRSLAFG-HYSERWKERRRAAYGTMRAFSTRHPRSR-----GLLE 167 117 -----RPA-FASFRVVSG-------GRSMAFG-HYSEHWKVQRRAAHSMMRNFFTRQPRSR-----QVLE 167 118 -----RPK-VATLDILSDN------QKGIAFA-DHGAHWQLHRKLALNAFALFKDGN---------LKLE 143 119 -----RPR-VMTLDILSDN------QKGIAFA-DHGTSWQLHRKLALSTFSLFKGGN---------LKLE 143 120 -----RPQ-MATLDIASNN------RKGIAFA-DSGAHWQLHRRLAMATFALFKDGD---------QKLE 143 121 -----RPQ-MVTLGLLSDQ------GKGVAFA-DSSSSWQLHRKLVFSTFSLFRD-D---------QKLE 142 122 -----RPQ-MVTQSLLSDQ------GKGVAFA-DAGSSWHLHRKLVFSTFSLFKDG----------QKLE 142 123 -----RPR-TVTTDLLSRG------GKDIAFA-SYGPLWKFQRKLVHAALSMFGEGS---------VALE 148 124 -----RPR-TVTTDLLTRD------GKDIAFA-DYGATWRFHRKTVHGALCMFGEGS---------ASIE 149 125 -----RPS-MVTTDLLSRG------GKDIAFG-KYGPAWKFHRKLVLSALHLFGDGS---------AGIE 148 126 -----RPQ-IPSYKLVSQR------CQDISLG-DYSLLWKAHKKLTRSALLLGTRSS-----------ME 137 127 -----RPQ-IPSYKLVSQR------CQDISLG-DYSLLWKAHKKLTRSALLLGTRSS-----------ME 138 128 -----RPQ-IPSYKLASQH------CPDISLG-DYSLFWKAHKKLTRSALLLGVRSS-----------ME 137 129 -----RPE-PLTYKLVSKN------YPDLSLG-DYSLLWKAHKKLTRSALLLGIRDS-----------ME 136 130 -----RPH-MLNGKMD----------LDLSLG-DYSLMWKAHKKLSRSALMLGMRDS-----------ME 133 131 -----RPS-TTAARRIFYD------CTDVAFS-PYGEYWRQVRKICVLELLSIKRVN---------SYRS 145 132 -----RPK-SSIVDRLSYG------SKDVGFS-PFGEYWRRAKSITVLHLLSNTRVQ---------SYRN 151 133 -----RPK-SKMADRLIYG------SKDVSFS-PHGEYWRQIRSITVLHLLSNKRVQ---------SYRA 139 134 -----RPK-YSIADSLLYG------SKDVGFS-PFGEYWWQVRSIVVLHLLSNKRVQ---------SYRD 150 135 ---------------------------------------------------------------------- 0 136 -----RPR-GSRSAALQLQ-------GRVG---GYGEYWRQLKTICVVQLLSNKRVQ---------SFRS 157 137 -----RPY-MTYPARITYN------LKDLVFS-PYDKYWRQVRKLTVVELYTAKRVQ---------SFRH 144 138 ---------------------------------------------------------------------- 0 139 ---------------------------------------------------------------------- 0 140 -----RPK-TAAGKYTTYN------YSDITWS-PYGPYWRQARRMCLTELFSTKCLD---------SYEY 0 141 -----RPP-HRGHEFISYG------RRDMALN-HYTPYYREIRKMGMNHLFSPTRVA---------TFKH 144 142 -----WPK-ATVALVGPRS---------FVAM-PYD-EHRRIRKLTAAPINGFDALT---------GYLP 161 143 -----SYP-ASICNLLGKH---------SLLL-MKGSLHKRMHSLTMSFANSSIIKD---------HLML 147 144 -----RPR-NPVADIIRYN------STDVAFA-PYGVYWRTARKVVNTHLLSAKMVF---------SKRR 172 145 -----RPP-WMAAEIIRYG------PSDVAFV-PYGEYGRQGRKLLTTHMLSTKKVQ---------SFRH 175 146 -----RPW-SMASHILRYN------TCDVAFS-PLGEYWQQTRKLMNTHLLSNKKVY---------SFRH 172 147 -----RPR-SLVSDIIMYG------ATDSCFA-PYGDHFRKARKLVTVHLLNASKVR---------SQRP 183 148 ----------------------------------YGEHWRQARKLVTAHLFTVKRVH---------SYRR 28 149 ---------------------------------------------------------------------- 0 150 -----RPI-VDVNLAHNYY------KGSMALA-PYGNYWRFSRRICTVEMFVHKRIN---------ETTN 106 151 -----RVI-PDVNQAHSYY------QGSLAIA-PYGPFWRFQRRICTIEMFVHKKIS---------ETEP 149 152 ---------------------------------------------------------------------- 0 153 -----RPP-NAGATHMAYN------AQDMVFA-PYGPRWKLLRKLSNLHMLGGKALE---------NWAN 150 154 -----RPP-NAGATHLAYN------AQDMVFA-HYGPRWKLLRKLSNLHMLGGKALE---------NWAN 147 155 -----RPP-NAGATHLAYG------AQDMVFA-HYGPRWKLLRKLSNLHMLGGKALE---------NWAN 147 156 --------------------------------------WLFQRKTAALEFTTRTLRQ---------AMGR 23 157 -----RPV-KRSARELMF-------ARAIGFA-PNGEYWRRLRRVASTHLFSPRRVA---------SHEP 140 158 -----RPI-KESAYELLF-------NRAMGFA-PFGDYWRNLRRISSTYLFSPRRVS---------SFEK 77 159 -----RTR-NVVFDIFTCK------CQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 160 -----RTR-NVVFDIFTGE------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRH 148 161 -----RTR-NVVFDIFTGK------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 162 -----RTR-NVVFDIFTGK------GQDMVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRY 148 163 ---------------------------------------------------------------------- 0 164 -----RTR-NVVFDIFTGK------GQDIVFT-VYGEHWRKMRRIMTVPFFTNKVVQ---------QYRF 146 165 -----RPR-ENPTRTIFSC------NKFSVNAAVYGPVWRSLRRNMVQNMLSPSRLK---------EFRE 145 166 -----RPR-ENPTRTVFSC------DKFTVNAAVYGPVWRSLRKNMVQNGLSSIRLK---------EFRA 161 167 -----RPL-TFASETFSGG------YRNAVLS-PYGDQWKKMRRVLTSEIICCPSRH---------AWLH 185 168 -----RQP-LPCFRIKPHI------DYSILWS-DSNSYWKKGRKILHTEIFSQKMLQ---------AQEK 147 169 -----RPK-PVAVELMSYN------QAFIGWA-PYGEYWRQLRKIVTLEILSNRRIE---------LLSH 151 170 ---------------------------------------------------------------------- 0 171 ---------------------------------------------------------------------- 0 172 -----RPE-TVGTRAISYN------FK-SGFA-PCG---------------------------------- 116 173 -----RPP-PPIEESLILG------SSSFINT-PYGDYSKFMKEFMGQKLLGPQ-LQ---------RSRN 130 174 --------------------------------------WKARRKFALREVF-LKK-Q---------SFRH 21 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 ---------------------------------------------------------------------- 0 180 --------------------------------------WRLLRKLSATQLFSPQRIE---------ATKT 23 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 DRVQEEARCLVEELRKTNGSPCN---------PTFILGAAPCNVICSVIF-------QNRF--DYTDQDF 194 2 ERVQEEAHCLVEELRKTNASPCD---------PTFILGAAPCNVICSVIF-------QNRF--DYTDQDF 194 3 DRVQEEARCLVEELRKTNGSPCD---------PTFILGAAPCNVICSVIF-------QNRF--DYKDETF 194 4 DRIQEEASCLVEELRKTNGSLCD---------PTFILSCAPSNVICSVVF-------HNRF--DYKDENF 193 5 ----------------------------------------------SIIF-------HNRF--DYTDPNF 15 6 ----------------------------------------------SILF-------NDRF--HYDNETF 15 7 ----------------------------------------------SIIF-------HNRF--DYTDPNF 15 8 ----------------------------------------------SIIF-------HNRF--DYTDPNF 15 9 ----------------------------------------------SIIL-------HNRF--DYTDPNF 15 10 DRVQEEARCLVEELRKTNALPCD---------PTFILGCAPCNVICSVIL-------HNRF--DYKDEEF 194 11 DRIQEEARCLVEELRKTNASPCD---------PTFILGCAPCNVICSVIF-------HNRF--DYKDEEF 194 12 DRVQEEARCLVEELRKTNASPCD---------PTFILGCAPCNVICSIIF-------HNRF--DYKDEEF 194 13 DRVQEEARCLVEELRKTNASPCD---------PTFILGCAPCNVICSIIF-------HNRF--DYKDEHF 85 14 DRVQEEARCLVEELRKTKASPCD---------PTFILGCAPCNVICSIIF-------HKRF--DYKDQQF 194 15 ---------------------------------------------------------------------- 0 16 DRIQEEASCLVKALKETNASPCD---------PSSLLFCVPCNVICSIIF-------QNRF--EYNDQTF 194 17 DRVQEEARCLVEELRKTKASTCD---------PTFILGCAPCNVICSIIF-------QKRF--DYKDQQF 194 18 DRVQEEARCLVEELRKTNASPCD---------PTFILGCAPCNVICSVIF-------HDRF--DYKDQRF 194 19 DRVQEEAHCLVEELRKTKASPCD---------PTFILGCAPCNVICSVVF-------QKRF--DYKDQNF 194 20 DRVQEEARCLVEELRKTKASPCD---------PTFILGCAPCNVICSVVF-------QKRF--DYKDENF 194 21 DRIQEEAQCLVEELRKSKGAPFD---------PTFILGCAPCNVICSIIF-------QNRF--DYKDPTF 194 22 DRVQEEAQCLVEELRKTKGSPCD---------PSLILNCAPCNVICSITF-------QNHF--DYKDKEM 194 23 DRVQEEAQCLVEELRKTLGSPCD---------PTFILSCAPCNVICSIIF-------QNRF--DYLDLEF 194 24 DRVQEEARCLVEELRKTNGSPCD---------PTFILGCAPCNVICSIIF-------QNRF--DYKDQDF 194 25 DKVQEEAKWLVKELKKTNGSPCD---------PQFIMGCAPGNVICSIIL-------QNRF--DYEDKDF 194 26 IKVQEEAEWLVMELKKTKGSPCD---------PKFIIGCAPCNVICSIIF-------QNRF--DYKDKDF 194 27 DRIQEEALYLVEALKKTNASPCD---------PTFLLGCAPCNVICSIIF-------QNRF--EYDDKDF 167 28 ERIQEEALCLIQALRKTNASPCD---------PTFLLFCVPCNVICSVIF-------QNRF--DYDDEKF 194 29 NRIQEEVVYLLEALRKTNGSPCD---------PSFLLACVPCNVISSVIF-------QHRF--DYSDEKF 194 30 ERVQEEAWCLVEELQKTKAQPFD---------PTFILACAPCNVICSILF-------NDRF--QYNDKTF 198 31 DRVQEEAQCLVEELRKTNGSPCD---------PTFILSCAPCNVICSIIF-------QNRF--DYKDQDF 194 32 DRVQEEAQCLVEELRKTNGSPCD---------PTFILGCAPCNVICSIIF-------QNRF--DYKDKDF 194 33 DRVQEEAQCLVEELRKTNGSPCD---------PTFILSCAPCNVICSIIF-------QNRF--DYTDQDF 194 34 DCIQEEARCLVEELRKTNGSPCD---------PTFFLSCAPSNVICSVVF-------HNRF--DYNDKNF 194 35 DRIQKEAHFLLEELRKTQGQPFD---------PTFVIGCTPFNVIAKILF-------NDRF--DYKDKQA 196 36 DRIQQEAHFLLEELRKTQGQPFD---------PTFVIGCTPFNVIAKILF-------NDRF--DYKDKQA 196 37 ARIQREAQFLVEELKKTKGQPFD---------PTFLIGCAPCNVIADILF-------NKRF--DYNDKKC 196 38 ARIQREAHFLVEELKKTKGQPFD---------PTFLIGCAPCNVIADILF-------NKRF--DYDDKKC 196 39 ARIQREAHFLMEELKKTNGQPFD---------PTFLVGCAPFNVISDILF-------HKRF--DYNDKTC 196 40 SRIQREAHFLLEALRKTQGQPFD---------PTFLIGCAPCNVIADILF-------RKHF--DYNDEKF 196 41 SRIQREAHFLLEALRKTQGQPFD---------PTFLIGCAPCNVIADILF-------RKRF--DYNDEKF 152 42 ERIQEEAHFLVERIRKTHEEPFN---------PGKFLIHAVANIICSIVF-------GDRF--DYEDKKF 197 43 ERIQEEARFLVERIRNTHEKPFN---------PTVFLMHAVSNIICSTVF-------GDRF--DYEDKKF 197 44 ERILEEGSFLLADVRKTEGEPFD---------PTFVLSRSVSNIICSVLF-------GSRF--DYDDERL 195 45 ERILEEGSFLLEVLRKMEGKPFD---------PVFILSRSVSNIICSVVF-------GSRF--DYDDERL 195 46 ERIQEEARCLVEELRKSKGALLD---------NTLLFHSITSNIICSIVF-------GKRF--DYKDPVF 195 47 ERIQEEARCLVEELRKSKGALLD---------NTLLFHSVTSNIICSIVF-------GKRF--DYRDPVF 195 48 ERIQEEAQCLVEELRKTEGVLQD---------PTFTFHSMTANIICSIVF-------GKRF--GYKDPEF 195 49 ERIQEEAQCLIEELRKSKGALMD---------PTFLFQSITANIICSIVF-------GKRF--HYQDQEF 195 50 ERIQEEAQCLIEELRKSKGALVD---------PTFLFHSITANIICSIVF-------GKRF--HYQDQEF 195 51 ERIKEESQCLVEELKKYQGAPLD---------PTFLFQCITSNIICSIVF-------GECF--DYTDHQF 195 52 ERIQEEAQCLVEELRKSQGAPLD---------PTFLFQCITANIICSIVF-------GERF--DYTDRQF 195 53 ERIQEEAQCLVEELRKSQGAPLD---------PTFLFQCITANIICSIVF-------GERF--DYTDRQF 195 54 ERIKEEAQCLVEELRKSQGAPLD---------PTFLFGCITANVICSIVF-------GERF--EYTDRQF 195 55 ERIKEEAQCLVEELKKYKGAPLN---------PTFLFQSIAANTICSIVF-------GERF--DYKDHQF 196 56 ERIKEEAQCLVEELKKYKGALLN---------PTSIFQSLAANIICSIVF-------GERF--DYKDHQF 196 57 ERIKEEAQCLVEELKKYQGVPLD---------PTFLFQCITANIICSIVF-------GERF--DYTDDQF 195 58 ERIKEEAQCLVEELKKYQGAPLD---------PTFFFQCVTANIICSIVF-------GERF--DYTDEQF 195 59 DQIKEEAKCLVEELKNHQVGSLD---------PTFLFQCVTGNIICSIVF-------GERF--DYRDRQF 195 60 ERIQEEAGYLLEELHKVKGAPID---------PTFYLSRTVSNVICSVVF-------GKRF--DYEDQRF 198 61 ERIQEEAGYLLEEFRKTKGAPID---------PTFFLSRTVSNVISSVVF-------GSRF--DYEDKQF 198 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ERIQEEAGFLIDALRGTGGANID---------PTFFLSRTVSNVISSIVF-------GDRF--DYKDKEF 198 65 ERIQEESGFLIEAIRSSHGANID---------PTFFLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 66 ERIQEEAGFLIDSFRKTNGAFID---------PTFYLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 67 ERIQEEAGFLIDSFRKTNGAFID---------PTFYLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 68 ERIQEEAGFLIESFRKTNGALID---------PTFYLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 69 ERTIEETSFLIQALRDTNGATID---------PTFYMSRTVSNVISSIVF-------GNRF--EYDDKEF 198 70 ERILEEAGYLIKMLQGTCGAPID---------PTIYLSKTVSNVISSIVF-------GERF--DYEDTEF 197 71 EHIQEEAGCLIKMLQGTCGAPID---------PTIYLSKTASNVISSIVF-------GDRF--NYEDKEF 197 72 ECILEEAGYLIKTLQGTCGAPID---------PSIYLSKTVSNVINSIVF-------GNRF--DYEDKEF 197 73 ---------------------------------------------------------------------- 0 74 ERIQEEAGFLIEAFRDTRGAFID---------PTFFLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 75 ERIQEEAGFLIEAFRDTRGAFID---------PTFFLSRTVSNVISSIVF-------GDRF--DYEDKEF 198 76 ERIQEEAQFVVEEIKSYKKKPFD---------PTDILVQCVSNVICSVVF-------GNRF--EYDNKDF 198 77 IKIMEELDARCA---------------------------TVGSIINSMLV-------GNRFE-DHNKQEF 118 78 EKILEEIPYLIEVFEKHEGKAFD---------TTQSVLYAVSNIISAIVY-------GSRF--EYTDPLF 206 79 ERVQEEAKMLVKAFGEYRDSVVN---------PKELLCNCVGNVICSIVF-------GHRF--ENDDPMF 201 80 ERIQEEARHLTEAMEKEGGQPFD---------AHFKINNAVSNIICSITF-------GERF--EYHDGQF 208 81 EWVTKEAGHLCDAFTAQAGQSIN---------PKAMLNKALCNVIASLIF-------ARRF--EYEDPYL 205 82 EWVTKEAGHLCDAFTAQNGRSIN---------PKAMLNKALCNVIASLIF-------ARRF--EYEDPYL 205 83 DWVTKEANHLCDAFTAQAGQPIN---------PNPMLNKSTCNVIASLIF-------ARRF--EYEDPFL 205 84 DWVTKEARHLCDAFTAQAGQPIN---------PNTMLNNAVCNVIASLIF-------ARRF--EYEDPYL 205 85 EWVTKEARHLCDAFTAQAGQPIN---------PNPMLNKSTCNVIASLIF-------ARRF--EYEDPFL 205 86 QWVTDEASHLCDALTAEAGRPLD---------PYTLLNKAVCNVIASLIY-------ARRF--DYGDPDF 205 87 QWVTEEAGHLCDTFAKEAEHPFN---------PSILLSKAVSNVIASLVY-------ARRF--EYEDPFF 205 88 QWVTEEARCLCAAFADHSGFPFS---------PNTLLDKAVCNVIASLLF-------ACRF--EYNDPRF 205 89 QWVTEEAACLCAAFANHSGRPFR---------PNGLLDKAVSNVIASLTC-------GRRF--EYDDPRF 202 90 QWVTEEASCSCAAFADQAGRPFS---------PMDLLNKAVSNVIASLTF-------GCRF--EYNDPRI 205 91 QWVTEEASCLCAAFAEQAGRPFG---------PGALLNKAVSNVISSLTY-------GRRF--EYDDPRL 205 92 EHVCKEGEYLVKQLTSVMDVSGSFD-------PFRHIVVSVANVICGMCF-------GRRY--SHDDQEL 219 93 EHVCKEGEYLVKQLTSVMDVSGSFD-------PFRHIVVSVANVICGMCF-------GRRY--SHDDQEL 219 94 EHVSKEAEYLVKQLHTVMEADGSFD-------PFRHIVVSVANVICGMCF-------GRRY--DHNHQEL 219 95 EHICKEGEYLVKQLNTSMKANGSFD-------PFRNIVVSVANVICGMCF-------GRRY--DHYDQEL 219 96 EHICKEGEYLIKQLNTVMKADGSFD-------PFRHIVVSVANVICGMCF-------GRRY--DHDDQEL 219 97 -ACLQGGRLPRQAAVQRHGTDASFD-------PFRHIVVSVANVICGMCF-------GRRY--GHEDQEL 216 98 EHICKEGECLINQLNTVMKADGSFD-------PFRHIVVSVANVICGMCF-------GRRY--DHNDQDL 219 99 EHVSKEAEYLISKFQKLMAEVGHFD-------PFKYLVVSVANVICAICF-------GRRY--DHDDQEL 218 100 EHVSKEANYLVSKLQKVMAEVGHFD-------PYKYLVVSVANVICAICF-------GQRY--DHDDQEL 218 101 EYVIKEADYLISKFQKLMAEVGHFD-------PDRYLVVSVTNVICAMCF-------GQRY--DHDDQEL 218 102 EHVKKEAEYLIKKFQELMAGPGHFD-------PYRYVVVSVANVISAICF-------GQRY--SHDDQQL 210 103 EHVSKEAEVLLSRLQEQMAEVGRFD-------PYRYIVVSVANVICAMCF-------SKRY--DHDDQEL 218 104 