Vitamin D3
Last modified: Thu Jun 3 18:32:02 BST 2004
Vitamin D3 carbon nomenclature
Summary of P450-dependent vitamin D3
metabolism
Trivial names: Vitamin D3; Activated 7-dehydrocholesterol;
Cholecalciferol; Calciol
Systematic name: (5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Molecular formula: C27H44O
CAS Number: 67-97-0
Merck Index (11th Ed) Number: 9929
Substrate [1]
Pathway:
Vitamin D3
25-Hydroxyvitamin D3
Reaction: sterol hydroxylation at C25
Enzyme: P450cc25 (vitamin D3 25-hydroxylase), CYP27
EC 1.14.-.-
Reference
-
Usui, E., Noshiro, M., Ohyama, Y. and Okuda, K. (1990)
Unique property of liver mitochondrial P450 to catalyze the two
physiologically important reactions involved in both cholesterol catabolism
and vitamin D activation.
FEBS Lett. 274, 175-177.
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