Cholesterol side-chain cleavage reaction

Cholesterol
	NADPH
22(R)-Hydroxyholesterol
	NADPH
20,22(R)-Hydroxycholesterol
	NADPH
+ Pregnenolone	Isocaproaldehyde

Steroid carbon nomenclature

Pathway: Cholesterol Pregnenolone
Reaction: cholesterol side-chain cleavage (hydroxylation at C22 and C20 and cleavage of C20-C22 bond)
Enzyme: P450scc (cholesterol side-chain cleavage), CYP11A1
EC 1.14.15.6

CPM1_BOVIN
CPM1_HUMAN
CPM1_PIG
CPM1_RAT
CPM1_ONCMY

Reference

1. Lambeth, J.D. (1990) Enzymology of mitochondrial side-chain cleavage by cytochrome P-450scc. In Ruckpaul, K. and Rein, H., Eds. Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London, pp. 58-100.

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