EHVSKEAEVLISTLQELMAGPGHFN-------PYRYVVVSVTNVICAICF-------GRRY--DHNHQEL 214 105 EHVSKEAEVLISKLQEQMAGPGHFN-------PYRYVVISVANVICAICF-------GQRY--DHNHQEL 214 106 EHVSQEAENLISKFQELMAAVGHFD-------PYRYVVMSVANVICAMCF-------GRRY--DHDDQEL 218 107 EHVSKEANHLISKFQKLMAEVGHFE-------PVNQVVESVANVIGAMCF-------GKNF--PRKSEEM 215 108 EHVSKEANHLVSKLQKAMAEVGHFE-------PVSQVVESVANVIGAMCF-------GKNF--PRKSEEM 215 109 DHVIKEANHLVSKLQKLTAEVGHFE-------PVNQVVESVANVIGAMCF-------GKNF--PRKSEEM 215 110 EHVSKEAEALLSRLQEQMAEVGRFD-------PYNQVLLSVANVIGAMCF-------GHHF--SQRSEEM 202 111 EHVSKEAKALISRLQELMAGPGHFD-------PYNQVVVSVANVIGAMCF-------GQHF--PESSDEM 216 112 EHVSREAEHLVTKLLDLMAGPGCFE-------PSSQIVGSVANVIGAMCF-------GKNF--PQTSEEM 216 113 EHVSQEAENLIGRFQELMAAVGRFD-------PYSQLVVSAARVIGAMCF-------GRRF--PQGSEEM 216 114 ---------------------------------------------------------------------- 0 115 GHALAEARELVAVLVRRCAGGAFLD-------PTQPVIVAVANVMSAVCF-------GCRY--NHDDAEF 221 116 GHALGEARELVAVLVRRCAGGACLD-------PTQPIIVAVANVMSAVCF-------GCRY--NHDDAEF 221 117 GHVLSEARELVALLVRGSADGAFLD-------PRPLTVVAVANVMSAVCF-------GCRY--SHDDPEF 221 118 KIINQEANVLCDFLATQHGEAID---------LSEPLSLAVTNIISFICF-------NFSF--KNEDPAL 195 119 NIINQEIKVLCDFLATRNGESID---------LAQPLSLAMTNIVSFLCF-------NFSF--KKGDPAL 195 120 KIICQEISTLCDMLATHNGQSID---------ISFPVFVAVTNVISLICF-------NTSY--KNGDPEL 195 121 KMICQEANSLCDLILTYDGESRD---------LSTLIFKSVINIICTICF-------NISF--ENKDPIL 194 122 KLICQEAKSLCDMMLAHDKESID---------LSTPIFMSVTNIICAICF-------NISY--EKNDPKL 194 123 KIICREAASLCETLGAAQDMALD---------MAPELTRAVTNVVCSLCF-------NSSY--RRGDPEF 200 124 KIICREALSLCDTLRESGSASLD---------LSPELTRAVTNVVCSLCF-------SSSY--CRGDPEF 201 125 KMICQEATSMCSTFERLNNAAHD---------MMPDVTRAVTNVICLLCF-------NSTY--EKEDPEF 200 126 PWVDQLTQEFCERMRVQAGAPVT---------IQKEFSLLTCSIICYLTF-------GNK-----EDTLV 186 127 PWVEQLTQEFCERMRVQAGAPVT---------IQKEFSLLTCSIICYLTF-------GDK-----EDTLV 187 128 PRVCQLTQEFCERMRAQAGTPVT---------IQKEFSVLTCSIICCLTF-------GDK-----EDTLV 186 129 PVVEQLTQEFCERMRAQPGTPVA---------IEEEFSLLTCSIICYLTF-------GDKI---KDDNLM 187 130 PLIEQLTQEFCERMRAQAGTPVA---------IHKEFSPLTCSIISCLTF-------GDL-----NSTLV 182 131 IREEEVGLMMERISQS-CSTGEA-------VNLSELLLLLSSGTITRVAF-------GKKYEGEEERKNK 200 132 VRAEETANMIGKIRQG-CDSSV--IN------LGEHLCSLTNNIISRVAL-------GRTYDEKESGIEH 205 133 AREEETSNMIEKLKQM-SNSSSSATD------LRDLFCWLAYNIINRVAL-------GKKYNDE---IDA 192 134 VREEETANMIEKIRQG-CDASV--IN------LGEHLCFLTNNITSRVAL-------GRTYDERESGIDA 204 135 ---------------------------------------------------------------------- 0 136 VREEETELLMKKIGDS-SGN----------VNLSHMFTQLTNDVVCRSAI-------GRKYGAGDENGEK 209 137 IREEEVASFVRFNKQA-ASSEET-------VNLSQKILKMSGSVICRIGF-------GINL-EGSKLENT 198 138 ---------------------------------------------------------------------- 0 139 ---------------------------------------------------------------------- 0 140 IRAEELHSLLHNLNKI-SGKP---------IVLKDYLTTLSLNVISRMVL-------GKRYLDESENSFV 0 141 VREEEARRMMDKINKA-ADKSEV-------VDISELMLTFTNSVVCRQAF-------GKKYNEDGEEMKR 199 142 FIDRTVTSSLRAWADH-GGS----------VEFLTELRRMTFKIIVQIFL-------GGADQA-TTRALE 212 143 DIDRLVRFNLDSWSSR--------------VLLMEEAKKITFELTVKQLM-------SFDPGE-WSESLR 195 144 EREEEVRLVVARIRDA-AEASPG-TA----LDMTELLGGYASDFVCRAVL-------GESHRK-QGRNKL 228 145 GRQEEVRLVMDKIRAA-ATAAPA--A----VDLSDLLSGYTNDVVSRAVL-------GASHRN-QGRNRL 230 146 GREEEVCLVVDNLREA-AAKSPS-TA----VDMSEVLAAYTNDVVSRSVL-------GSTHRK-KGRNTL 228 147 AREEEVRGALDRVRRA-AAAREP-------VDMSELLHSFVNNLVCRAVS-------GKFSME-EGRNRL 237 148 ARKEEVRLVVAKVREA-AVAGTA-------TDMSLAMNTFANDIISRAVS-------GKFFRA-EGRNKL 82 149 ---------------------------------------------------------------------- 0 150 IRQESVDKMLRLDEEKASSSGGGGEGIE----VTRYMFLASFNMVGNMIF------SKDLTDPESKQGSE 166 151 VRRKCVDNMLKWIEKEANSAEK-GSGIE----VTRFVFLASFNMLGNLIL------SKDLADLESEEASE 208 152 ---------------------------------------------------------------------- 0 153 VRANELGHMLKSMFDA-SHVGER-IV------VADMLTFAMANMIGQVML------SKRVFVEKGKEVNE 206 154 VRANELGHMLKSMSDM-SREGQR-VV------VAEMLTFAMANMIGQVML------SKRVFVDKGVEVNE 203 155 VRANELGHMLKSMFDM-SREGER-VV------VAEMLTFAMANMIGQVIL------SKRVFVNKGVEVNE 203 156 WVNRGIKLRFCPILETAQNNYEP-VD------LQDLILRLTFDNICGLAF-------GK----------- 68 157 GRQGDAEAMLRSIAAE-QSASGA-VA------LRPHLQAAALNNIMGSVF-------GTRYDVTSGAGAA 195 158 QRSEIGEGMVRDMKRM-MERNGV-VE------VRRMLHYGSLNNIMLTVF-------GKKFD-FAKD--- 128 159 GWEAEAAAVVDDVKKNPAAATEG-IV------IRRRLQLMMYNNMFRIMF-------DRRF--ESEDDPL 202 160 GWEAEAAAVVDDVRKNPDAAVSG-LV------IRRRLQLMMYNNMYRIMF-------DRRF--ESEEDPL 202 161 GWESEAESVVNDVKNNAEASVGG-IV------IRKRLQLMMYNIMYRIMF-------DRRF--ESEEDPL 202 162 GWEEEAARVVEDVKKNPESATNG-IV------LRRRLQLMMYNNMYRIMF-------DRRF--ESEDDPL 202 163 ---------------------------------------------------------------------- 0 164 GWESEAASVVDDVKKNSKASVNG-IV------IRRRLQLMMYNIMYRIMF-------DRRF--ESEEDPL 200 165 FREIAMDKLIERIRVD-AKENND-VV------WALKNARFAVFYILVAMC------FGVEMDNEEMIERV 201 166 VRKSAMDKMIEKIRAE-ADANEG-VV------WVLKNARFAVFCILLAMC------FGVEM-DEKTIEKI 216 167 DKRTDEADNLTRYVYNLATKAAT-GD--VAVDVRHVARHYCGNVIRRLMF-------NRRY--FGEPQAD 243 168 NRERVAGNLVNFIMTK-VGDVVE---------LRSWLFGCALNVLGHVVF------SKDVFEYSDQSDEV 201 169 IRVSEVQTSIKELVNV-WSNQIS-SQ---YGLLDDTKSSSTNDEPSTTDY-------VVPELKKWFAQLT 209 170 ---------------------------------------------------------------------- 0 171 ---------------------------------------------------------------------- 0 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 IREEECNFLVKQLSES-AVNRSP-------VDLSKSLFWLTASIFFRVAL----GQNFHESNF-IDKEK- 77 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 ---------YKTLLDK-AMKKQT-VE------IRNEAMKLTNNTICKMIM-------GRSCSEENGEAET 46 180 LRENKVLELVSFMSES-SEREEA-VD------ISRATFITALNIIS------------------------ 61 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 LSLMGKLNENFK----------ILNSPWVQM-CNNFPILIDY----LPGSH------------------- 230 2 LSLMGKFNENFK----------ILNSPWVQF-CNCFPILFDY----FPGSH------------------- 230 3 LNLMGKFNENFR----------ILNSPWLQV-CNIFPILMDY----LPGTH------------------- 230 4 LNLMEKLNENFK----------ILNSPWMQV-CNALPAFIDY----LPGSH------------------- 229 5 LTLLEKLNENFR----------ILSSPWIQD-CNNFPALIDY----LPGSH------------------- 51 6 LSLMNLLNANFR----------QISSPWIQI-YNLWPQIIKH----LPGEH------------------- 51 7 LTLLEKFNENFK----------IMSTPWMQV-CSNFPALIDY----LPGSH------------------- 51 8 LTLLEKFNENFK----------IMSTPWMQV-CNTFPALIDY----LPGSH------------------- 51 9 LTFLGKLNENFR----------ILNSLWIQA-CNIFPALIDY----LPGSH------------------- 51 10 LKLMERLNENIR----------ILSSPWLQV-YNNFPALLDY----FPGIH------------------- 230 11 LKLMESLNENVR----------ILSSPWLQV-YNNFPALLDY----FPGIH------------------- 230 12 LKLLEKFNENVR----------ILSSPWLQV-CNNFPALIDY----LPGSH------------------- 230 13 LKLMEKFNENVR----------ILSSPWLQI-CNNFPVLTDY----FPGIH------------------- 121 14 LNLMEKLNENIK----------ILSSPWIQI-CNNFSPIIDY----FPGTH------------------- 230 15 ----------------------LVSTPWIEL-FNAFPSLLRH----FPGSH------------------- 24 16 QTLVKHFLDSIR----------LFNTPWMQL-YNTF-PILHY----LPGSH------------------- 229 17 LNLMEKLNENIR----------IVSTPWIQI-CNNFPTIIDY----FPGTH------------------- 230 18 LNLMEKFNENLR----------ILSSPWIQV-CNNFPALIDY----LPGSH------------------- 230 19 LTLMKRFNENFR----------ILNSPWIQV-CNNFPLLIDC----FPGTH------------------- 230 20 LTLIKRFTVNFR----------ILTSPWIQV-CNNFPLLIDC----FPGTH------------------- 230 21 LNLMHRFNENFR----------LFSSPWLQV-CNTFPAIIDY----FPGSH------------------- 230 22 LTFMEKVNENLK----------IMSSPWMQV-CNSFPSLIDY----FPGTH------------------- 230 23 LILMDKINENVK----------ILSSPWLQV-CNSFPSLIDY----CPGSH------------------- 230 24 LNLMEKLNENMK----------ILSSPWTQF-CSFFPVLIDY----CPGSH------------------- 230 25 LNLIEKVNEAVK----------IISSPGIQV-FNIFPILLDY----CPGNH------------------- 230 26 LSLIENVNEYIK----------IVSTPAFQV-FNAFPILLDY----CPGNH------------------- 230 27 LTLLEYFHENLL----------ISSTSWIQL-YNAFPLLIHY----LPGSH------------------- 203 28 KTLIKYFHENFE----------LLGTPWIQL-YNIFPILFHY----LPGSH------------------- 230 29 QKFIENFHTKIE----------ILASPWAQL-CSAYPVLY-Y----LPGIH------------------- 229 30 LNLMDLLNKNFQ----------QVNSVWCQM-YNLWPTIIKY----LPGKH------------------- 234 31 LTFMKKVNENVR----------ILSSPWLQV-CNNFPSLIDY----CPGSH------------------- 230 32 LTFMKKLNENAR----------ILSSPWFQV-CNNFPLLIDY----CPGSH------------------- 230 33 LTFMEKVNENVR----------ILSSPWLQV-CNNFPSLIDY----CPGSH------------------- 230 34 LNLMEKLNENFE----------ILNSPWLQV-CNVIPAFLDY----LPGSH------------------- 230 35 LRLMSLFNENFY----------LLSTPWLQV-YNNFSNYLQY----MPGSH------------------- 232 36 LRLMSLFNENFY----------LLSTPWLQV-YNNFSNYLQY----MPGSH------------------- 232 37 LRLMSLFNENFY----------LLSTPWIQL-YNNFADYLRY----LPGSH------------------- 232 38 LELMSLFNENFY----------LLSTPWIQA-YNYFSDYLQY----LPGSH------------------- 232 39 LRLMSLFNENFY----------LLSTPWIQA-YNNFENYLRY----LPGSH------------------- 232 40 LRLMYLFNENFH----------LLSTPWLQL-YNNFPSFLHY----LPGSH------------------- 232 41 LRLMYLFNENFQ----------GLSCPWLQL-YNNFPSLLHY----LPGSH------------------- 188 42 LDLIEMLEENNK----------YQNRIQTLL-YNFFPTILDS----LPGPH------------------- 233 43 LDLIEMLDENER----------YQNRIQTQL-YNFFPTILDY----LPGPH------------------- 233 44 LTIIRLINDNFQ----------IMSSPWGEL-YDIFPSLLDW----VPGPH------------------- 231 45 LTIIHFINDNFK----------IMSSPWGEM-YNIFPSVLDW----IPGPH------------------- 231 46 LRLLDLFFQSFS----------LISSFSSQV-FELFPGFLKH----FPGTH------------------- 231 47 LRLLDLFFQSFS----------LTSSFSSQV-FELFSGFLKH----FPGTH------------------- 231 48 LRLMNLFYVSFA----------LISSFSSQM-FELFHSFLKY----FPGTH------------------- 231 49 LKMLNLFYQTFS----------LISSVFGQL-FELFSGFLKY----FPGAH------------------- 231 50 LKILNLFYHTFS----------LASSMFGQL-FELLSGFLKY----FPGAH------------------- 231 51 LHLLDLMYQTFS----------LLSSIFSQV-FELFPGVLKY----FPGAH------------------- 231 52 LRLLELFYRTFS----------LLSSFSSQV-FEFFSGFLKY----FPGAH------------------- 231 53 LRLLELFYRTFS----------LLSSFSSQV-FEFFSGFLKY----FPGAH------------------- 231 54 LRLLELFYQTFS----------LISSFSSQM-FELFSGFLKY----FPVAH------------------- 231 55 LHLLDLVYKTSV----------LMGSLSSQV-FELYSGFLKY----FPGAH------------------- 232 56 LRLLDLIYQTFS----------LMGSLSSQV-FELFSGFLKY----FPGVH------------------- 232 57 LHLLNLMYKIFS----------LLSSFSGQM-FELFSGFLKY----FPGVH------------------- 231 58 LRLLNLMYQIYS----------LLRSFSCQM-FELFSVFLKY----FPGVH------------------- 231 59 LRLLDLLYRTFS----------LISSFSSQM-FEVYSDFLKY----FPGVH------------------- 231 60 RSLMKMINESFV----------EMSMPWAQL-YDMYWGVIQY----FPGRH------------------- 234 61 LSLLRMINESFI----------EMSTPWAQL-YDMYSGVMQY----LPGRH------------------- 234 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 LSLLRMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 234 65 LSLLSMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 234 66 LSLLRMMLGSLQ----------FTATSMGQV-YEMFSSVMKH----LPGPQ------------------- 234 67 LSLLRMMLGSFQ----------FTATSMGQL-YEMFSSVMKH----LPGPQ------------------- 234 68 LSLLRMMLGSFQ----------FTATSTGQL-YEMFSSVMKH----LPGPQ------------------- 234 69 LSLLGMIMRSFQ----------FMSTSTGQL-FEMFYSVMKH----LPGCQ------------------- 234 70 LSLLQMMGQMNR----------FAASPTGQL-YDMFHSVMKY----LPGPQ------------------- 233 71 LSLLQMMGQVNK----------FAASPTGQL-YDMFHSVMKY----LPGPQ------------------- 233 72 LSLLEMIDEMNI----------FAASATGQL-YDMFHSVMKY----LPGPQ------------------- 233 73 ----------NK----------FAASPVGQL-YDMFHSVMKY----LPGPQ------------------- 26 74 LSLLRMMLGSFQ----------FTATPTGQL-YEMFYSVMKH----LPGPQ------------------- 234 75 LSLLRMMLGSFQ----------FTATPTGQL-YEMFYSVMKH----LPGPQ------------------- 234 76 QNLLSLFQSVFR----------ESSSAWGQL-LNMFPLIMNH----IPGPH------------------- 234 77 LG-------------------------------------------------------------------- 120 78 TGMADRAKESIH----------LTGSASIQM-YNMFPWLGPW----INNLT------------------- 242 79 QLIQKAVDAYFN----------VLSSPIGAM-YNMFPRIVWCF---PGNHH------------------- 238 80 QELLKLFDEVMY----------LEASMLCQL-YNIFPWIMKF----LPGAH------------------- 244 81 IRMVKLVEESLT----------EVSGFIPEV-LNTFPALLR-----IPGLA------------------- 240 82 IRMLTLVEESLI----------EVSGFIPEV-LNTFPALLR-----IPGLA------------------- 240 83 IRMLKVLEQSLT----------EVSGLIPEV-LNAFPILLR-----IPRLA------------------- 240 84 IRMQKVLEDSLT----------EISGLIPEV-LNMFPILLR-----IPGLP------------------- 240 85 IRMLKMLKECFT----------EISGFIPGV-LNEFPIFLR-----IPGLA------------------- 240 86 IKVLKILKESMG----------EQTGLFPEV-LNMFPVLLR-----IPGLA------------------- 240 87 NRMLKTLKESFG----------EDTGFMAEV-LNAIPILLQ-----IPGLA------------------- 240 88 IRLLDLLKDTLE----------EESGFLPML-LNVFPMLLH-----IPGLL------------------- 240 89 LRLLDLAQEGLK----------EESGFLREV-LNAVPVLLH-----IPALA------------------- 237 90 IKLLDLTEDGLK----------EEPNLVRKV-VEAVPVLLS-----IPGLA------------------- 240 91 LQLLELTQQALK----------QDSGFLREA-LNSIPVLLH-----IPGLA------------------- 240 92 LGLVNM-SDEFG----------QVVG-SGNP-ADFIPI-LRY----LPNRT------------------- 252 93 LGLVNM-SDEFG----------QVVG-SGNP-ADFIPI-LRY----LPNRT------------------- 252 94 LNLVNL-SDEFG----------QVVA-SGNP-ADFIPI-LQY----LPSTT------------------- 252 95 