Steroid 1-hydroxylation

Sterol
	NADPH
1-Hydroxysterol

Vitamin D₃ carbon nomenclature
Summary of P450-dependent vitamin D₃ metabolism

Pathways:

• 24,25-Dihydroxyvitamin D₃ 1,24,25-Trihydroxyvitamin D₃
• 25-Hydroxyvitamin D₃ 1,25-Dihydroxyvitamin D₃

1

CP27_HUMAN
CP27_RABIT
CP27_RAT

References

1. Axén, E., Postlind, H., Sjöberg, H. and Wikvall, K. (1994) Liver mitochondrial cytochrome P450 CYP27 and recombinant-expressed human CYP27 catalyze 1-hydroxylation of 25-hydroxyvitamin D₃. Proc. Natl. Acad. Sci. USA 91, 10014-10018.
2. Mandel, M.L., Swartz, S.J. and Ghazarian, J.G. (1990) Avian kidney mitochondrial hemeprotein P-450₁: isolation, characterization and NADPH-ferredoxin reductase-dependent activity. Biochim. Biophys. Acta 1034, 239-246.

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