Vitamin D3

Last modified: Thu Jun 3 18:32:02 BST 2004

Vitamin D3 carbon nomenclature
Summary of P450-dependent vitamin D3 metabolism

Trivial names: Vitamin D3; Activated 7-dehydrocholesterol; Cholecalciferol; Calciol
Systematic name: (5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Molecular formula: C27H44O
CAS Number: 67-97-0
Merck Index (11th Ed) Number: 9929

Substrate [1]

Pathway: Vitamin D3 -> 25-Hydroxyvitamin D3
Reaction: sterol hydroxylation at C25
Enzyme: P450cc25 (vitamin D3 25-hydroxylase), CYP27
EC 1.14.-.-


  1. Usui, E., Noshiro, M., Ohyama, Y. and Okuda, K. (1990) Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation. FEBS Lett. 274, 175-177.

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