Corticosterone

Last modified: Tue Jul 6 12:00:52 BST 2004

Steroid carbon nomenclature

Trivial names: Corticosterone; Kendall's compound B; Reichstein's substance H
Systematic name: 11ß,21-Dihydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O4
CAS Number: 50-22-6
Merck Index (11th Ed) Number: 2532
COMPOUND: C02140


Substrate

Pathway: Corticosterone -> 18-Hydroxycorticosterone
Reaction: steroid hydroxylation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B1
EC 1.14.15.4 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B2
EC 1.14.15.5 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B3
EC 1.14.15.4

Product

Pathway: 11-Deoxycorticosterone -> Corticosterone
Reaction: steroid ß-hydroxylation at C11
Enzyme: P450c11 (steroid 11ß-hydroxylase), CYP11B
EC 1.14.15.4

Product

Pathway: 11ß-Hydroxyprogesterone -> Corticosterone
Reaction: steroid hydroxylation at C21
Enzyme: P450c21 (steroid 21-hydroxylase), CYP21A
EC 1.14.99.10

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.


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