Vitamin D3

Last modified: Thu Jun 3 18:32:02 BST 2004

Vitamin D3 carbon nomenclature
Summary of P450-dependent vitamin D3 metabolism

Trivial names: Vitamin D3; Activated 7-dehydrocholesterol; Cholecalciferol; Calciol
Systematic name: (5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Molecular formula: C27H44O
CAS Number: 67-97-0
Merck Index (11th Ed) Number: 9929


Substrate [1]

Pathway: Vitamin D3 -> 25-Hydroxyvitamin D3
Reaction: sterol hydroxylation at C25
Enzyme: P450cc25 (vitamin D3 25-hydroxylase), CYP27
EC 1.14.-.-

Reference

  1. Usui, E., Noshiro, M., Ohyama, Y. and Okuda, K. (1990) Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation. FEBS Lett. 274, 175-177.


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