Sterol 24-hydroxylation

Sterol
	NADPH
24-Hydroxysterol

Vitamin D₃ carbon nomenclature
Summary of P450-dependent vitamin D₃ metabolism

Pathways:

• 1,25-Dihydroxyvitamin D₃ 1,24,25-Trihydroxyvitamin D₃
• 25-Hydroxyvitamin D₃ 24,25-Dihydroxyvitamin D₃

CP24_HUMAN
CP24_MOUSE
CP24_RAT

References

1. Ohyama, Y., Noshiro, M. and Okuda, K. (1991) Cloning and expression of cDNA encoding 25-hydroxyvitamin D₃ 24-hydroxylase. FEBS Lett. 278, 175-177.
2. Dilworth, F.J., Scott, I., Green, A., Strugnell, S., Guo, Y.-D., Roberts, E.A., Kremer, R., Calverley, M.J., Makin, H.L.J. and Jones, G. (1995) Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism. J. Biol. Chem. 270, 16766-16774.

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