VSLVNL-SEEFG----------QVVG-TGNL-ADFIPV-LRF----LPSTA------------------- 252 96 VSLVTL-SDEFG----------RVVG-SGNP-ADFIPI-LQY----LPSAE------------------- 252 97 LSLVNL-TDEFG----------KVVG-SGNL-ADFIPL-LRF----LPNAT------------------- 249 98 LRLVNL-SDEFG----------QVAG-SGNP-ADFINI-LRF----LPSTT------------------- 252 99 LSIVNL-SNEFG----------EVTG-SGYP-ADFIPI-LRY----LPNSS------------------- 251 100 LSIVNL-SNEFG----------EVTG-SGYP-ADFIPV-LRY----LPNSS------------------- 251 101 LSIVNL-SNEFG----------KVTG-SGYP-PDFIPI-LRY----LPNSS------------------- 251 102 LELIDL-NNEFG----------EVTG-SGNP-SDFIPI-LRY----LPSAT------------------- 243 103 LSLVNL-SNEFG----------EGVA-SANP-LDFFPI-LRY----LPNPA------------------- 251 104 LSLVNL-NNNFG----------EVVG-SGNP-ADFIPI-LRY----LPNPS------------------- 247 105 LSLVNL-SNNFG----------EVVG-SGNP-ADFIPI-LRY----LPNRS------------------- 247 106 LSLVNL-NDEFG----------KVAA-SGSP-ADFFLI-LRY----LPNPA------------------- 251 107 LNLVKS-SKDFV----------ENVT-SGNA-VDFFPV-LRY----LPNPA------------------- 248 108 LNIVNN-SKDFV----------ENVT-SGNA-VDFFPV-LRY----LPNPA------------------- 248 109 LRIVKG-SSDFV----------ENVS-SGNA-VDFFPI-LRY----LPNPD------------------- 248 110 LPLLMS-SSDFV----------ETVS-SGNP-LDFFPI-LQY----MPNSA------------------- 235 111 LSLVKN-THEFV----------ETAS-SGNP-LDFFPI-LRY----LPNPA------------------- 249 112 LQIVNT-SKEFT----------EFAS-SGNP-VDFFPI-LRY----LPNPM------------------- 249 113 LDVVRN-SSKFV----------ETAS-SGSP-VDFFPI-LRY----LPNRP------------------- 249 114 ---------------------------------------------------------------------- 0 115 LELLSH-NEEFG----------RTVG-AGSL-VDVLPW-LQL----FPNPVRTT---------------- 257 116 LELLSH-NEEFG----------RTVG-AGSL-VDVMPW-LQL----FPNPVRTI---------------- 257 117 RELLSH-NEEFG----------RTVG-AGSL-VDVMPW-LQY----FPNPVRTV---------------- 257 118 KAIQNV-NDGIL----------EVLS-KEVL-LDIFPV-LKI----FPSKA------------------- 228 119 QAIVNF-NDGIL----------DAVG-KEIL-YDMFPG-IRI----LPSQT------------------- 228 120 NVIQNY-NEGII----------DNLS-KDSL-VDLVPW-LKI----FPNKT------------------- 228 121 TTIQTF-TEGIV----------DVLG-HSDL-VDIFPW-LKI----FPNKN------------------- 227 122 TAIKTF-TEGIV----------DATG-DRNL-VDIFPW-LTI----FPNKG------------------- 227 123 EAMLEY-SQGIV----------DTVA-KESL-VDIFPW-LQI----FPNRD------------------- 233 124 EAMLQF-SQGIV----------DTVA-KDSL-VDIFPW-LQV----FPNAD------------------- 234 125 QTMRKY-SQGIV----------NTVA-KDSL-IDIFPW-LQF----FPNEN------------------- 233 126 HAFHDCVQDLMK----------TWDH-WSIQILDMVPF-LRF----FPNPG------------------- 221 127 HAFHDCVQDLMK----------TWDH-WSIQILDMVPF-LRL----FPNPG------------------- 222 128 HALHDCVQDLMK----------TWDH-WSIQILDMVPF-LRF----FPSPG------------------- 221 129 PAYYKCIQEVLK----------TWSH-WSIQIVDVIPF-LRF----FPNPG------------------- 222 130 QTLHDCVQDLLQ----------AWNH-WSIQILTIIPL-LRF----LPNPG------------------- 217 131 FADLATELTTLM----------GAFFVGDYFPSFAWVD-VLT-------GM------------------- 233 132 ---IIEQFVELL----------GIFNVGDYIPRLEWVN-KFT-------GL------------------- 235 133 -KATLDKFVELL----------GTFNVGDYIPCLEWVN-KIT-------GF------------------- 224 134 -KDILEQFLQLL----------DTFNVGDYIPWLKWVN-KIT-------GL------------------- 236 135 ---------------------------------------------------------------------- 0 136 FLIELREFLELL----------GAISIGDFVPSLWWIN-RIN-------GF------------------- 242 137 YQEIIVQAFEVL----------GSLAAVDYFPVIGTIIDRIT-------GL------------------- 232 138 ---------------------------------------------------------------------- 0 139 ---------------------------------------------------------------------- 0 140 NPEEFKK------MLDELFLLNGVLNIGDSIPWIDFMDLQ---------GY------------------- 0 141 FIKILYGTQSVL----------GKIFFSDFFPYCGFLDDLS--------GL------------------- 232 142 RSYTELNYGMRA----------MAINLPGFAYRGALRARRRLVAVLQ--GV------------------- 251 143 KEYLLVIEGFFS----------LPLPLFSTTYRKAIQARRKVAEALT--VV------------------- 234 144 FRELTETSAALL----------GGFNVEDYFP-KLADVDLFLRII------------------------- 262 145 FSELTEINVSLL----------AGFNLEDYFPPNMAMADVLLRLV------------------------- 265 146 FREMTMTNVDLL----------VGFNLEYYIP-RWPLTDLLFRLV------------------------- 262 147 FRELTDINAGLL----------GGFHIQDYFP-RLGRIELVRKVA------------------------- 271 148 FR--ELVEANSALF--------GGFNPGDYFP-GLARALGFLSRRLLFLRS------------------- 122 149 ---------------------------------------------------------------------- 0 150 FFNAMIGIMEWA----------GVPNISDIFPCLKMFD-VQ--------GL------------------- 198 151 FFIAMKRINEWS----------GIANVSDIFPFLKKFD-LQ--------SL------------------- 240 152 ---------------------------------------------------------------------- 0 153 FKNMVVELMTVA----------GYFNIGDFIPQIAWMD-LQ--------GI------------------- 238 154 FKDMVVELMTIA----------GYFNIGDFIPCLAWMD-LQ--------GI------------------- 235 155 FKDMVVELMTTA----------GYFNIGDFIPCLAWMD-LQ--------GI------------------- 235 156 ---------------------------------------------------------------------- 68 157 EAEHLKSMVREGFELL------GAFNWSDHLPWLAHLY-DP--------SN------------------- 231 158 EGLELELILKEGYELL------GIFNWGDHLPLLGWLD-LQ--------GV------------------- 164 159 FLKLKALNCERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 160 FQRLKALNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 161 FVKLKALNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 235 162 FVKLKALNGERS-----RLAQGFEYNYGDFIPILRPFL-------------------------------- 235 163 ---------------------------------------------------------------------- 0 164 FVKLKRLNGERS-----RLAQSFEYNYGDFIPILRPFL-------------------------------- 233 165 --DQMMKDVLIV----------LDPRIDDFLPILRLFV-GY--------KQ------------------- 231 166 --DQMMKSVLIA----------LDPRLDDYLPILSPFF-S---------KQ------------------- 245 167 GGPGPMEVLHMD-AVFTSLGLLYAFCVSDYLPWLRGLD-LD--------GHEK----------------- 286 168 GM--DKLIHGMLMT-------GGDFDVASYFPVLARFD-LH--------GL------------------- 234 169 FL--ENIRDFMRLI--------GTFTVGDGVPFLKWLDLGGHEK-------------------------- 243 170 ---------------------------------------------------------------------- 0 171 ---------------------------------------------------------------------- 0 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 EELVF-EAETAL----------ASFTC-DFFP-------------------------------------- 97 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 VRGLVTESIFLT----------KKHFLGAMFHKPLKKL-GI--------SL------------------- 78 180 ---------------------------------------------------------------------- 61 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 ---NKILRNNIYIRNYVLEKIKEHQETLDINNPRD---FIDCFLI-KMEQEK--DNQQSE----FTIENL 287 2 ---RKAVKNIFYVKNYITEQIKEHQKSLDINNPRD---FIDCFLI-KMEQEK--CNQQSE----FTIENL 287 3 ---KTVFENFDYVRNFVLEKTKEHQESLDINNPRD---FIDCFLI-KMKQEK--HNQQSE----FTIENL 287 4 ---NRVIKNFAEIKSYILRRVKEHQETLDMDNPRD---FIDCFLI-KMEQEK--HNPRTE----FTIESL 286 5 ---NKVFKNYAYVKSYIWEKVKQHQASLDLNDPRD---FIDCFLI-KMEQEK--HNHQVA----FTFENL 108 6 ---RAFSKRLKDRRSFILEKVKEHQKSPNLNIPQD---YIDCFLS-KMEQEK--QNPDSE----FHLENL 108 7 ---NKVLKNSAYVKSYILEKVKEHQASLDVNDPRD---FIDCFLI-KMEQEK--HNHQMA----FTFENL 108 8 ---NTVFKNFAYVKSYILEKVKEHQASLDVNDPRD---FIDCFLI-KMEKEK--HNHQMA----FTFENL 108 9 ---NKVFKNFAYLKSYILEKVKEHQASLDVNDPRD---FIDCFLI-KMEQEK--HNHQMV----FTLENL 108 10 ---KTLLKNADYTKNFIMEKVKEHQKLLDVNNPRD---FIDCFLI-KMEKEN--NL---E----FTLGSL 284 11 ---KTLLKNADYIKNFIMEKVKEHQKLLDVNNPRD---FIDCFLI-KMEQEN--NL---E----FTLESL 284 12 ---KTLLKNSDYVKNFIMEKVKEHQKFLDVNNPRD---FIDCFLI-KMEQEN--HL---E----FTLESL 284 13 ---NTLVKNIEYTKNFIMEKVKEHQKSLDVNNPRD---FIDCFLI-KMDQEN--HL---E----FTLESL 175 14 ---NKLLKNVAFMKSYILEKVKEHQESMDMNNPQD---FIDCFLM-KMEKEK--HNQPSE----FTIESL 287 15 ---NTIFKNMTEQRKFILEEIKKHQESLDLNNPQD---FIDYFLI-KMEKEK--HNKHSE----FTMDNL 81 16 ---HELFKVFNDQMKFFSEKIREHQESLDHNNPRD---FIDYLLI-KMEKEK--HNKQSQ----FTMHHL 286 17 ---NKLLKNLAFMESDILEKVKEHQESMDINNPQD---FIDCFLI-KMEKEK--QNQQSE----FTIESL 287 18 ---NKIAENFAYIKSYVLERIKEHQESLDMNSARD---FIDCFLI-KMEQEK--HNQQSE----FTVESL 287 19 ---NKVLKNVALTRSYIREKVKEHQASLDVNNPRD---FIDCFLI-KMEQEK--DNQKSE----FNIENL 287 20 ---NKLLKNVALTKSYIREKVKEHQATLDVNNPRD---FIDCFLI-KMEQEK--DNQQSE----FTIENL 287 21 ---NQVLKNFFYIKNYVLEKVKEHQESLDKDNPRD---FIDCFLN-KMEQEK--HNPQSE----FTLESL 287 22 ---HKIAKNINYMKSYLLKKIEEHQESLDVTNPRD---FVDYYLI-KQKQAN--NIEQSE----YSHENL 287 23 ---HKIVKNFNYLKSYLLEKIKEHKESLNVTNPRD---FIDYYLI-KQKQVN--HIEQSE----FSLENL 287 24 ---TTLAKNVYHIRNYLLKKIKEHQESLDVTNPRD---FIDYYLI-KWKQEN--HNPHSE----FTLENL 287 25 ---NIYFKNHTWLKSYLLEKIKEHEESLDVSNPRD---FIDYFLI-ERNQEN--ANQWMN----YTLEHL 287 26 ---KTHSKHFAAIKSYLLKKIKEHEESLDVSNPRD---FIDYFLI-QRCQEN--GNQQMN----YTQEHL 287 27 ---HVLFKNIANQFKFISEKIKEHEESLNFSNPRD---FIDYFLI-KIEKEK--HNKQSE----FTMDNL 260 28 ---RQLFKNIDGQIKFILEKVQEHQESLDSNNPRD---FVDHFLI-KMEKEK--HKKQSE----FTMDNL 287 29 ---NKFLKDVTEQKKFILMEINRHRASLNLSNPQD---FIDYFLI-KMEKEK--HNEKSE----FTMDNL 286 30 ---IEFAKRIDDVKNFILEKVKEHQKSLDPANPRD---YIDCFLS-KIEEEK--DNLKSE----FHLENL 291 31 ---HKITKNVNYLKKYILEKIEEHQESLDIENPRD---FIDYYLI-KLKQAN--HNQQSE----FSLENL 287 32 ---HRITKNINYIRSYLSEKMKEHQESLDVANPRD---FIDYYLI-KLKQGN--YNQQSE----FSPENL 287 33 ---HTITKNVNYIRSYLSEKIKEHQETLDVANPRD---FIDYYLI-KLKQGN--YNQQSE----FTLENL 287 34 ---NKALKNFAEIKSYILKRVKEHQETLDMNNPRD---FIDCFLI-KMEKEK--DNPHSE----FTTESL 287 35 ---RKVIKNVSEIKEYTLARVKEHHKSLDPSCPRD---FIDSLLI-EMEKDK--HSTEPL----YTLENI 289 36 ---RKVIKNTCEIKEYTLARVKEHQKSLDPSCPRD---FIDCLLI-EMEKDK--HGTEPL----YTLENI 289 37 ---RKIMKNVSEIKQYTLEKAKEHLQSLDINCARD---VTDCLLI-EMEKEK--HSQEPM----YTMENV 289 38 ---RKVMKNVSEIRQYTLGKAKEHLKSLDINCPRD---VTDCLLI-EMEKEK--HSQEPM----YTMENI 289 39 ---RKIMKNASEIRQYTLAKAKEHLQSLDSSCPRD---VTDCLLI-EMEKEK--DSQEPM----YTMENI 289 40 ---RKVIKNVAEVKEYVSERVKEHHQSLDPNCPRD---LTDCLLV-EMEKEK--HSAERL----YTMDGI 289 41 ---RKVMKNVAEIKEYVSERVKEHHQSLDPNCPRD---LTDCLLV-EMEKEK--HSAERL----YTMDGI 245 42 ---KTLIKNTETVDDFIKEIVIAHQESFDASCPRD---FIDAFIN-KMEQEK--EN--SY----FTVESL 288 43 ---KTLIKSIETVDDFITEIIRAHQESFDASCPRD---FIDAFIN-KMQQEK--EN--SY----FTVESL 288 44 ---QRIFQNFKCLRDLIAHSVHDHQASLDPRSPRD---FIQCFLT-KMAEEK--EDPLSH----FHMDTL 288 45 ---KRLFRNFGGMKDLIARSVREHQDSLDPNSPRD---FIDCFLT-KMAQEK--QDPLSH----FNMDTL 288 46 ---RQIYRNLQEINTFIGQSVEKHRATLDPSNPRD---FIDVYLL-RMEKDK--SDPSSE----FHHQNL 288 47 ---RQIYRNLQEINTFIGQSVERHRETLDPSNPRD---FIDVYLL-RMEKDK--SDPSSE----FHHQNL 288 48 ---RQVYNNLQEIKAFIARMVEKHRETLDPSAPRD---FIDAYLI-RMDKEK--AEPSSE----FHHRNL 288 49 ---RQVYKNLQEINAYIGHSVEKHRETLDPSAPKD---LIDTYLL-HMEKEK--SNAHSE----FSHQNL 288 50 ---RQVYKNLQEINAYIGHSVEKHRETLDPSAPQD---LIDSYLL-QMEKEK--SNPHSE----FSHRNL 288 51 ---RQISRNLHEILDFIGQSVEKHRATLDPNAPRD---FIYTYLL-HMEK-K--SNHYTE----FHHWNL 287 52 ---RQISKNLQEILDYIGHIVEKHRATLDPSAPRD---FIDTYLL-RMEKEK--SNHHTE----FHHENL 288 53 ---RQISKNLQEILDYIGHIVEKHRATLDPSAPRD---FIDTYLL-RMEKEK--SNHHTE----FHHENL 288 54 ---RQISNNLQELLDYIGHSVEKHRATLDPSVPRD---FIDTYLL-RMDKEK--SNQNTE----KHHQNL 288 55 ---KQIFKNLQEMLNYIGHIVEKHRATLDPSAPRD---FIDTYLL-RMEKEK--SNHHTE----FNHQNL 289 56 ---KQISKNLQEILNYIDHSVEKHRATLDPNTPRD---FINTYLL-RMEKEK--SNHHTE----FHHQNL 289 57 ---RQIVKKQQELLDYIAHSVEKHKATLDPSAPRD---YIDTYLL-RMEKEK--SNHNTE----FHHQNL 288 58 ---RQIAKNQQEILNFITHRVEKHRASLDPSEPRD---FIDTYLL-RMEKEK--SNHNTE----FHHQNL 288 59 ---REIYKNLKEVLDYIDHSVENHRATLDPNAPRD---FIDTFLL-HMEKEK--LNHYTE----FHHWNL 288 60 ---NRLYNLIEELKDFIASRVKINEASFDPSNPRD---FIDCFLI-KMYQDK--SDPHSE----FNLKNL 291 61 ---NRIYYLIEELKDFIAARVKVNEASLDPQNPRD---FIDCFLI-KMHQDK--NNPHTE----FNLKNL 291 62 ---------------------------------------------------------------------- 0 63 ---------------------------------------------------------------------- 0 64 ---QQAFQLLQGLENFIAKKVEHNQRTLDPNSPRD---FIDSFLI-RMQEEE--KNPNTE----FYLKNL 291 65 ---QQAFKLLQGLENFIAKKVEHNQRTLDPNSPQD---FIDSFLI-HMQEEE--KNPNTE----FYLKNL 291 66 ---QQAFKELQGLEDFITKKVEHNQRTLDPNSPRD---FIDSFLI-RMLEEK--KNPNTE----FYMKNL 291 67 ---QQAFKELQGLEDFITKKVEHNQRTLDPNSPRD---FIDSFLI-RMLEEK--KNPNTE----FYMKNL 291 68 ---QQAFKELQGLEDFITKKVEQNQRTLDPNSPRD---FIDSFLI-RMLEEK--KNPNTE----FYMKNL 291 69 ---HQAYKEMQGLEDFIARKVEENQRTLDPNSPRD---FIDSFLI-RMQEEK--KNPRTQ----FHMRNL 291 70 ---QQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRN---FIDSFLI-RMQEE---KNGNSE----FHMKNL 289 71 ---QQIIKDSHKLEDFMIQKVKQNQSTLDPNSPRD---FIDSFLI-HMQKE---KYVNSE----FHMKNL 289 72 ---QQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRN---FIDSFLI-RMQEE---KYVNSE----FHMNNL 289 73 ---QQIIKNTKELEDFMIRKVKQNQSTLDLNSARN---FIDSFLI-HMHEEK--KNPTSE----FNIKNL 83 74 ---QQAFKELEGLRDFIAKKVERNQRTLDPNSPRD---FIDSFLI-RMQEEK--KDPKSE----FHMKNL 291 75 ---QQAFKELEGLRDFIAKKVERNQRTLDPNSPRD---FIDSFLI-RMQEEK--KDPKSE----FHMKNL 291 76 ---KKVIRDMNKLEAFVLQRVKENEKTLDSNSPRD---IIDSFLI-KMQQEN--ENPTSA----FHMKNL 291 77 ---------------------------------------------------------------------- 120 78 ---RLKKNIADMKMEVI-ELVRGLKETLNPHMCRG---FVDSFLV-RKLEES--GHMDSF----YHDDNL 298 79 ---EMFAIVNKAKDYIQ-EQAEIRLKTLNISEPQD---FIEAFLV-KMLEEK--DDPNTE----FNNDNM 294 80 ---QTLFSNWKKLELFVSRMLENHKKDWNPAETRD---FIDAYLK-EMSKYP--GSATSS----FNEENL 301 81 ---DKVFQGQKTFMALLDNLLAENRTTWDPQPPRN---LTDAFLA-EVEKAK--GNPESS----FNDENL 297 82 ---DKVFQGQKTFMAFLDNLLAENRTTWDPQPPRN---LTDAFLA-EVEKAK--GNPESS----FNDENL 297 83 ---DKALQGQKSFIAILDNLLTENRTTWDPQAPRN---LTDAFLA-QIEKAK--GNPESS----FNDENL 297 84 ---GKVFQGQKSLLAIVENLLTENRNTWDPQPPRN---LTDAFLA-EIEKVK--GNAESS----FNDENL 297 85 ---DMVFQGQKSFMAILDNLLTENRTTWDPQPPRN---LTDAFLA-EIEKAK--GNAESS----FNDENL 297 86 ---DKVFPGQKTFLTMVDNLVTEHKKTWDPQPPRD---LTDAFLA-EIEKAK--GNPESS----FNDANL 297 87 ---GKVFPKLNSFIALVDKMLIEHKKSWDPQPPRD---MTDAFLA-EMQKAK--GNPESS----FNDENL 297 88 ---GKVFSGKKAFVAMLDELLTEHKVTWDPQPPRD---LTDAFLA-EVEKAK--GNPESS----FNDENL 297 89 ---GKVLRFQKAFLTQLDELLTEHRMTWDPQPPRD---LTEAFLA-EMEKAK--GNPESS----FNDENL 294 90 ---ARVFPAQKAFMALIDELIAEQKMTRDPQPPRH---LTDAFLD-EVKEAK--GNPESS----FNDENL 297 91 ---SKVFSAQKAIITLTNEMIQEHRKTRDPQPPRH---LIDAFVD-EIEKAK--GNPKTS----FNEENL 297 92 --MKRFMDINDRFNTFVQNIISEHYESYDKDNIRD---ITDSLID-HCEDRKLDENANIQ----VSDEKI 312 93 --MKRFMDINDRFNNFVQKIVSEHYESYDKDNIRD---ITDSLID-HCEDRKLDENANIQ----VSDEKI 312 94 --MKKFLNINDRFNTFVQKIVSEHYTTFDKDNIRD---ITDSLID-HCEDRKLDENSNVQ----MSDEKI 312 95 --MKKFLSINDRFDKFVKKIVSEHYATYNKDNIRD---ITDSLID-HCEDRKLDENCNVQ----VSDEKI 312 96 --MKNFLRINEHFTEFVQKIVTEHYTTFNKDNIRD---ITDSLID-HCEDRKLDENSNVQ----MSDEKI 312 97 --MKRFMAINERFMTFVQKIVTEHYNTYDKDNIRD---ITDSLID-HCEDRKLDENSNIQ----MSDEKI 309 98 --MKKFMTINADFNTFVKKIVGEHYATFDKNNIRD---ITDSLID-HCEDRKLDENCNVQ----MSDEKI 312 99 --LDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRD---ITDSLIE-HCQDRRLDENANVQ----LSDDKV 311 100 --LDAFKDLNDKFYSFMKKLIKEHYRTFEKGHIRD---ITDSLIE-HCQDRKLDENANVQ----LSDDKV 311 101 --LDAFKDLNKKFYSFMQKSVKEHYRTFEKGHIRD---ITDSLIE-HCQDKSLDENANVQ----LSDDRV 311 102 --MDTFKDLNRRFSVFIQKMIKEHYKTFEKGHIRD---ITDSLIE-HCQDRKLDKNANIQ----ISDQKI 303 103 --LDFFKDLNKRFYSFMQKMVKEHYKTFEKGQIRD---VTDSLIE-HCQDKRLDENANIQ----LSDEKI 311 104 --LNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD---ITDSLIE-HCQEKQLDENANVQ----LSDEKI 307 105 --LNGFKDLNEKFHSFMQKMIKEHYKTFEKGYIRD---ITDSLIE-HCQEKQLDENANIQ----LSDEKI 307 106 --LDTFKDLNERFYSFTQERVKEHCRSFEKGHIRD---ITDSLIK-HYRVDRLDENANVQ----VSDEKT 311 107 --LKRFKNFNDNFVLFLQKTVQEHYQDFNKNSIQD---ITGALFK-HSENY--KDNGGL-----IPQEKI 305 108 --LKRFKTFNDNFVLFLQKTVQEHYQDFNKNSIQD---ITSALFK-HSENY--KDNGGL-----IPEEKI 305 109 --LKRFKNFNDNFVLFLQKTVQEHYQDFNKNSIQD---ITGALFK-HSENS--KDSGGL-----IPQEKI 305 110 --LQRFKNFNQTFVQSLQKIVQEHYQDFDERSVQD---ITGALLK-HNEKSS-RASDGH-----IPQEKI 293 111 --LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRD---ITGALFK-HSKKGP-RASGNL-----IPQEKI 307 112 --LQQFKDFNKRFLQFLQKTVQEHYQDFDKNHVQD---IASALFK-HSEQSP-HVNGDL-----IPRKKI 307 113 --LQRFKDFNQRFLRFLQKTVREHYEDFDRNSIQD---ITGALFK-HSEKNS-KANGGL-----IPQEKI 307 114 --------------KFLQIAVEEHYQSFDKNNIRD---VTDSLWR-SKKTKP-RGAAD-------PNEKI 44 115 --FRKFEQLNRNFSNFVLDKFLRHRESLVPGAPRD---MTDAFIL-SAEKKASGAPGDDSSG--LDLEDV 319 116 --FREFEQINRNFSNFVLDKFLRHRESLVPGAPRD---MMDAFIL-SAEKKATGDPGDSPSG--LDLEDV 319 117 --FREFEQLNRNFSNFILDKFLRHCESLRPGAPRD---MMDAFIL-SAEKKAAGDSHGGGAR--LDLENV 319 118 --MEKMKGCVQTRNELLNEILEKCQENFSSDSITN---LLHILIQ-AKVNADNNNAGPDQDSKLLSNRHM 292 119 --LENMKQCVRMRNELLREILENRKENYSRNSITN---LLDIMIQ-AKTNAESNTGGPDHNLKLLSDRHM 292 120 --LEKLKSHVKIRNDLLNKILENYKEKFRSDSITN---MLDTLMQ-AKMNSDNGNAGPDQDSELLSDNHI 292 121 --LEMIKEHTKIREKTLVEMFEKCKEKFNSESLSS---LTDILIQ-AKMNAENNNTGEGQDPSVFSDKHI 291 122 --LEVIKGYAKVRNEVLTGIFEKCREKFDSQSISS---LTDILIQ-AKMNSDNNNSCEGRDPDVFSDRHI 291 123 --LALLKRCLKVRDQLLQQKFTEHKEAFCGDTVRD---LMDALLQ-VRLNAENNS--PLEPGLELTDDHL 295 124 --LRLLKQCVSIRDKLLQKKYEEHKSDYSDHEQRD---LLDALLR-AKRSAENNTAEITMETVGLSEDHL 298 125 --LHTLKQCIATRDSILQKKFEDHKANYSSDSAND---LFNILLK-AKMNAENNNSSVHE--AGLTDDHM 295 126 --LWRLKQAIENRDHMVEKQLTRHKESMVAGQWRD---MTDYMLQ-GVGRQRVEE-GPGQ----LLEGHV 280 127 --LWRLKKAIENRDHMVEKQLRRHKESMVAGQWRD---MMDYMLQ-GVGRQRVEE-GPGQ----LLEGHV 281 128 --LRRLKQAIENRDHLVEKQLRRHKESMVAGQWRD---MLDYMLQ-EAGRQRVEE-GQGQ----LLEGHV 280 129 --LRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRD---MMDYMLQ-GVAQPSMEE-GSGQ----LLEGHV 281 130 --LQKLKQIQESRDHIVKQQLKQHKESLVAGQWKD---MIDYMLQ-GVEKQRDGK-DEEQ----LHEGHV 276 131 --DARLKRNHGELDAFVDHVIDDHLLSRKANGSDG---VEQKDLVDVLLHLQKDS-SLGVH---LNRNNL 294 132 --DAKVKKVAKELDMFLEIVIEEHIIRKKKEEYTS--TGEAKDFVDVLLEIQNGNETDFP----LQRDSL 297 133 --DSKVDKVAKDLDTFLEFVIEAHMIRNEKEENNR--AGESKDLVDVLLEIQNGKETGFP----IQRDSL 286 134 --DTKVEKIAKKLDTFLDSVIEEHIIRNKKEEYAI--TDEAKDFVDVLLEIQNGKETDFP----LQRDSL 298 135 ---------------------------------------------------------------------- 0 136 --DRRVDRIAKEMDEFLEKVIHERLENPAAKAEEN--------FVDILLEIYRNN-SAGVS---IDRDSI 298 137 --HAKCEKVFHGIDSFFDQAIQRHI-------DDP---SIKDDIIDLLLKMERGEGSLGEYE--LTREHT 288 138 --------------------------------------------------------------------NT 0 139 ------------------------------------------------------EDSSLE----LTIDHI 12 140 --VKRMKVVSKKFDKFLEHVIDEHNIRR-NGVENY----VAKDMEDVLLQLADDPKLEVK----LERHGV 0 141 --TAYMKECFERQDTYYIQEVVNET-------LDP---KRVKPETESMIDLLMGIYTEQPFASEFTVDNV 290 142 --LDERRAARAKGVSGGGVDMMDRLIEAQDERGRH-----------------------------LDDDEI 290 143 --VMKRREEEEEGAERKKDMLAALLAADDG----------------------------------FSDEEI 268 144 --CAKAKSVSKRWDSLFNELLSEYALSGGKQGD-----HNSEDFVHLLLSLQKDYG--------LTTDNI 317 145 --SVKARRLNQRWNDVFDELIQEHVQSRPSGES----EESEADFIHVLLSIQQEYG--------LTTDNL 321 146 --CWKVTRHLKRWDALLEEVIHEHVEMRKLSGD---KEKESDDFIDIFLSRYEEYG--------FTMDNV 319 147 --CAKTRRVRKRWDDLLDKLIDDHAARMATHQD----EDDDKDFIYVLLSLQKEYG--------LTRDHI 327 148 --RRRVQETHRRWDELLETILSDHEGRRGSVSV-----DGGGDFTDVLLSVQTEYG--------MTRDHL 177 149 ---------------------------------------------------------------------- 0 150 --RKKMERDMGKGKEIT-KKFIEERIEERKKGEKN---RSIKDLLDVLIDFEGSGKDEPDK---LSEDEI 259 151 --RKKMARDMGKAVEIM-SMFLKEREEERKKGTEK-----GKDFLDVLLEFQGTGKDEPAK---LSEHEI 299 152 ---------------------------------------------------------------------- 0 153 --EKGMKKLHKKFDDLLTKMFEEHEATSNERKGKP-------DFLDFIMA-NRDNSEGER----LSITNI 294 154 --EKRMKRLHKKFDALLTKMFDEHKATTYERKGKP-------DFLDVVME-NGDNSEGER----LSTTNI 291 155 --EKGMKRLHKKFDALLTKMFDEHKATSYERKGKP-------DFLDCVME-NRDNSEGER----LSTTNI 291 156 ---------------------------------------------------------------------- 68 157 --VTRRCAALPRVQTFVRGVIDEHRRRRQ-NSAAL---NDNADFVDVLLSLEGDEK--------LGDDDM 287 158 --RRRCRTLVAKVNVFVKKIIDEHKRRANGVGIDE---GEGEDFVDVLLGLEEKDR--------LSESDM 221 159 --RNYLKLCKEVKDKRIQLFKDYFVDERKKIGSTK---KMDNNQLKCAIDHILEAKEKGE----INEDNV 296 160 --KGYLKICKEVKETRLKLFKDYFVDERKNIGSTK---STNNEGLKCAIDHILDAEKKGE----INEDNV 296 161 --KGYLKVCKEVKDRRLQLFKDYFVDERKKLESTK--STTSNDGLKCAIDHILDAQKKGE----INDDNV 297 162 --RGYLRICKEVKERRLQLFKDYFVDERKKFGSTK---SMDNNSLKCAIDHILEAQQKGE----INEDNV 296 163 ---------------------------------------------------------------------- 0 164 --KGYLKVCKEVKDRRLQLFKDYFVDERKKLGSTK--STY-NEGLKCAIDHILDAQKKGE----INDDNV 294 165 --RKRVNEVRKRQIETL-VPLIEKRRSVVQN-PGSD--KTAASFSYLDTLFDVKVEGRKSG---PTNAEL 292 166 --RKHAMDVRKQQIKTI-VPFIEQRKKKILESPEID--KTAASFSYLDTLFDLKIEGRNST---PTYPEL 307 167 --IVKEANVAVNRLHDTVIDDRWRQWKSGERQEME-------DFLDVLIT-LKDAQGNPL----LTIEEV 342 168 --KRKMDEQFKLLIKIWEGEVLARRANRNPEP---------KDMLDVLIAND------------FNEHQI 281 169 ----EMKKCAKKFDVMLNEWLEEHREKKKGLGSEDK--VVPERDFMDRMLLVLKDKPIEG----FDVDTI 303 170 ----------------------------------------------------------------LTDTEI 6 171 ---------------------------------------------------------------------- 0 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 ---------------------------------------------------------------------- 97 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 --FAKELMNVSNRFDELLEKILVEHEEKLQEHH------QTSDMLDMLLEAYGDENAEYK----ITR-QI 135 180 ---------------------------------------------------------------------- 61 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 MTTVTDVFGAGTETTSTTLRYGLLLLMKH-PEVIAKVQEEIERVIG----RHR-------SPCMQDRSRM 345 2 LTTVSDVFMAGTETTSTTLRYGLLLLMKH-PEVIAKVQEEIERVIG----RHR-------SPCMQDRSRM 345 3 MATVTDVFAAGTETTSTTLRYGLLLLMKH-PEVTAKVQEEIERVIG----RHR-------SPCMQDRSRM 345 4 MATVSDVFVAGSETTSTTLRYGLLLLLKH-IEVTAKVQEEIDHVIG----RHR-------RPCMQDRTRM 344 5 IDTITDLFGAGTETTSTTLRYGLLLLLKH-PDVTAKVQKEIDSVIE----RHR-------SPCMQDRSRM 166 6 INSGSNLFAAGTETTTSTLRYGLLLLMKH-PEVQAKVHEEIDRVIG----RSQ-------RPCMQDKMKL 166 7 IATISDLFEAGTETTSTTLRYGLLLLLKH-PDVTAKVQKEIDSVIE----RHR-------SPCMQDRIHM 166 8 IATISDLFEAGTETTSTTLRYGLLLLLKH-PDVTAKVQEEIDSVIE----RHR-------SPCMQDRSRM 166 9 IATAVDLIRAGTETTSITLRYGLLLLLKH-PDVTAKVQKEIDSVIE----RHR-------SPCMQDRIHM 166 10 VIAVFDLFGAGTETTSTTLRYSLLLLLKH-PEVAARVQEEIERVIG----RHR-------SPCMQDRSHM 342 11 VIAVSDLFGAGTETTSTTLRYSLLLLLKH-PEVAARVQEEIERVIG----RHR-------SPCMQDRSRM 342 12 VTTVFDLFGAGTETTSTTLRYSLLLLLKH-PEVADKVQEEIERVIG----RHR-------SPCMQDRSRM 342 13 VTTVSDLFGAGTETTSTTLSISLLLLLKH-PEVAAKVQEEIERVIG----RHR-------SPCMQDRSRM 233 14 ENTAVDLFGAGTETTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRSHM 345 15 ITTVWDVFSAGTETTSLTLRYGLLLLLKH-PEVTAKVQEEIDRVVG----RNR-------SPCMQDRSRM 139 16 LVTIWDVFDAGSQTTSSTMQFGLLLLMKH-PEIAAKVQEEIERVIG----RDR-------SPCMQDRSCM 344 17 VITAADLLGAGTESTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRGHM 345 18 IATVTDMFGAGTETTSTTLRYGLLLLLKY-PEVTAKVQEEIECVVG----RNR-------SPCMQDRSHM 345 19 VGTVADLFVAGTETTSTTLRYGLLLLLKH-PEVTAKVQEEIDHVIG----RHR-------SPCMQDRSHM 345 20 VGTVADLFVAGTETTSTTLRYGLLLLLKH-PEVTAKVQEEIDHVIG----RHR-------SPCMQDRSHM 345 21 VATVTDMFGAGTETTSTTLRYGLLLLLKH-VDVTAKVQEEIERVIG----RNR-------SPCMKDRSQM 345 22 TCSIMDLIGAGTETMSTTLRYALLLLMKY-PHVTAKVQEEIDRVIG----RHR-------SPCMQDRKHM 345 23 ASTINDLFGAGTETTSTTLRYALLLLLKY-PDVTAKVQEQIDRVVG----RHR-------SPCMQDRSHM 345 24 SITVTDLFGAGTETTSTTLRYALLLLLKC-PEVTAKVQEEIDRVVG----KHR-------SPCMQDRSRM 345 25 AIMVTDLFFAGIETVSSTMRFALLLLMKY-PHVTAKVQEEIDHVIG----RHR-------SPCMQDRSHM 345 26 AILVTNLFIGGTETSSLTLRFALLLLMKY-PHITDKVQEEIGQVIG----RHR-------SPCMLDRIHM 345 27 IITIWDVFSAGTETTSTTLRYGLLVLLKH-PDVTAKVQEEIHRVVG----RHR-------SPCM------ 312 28 ITTIWDVFSAGTDTTSNTLKFALLLLLKH-PEITAKVQEEIEHVIG----RHR-------SPCMQDRSRM 345 29 IVTIGDLFGAGTETTSSTIKYGLLLLLKY-PEVTAKIQEEITRVIG----RHR-------RPCMQDRNHM 344 30 AVCGSNLFTAGTETTSTTLRFGLLLLMKY-PEVQAKVHEELDRVIG----RHQ-------PPSMKDKMKL 349 31 TTTVSDLFGAGTETTSTTLRYALLLLLKH-PHVTAKVQEEIDQVVG----RHR-------KPCMQDRSHM 345 32 ATTVSDLFAAGTETTSTTLRYALLLLLKH-PHVTAKVQEEIDQVVG----RHR-------NPCMQDRSHM 345 33 ATTVRDLFAAGTETTSTTLRYALLLLLKH-PHVTAKVQEEIDQVVG----RHR-------NPCMQDRSHM 345 34 MATVADVFVAGSETTSTTLRYGLLLLLKH-KEVTAKVQKEIDHVIG----RDR-------SPCMQDRTRM 345 35 AVTVADMFFAGTETTSTTLRYGLLILLKH-PEIEEKLHEEIDRVIG----PSR-------MPSVRDRVQM 347 36 AVTVADLFFAGTETTSTTLRYGLLILLKH-PEIEEKLHEEIDRVIG----PSR-------MPSVRDRVQM 347 37 SVTLADLFFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------VPAVRDRLDM 347 38 SVTLADLFFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------APAVRDRMNM 347 39 SVTLADLFFAGTETTSTTLRYGLLILMKY-PEVEEKLHEEIDRVIG----PSR-------VPVFKDRLEM 347 40 TVTVADLFFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------IPAIKDRQEM 347 41 TVTVADLFFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------IPAIKDRQEM 303 42 TRTTLDLFLAGTGTTSTTLRYGLLILLKH-PEIEEKMHKEIDRVVG----RDR-------SPCMADRSQL 346 43 TRTTLDLFLAGTGTTSTTLRYGLLILLKH-PEIEEKMHKEIDRVVG----RDR-------SPCMADRSQL 346 44 LMTTHNLLFGGTKTVSTTLHHAFLALMKY-PKVQARVQEEIDLVVG----RAR-------LPALKDRAAM 346 45 LMTTHNLLFGGTETVGTTLRHAFLILMKY-PKVQARVQEEIDRVVG----RSR-------MPTLEDRTSM 346 46 ILTVLSLFFAGTETTSTTLRYGFLLMLKY-PHVTERVQKEIEQVIG----SHR-------PPALDDRAKM 346 47 ILTVLTLFFAGTETTSTTLRYGFLLLLKY-PHVTERVQKEIEQVIG----SHR-------PPALDDRAKM 346 48 IDTALSLFFAGTETTSTTLRYGFLLMLKY-PHIAERIYKEIDQVIG----PHR-------LPSLDDRAKM 346 49 NLNTLSLFFAGTETTSTTLRYGFLLMLKY-PHVAERVYREIEQVIG----PHR-------PPELHDRAKM 346 50 IINTLSLFFAGTETTSTTLRYGFLLMLKY-PHVAERIYKEIEQVIG----PHR-------PPALDDRAKM 346 51 LSSVLSLFFAGTETSSTTLRYGFLIMLKY-PHITEKVQKEIDCVIG----SHR-------LPTLDDRSKM 345 52 MISLLSLFFAGTETGSTTLRYGFLLMLKY-PHVTVKVQKEIDQVIG----SHR-------PPSLDDRTKM 346 53 MISLLSLFFAGTETSSTTLRYGFLLMLKY-PHVAEKVQKEIDQVIG----SHR-------LPTLDDRSKM 346 54 MNSVLSLFFAGTETSSTRLRYGFLLMLKY-PHVAEKVQKEIDQLIG----SHR-------LPTLDDRTKM 346 55 VISVLSLFFAGTETTSTTLRCTFLIMLKY-PHVAEKVQKEIDQVIG----SHR-------LPTPDDRTKM 347 56 VISVLSLFFTGTETTSTTLRYSFLIMLKY-PHVAEKVQKEIDQVIG----SHR-------LPTLDDRTKM 347 57 MMSVLSLFFAGTETTSATLHYGVLLMLKY-PHVTEKVQKEIDQVIG----SHR-------LPTLDDRTKM 346 58 MMSVLSLFFAGTETTSTTLCCGFLLMLMY-PHVAEKVQKEIDQVIG----SHR-------LPTLDDRTKM 346 59 MISVLFLFLAGTESTSNTLCYGFLLMLKY-PHVAEKVQKEIDQVIG----SQR-------VPTLDDRSKM 346 60 VLTTLNLFFAGTETVSSTLRYGFLLLMKY-PEVEAKIHEEINQVIG----THR-------TPRVDDRAKM 349 61 VLTTLNLFFAGTETVSSTLRYGFLLIMKH-PEVQTKIYEEINQVIG----PHR-------IPSVDDRVKM 349 62 ---------------------------------------ELNRELG----AGQ-------APSLGDRTRL 0 63 ---------------------------------------------------------------------- 0 64 VMTTLNLFIGGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRAKM 349 65 MMSTLNLFIAGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRTKM 349 66 VLTTQNLFFAGTETGSTTLRYGFLLLMKY-PDIEAKVHEEIDRVIG----RNR-------QPKYEDRMKM 349 67 VLTTQNLFFAGTETGSTTLRYGFLLLMKH-PDIEAKVHEEIDRVIG----RNR-------QPKYEDRMKM 349 68 VLTTLNLFFAGTETVSTTLRYGFLLLMKH-PDIEAKVHEEIDRVNG----RNR-------QAKYEDRMKM 349 69 LMTTLNLFFAGTETVSTTTRYGFLLLMKY-PHIAAKMHEEIDQVIG----RNR-------QPKYEDHLKM 349 70 VMTTLSLFFAGSETVSSTLRYGFLLLMKH-PDVEAKVHEEIEQVIG----RNR-------QPQYEDHMKM 347 71 VMTSLNLFFAGSETVSSTLRYGFLLLMKH-PDVEAKVHEEIDRVIG----RNR-------QPQYEDHMKM 