Estradiol

Last modified: Fri Jul 9 14:33:37 BST 2004

Steroid carbon nomenclature

Trivial names: Estradiol; Estradiol-17ß; Oestradiol; Oestradiol-17ß
Systematic name: Estra-1,3,5(10)-triene-3,17ß-diol
Molecular formula: C18H24O2
CAS Number: 50-28-2
Merck Index (11th Ed) Number: 3653
COMPOUND: C00951

Substrate

Pathway: Estradiol -> 2-Hydroxyestradiol
Reaction: steroid hydroxylation at C2
Enzyme: P450HP, CYP4B1 [1]
EC 1.14.14.1 Enzyme: P450NMb, CYP2G1 [2]
EC 1.14.14.1

Substrate [2]

Pathway: Estradiol -> 4-Hydroxyestradiol
Reaction: steroid hydroxylation at C4
Enzyme: P450NMb, CYP2G1
EC 1.14.14.1

References

  1. Waxman, D.J., Lapenson, D.P., Aoyama, T., Gelboin, H.V., Gonzalez, F.J. and Korzekwa, K. (1991) Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch. Biochem. Biophys. 290, 160-166.
  2. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.

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