Sterol 25-hydroxylation

Last modified: Thu Jun 3 18:32:02 BST 2004

Sterol
NADPH
25-Hydroxysterol


Vitamin D3 carbon nomenclature
Summary of P450-dependent vitamin D3 metabolism

Pathway:

Reaction: sterol hydroxylation at C25
Enzyme: P450cc25 (vitamin D3 25-hydroxylase), CYP27 [1]
EC 1.14.-.-

Reference

  1. Usui, E., Noshiro, M., Ohyama, Y. and Okuda, K. (1990) Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation. FEBS Lett. 274, 175-177.


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