347 72 VMSSLGLLFAGTGSVSSTLYHGFLLLMKH-PDVEAKVHEEIERVIG----RNR-------QPQYEDHMKM 347 73 VMTSLNLFFAGSETVSSTIRYGFLLLMKY-PEVEAKVHEEIDRVIG----RNR-------QPQFEDRMKM 141 74 VMTTLNLFFAGTETVSTTMRYGFLLLMKH-PDVEAKVHEEIDRVIG----RNR-------QPKFEDRAKM 349 75 VLTTLNLFFAGTETVSTTMRYGFLLLMKH-PDVEAKVHEEIDRVIG----RNR-------QPKFEDRAKM 349 76 LATVLSIFFAGTETVSTTLRHGFLILLIY-PEIEAKLREEIDRVIG----QNR-------SPTIEDRSKM 349 77 ---------------------------------------------------------------------- 120 78 VFSVGNLFSAGTDTTGTTLRWGLLLMTKY-PHIQDQVQEEISRVIG-----SR-------QTLVEDRKNL 355 79 VMTAWSLFAAGTETTSSTLRQSFLMMIKY-PHIQESVQKEIDRVIG-----SR-------VPTVDDRVKM 351 80 ICSTLDLFLAGTETTS-DMRWGLLFMALY-PEIQEKVHAEIDSVIG----QWQ-------QPSMASRESL 358 81 RMVVVDLFTAGMVTTATTLTWALLLMILY-PDVQRRVQQEIDEVIG----QVR-------CPEMTDQAHM 355 82 RMVVVDLFTAGMVTTATTLTWALLLMILY-PDVQRRVQQEIDEVIG----QVR-------CPEMTDQAHM 355 83 LMVVRDLFGAGMLTTSTTLSWALMLMILH-PDVQRRVQQEIDEVIG----QVR-------HPEMADQAHM 355 84 RMVVLDLFTAGMVTTSTTLSWALLLMILH-PDVQRRVQQEIDAVIG----QVR-------HPEMADQARM 355 85 RMVVLDLFTAGMVTTSTTLSWALLLMILH-PDVQRRVQQEIDAVIG----QVQ-------HPEMADQARM 355 86 RLVVNDLFGAGMVTTSITLTWALLLMILH-PDVQCRVQQEIDEVIG----QVR-------HPEMADQAHM 355 87 RLVVIDLFMAGMVTTSTTLSWALLLMILH-PDVQRRVHEEIDEVIG----QVL-------RPEMADQARM 355 88 RVVVADLFMAGMVTTSTTLTWALLFMILH-PDVQCRVQQEIDEVIG----QVR-------RPEMADQARM 355 89 RIVVADLFSAGMVTTSTTLAWGLLLMILH-PDVQRRVQQEIDDVIG----QVR-------RPEMGDQAHM 352 90 RLVVADLFSAGMVTTSTTLAWALLLMILH-PDVQRRVQQEIDEVIG----QVR-------RPEMGDQALM 355 91 CMVTSDLFIAGMVSTSITLTWALLLMILH-PDVQRRVQQEIDEVIG----REQ-------LPEMGDQTRM 355 92 VGIVNDLFGAGFDTISTALSWAVVYLVAY-PEIQERLHQELKEKVG----MIR-------TPRLSDKINL 370 93 VGIVNDLFGAGFDTISTALSWAVVYLVAY-PEIQERLHQELKEKVG----MIR-------TPRLSDKINL 370 94 VGIVNDLFGAGFDTISTALSWSVMYLVAY-PEIQERLYQEMNETVG----PDR-------TPCLSDKPKL 370 95 VGIVNDLFGAGFDTVSTGLSWSVMYLVAY-PEIQERLYQEIKDSVG----TER-------MPLLSDRPSL 370 96 VGIVNDLFGAGFDTVSTALSWSVMYLVAH-PEIQERLYQEIEDKVG----LDR-------MPLLSDKPNL 370 97 VGIVNDLFGAGFDTVSTALSWSVMYLVAH-PEIQERLHQEIKDKVG----LSR-------SPVLTDRHNL 367 98 VGIVNDLFGAGFDTVSTALSWSVMYLVAY-PDIQERLFQEIKDNVG----LDR-------TPLLSDRSKV 370 99 ITIVFDLFGAGFDTITTAISWSLMYLVTN-PRIQRKIQEELDTVIG----RDR-------QPRLSDRPQL 369 100 ITIVLDLFGAGFDTVTTAISWSLMYLVTN-PRVQRKIQEELDTVIG----RDR-------QPRLSDRPQL 369 101 INIIVDLFGAGFDTVTTAISWSLMYLVTN-PGVQRKIQEELDTVIG----RSR-------RPRLCDRSQL 369 102 IGIVLDLFGAGFDTITTAISWSLLYLVMN-PRIQKKIQEELDTVIG----RER-------QPQLADRPKL 361 103 VNVVLDLFGAGFDTVTTAISWSLLYLVTN-PNVQKKIQKELDTVIG----RAR-------QPRLSDRPQL 369 104 INIVLDLFGAGFDTVTTAISWSLMYLVMN-PRVQRKIQEELDTVIG----RSR-------RPRLSDRSHL 365 105 VNVVLDLFGAGFDTVTTAISWSLMYLVTN-PRVQRKIQEELDTVIG----RSR-------RPRLSDRSHL 365 106 VGIVLDLFGAGFDTVTTAISWSLMYLVTK-PRIQRKIQEELDAVVG----RAR-------RPRFSDRPQL 369 107 VNIVNDIFGAGFETVTTAIFWSILLLVTE-PKVQRKIHEELDTVIG----RDR-------QPRLSDRPQL 363 108 VNIVNDIFGAGFDTVTTAITWSILLLVTW-PNVQRKIHEELDTVVG----RDR-------QPRLSDRPQL 363 109 VNIVNDLFGAGFDTVTTAITLSILLLVTW-PNVQRKIHKELDTVIG----RDR-------QPLLSDRLQL 363 110 VNLINDIFGAGFDTVTTAISWSLMYLVAN-PEIQRKIQKELDTVIG----RAR-------QPRLSDRPQL 351 111 VNLVNDIFGAGFDTVTTAISWSLMYLVTK-PEIQRKIQKELDTVIG----RER-------RPRLSDRPQL 365 112 VNLVNDIFGAGFDTVTTAISWSLLYLVTK-PEIQKKIHKELDAVIG----RDR-------KPRLADRPQL 365 113 VNLVNDIFGAGFDTITTALSWSLMYLVTN-PRRQRKIQEELDAVVG----RAR-------QPRLSDRPQL 365 114 INLVNDIFGAGFDTVTTALSWSLMYLVTQ-PHSQKKIQEELDTAIG----RER-------RSWLSERSML 102 115 PATITDIFGASQDTLSTALLWLLILFTRY-PDVQARVQAELDQVVG----RDR-------LPCMSDQPNL 377 116 PATITDIFGASQDTLSTALLWLLILFTRY-PDVQARVQAELDQVVG----RDR-------LPCMSDQPNL 377 117 PATITDIFGASQDTLSTALQWLLLLFTRY-PDVQTRVQAELDQVVG----RDR-------LPCMGDQPNL 377 118 LATIGDIFGAGVETTTSVIKWIVAYLLHH-PSLKKRIQDDIDQIIG----FNR-------TPTISDRNRL 350 119 LATVADIFGAGVETSASVVKWIVAFLLHY-PLLRKKIQDAIDQNIG----FNR-------APSISDRNQL 350 120 LTTIGDIFGAGVETTTSVVKWTLAFLLHN-PQVKKKLYEEIDQNVG----FSR-------TPTISDRNRL 350 121 LVTVGDIFGAGIETTSSVLNWILAFLVHN-PEVKRKIQKEIDQYVG----FSR-------TPSFNDRTHL 349 122 LATVGDIFGAGIETTTTVLKWILAFLVHN-PEVKKKIQKEIDQYVG----FSR-------TPTFNDRSHL 349 123 LMTVGDIFGAGVETTTTVLKWAVLYLLHY-PEVQKKIQEEMDQKIG----LAR-------HPHLSDRPLL 353 124 LMTVGDIFGAGVETTSTVLKWAIAYLIHH-PQVQQRIQEELDSVVG----GDR-------TPQLSDRGSL 356 125 VMTVADIFGAGVETSSTAFAWMIIYLIHH-PEVQKKIQEEIDSNIG----FER-------TPKMSDKGNM 353 126 HMSVVDLFIGGTETTASTLSWAVAFLLHH-PEIQRRLQEELDRELGPGASCSR-------VT-YKDRARL 341 127 HMSVVDLFIGGTETKASTLSWAVAFLLHH-PEIQRRLQEELDRELGPGASCSG-------VT-YKDRARL 342 128 HMSVVDLFIGGTETTANTLSWAVVYLLHH-PEIQWRLQEELDRELGPGAAGSR-------VP-YKDRARL 341 129 HMAAVDLLIGGTETTANTLSWAVVFLLHH-PEIQQRLQEELDHELGPGASSSR-------VP-YKDRARL 342 130 HMSVVDLFIGGTETTATTLSWAVAFLLHH-PEIQKRLQEELDLKLGPG---SQ-------LL-YRNRMQL 334 131 KAVILDMFSGGTDTTAVTLEWAMAELIKH-PDVMEKAQQEVRRVVG----KKA-------KVEEEDLHQL 352 132 KAILLDSFAAGTDTTFATLDWTMAELLRQ-PRALKTLQDEVRGLQG----KSE--------ITEDDLKNM 354 133 KALLLDPFSAGTDTIYTVLEWTMTELLRH-PRAMEKLQNEVQGLAQ----EKA-------EITEDDLPNM 344 134 KAILLDAFAAGTDTIYTNLDWTMADVLRQ-PRAMKTLQNEVRGLAQ----GKS-------EITEDDLKNM 356 135 ---------------------------------------------------------------------- 0 136 KAIILDVFAAGTDTTAVVLEWAMTELLRH-PEIMKKLQSEVRQVVK----DKH-------NITDDDIEKM 356 137 KGILMNILTAGIDTSAQTMTWAMTHLLAN-PRVMKKLQAEIREKIK----NID-------EITDDDVEQL 346 138 KGILFNILNAGIDTSAQVMTWVMTYLISN-PRVMKKAQAEVREVIK----NKD-------DIIEEDIERL 0 139 KGFLANIFLAGIDTGALTMIWAMTELVKN-PKLIKKVQGEIREQLG----SNKA------RITEEDIDKV 71 140 KAFTQDMLAGGTESSAVTVEWAISELSKK-PEIFKKATEELDRVIG----QNR-------WVQEKDIPNL 0 141 KAVILDIVVAGTDTAAAAVVWGMTYLMKY-PQVLKKAQAEVREYMK----EKGST-----FVTEDDVKNL 350 142 IDVLVMYLNAGHESSGHITMWATVFLQEN-PDMFARAKAEQEAIMR----SIPSSQR---GLTLRDFRKM 352 143 VDFLVALLVAGYETTSTIMTLAVKFLTET-PLALAQLKEEHEKIRA----MKSDSY----SLEWSDYKSM 329 144 KGILVNMFEAAIETSFLVLEYSMSELMNN-RHVLAKLQKEVRT--ATPDGR---------MVMEEDLSRM 375 145 KAILVDMFEAGIETSYLTLEYGMAELINN-RHVMEKLQTEVRTTMGSPDGKKLD------MLAEEDLGSM 384 146 KSLLMNVFEAAIETSYLVLESAMAELMNH-RRVMKKLQAEVRAYGA---EKKLD------MIREDDLSSL 379 147 KAILIDMFEAGTDTSYMTLEFAMTELIRK-PHLMKKLQEEVRRNVPAGQE----------MVTEDNLPGM 386 148 KAILVDMFGAGTDTSSLVLELAMAELMRN-PQQMAKLQAQVRRHTPEGQE----------TVEEENLSDM 236 149 ---------------------------------------------------------------------- 0 150 TVIILEMFLAGTETTSSSVEWALTELLRH-PQAMAKVKLEILQVIG----PNK-------KFEECDIDSL 317 151 KIFVLEMFLAGTETTSSSVEWALTELLRH-PEAMAKVKTEISQAIE----PNR-------KFEDSDIENL 357 152 ---------------------------------------------------------------------- 0 153 KALLLNLFTAGTDTSSSVIEWALTEMMKN-PTIFKKAQQEMDQIIG----KNR-------RFIESDIPNL 352 154 KALLLNLFTAGTDTSSSAIEWALAEMMKN-PAILKKAQAEMDQVIG----RNR-------RLLESDIPNL 349 155 KALLLNLFTAGTDTSSSAIEWALAEMMKN-PAILKKAQGEMDQVIG----NNR-------RLLESDIPNL 349 156 ---------------------------------------------------------------------- 68 157 VAILWEMVFRGTDTTALLTEWCMAELVRH-PAVQARVRAEVDAAVG----AGG-------CPTDADVARM 345 158 VAVLWEMIFRGTDTVAILLEWTLARMVLH-PDIQSKAQVEIDSVVD----SSR-------PVLDSDIQRL 279 159 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQAKLRHELDTKLG----PGV-------QITEPDVQNL 354 160 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQQKVRDEIDRVLG----VGH-------QVTEPDIQKL 354 161 LYIVENINVAAIETTLWSIEWGIAELVNH-QDIQNKVREEMDRVLG----PGH-------QVTEPDLHKL 355 162 LYIVENINVAAIETTLWSIEWGIAELVNH-PEIQKKLRDELETVLG----PGV-------QITEPDTYKL 354 163 ---------------------------------------------------------------------- 0 164 LYIVENINVAAIETTLWSIEWGIAELVNH-QEIQNKLREEMDKVLG----PGH-------QVTEPDLEKL 352 165 VTLCSEFLNGGTDTTATALEWGIGRLMEN-PTIQNQLYQEIKTIVG-----DK-------KVDENDIEKM 349 166 VTLCSEFLNGGTDTTATAIEWAIGRLIEN-PNIQSQLYEEIKKTVG-----EN-------KIDEKDIEKM 364 167 KAQSQDITFAAVDNPSNAVEWALAEMVNN-PEVMAKAMEELDRVVG----RER-------LVQESDIPKL 400 168 NAMFMETFGPGSDTNSNIIEWALAQLIKN-PDKLAKLREELDRVVG----RSS-------TVKESHFSEL 339 169 IKAHIELILGGSDTTAGTLTWAMCLLLKH-PHVLEKLKEELNTYIG----KER-------CVNESDINKL 361 170 KALLLNMFTAGTDTSASTVDWAIAELIRH-PEIMRKAQEELDSVVG----RGR-------PINESDLSQL 64 171 ---------------------------------------------------------------------- 0 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 ---------------------------------------------------------------------- 97 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 KSLFV-LFSAGT---------------------------------------------------------- 146 180 ---------------------------------------------------------------------- 61 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 PYTDATVHEIQRYINLIPNNV--PRATTCNVKFRS--------YLIPKGTAVITSLTSMLYNDKE-FPNP 404 2 PYTDATVHEIQRYINLIPNNV--PHTTICNLKFRN--------YLIPKGTDVLTSLSSVLHDDKE-FPNP 404 3 PYTDATVHEIQRYINLVPNNV--PHATTCNVKFRN--------YFIPKGTAVLTSLTSVLHDNQE-FLKP 404 4 PYTDAMVHEIQRYINLIPNNV--PHAATCNVRFRN--------YVIPKGTDLLTSLTSVLHDDKE-FPNP 403 5 PYTDAVVHEIQRYIDLIPISL--PHAATRDIKFRN--------YLIPKGMTVLRSLTSVLHDDQE-FPNP 225 6 PYTEAVLHEIQRYIALLPSNL--PHATVRDTKFRE--------YIIPKGTTVLPLLSSVLHDCKE-FPNP 225 7 PYTDAVVHEIQRYIDLVPIGL--PHTVTRDIKFRN--------YLIPKGTTVLTSLTSVLNDDQE-FPNP 225 8 PYTDAVVHEIQRYIDLIPIGL--PHAVTRDIKFRN--------YLIPKGTTVLTSLTSVLRDDQE-FPNP 225 9 PYTDAVVHEIQRYIDLVPISL--PHAVTRDIKFRN--------YLIPKGTTVLTSLTSLLHDVQE-FPNP 225 10 PYTDAVIHEIQRFIDLLPTNL--PHAVTRDVKFRN--------YFIPKGTDIITSLTSVLHDEKA-FPNP 401 11 PYTDAVIHEIQRFIDLLPTNL--PHAVTRDVRFRN--------YFIPKGTDIITSLTSVLHDEKA-FPNP 401 12 PYTDAVIHEIQRFIDLVPNNL--PHTVTRDIKFRN--------YFIPKGTDIMTSLTSVLHDEKA-FPNP 401 13 PYTDAVIHEIQRYIDLIPINL--PHAVTRDIKFRN--------YFIPKGMNIITSLTSVLHDEKE-FPNP 292 14 PYTDAVVHEVQRYIDLLPTSL--PHAVTCDIKFRN--------YLIPKGTTILISLTSVLHDNKE-FPNP 404 15 PYTDAVLHEIQRYIDLVPSNL--PHAVTQDVKFRE--------YLIPKGTAILTSLTSVLHDGKE-FPNP 198 16 PYTDAVIHEIQRYIDMVPNNV--PHAVTQDIQFRG--------YLIPKGTHILPSLTSVLYDEKE-FPNP 403 17 PYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRN--------YLIPKGTTILTSLTSVLHDNKE-FPNP 404 18 PYTDAVVHEIQRYIDLLPTNL--PHAVTCDVKFKN--------YLIPKGTTIITSLTSVLHNDKE-FPNP 404 19 PYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFRN--------YLIPKGTTIMALLTSVLHDDKE-FPNP 404 20 PYTDAVIHEIQRYIDLVPTGV--PHAVTTDIKFRN--------YLIPKGTIIITLLTSVLHDDKE-FPNP 404 21 PYTDAVVHEIQRYIDLVPTNL--PHLVTRDIKFRN--------YFIPKGTNVIVSLSSILHDDKE-FPNP 404 22 PYTDAMIHEVQRFINFVPTNL--PHAVTCDIKFRN--------YLIPKGTKVLTSLTSVLHDSKE-FPNP 404 23 PYTDAMIHEVQRFIDLLPTSL--PHAVTCDIKFRK--------YLIPKGTTVITSLSSVLHDSKE-FPNP 404 24 PYTDAHDHEVQRFIDLIPTNL--PHAVTCDIKFRN--------YLIPKGTTIITSLSSVLHDSKE-FPDP 404 25 PYTNAMVHEVQRYIDIGPNGL--LHEVTCDTKFRN--------YFIPKGTAVLTSLTSVLHDSKE-FPNP 404 26 PYTNAMIHEVQRYIDLAPNGL--LHEVTCDTKFRD--------YFIPKGTAVLTSLTSVLHARKE-FPNP 404 27 PYTDAVVHEIQRYIDLVPNNL--PHSVTQDIKFRE--------YLIPKGTTILTSLTSVLHDEKG-FPNP 371 28 PYTDAVMHEIQRYVDLVPTSL--PHAVTQDIEFNG--------YLIPKGTDIIPSLTSVLYDDKE-FPNP 404 29 PYTDAVLHEIQRYIDFVPIPL--PRKTTQDVEFRG--------YHIPKGTSVMACLTSALHDDKE-FPNP 403 30 PYTDAVLHEIQRYITLVGSSL--PHAVVQDTKFRD--------YVIPKGTTVLPMLSSVMLDQKE-FANP 408 31 PYTDAMIHEVQRFIDLIPISL--PHAVTCDIKFRD--------YFIPKGTTVITSLSSVLHDNKE-FPNP 404 32 PYTDAMIHEVQRFIDLIPTNL--PHAVTCDIKFRD--------YFIPKGTTIITSLSSVLHDSKE-FPNP 404 33 PYTDAMIHEVQRFIDLIPTNL--PHAVTCDIKFRD--------YFIPKGTTIITSLSSVLHDSKE-FPNP 404 34 PYTDAMVHEVQRYVNLIPNNV--PHAATCNVKFRN--------YVIPKGTDLITSLTSVLHDDKE-FPNP 404 35 PYMDAVVHEIQRFIDLVPSNL--PHEATRDTTFQG--------YVIPKGTVVIPTLDSLLYDKQE-FPDP 406 36 PYMDAVVHEIQRFIDLVPSNL--PHEATRDTTFQG--------YVIPKGTVVIPTLDSLLYDKQE-FPDP 406 37 PYMDAVVHEIQRFINLVPSNL--PHEATRDTVFQG--------YVIPKGTVVIPTLDSLLYDSHE-FPDP 406 38 PYMDAVVHEIQRFINLVPSNL--PHEATRDTVFRG--------YVIPKGTVVIPTLDSLLFDNYE-FPDP 406 39 PYMDAVVHEIQRFISLIPSNL--PHEATRDTMFRG--------YVIPKGTVVIPTLDSLLYDSQE-FPDP 406 40 PYMHAVVHEIQRFITLVPSNL--PHEATRDTIFRG--------YIIPKGTVIVPTLDSVLYDNQE-FPDP 406 41 PYMHAVVHEIQRFITLVPSNL--PHEATRDTIFRG--------YIIPKGTVIVPTLDSVLYHNQE-FPDP 362 42 PYTDAVIHEIQRFIDFLPLNV--PHAVIKDTKLRD--------YFIPKDTMIFPLLSPILQDCKE-FPNP 405 43 PYTDAVIHEIQRFIDFLPVNL--PRAVIKDTKLRD--------YFIPKDTMIFPLLSPILQDCKE-FPNP 405 44 PYTDAVIHEVQRFADIIPMNL--PHRVTRDTAFRG--------FLIPKGTDVITLLNTVHYDPSQ-FLTP 405 45 PYTDAVIHEVQRFADVIPMNL--PHRVTRDTPFRG--------FLIPKGTDVITLLNTVHYDSDQ-FKTP 405 46 PYTDAVIHEIQRLGDLIPFGV--PHTVTKDTQFRG--------YVIPKNTEVFPVLSSALHDPRY-FETP 405 47 PYTDAVIHEIQRLGDLIPLGV--PHMVTKDTQFRG--------YVIPKNTEVFPVLSSALHDPRY-FETP 405 48 PYTDAVIHEIQRFGDLLPIGV--PHMVTKDICFRG--------YIIPKGTEVFPILHSALNDPHY-FEKP 405 49 PYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRG--------YIIPKDTEVFLILSTALHDPHY-FEKP 405 50 PYTEAVIHEIQRFADLLPMGV--PHIVTQQTSFRG--------YIIPKDTEVFPLLSTALHDPHY-FEKP 405 51 PYTEAVIHEIQRFSDLAPIGT--PHRVIKDTIFRG--------YLLPKNTEVFPILSSVLHDPQY-FEQP 404 52 PYTDAVIHEIQRFADLAPIGL--PHRVTKDTMFRG--------YLLPKNTEVYPILSSALHDPQY-FDHP 405 53 PYTDAVIHEIQRFSDLVPIGV--PHRVTKDTMFRG--------YLLPKNTEVYPILSSALHDPQY-FDHP 405 54 PYTDAVIHEIQRFSDLIPIGV--PHKVTKDTLFRG--------YLLPKNTEVYPILSSALHDPQY-FEQP 405 55 PYTDAVIHEIQRFADLTPIGL--PHRVTKDTVFRG--------YLLPKNTEVYPILSSALHDPRY-FEQP 406 56 PYTDAVIHEIQRFADLIPIGL--PHRVTNDTMFLG--------YLLPKNTEVYPILSSALHDPRY-FDHP 406 57 PYTDAVIHEIQRFSDLVPIGL--PHKVIKDTLFRG--------YLLPKNTEVYPVLSSALHDPQY-FEQP 405 58 PYTDAVIHEIQRFSDIVPIGL--PHKVIKDTLFRG--------YLLPKNTEVYPILSSALHDPQY-FEQP 405 59 PYTEAVIHEIQRFSDVSPMGL--PCRITKDTLFRG--------YLLPKNTEVYFILSSALHDPQY-FEQP 405 60 PYTDAVIHEIQRLTDIVPLGV--PHNVIRDTHFRG--------YFLPKGTDVYPLIGSVLKDPKY-FRYP 408 61 PFTDAVIHEIQRLTDIVPMGV--PHNVIRDTHFRG--------YLLPKGTDVFPLLGSVLKDPKY-FCHP 408 62 PYTDAVLHEAQ-----LPMGI--PRTLMRDTRFRG--------YTLPQGTEVFPLLGSILHEPKH-FKHP 0 63 ---------------------------------------------IPKGTTVITNL--VHFDEKY-WRDP 0 64 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVYPMLGSVLRDPSF-FSNP 408 65 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVFPMLGSVLRDPSF-FSNP 408 66 PYTEAVIHEIQRFADLIPMGL--ARRVTKDTKFRD--------FLLPKGTEVFPMLGSVLKDPKF-FSNP 408 67 PYTEAVIHEIQRFADMIPMGL--ARRVTKDTKFRD--------FLLPKGTEVFPMLGSVLKDPKF-FSNP 408 68 PYTEAVIHEIQRFADMIPMGL--ARRVTKDTKFRE--------FLLPKGTEVFPMLGSVLKDPKF-FSNP 408 69 PYTEAVIYEIQRFVDVVPLGL--PRSTTKDIKFRD--------FLIPKGTDVFPVLSSVLKDPKF-FSNP 408 70 PYTQAVINEIQRFSNLAPLGI--PRRIIKNTTFRG--------FFLPKATDVFPILGSLMTDPKF-FPSP 406 71 PYTQAVINEIQRFSNFAPLGI--PRRITKNTSFRG--------FFLPKATEVFPILGSLMTDPKF-FSSP 406 72 PYTQAVINEIQRFSNLAPLGI--PRRIIKNTTFRG--------FFLPKGTDVFPIIGSLMTEPKF-FPNH 406 73 PYTEAVINEIQRFANLAPCGI--PRKTIKNTTFRG--------FFLPKDTDVYPILGSLLTDPKF-FTSP 200 74 PYTEAVIHEIQRFTDMIPMGL--AHRVTRDTKFRD--------FLLPKGAEVFPMLGSVLKDPKF-FSKP 408 75 PYTEAVIHEIQRFTDMIPMGL--ARRVTRDTKFRD--------FLLPKGTEVFPMLGSVLKDPKF-FSKP 408 76 PYTDAVIHEIQRFSDVIPMNV--PHLVTKDTQFRG--------YTIPKGTDVYPLLCAVLRDPEK-FATP 408 77 ---------------------------------------------------------------------- 120 78 PYTDAVIHETQRLANIVPMSV--PHTTSRDVTFQG--------YFIKKGTSVIPLLTSVLQDDSE-WESP 414 79 PYTDAVIHEVQRYMDLSPTSV--PHKVMRDTEFYN--------YHIPEGTMVLPLLSSVLVDPKL-FKNP 410 80 PYTNAVIHEVQRMGNILPLNV--PREVTVDTTLAG--------YHLPKGTVVLTNLTALHKDPEE-WATP 417 81 PYTNAVIHEVQRFGDIAPLNL--PRFTSCDIEVQD--------FVIPKGTTLIINLSSVLKDETV-WEKP 414 82 PYTNAVIHEVQRFGDIAPLNL--PRITSCDIEVQD--------FVIPKGTTLIINLSSVLKDETV-WEKP 414 83 PYTNAVIHEVQRFGDIVPVNL--PRITSHDIEVQD--------FLIPKGTILLPNMSSMLKDESV-WEKP 414 84 PYTNAVIHEVQRFGDIAPLNL--PRITSRDIEVQD--------FLIPKGSILIPNMSSVLKDETV-WEKP 414 85 PYTNAVIHEVQRFGTLLHCLCH-ASQVVTFTQVQD--------FLVTKGSTLIPNLSSVLKGETV-WEKP 415 86 PFTNAVIHEVQRFADIVPMNL--PHKTSRDIEVQG--------FLIPKGTTLIPNLSSVLKDETV-WEKP 414 87 PLTNAVIHEVQRFADIVPTNI--PHMTSRDIKFQG--------FLIPKGTTLIPNLSSVLEDETV-WEKP 414 88 PFTNAVIHEVQRFADILPLGV--PHKTSRDIEVQG--------FLIPKGTTLITNLSSVLKDETV-WEKP 414 89 PYTTAVIHEVQRFGDIVPLGM--THMTSRDIEVQG--------FRIPKGTTLITNLSSVLKDEAV-WEKP 411 90 PFTVAVVHEVQRFADIVPLGL--PHMTSRDIEVQG--------FHIPKGTTLITNLSSVLKDETV-WEKP 414 91 PFTVAVIHEVQRFGDIVPLGV--PHMTSRDTEVQG--------FLIPKGTTLITNLSSVLKDEKV-WKKP 414 92 PLLEAFILEIFRHSSFLPFTI--PHCTIKDTSLNG--------YFIPKDTCVFINQWQVNHDPDL-WKEP 429 93 PLLEAFILEIFRHSSFLPFTI--PHCTIKDTSLNG--------YFIPKDTCVFINQWQVNHDPEL-WKEP 429 94 PFLEAFILETFRHSSFLPFTI--PHCTSKDTSLNG--------YFIPKDTCVFINQWQINHDAEL-WKDP 429 95 PFLDAFILEIFRHSSFLPFTI--PHCTTKNTSLNG--------YFIPKDTCVFINQWQINHDPEL-WKDP 429 96 PFLEAFILEILRHSSFLPFTI--PHCTTKDTSLNG--------YFIPKDTCVFINQWQINHDPEL-WKDP 429 97 PILEAFIFEIFRHSSFLPFTI--PHCATKDTSLDG--------YFIPKDTCVFINQWQINHDPEL-WKEP 426 98 PYLEAFILELFRHSSFLPFTI--PHCSAKDTSLNG--------YFIPKDTCVFINQWQINRDPEL-WKDP 429 99 PYLEAFILETFRHSSFVPFTI--PHSTIRDTSLNG--------FYIPKGHCVFVNQWQVNHDQEL-WGDP 428 100 PYLEAFILETFRHSSFVPFTI--PHSTTRDTSLNG--------FYIPKGCCVFVNQWQVNHDREL-WGDP 428 101 PYLEAFILETFRHSSFLPFTI--PHSTTRDTSLCG--------FYIPKGHCVFVNQWQINHNQEL-WGDP 428 102 PYMEAFISEVFRYSSFMPFTI--PHSTTKDTSLNG--------FYIPKGCCIFVNQWQINHDQKL-WGDP 420 103 PYMEAFILETFRHASFVPFTI--PHSTTRDTSLSG--------FYIPKGRCVFVNQWQINHDQKL-WGNP 428 104 PYMEAFILETFRHSSFVPFTI--PHSTTRDTSLKG--------FYIPKGRCVFVNQWQINHDQKL-WVNP 424 105 PYMEAFILETFRHSSFVPFTI--PHSTTRDTSLKG--------FYIPKGRCVFVNQWQINHDQKL-WVNP 424 106 PYLEAVIMETFRHTSFLPFTI--PHSTTRDTSLGG--------FYIPKGRCVFVNQWQNNHDPEL-WGDP 428 107 PYLEAFILEIYRYTSFVPFTI--PHSTTRDTSLNG--------FHIPKECCIFINQWQVNHDEKQ-WKDP 422 108 PYLEAFILEIYRYTSFVPFTI--PHSTTRDTSLNG--------FHIPKERCIYINQWQVNHDEKQ-WKDP 422 109 PYMEAFILELYRYTSFVPFTI--PHSTTRDTSLNG--------FYIPKDRCIFINQWQVNHDEKQ-WKDP 422 110 PLMEAFILEIFRHTSFVPFTI--PHSTTKDTTLKG--------FYIPKECCVFINQWQVNHDQQV-WGDP 410 111 PYLEAFILETFRHSSFLPFTI--PHSTTRDTTLNG--------FYIPKKCCVFVNQWQVNHDPEL-WEDP 424 112 PYMEAFILEVFRYSSFLPFTI--PHCTTRDTILNG--------FYIPKDRCVFINQWQVNHDPKQ-WEDP 424 113 PYLEAFILELFRHTSFVPFTI--PHSTTRDTTLNG--------FHIPKECCIFINQWQINHDPQL-WGDP 424 114 PYKEAFILETVPTWQFVPFTI--PHSTTRDTTLNG--------FHIPKECCVFVNQWQVNHEAEL-WEDP 161 115 PYVMAFLYESMRFSSFLPVTI--PHATTANTFVLG--------YYIPKNTVVFVNQWSVNHDPAK-WPNP 436 116 PYVMAFLYESMRFTSFLPVTL--PHATTANTFVLG--------YYIPKNTVVFVNQWSVNHDPAK-WSNP 436 117 PYVLAFLYEAMRFSSFVPVTI--PHATTANTSVLG--------YHIPKDTVVFVNQWSVNHDPVK-WPNP 436 118 VLLEATIREVLRIRPVAPTLI--PHKAVIDSSIGD--------LTIDKGTDVVVNLWALHHSEKE-WQHP 409 119 VLLEATIREVLRFRPVSPTLI--PHRAIIDSSIGE--------FTIDKATDVVVNLWALHHNEKE-WLRP 409 120 LLLEATIREVLRLRPVAPMLI--PHKANVDSSIGE--------FAVDKGTEVIINLWALHHNEKE-WHQP 409 121 LMLEATIREVLRIRPVAPLLI--PHKANIDSSIGE--------FAIPKDTHVIINLWALHHDKNE-WDQP 408 122 LMLEATIREVLRIRPVAPMLI--PHKANVDSSIGE--------FTVPKDTHVVVNLWALHHDENE-WDQP 408 123 PYLEATISEGLRIRPVSPLLI--PHVSLADTSIGE--------YSIPKGARVVINLWSVHHDEKE-WDKP 412 124 PYLEATIREVLRIRPVAPLLI--PHVAQTDTSIGK--------FTVRKGARIIINLWSLHHDEKE-WKNP 415 125 NFLNATIHEILRIQPVSPLLI--PHVALADSSIGD--------YTIPKGTRVIINLWAIHHDEKE-WKNP 412 126 PLLNATIAEVLRLRPVVPLAL--PHRTTRPSSIFG--------YDIPEGMVVIPNLQGAHLDETV-WEQP 400 127 PLLNATIAEVLRLRPVVPLAL--PHRTTRPSSIFG--------YDIPEGMVVIPNLQGAHLDETV-WEQP 401 128 PLLNATIAEVLRLRPVVPLAL--PHRATRPSSIFG--------YDIPEGTVVIPNLQGAILDETV-WEQP 400 129 PLLNATIAEVLRLRPVVPLAL--PHRTTRPSSISG--------YDIPEGTVIIPNLQGAHLDETV-WERP 401 130 PLLMATIAEVLRLRPVVPLAL--PHRATRASSISG--------YDIPKDMVIIPNIQGANLDEMV-WELP 393 131 HYLKLIIKETLRLHPVAPLLV--PRESTRDVVIRG--------YHIPAKTRVFINAWAIGRDPKS-WENA 411 132 QYLRAVIKESLRLHPTQSLLV--PRESMEDVNLLG-------YYHIPARTQAIINAWAIGRDPLS-WENP 414 133 HYLKAVIKETLRLHPPIPLLL--P---------------------------------------------- 366 134 QYLRAVIKESLRLHPPNSLLV--PRESMEDVKLLG-------YYHIPARTQALINVWAIGRDPLS-WENP 416 135 ---------------------------------------------------------------------- 0 136 HYLKAVMKETMRFHTPIPLLV--PRVARNDVEVMG--------YDVPVGTMVMINAWAIGRDPTS-WDEP 415 137 DYFKLVLKETFRISPIVPVLV--PRVAAKDLKIAG--------YDVPEKTWIHVNMWAVHMSPSI-WKDP 405 138 EYLKMVVKETFRVLPLVPLLI--PREASKDVKIGG--------YDIPKKTWIHVNIWAIHRNPNV-WKDP 0 139 PYLKMVVKETFRLHPAAPLIL--P-G-MAYIKVQG----------------------------------- 102 140 PYIEAIVKETMRLHPVAPMKA---TECRENSKVAG--------YDVQKGTRVLVSVWTIGRDPTL-WDEP 0 141 PYFRALVKETLRIEPVIPLLI--PRACIQDTKIAG--------YDIPAGTTVNVNAWAVSRDEKE-WGPN 409 142 EYLSQVIDETLRLVNISFVSF---RQATRDVFVNG--------YLIPKGWKVQLWYRSVHMDPQV-YPDP 410 143 PFTQCVVNETLRVANIIGGVF---RRAMTDVEIKG--------YKIPKGWKVFSSFRAVHLDPNH-FKDA 387 144 PYLKATIKESMRIHPPAPFLL--PHFSTHDCEING--------YTIPAGTRVIVNAWALARDPTC-WDKA 434 145 PYLKATIKETLRLHPPAPFLL--PHYSTADSEIDG--------YFVPAGTRVLVHAWALGRDRTT-WEKP 443 146 PYLKASMKEALRLHPPGPLLL--PHYSTADCQIDG--------YHIPANPRVLVNGWAIGRDPAV-WEKP 438 147 TDLKAVIKETLRLHPPVPLLL--PHYSLDACEVAG--------YTIPANTRVVVNAWALGRHSGY-WERE 445 148 PFLRAVVKETLRLHPPAPLLV--PHLSLADCVVDG--------YHVPSGTRVIINAWALGRDPGE-WEKP 295 149 DVLYRCIKEALRLHPPLIMLL--RQSHSDFTVTTKEGKE----YDIPKATSS------------------ 46 150 PYMQAVLKEQLRLHPPLPLLI--PRKAIQDTKFMG--------YDIPKGTQVLVNAWAIGRDPEY-WDNP 376 151 PYMQAVLKESLRLHPPLPFLI--PRETIQDTKFMG--------YDVPKDTQVLVNAWAIGRDPEC-WDDP 416 152 ---------------------------------------------------------------------- 0 153 PYLRAICKEAFRKHPSTPLNL--PRVSSDACTIDG--------YYIPKNTRLSVNIWAIGRDPDV-WENP 411 154 PYLRAICKETFRKHPSTPLNL--PRISNEPCIVDG--------YYIPKNTRLSVNIWAIGRDPQV-WENP 408 155 PYLRAICKETFRKHPSTPLNL--PRISNEPCIVDG--------YYIPKNTRLSVNIWAIGRDPEV-WENP 408 156 ---------------------------------------------------------------------- 68 157 PYLQAVVKETLRAHPPGPLLSWARLATADVPLCNG--------MVVPAGTTAMVNMWAITHDAAV-WADP 406 158 PYLQSIVKETLRMHPPGPLLSWARLAIHDVPV-DG--------HMIPAGTTAMVNMWAITHDECN-WAEP 339 159 PYLQAVVKETLRLRMAIPLLV--PHMNLHDAKLGG--------FDIPAESKILVNAWWLANNPDQ-WKKP 413 160 PYLQAVVKETLRLRMAIPLLV--PHMNLHDAKLGG--------YDIPAESKILVNAWWLANNPAH-WKKP 413 161 PYLQAVIKETLRLRMAIPLLV--PHMNLHDPKLNG--------FDIPAESKILVNAWWLPNNPAH-WKKP 414 162 PYLQAVIKETLRLRMAIPLFL--PHMNLHDAKLGG--------YDIPAESKILVNAWFLANNPEH-WKKP 413 163 ---------------------------------------------------------------------- 0 164 PYLQAVIKETLRLRMAIPLLV--PHMNLHDAKLGG--------FDIPAETKILVNAWWLRNNPAL-WKKP 411 165 PYLNAVVKELLRKHPPTYFTL--THSVTEPVKLAG--------YDIPMDTNVEFFVHGISHDPNV-WSDP 408 166 PYLNAVVKELLRKHPPTYMSL--THAVTEPAKLGG--------YDIPTGVNVEIFLPGISDDPNL-WSEP 423 167 NYVKACIREAFRLHPVAPFNV--PHVALADTTIAG--------YRVPKGSHVILSRTGLGRNPRV-WDEP 459 168 PYLQACVKETMRLYPPISIMI--PHRCMETCQVMG--------YTIPKGMDVHVNAHAIGRDPKD-WKDP 398 169 VYLHAIIKETLRLYPPAPFSS--PREFTEDCTIGG--------YHIKKGTRLMPNLWKIHRDPSV-WPDP 420 170 PYLQAVIKENFRLHPPTPLSL--PHIASESCEIHG--------YHIPKGSTLLTNIWAIGRD-------- 116 171 HYLKMVINETWRLHPPAPLLV--PREVMSIFEING--------YTIPAKTRLYVNVWGIGRDPDT-WKDP 59 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 ---------------------------------------------------------------------- 97 175 ---------------------------------------------------------------------- 0 176 ---------------------------------------------------------------------- 0 177 ---------------------------------------------------------------------- 0 178 ---------------------------------------------------------------------- 0 179 ---------------------------------------------------------------------- 146 180 ---------------------------------------------------------------------- 61 181 ---------------------------------------------------------------------- 0 182 ---------------------------------------------------------------------- 0 183 ---------------------------------------------------------------------- 0 184 ---------------------------------------------------------------------- 0 185 ---------------------------------------------------------------------- 0 186 ---------------------------------------------------------------------- 0 187 ---------------------------------------------------------------------- 0 188 ---------------------------------------------------------------------- 0 189 ---------------------------------------------------------------------- 0 190 ---------------------------------------------------------------------- 0 191 ---------------------------------------------------------------------- 0 192 ---------------------------------------------------------------------- 0


1 -DRFDPGHFLDASG--------------------KFRKSDYFMPFSTGKRVCVGEALVRMELFLF-LTAI 452 2 -DRFDPGHFLDASG--------------------NFRKSDYFMPFSTGKRVCVGEALARMELFLF-LTAI 452 3 -DKFDPGHFLDASG--------------------NFKKSDYFMPFSTGKRVCMGEALARMELFLF-LTAI 452 4 -EVFVPGHFLDKNG--------------------NFKKSDYFMPFSTGKRMCVGEALARMELFLL-LTTI 451 5 -EV------------------------------------------------------------------- 227 6 -EK------------------------------------------------------------------- 227 7 -EV------------------------------------------------------------------- 227 8 -EV------------------------------------------------------------------- 227 9 -EV------------------------------------------------------------------- 227 10 -KVFDPGHFLDESG--------------------NFKKSDYFMPFSAGKRMCVGEGLARMELFLF-LTSI 449 11 -KVFDPGHFLDESG--------------------NFKKSDYFMPFSAGKRMCVGEGLARMELFLF-LTSI 449 12 -KVFDPGHFLDESG--------------------NFKKSDYFMPFSAGKRICVGEALARMELFLF-LTSI 449 13 -KVFDPGHFLDESG--------------------NFKKSDYFMPFSAGKRMCVGEGLARMELFLF-LTSI 340 14 -EMFDPHHFLDEGG--------------------NFKKSKYFMPFSAGKRICVGEALAGMELFLF-LTSI 452 15 PGQFDPAHFLDESG--------------------NFKKTDHFMAFSAGKRVCVGEGLARMELFLL-LVSI 247 16 -EKFDPGHFLDASG--------------------NFKKSDYFLPFSIGKRACAGEGLARMELFLV-LTTI 451 17 -EMFDPRHFLDEGD--------------------NFKKSNYFMPFSAGKRICVGEGLARMELFLF-LTFI 452 18 -EMFDPGHFLDKSG--------------------NFKKSDYFMPFSAGKRMCMGEGLARMELFLF-LTTI 452 19 -NIFDPGHFLDKNG--------------------NFKKSDYFMPFSAGKRICAGEGLARMELFLF-LTTI 452 20 -KIFDPGHFLDENG--------------------NFKKSDYFMPFSAGKRICAGEGLARMELFLF-LTTI 452 21 -EKFDPGHFLDERG--------------------NFKKSDYFMPFSAGKRICAGEALARTELFLF-FTTI 452 22 -EMFDPGHFLDENG--------------------NFKKSDYFLPFSAGKRACVGEGLARMQLFLF-LTTI 452 23 -EMFDPGHFLNGNG--------------------NFKKSDYFMPFSTGKRICAGEGLARMELFLI-LTTI 452 24 -EIFDPGHFLDGNG--------------------KFKKSDYFMPFSAGKRMCAGEGLARMELFLF-LTTI 452 25 -EMFDPGHFLDENG--------------------NFKKSDYFIPFSAGKRMCLGESLARMELFLF-LTTI 452 26 -EMFDPGHFLDENG--------------------NFKKSDYFMPFSAGKRKCVGEGLASMELFLF-LTTI 452 27 -DQFDPGHFLDENG--------------------SFKKSDYFMAFSAGKRVCVGEGLARMELFLL-LTNI 419 28 -EKFDPGHFLDESG--------------------NFKKSDYFMPFSAGKRACVGEGLARMELFLL-LTTI 452 29 -EKFDPGHFLDEKG--------------------NFKKSDYFMAFSAGRRACIGEGLARMEMFLI-LTSI 451 30 -EKFDPGHFLDKNG--------------------CFKKTDYFVPFSLGKRACVGESLARMELFLF-FTTL 456 31 -EVFDPGHFLDKNG--------------------NFKKSDYFMPFSAGKRICAGEGLARMELFLF-LTTI 452 32 -EVFDPGHFLDKNG--------------------NFKKSDYFMPFSTGKRMCAGEGLARMELFLF-LTTI 452 33 -EVFDPGHFLDKNG--------------------KFKKSDYFMPFSTGKRMCAGEGLARMELFLF-LTTI 452 34 -KIFDPAHFLDENG--------------------NFKKSDYFMPFSIGKRMCMGEALARMELFLL-LTTI 452 35 -EKFKPEHFLNEEG--------------------KFKYSDYFKPFSAGKRVCVGEGLARMELFLL-LSAI 454 36 -EKFKPEHFLNEEG--------------------KFKYSDYFKAFSAGKRVCVGEGLARMELFLL-LSAI 454 37 -EKFKPEHFLNENG--------------------KFKYSDYFKAFSAGKRVCVGEGLARMELFLL-LSAI 454 38 -ETFKPEHFLNENG--------------------KFKYSDYFKAFSAGKRVCVGEGLARMELFLL-LSAI 454 39 -EKFKPEHFLNENG--------------------KFKYSDHFKAFSAGKRVCVGEGLARMELFLL-LTAI 454 40 -EKFKPEHFLNENG--------------------KFKYSDYFKPFSTGKRVCAGEGLARMELFLL-LCAI 454 41 -EKFKPEHLVDESG--------------------KFKYSDYFKPFSAGKRVCAGEGLARMELFLL-LSAI 410 42 -EKFDPGHFLNANG--------------------TFRRSDYFMPFSAGKRICAGEGLARMEIFLF-LTSI 453 43 -EKFDPGHFLNANG--------------------TFRKSNYFMPFSAGKRICAGEGLARMELFLF-LTSI 453 44 -QEFNPEHFLDANQ--------------------SFKKSPAFMPFSAGRRLCLGELLARMELFLY-LTAI 453 45 -QEFNPEHFLDDNH--------------------SFKKSPAFMPFSAGRRLCLGEPLARMELFIY-FTSI 453 46 -NTFNPGHFLDANG--------------------ALKRNEGFMPFSLGKRICLGEGIARTELFLF-FTTI 453 47 -NTFNPGHFLDADG--------------------ALKRIEGFMPFSLGKRICLGEGIARTELFLF-FTTI 453 48 -DVFNPDHFLDANG--------------------ALKKNEAFIPFSIGKRICLGEGIARMELFLF-FTTI 453 49 -DAFNPDHFLDANG--------------------ALKKTEAFIPFSLGKRICLGEGIARAELFLF-FTTI 453 50 -DTFNPDHFLDANG--------------------ALKKNEAFIPFSLGRRMCLGEGIARNELFLF-FTTI 453 51 -DIFNLQHFLDANG--------------------ALKIIEAFLPFSTGKRICLGESIARNELFLF-FTTI 452 52 -DTFNPEHFLDADG--------------------TLKKSEAFMPFSTGKRICLGEGIARNELFLF-FTTI 453 53 -DSFNPEHFLDANG--------------------ALKKSEAFMPFSTGKRICLGEGIARNELFLF-FTTI 453 54 -DSFNPDHFLDANG--------------------ALKKSEAFLPFSTGKRICLGESIARNELFLF-FTSI 453 55 -DTFNPEHFLDANG--------------------ALKKSEAFLPFSTGKRICLGEGIARNELFIF-FTAI 454 56 -DTFNPEHFLDVNG--------------------TLKKSEAFLPFSTGKRICLGEGIAQNELFIF-FTAI 454 57 -DKFNPEHFLDANG--------------------ALKKCEAFLPFSTGKRICLGESIARNELFIF-FTTI 453 58 -DSFNPDHFLDANG--------------------ALKKSEAFLPFSTGKRICLGESIARNELFLF-FTSI 453 59 -DTFNPEHFLDANG--------------------ALKKCEAFMPFSIGKRMCLGEGIARSELFLF-FTTI 453 60 -EAFYPQHFLDEQG--------------------RFKKNDAFVAFSSGKRICVGEALARMELFLY-FTSI 456 61 -DDFYPQHFLDEQG--------------------RFKKNEAFVPFSSGKRICLGEAMARMELFLY-FTSI 456 62 -EEFNPDRFLDADG--------------------RFRKHEAFLPFSLGKRFCLGEGLGKSDLF------- 0 63 -EVF-PERFLDSSG-------------------IFWPRREALVPFSLGRRHCLGEHLARME-FLF-FTAL 0 64 -QDFNPQHFLNEKG--------------------QFKKSDAFVPFSIGKRNCFGEGLARMELFLF-FTTV 456 65 -QDFNPQHFLDDKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-FTTV 456 66 -KDFNPKHFLDDKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-LTNI 456 67 -KDFNPKHFLDDKG--------------------QFKKNDAFVPFSIGKRYCFGEGLARMELFLF-LTNI 456 68 -NDFNPKHFLDDKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-LTNI 456 69 -NDFNPQHFLDDKG--------------------QFKKSNAFMPFSVGKRYCFGESLAKMELFIF-FTTI 456 70 -KDFDPQNFLDDKG--------------------QLKKNAAFLPFSTGKRFCLGDGLAKMELFLL-LTTI 454 71 -KDFNPQHFLDDKG--------------------QLKKIPAFLPFSTGKRFCLGDSLAKMELFFL-FTTI 454 72 -KDFNPQHFLDDKG--------------------QLKKNAAFLPFSIGKRFCLGDSLAKMELFLL-LTTI 454 73 -KHFNPQNFLDDRG--------------------QLKKIAAFVPFSVGKRFCLGDGLARMELFLF-LTTI 248 74 -REFYPQHFLDEKG--------------------QFKKSDAFMPFSVGKRYCLGEGLARMELFLF-FTTI 456 75 -REFYPQHFLDEKG--------------------QFKKSDAFMPFSVGKRYCLGEGLARMELFLF-FTTI 456 76 -YEFNPNHFLDDNG--------------------CFKSNDGFMPFSTGKRICLGEGLARMELFLF-LTNI 456 77 ---------------------------------------------------------------------- 120 78 -NTFNPSHFLDEQG--------------------GFVKRDAFMAFSAGRRVCLGEGLARMELFLF-FTSL 462 79 -DEFDPENFLDENG--------------------VFKKNDGFFAFGVGKRACPGEALARVELFLF-FTSV 458 80 -DTFNPEHFL-ENG--------------------QFKKKEAFIPFSIGKRACLGEQLAKSELFIF-FTSL 464 81 -HRFHPEHFLDAQG--------------------NFVKHEAFMPFSAGRRACLGEPLARMELFLF-FTCL 462 82 -LRFHPEHFLDAQG--------------------NFVKHEAFMPFSAGRRACLGEPLARMELFLF-FTCL 462 83 -LRFHPEHFLDAQG--------------------HFVKPEAFMPFSAGRRSCLGEALARMELFLF-FTCL 462 84 -LRFHPEHFLDAQG--------------------HFVKPEAFMPFSAGRRSCLGEPLARMELFLF-FTCL 462 85 -LRFHPEHFLDAQG--------------------HFVKPEAFMPFSAGHRSCLGEALARMELFLF-FTCL 463 86 -LRFHPEHFLDAQG--------------------NFVKHEAFMPFSAGRRACLGEPLARMELFLF-FTCL 462 87 -LRFHPEHFLDAQG--------------------NFVKHEAFMPFSAGRRACLGEPLARMELFLF-FTCL 462 88 -LRFHPEHFLDAQG--------------------NFVKHEAFMPFSAGRRACLGEPLARMELFLF-FTCL 462 89 -FRFHPEHFLDAQG--------------------HFVKPEAFLPFSAGRRACLGEPLARMELFLF-FTSL 459 90 -FRFHPEHFLDAQG--------------------RFVKQEAFIPFSAGRRACLGEPLARMELFLF-FTSL 462 91 -FRFYPEHFLDAQG--------------------HFVKHEAFMPFSAGRRVCLGEPLARMELFLF-FTCL 462 92 -SSFNPDRFLSADG-----------------TELNKLEGEKVLVFGMDKRRCIGEAIGRNEVFLF-LAIL 480 93 -SSFNPDRFLSADG-----------------TELNKLEGEKVLVFGMDKRRCIGEAIGRNEVFLF-LAIL 480 94 -SSFNPDRFLNADG-----------------TEVNKLEGEKMMVFGMGKRRCIGEVIARSEVFLF-LAIL 480 95 -FSFNPERFLSADG-----------------TELNRLEGEKVMLFGLGKRRCIGEVIARNEVFLF-LAII 480 96 -SSFNPDRFLSADG-----------------SEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLF-LAII 480 97 -STFNPDRFLSADA-----------------SELNKLAGEKVMLFGMGKRRCIGEMVARNEVFLF-LAIL 477 98 -SSFNPDRFLSCNG-----------------TEVNKQEGEKVMVFGMGKRRCIGEVIARNEVYRG-LAIL 480 99 -NEFRPERFLTSSG------------------TLDKHLSEKVILFGLGKRKCIGETIGRLEVFLF-LAIL 478 100 -NEFRPERFLTPSG------------------TLDKRLSEKVTLFGLGKRKCIGETIGRSEVFLF-LAIL 478 101 -NKFRPERFLTSSG------------------TLDKVLSGKVTLFGLGKRKCIGETIGRLEVFLF-LAIL 478 102 -SVFRPERFLSPDG------------------TVDKALSEKVTIFGLGKRRCLGEVIGRWEVFLF-LAIL 470 103 -SEFQPERFLTLDG------------------TINKALSEKVILFGLGKRKCIGETIARLEVFLF-LAIL 478 104 -SEFLPERFLTPDG------------------AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF-LAIL 474 105 -SEFLPERFITPDG------------------AIDKVLSEKVILFGLGKRKCIGETIARWEVFLF-LAIL 474 106 -EAFRPERFLTPSG------------------AVDKALTEKVLLFGLGKRKCIGETIGRLEVFLF-LATL 478 107 -FVFRPERFLTNDN-----------------TAIDKTLSEKVMLFGLGKRRCIGEIPAKWEVFLF-LAIL 473 108 -FVFRPERFLTNNN-----------------SAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLF-LAIL 473 109 -FVFRPERFLTDND-----------------TVINKTLSEKVMLFGLGKRRCIGEIPAKWEVFLF-LAIL 473 110 -FAFRPERFLTADG-----------------TTINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLF-LAIL 461 111 -SEFRPERFLTADG-----------------TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF-LAIL 475 112 -FEFRPERFLLANN-----------------TAVDKTLSDKILLFGLGKRRCIGETLGRWEVFLF-LAIL 475 113 -EEFRPERFLTADG-----------------AAINKPLSEKVTLFGLGKRRCIGETLARWEVFLF-LAIL 475 114 -FVFRTERFLTDDS-----------------TAIDKTLSEKVM--------------------------- 186 115 -EDFDPARFLDKDG------------------FINKALASSVMIFSVGKRRCIGEELSKMLLFLF-ISIL 486 116 -EDFDPARFLDKDG------------------FINKALASSVMIFSVGKRRCIGEELSKTLLFLF-ISIL 486 117 -ENFDPARFLDKDG------------------LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF-ISIL 486 118 -DLFMPERFLDPTG------------------TQLISPSLSYLPFGAGPRSCVGEMLARQELFLF-MSRL 459 119 -DLFMPERFLDPTG------------------TQLISPSLSYLPFGAGPRSCVGEMLARQELFLF-TAGL 459 120 -DQFMPERFLNPAG------------------TQLISPSVSYLPFGAGPRSCIGEILARQELFLI-MAWL 459 121 -DRFMPERFLDPTG------------------SHLITPTPSYLPFGAGPRSCIGEALARQELFIF-MALL 458 122 -DQFMPERFLDPTG------------------SHLITPTQSYLPFGAGPRSCIGEALARQELFVF-TALL 458 123 -EEFNPGRFLDEQG------------------QHIHSPSPSYLPFGAGIRVCLGEVLAKMELFLF-LAWV 462 124 -EMFDPGRFLNEEG------------------TGLCIPSPSYLPFGAGVRVCLGEALAKMEIFLF-LSWI 465 125 -DAFDPGRFLDEDG------------------KYVCSSSESYLPFGAGTRVCLGEMLARMELFLF-TSWI 462 126 -HEFRPDRFLEPGA------------------------NPSALAFGCGARVCLGESLARLELFVV-LLRL 444 127 -YEFRPDRFLEPGA------------------------NTSALAFGCGARVCLGESLARLELFVV-LLRL 445 128 -HEFRPDRFLAPGA------------------------NPSALAFGCGARVCLGEPLARLELFVV-LVQL 444 129 -HEFWPDRFLEPGK------------------------NSRALAFGCGARVCLGEPLARLELFVV-LTRL 445 130 -SKFWPDRFLEPGK------------------------NPRTPSFGCGARVCLGEPLARLELFVV-LARL 437 131 -EEFLPERFVNNSVD-------------------FKGQDFQLIPFGAGRRGCPGIAFGISSVEIS-LANL 460 132 -EEYQPERFLNSDAD-------------------VKGLNFKLLPFGAGRRGCPGSSFAIAVIELA-LARL 463 133 ---------------------------------------------------------------------- 366 134 -EEFCPERFLNNDID-------------------MKGLKFELLPFGSGRRGCPGSSFAIAVIELA-LARL 465 135 --------------------------------------------------ICPGISFALPNVELP-IAQL 19 136 -EKFRPERFLNSSVD-------------------FKGLDFELIPFGAGRRGCPGTTFPMATLEFT-LANL 464 137 -ETFNPERFIDNQTD-------------------FKGLNFELLPFGSGRRMCPGMGMGLAVVHLT-LINL 454 138 -EAFIPERFMDNQID-------------------YKGLNFEF-PFGSGRRMCPGIGMGMALVHLT-LINL 0 139 ---------------------------------------------------------------------- 102 140 -EVFKPERFHEKASID------------------VKGHDYELLPFGVGRRMCPGYSLGLKVIQAS-LANL 0 141 PDEFRPERFLEKEVD-------------------FKGTDYEFIPFGSGRRMCPGMRLGAAMLEVP-YANL 459 142 -TKFDPSRWEG-----------------------HSPRAGTFLAFGLGARLCPGNDLAKLEISVF-LHHF 455 143 -RTFNPWRWQSNSV--------------------TTGPSNVFTPFGGGPRLCPGYELARVALSVF-LHRL 435 144 -EEFFPERFLEQGRDAEVD---------------MYGKDIRFVPFGAGRRICAGATFAIATVEIM-LANL 487 145 -EEFMPERFVQEPGAVDVH---------------MKGKDLRFIPFGSGRRICPGMNFGFATMEVM-LANL 496 146 -EEFMPERFMRDGWDKSNS---------------YSGQDFRYLPFGSGRRICPGANFGLATMEIM-LANL 491 147 -NEFVPERFLSGDVAGGVD---------------LKPNEFQFLAFGSGRRMCPGVHSASATIEAM-LSNL 498 148 -EEFLPERFMDGGSAAGVD---------------IKGNHFHLLPFGAGRRICPGLNFGMATVEIM-LANL 348 149 ---------------------------------------------------------------------- 46 150 -FEFKPERFLESKVD-------------------VKGQNYELIPFGAGRRMCVGLPLGHRMMHFT-FGSL 425 151 -MSFKPERFLGSKID-------------------VKGQHYGLIPFGAGRRMCVGLPLGHRMMHFA-LGSL 465 152 --------------------------------------------------ICPGLPLAYRTLHTM-LATC 19 153 -LEFIPERFLSEKNAKIE----------------HRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 463 154 -LEFNPERFLSGRNSKID----------------PRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 460 155 -IEFYPERFLSGRNSKID----------------PRGNDFELIPFGAGRRICAGTRMGIVMVEYI-LGTL 460 156 ---------------------------------------------------------------------- 68 157 -DAFAPERFLPSEGGADVD---------------VRGVDLRLAPFGAGRRVCPGKNLGLTTVGLW-VARL 459 158 -NKFNPDRFIDEDVN-------------------ILGSDLRLAPFGSGKRVCPGKTMALAAVHLW-LAQL 388 159 -EEFRPERFLEEEAKVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 464 160 -EEFRPERFFEEESHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-LGRL 464 161 -EEFRPERFLEEESHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 465 162 -EEFRPERFLEEESKVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIT-IGRL 464 163 -------------SHVE-----------------ANGNDFRYVPFGVGRRSCPGIILALPILGIT-IGRM 39 164 -EEFRPERFLEEEAHVE-----------------ANGNDFRYLPFGVGRRSCPGIILALPILGIH-IGRL 462 165 -EKFDPDRFLSGREDADI----------------TGVKEVKMMPFGVGRRICPGLGMATVHVNLM-LARM 460 166 -EKFDPDRFYLGKEDADI----------------TGVSGVKMIPFGMGRRICPGLNMATVHVSLM-LARL 475 167 -LRFYPDRHLATAASDVA----------------LTENDLRFISFSTGRRGCIAASLGTAMSVML-FGRL 511 168 -LKFQPERFLDSDIE-------------------YNGKQFQFIPFGSGRRICPGRPLAVRIIPLV-LASL 447 169 -LEFKPESFLSTHKDVD-----------------VRGQNFELLPFGSGRRMCAGMSLGLHMVHYI-LANF 471 170 ---------------------------------------------------------------------- 116 171 -EEFLPERFVNSNID-------------------AKGQNFELLPFGSGRRMCPAM------VEFG-LANL 102 172 ---------------------------------------------------------------------- 116 173 ---------------------------------------------------------------------- 130 174 ---------------------------------------------------------------------- 97 175 -NEFKPERFLENSLD-------------------FNGGDFKYLPFGSGRRICAAINMAERLV-LF-CSTL 48 176 ------------DID-------------------LRGRDYELTPFGAGRRICPGFPLAVKTVPLM-LASL 38 177 -------------------------------------------------RICPGCPMGIAAVELG-LLNL 20 178 ----------------------------------------KLMPFGIGRRSCPGSGLAQRLVTLA-LGSL 29 179 ---------------------------------------------------------------------- 146 180 ---------------------------------------------------------------------- 61 181 -------------------------------------------PF--G--VCIGQNFAMLEAKIA-LSMI 22 182 -------------------------------------------PF--G--ICVGQNFAMLEAKLV-MAMI 22 183 -------------------------------------------PF--G--ACPGVNFAIPIAELA-LANL 22 184 -------------------------------------------PF--G--MCPGISFALANVELP-LAQL 22 185 -------------------------------------------PF--G--SCPGMLFGIANIELP-LALL 22 186 -------------------------------------------PF--G--ICPGISYAIANVQLP-LAQL 22 187 -------------------------------------------PF--G--ICPGISYAIANIQLP-LRQL 22 188 -------------------------------------------PF--G--VCPGILFGTTNVELL-LAAF 22 189 -------------------------------------------PF--G--ICPGLPMAARVVPLV-IASF 22 190 -------------------------------------------PF--G--ICPGMSFAIPNVTLP-LAQL 22 191 -------------------------------------------PF--G--MCPGISFGIPNIELP-LALL 22 192 -------------------------------------------PF--G--ICPGYGLALLHLEYF-VANL 22


1 LQNF-TPKPLVDPKDIDTTPLVSGLGRVPPLYQLSFI-PA*------------------- 490 2 LQNF-TPKPLVNPNNVDENPFSSGIVRVPPLYRVSFI-PV*------------------- 490 3 LQNF-TLKPLVDPKDIDTTPLVSGARSCATLYQLSFI-PA*------------------- 490 4 VQNF-NLKSFVDTKDIDTTPMANTFGRVPPSYQLCFI-PR*------------------- 489 5 ----------------------------------------*------------------- 227 6 ----------------------------------------*------------------- 227 7 ----------------------------------------*------------------- 227 8 ----------------------------------------*------------------- 227 9 ----------------------------------------*------------------- 227 10 LQNF-KLQSLVEPKDLDITAVVNGFVSVPPSYQLCFI-PI*------------------- 487 11 LQNF-KLQSLVEPKDLDITAVVNGFVSVPPSYQLCFI-PI*------------------- 487 12 LQNF-KLQSLVEPKDLDITAVLNGFVSVPPSFQLCFI-PV*------------------- 487 13 LQNF-KLQSLVEPKDLDITAVVNGFASVPPAYQLCFS-PV*------------------- 378 14 LQNF-NLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI-PV*------------------- 490 15 LQHF-TLKPVVDPKHIDIAPSFKGMLSIPPFCEMCFI-PV*------------------- 285 16 LQHF-TLKPLVDPKDIDPTPVDNGFLSVPPSYELCFV-PV*------------------- 489 17 LQNF-NLKSLIDPKDLDTTFVVNGFASVPPFYQLCFI-PV*------------------- 490 18 LQNF-NLKSQVDPKDIDITPLPMHLVGVPPLYQLCFI-PV*------------------- 490 19 LQNF-NLKSVDDLKNLNTTAVTKGIVSLPPSYQICFI-PV*------------------- 490 20 LQNF-NLKSVADLKNLNTTSATRGIISLPPSYQICFI-PV*------------------- 490 21 LQNF-NLKSLVDVKDIDTTPAISGFGHLPPFYEACFI-PVQRADSLSSHL*--------- 500 22 LQNF-NLKSLVHPKDIDTMPVLNGFASLPPTYQLCFI-PS*------------------- 490 23 LQNF-KLKSLVHPKEIDITPVMNGFASLPPPTQLCFI-PL*------------------- 490 24 LQNF-KLKSVLHPKDIDTTPVFNGFASLPPFYELCFI-PL*------------------- 490 25 LQNF-KLKSLVDPKDINTTPICSSLSSVPPTFQMRFI-PL*------------------- 490 26 LQNF-KLKSLSDPKDIDINSIRSEFSSIPPTFQLCFI-PV*------------------- 490 27 LQHF-TLKPLVDPKDIDTTPIANGLGATPPSYKLCFV-PV*------------------- 457 28 LQHF-TLKPLVDPKDIDPTPVENGFVSVPPSYELCFV-PV*------------------- 490 29 LQHF-TLKPLVNPEDIDTTPVQPGLLSVPPPFELCFI-PV*------------------- 489 30 LQKF-SLKTLVEPKDLDIKPITTGIINLPPPYKLCLV-PR*------------------- 494 31 LQNF-KLKSMIHPKDIDTTPVVNGFASLPPSYQLCFI-PV*------------------- 490 32 LQNF-KLKSLVHPKDIDTTPVLNGFASLPPSYQLCFI-PV*------------------- 490 33 LQNF-KLKSLVHPKDIDTTPVVNGLASLPPSYQLCFI-PV*------------------- 490 34 LQNF-DLKSLADTKDIDTTPVASTFGCVPPSYQLYFI-PR*------------------- 490 35 LQHF-NLKPLVDPEDIDLRNITVGFGRVPPRYKLCVI-PRS*------------------ 493 36 LQHF-NLKPLVDPEDIDLRSIAVGFGRIPPRYKLCVV-PRS*------------------ 493 37 LQHF-NLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVI-PRS*------------------ 493 38 LQHF-NLKSLVDPKDIDLSPVTIGFGSIPREFKLCVI-PRS*------------------ 493 39 LQHF-NLKSLVDPKDIDLNPVTIGFGCVPPEFKLCVI-PRS*------------------ 493 40 LQHF-NLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVI-PRS*------------------ 493 41 LQHF-NLKPLVDPKDIDISPVNIGFGCIPPRFKLCVI-PRS*------------------ 449 42 LQNF-SLKPVKDRKDIDISPIITSLANMPRPYEVSFI-PR*------------------- 491 43 LQNF-SLKPVKDRKDIDISPIVTSAANIPRPYEVSFI-PR*------------------- 491 44 LQSF-SLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLR-PR*------------------- 491 45 LQNF-TLQPLVDPEDIDLTPLSSGLGNLPRPFQLCMH-IR*------------------- 491 46 LQNF-SIASPVPPEDIDLTPRESGVGNVPPSYQIRFL-AR*------------------- 491 47 LQNF-SIASPVPPEDIDLTPRESGVGNVPPSYQIRFL-AR*------------------- 491 48 LQNF-SVASPMAPEDIDLTPQEIGVGKLPPVYQISFL-SRGGC*---------------- 494 49 LQNF-SMASPVAPEDIDLTPQECGVGKIPPTYQIRFL-PR*------------------- 491 50 LQNF-SVASPVAPEDIDLTPQESGVGKIPPTYQIRFL-PR*------------------- 491 51 LQNF-SVSSHLAPKDIDLTPMESGIAKIPPTYQICFS-AR*------------------- 490 52 LQNF-SVSSPVAPKDIDLTPKESGIGRIPQVYQICFL-AH*------------------- 491 53 LQNF-SVSSHLAPKDIDLTPKESGIGKIPPTYQICFS-AR*------------------- 491 54 LQNF-SVAAHVAPKDIGLTPKESGIGKIPPTYQICFL-AR*------------------- 491 55 LQNF-TLASPVAPEDIDLTPINIGVGKIPSPYQINFL-SR*------------------- 492 56 LQNF-SLASPVAPEDIDLSPINSGISKIPSPYQIHFL-SRCVG*---------------- 495 57 LQNF-SVASPVAPKDIDLTPKESGIGKIPPAHQIYFL-AR*------------------- 491 58 LQNF-SVASPVASKDIDLTPKESGIGKIPPTYQICFL-AR*------------------- 491 59 LQNY-SVSSPVDPNTIDMTPKESGLAKVAPVYKICFV-AR*------------------- 491 60 LQRF-SLRSLVPPADIDIAHKISGFGNIPPTYELCFM-AR*------------------- 494 61 LQNF-SLHPLVPPVNIDITPKISGFGNIPPTYELCLI-AR*------------------- 494 62 ----------------------------------------*------------------- 0 63 LQRF-HLHFPHE-LVPDLQPRV-GMTLQPQPYLICAE-RR*------------------- 0 64 MQNF-RLKSSQSPKDIDVSPKHVGFATIPRNYTMSFL-PR*------------------- 494 65 MQNF-RLKSSQSPKDIDVSSKHVGFATIPRNYTMSFL-PR*------------------- 494 66 MQNF-HFKSTQAPQDIDVSPRLVGFVTIPPTYTMSFL-SR*------------------- 494 67 MQNF-HFKSTQAPQDIDVSPRLVGFATIPPTYTMSFL-SR*------------------- 494 68 MQNF-CFKSPQAPQDIDVSPRLVGFATIPPNYTMSFL-SR*------------------- 494 69 MQNF-CFKSPQAPQDIDVTPQYFSFAAIPPKFTMSFL-PR*------------------- 494 70 LQNF-RFKFPMKLEDINESPKPLGFTRIIPKYTMSFM-PI*------------------- 492 71 LQNF-RFKFPRKLEDINESPTPEGFTRIIPKYTMSFV-PI*------------------- 492 72 LQNF-RFKFPMNLEDINEYPSPIGFTRIIPNYTMSFM-PI*------------------- 492 73 LQNF-RLKFPKKLEDIDASPKPLGFSRIIPRYTMSFL-PI*------------------- 286 74 MQNF-RFRSQQAPQDIDVSPKHVGFATIPRTYTMSFV-PR*------------------- 494 75 MQNF-RFRSQQAPQDIDVSPKHVGFATIPRTYTMSFV-PR*------------------- 494 76 LQHF-KLHTESRLIEDDIAPKMNGFANYPTSYQLSFI-PR*------------------- 494 77 ----------------------------------------*------------------- 120 78 LQRF-RFSPPGVTEDDLDLTPLLGFTLNPSPHQLCAV-SRV*------------------ 501 79 LQRF-TFTGTKPPEEINIEPACSSFGRLPRSYDCYIK-LRT*------------------ 497 80 MQKF-TFKPPSDEKLTLNFRM--GITLSPVKHRICAI-PRA*------------------ 501 81 LQRF-SFSVPVG-QPRPSTHGFFAFPVAPLPYQLCAV-VREQGL*--------------- 503 82 LQHF-SFSVPAG-QPRPSTLGNFAISVAPLPYQLCAA-VREQGH*--------------- 503 83 LQRF-SFSVPDG-QPQPSNSGVYGILVAPSPYQLCAV-VRDQGH*--------------- 503 84 LQHF-SFSVPNG-QPRPRNLGVFPFPVAPYPYQLCAV-MREQGH*--------------- 503 85 LQRF-SISVPDG-QPQPSNYRVHAIPVAPFPYQLCAV-MHEQGH*--------------- 504 86 LQRF-SFSVPTG-QPRPSDYGVFAFLLSPSPYQLCAF-KR*------------------- 499 87 LQRF-SFSVLAG-RPRPSTHGVYALPVTPQPYQLCAV-AR*------------------- 499 88 LQRF-SFSVPTG-QPRPSDYGIFGALTTPRPYQLCAS-PR*------------------- 499 89 LQHF-SFSVPTG-QPRPSHHGVFAFLVSPSPYELCAV-PR*------------------- 496 90 LQHF-SFSVPAG-QPRPSEHGVFAFLVTPAPYQLCAV-PR*------------------- 499 91 LQRF-SFSVPAG-QPRPSDHGVFTFLKVPAPFLQCVE-PR*------------------- 499 92 LQRL-RFQEKPG-HPLDMTPEYGLTMKHKRCQ-LKAS-MRPWGQEE*------------- 522 93 LQRL-RFQEKPG-HPLDMTPEYGLTMKHKRCQ-LKAS-MRPWGQEE*------------- 522 94 VQNL-RFHSMPG-EPLDMTPEYGLTMKHKRCQ-LRAA-MRAR-NEE*------------- 521 95 IQRL-QFHMLPG-EPLDMTPEYGLTMKHKRCQ-LRAT-MREKNEQ*-------------- 521 96 IQKL-HFLPIPG-EKLDMTPEYGLTMKHKRCH-LKAT-MRARNEH*-------------- 521 97 VQRL-TFHAVPG-EPLDMTPEYGLTMKHKRCH-LRAT-VRTTE*---------------- 516 98 IQRL-QFHEMPG-ELLDMTPEYGLTMKHKRCH-LRAT-MRARNEQ*-------------- 521 99 LQQM-EFNVSPG-EKVDMTPAYGLTLKHARCEHFQVQ-MRSSGPQHLQA*---------- 524 100 LQQI-EFKVSPG-EKVDMTPTYGLTLKHARCEHFQVQ-MRSSGPQHLQA*---------- 524 101 LQQI-EFTVSPG-EKVDMTPIYGLTLKHARCEYFQAQ-TRSSGPQYPQA*---------- 524 102 LQQL-EFSTSPG-VKIDMTPIYGLTMKYSRCEHFQAQ-TRPFVLKCPEA*---------- 516 103 LQQV-EFSVEPG-TKVDMTPIYGLTMKHARCEHFQVR-VRTEGAESPAA*---------- 524 104 LQRV-EFSVPLG-VKVDMTPIYGLTMKHACCEHFQMQ-LRS*------------------ 512 105 LQRV-EFSVPPG-VKVDMTPIYGLTMKHACCEHFQMQ-LRS*------------------ 512 106 LQQV-EFSVSPG-TTVDMTPIYGLTMKHARCEHFQAK-LRFEA*---------------- 518 107 LHQL-EFTVPPG-VKVDLTPSYGLTMKPRTCEHVQAW-PRFSK*---------------- 513 108 LQHL-EFSVPPG-VKVDLTPNYGLTMKPGTCEHVQAW-PRFSK*---------------- 513 109 LQQL-EFSVPPG-TKVDLTPTYGLTMKPQTCKYIQAW-PRFSK*---------------- 513 110 LQRL-EFSVPAG-VKVDLTPIYGLTMKHTRCEHVQAR-PRFSIK*--------------- 502 111 LQQL-EFSVPPG-VKVDLTPIYGLTMKHARCEHVQAR-LRFSIN*--------------- 516 112 LQQL-EFSVPPG-VKVDLTPVYGLTMKPPHCQHVQAR-PRFSK*---------------- 515 113 LQRL-EFSVPPG-VPVDLTPIYGLTMKHPRCEHVQAR-PRFSDQ*--------------- 516 114 -------------------PIYGLSMKHKRCEHFQVK-KRFSMKSSN*------------ 213 115 AHQC-NFKANQN-ESSNMSFSYGLTIKPKSFRIHVSL-RESMELLDNAVKKLQTEEGCK* 542 116 AHQC-NFKANQN-EPSNMSFSYGLSIKPKSFKIHVSL-RESMKLLDSAVEKLQAEEACQ* 542 117 AHQC-DFRANPN-EPAKMNFSYGLTIKPKSFKVNVTL-RESMELLDSAVQNLQAKETCQ* 542 118 LQRF-NLEIPDD-GKLPSLEGHASLVLQIKPFKVKIE-VRQAWKEAQAEGSTP*------ 509 119 LQRF-DLELPDD-GQLPCLVGNPSLVLQIDPFKVKIK-ERQAWKEAHTEGSTS*------ 509 120 LQRF-DLEVPDD-GQLPSLEGIPKVVFLIDSFKVKIK-VRQAWREAQAEGST*------- 508 121 LQRF-DFDVSDD-KQLPCLVGDPKVVFLIDPFKVKIT-VRQAWKDAQVEVST*------- 507 122 LQRF-DLDVSDD-KQLPRLEGDPKVVFLIDPFKVKIT-VRQAWMDAQAEVST*------- 507 123 LQRF-TLECPQD-QPLPSLEGKFGVVLQVQKFRVKAR-LREAWRGEMVR*---------- 508 124 LQRL-TMTVSPG-QPLPSLEGKFGVVLQPVKYKVNAT-PRAGWEKSHLQTS*-------- 513 125 LQRF-TVQVPPG-YPPPDKEGKFGIVLQPLKFKVQLK-LRKAWENRGLHD*--------- 509 126 LQAF-TLLPPPVGALPSLQPDPYCGVNLKVQPFQVRL-QPRGVEAGAWESASAQ*----- 496 127 LQAF-TLLPPPGGALPSLQPDPYCGVNLKVQPFQVRL-QPRGVEAGAWESTSAQ*----- 497 128 LQAF-TLLPP-EGALPSLQPVPYSGINLKVQPFQVRL-QPRGGRGEGPGPA*-------- 492 129 LQAF-TLLPS-GDALPSLQPLPHCSVILKMQPFQVRL-QPRGMGAHSPGQNQ*------- 494 130 LQAF-TLLPPPDGTLPSLQPQPYAGINLPIPPFQVRL-QPRNLAPQDQGERP*------- 487 131 LYWF-NWELPGI---------------------------------------*-------- 471 132 VHKF-DFALPEGIKP--EDLDMTETIGITTRRKLPLLVVATPC*---------------- 503 133 -----------------------------------------*------------------ 366 134 VHKF-NFALPKGTKP--EDLDMTECTGIATRRKSPLPVVATPFSG*-------------- 507 135 LYHF-DWKLPNDAKP--EELDMNEKFGLTVGRENDLELIAIPYCHSFLQ*---------- 65 136 MQKF-DWELPHEC----RELDMSERPGVAIRRVIPLLAIGTKM*---------------- 502 137 LYRF-DWKLPNGMKA--EELSIEENYGLICVKKLPLEAIPVLTQWT*------------- 497 138 LYRF-DWKLPEGMEV--EDVDLEESYGLVCPKKVPLQLIPVL*----------------- 0 139 -----------------------------------------*------------------ 102 140 LHGF-NWSLPDNMTP--EDLNMDEIFGLSTPKKFPLATVIEPRLSPKLYSV*-------- 0 141 LLSF-NFKLPNGMKP--DDINMDVMTGLAMHKSQHLKLVPEKVNKYM*------------ 503 142 LLGY-KLARTNPRCR--VRYLPHPRPVDNCLAKITRVGS*-------------------- 491 143 VTGF-SWVPAEQDKL--VFFPTTRTQKRYPIFVKRRDFAT*------------------- 472 144 IYHF-DWEMPAEMERTGAKVDMSDQFGMTLRRTQKLYLVPRIPKCVSSS*---------- 535 145 MYHF-DWEVPG----SGAGVSMEESFGLTLRRKEKLLLVPRIAS*--------------- 535 146 MYHF-DWEVPNEKEDGCWKVSMDEKFGLMLRRNELLYLVPRAS*---------------- 533 147 MYRF-DWQLPAGMKAED--VDMTEVFGITVSRKEKLLLVPQAA*---------------- 538 148 VYCF-DWQLPMGMEEKD--IDMTEVFGLTVHPKEKLMLVPKVARVLQLLVNNSIVQVAD* 404 149 -------------------------------------------*---------------- 46 150 LHEF-DWELPHNVSPKSINMEESMGITARKKQPL--KVIPKKA*---------------- 465 151 LREF-EWELPDGVSPKSINMDGSMGVTARKRDSL--KVIPKKA*---------------- 505 152 IHNF-DWKLKDGMKPEDIDIEEKYGLTLQLAVPL--NVIPVKL*---------------- 59 153 IHSF-DWKLPNDVVDINMEETFGLALQKAVPLEA--IVTPRLSFDIYQSSEPF*------ 513 154 VHSF-DWKLPSEVIELNMEEAFGLALQKAVPLEA--MVTPRLQLDVYVP*---------- 506 155 VHSF-DWKLPSEVIELNMEEAFGLALQKAVPLEA--MVTPRLPIDVYAPLA*-------- 508 156 --------------------------------------------*--------------- 68 157 VHAF-QWALPDGAAAVCLDEVLKLSLEMKTPLVA--AAIPRTA*---------------- 499 158 LKSF-KLLPSRNG--VDLSECLKMSLEMKNPLVC--VAVPRFE*---------------- 426 159 VQNF-ELLPPPGQSKIDTDEKGGQFSLHILKHST-IVAKPRSF*---------------- 505 160 VQNF-ELLPPPGQSQIDTSEKGGQFSLHILKHST-VVAKPRSF*---------------- 505 161 VQNV-ELLPPPGQSKIDTSEKGGQFSLHILKHST-IVAKPRSF*---------------- 506 162 VQNF-ELLPPPGKSKIDTSEKGGQFSLHILKHST-IVLKPRTF*---------------- 505 163 VQNF-ELLPPPGQSKVDTSEKGGQFSLHILNHSI-IVMKPRNC*---------------- 80 164 VQNF-ELLPPPGQSKIDTSEKGGQFSLHILKHST-IVAKPRAF*---------------- 503 165 VQEF-EWFAYPGNNKVDFSEKLEFTVVMKNPLRA--KVKLRI*----------------- 499 166 VQEF-EW-ADPENTRVDFTEKLEFTVVMKNTLRA--KIKPRM*----------------- 513 167 LQGF-TWSKPAGVEAVDLSESKSDTFMATPLVLH---AEPRLPAHLYPSISI*------- 559 168 VHAF-GWELPDGVPNEKLDMEELFTLSLCMAKPL--RVIPKVRI*--------------- 488 169 LHSF-EILNPS-PESIDVTEVLEFVTTKATPLEV--LVKPCLSFKCYESM*--------- 517 170 -----------------------------------------*------------------ 116 171 LYHF-DW----------------------------------*------------------ 108 172 -----------------------------------------*------------------ 116 173 -----------------------------------------*------------------ 130 174 -----------------------------------------*------------------ 97 175 LHFF-TLLIGKLLKDRSLRLKRSLVLFLSLKSPLVLFLFQGCPIQTLHSLSKKDVEKRV* 106 176 LYSF-DWKLPNGVGSEDLDMDETFGLTLHKTNPLHAVPVKKRGRN*-------------- 82 177 LYFL-DWKLPDGMTHKDIDTEEAGTLTIVKKVPLQLVPVRVQ*----------------- 61 178 VQCF-EWERVGEKYLDMRSEKGTTMRKRTSLQAMCKARPIVHKVLDASCP*--------- 78 179 -----------------------------------------*------------------ 146 180 -----------------------------------------*------------------ 61 181 LQNF-SFELSPSYSHAPHTVITLQPQRGAQLIVRKVQTS*-------------------- 60 182 LQRF-SFELSPSYAHAPTSIVTLQPQHGAHLILRKL*----------------------- 57 183 IHKF-NFSLPDGVTAEDLDPTDVVGFISQKETPLSFIATVA*------------------ 62 184 LYHF-DWKLPGELKLEELDMEESFGLTVRRKKDLLLIPISYACSSVK*------------ 68 185 LYHF-NWSLPDGLTSETLDMSETWGITTPRKYDLHLIPTSYYP*---------------- 64 186 LYHF-EWKLPAGMKPEELDMTEILGTAAQRKENLLLIPNSHSCSSLKQV*---------- 70 187 LYHF-DWKLAGGMKPEELDMAEILGTAAQRKEDLLLIPNSHSCSSLKQQV*--------- 71 188 LFHF-DWELPGGMKPEELDMNELFGAGCIRENPLCLIPSISTVVEGN*------------ 68 189 LHFF-SWSFPNGKDAQQLDMNEKLDAALVKEQPLFVIPQPRTTT*--------------- 65 190 LLHF-DWKSAVGKLEDLDMTEARV*----------------------------------- 45 191 LFHF-NWNLPAGHVLDMEEAMGLTATRKNHLWLVATPIKKCLNLLSKLHNLDNMFSLDS* 80 192 IWYF-EWTAMDG---NDIDLSEKQEFTICMKNPLSAYISPRVNTF*-------------- 63