Aromatase reaction
Last modified: Fri May 21 16:12:50 BST 2004
Steroid carbon nomenclature
Pathway:
Androstenedione
Estrone + HCOOH
Reaction:
aromatase
(aromatisation of the A ring and C19 demethylation)
Enzyme: P450arom (aromatase), CYP19
EC 1.14.14.1
References
-
Akhtar, M., Njar, V.C.O. and Wright, J.N. (1993)
Mechanistic studies on aromatase and related C-C bond cleaving P450 enzymes.
J. Steroid Biochem. Mol. Biol. 44, 375-387.
-
Graham-Lorence, S., Amarneh, B., White, R.E., Peterson, J.A. and Simpson, E.R.
(1995)
A three-dimensional model of aromatase cytochrome P450.
Protein Science 4, 1065-1080.
-
Korzekwa, K.R., Trager, W.F., Smith, S.J., Osawa, Y. and Gillette, J.R.
(1991)
Theoretical studies on the mechanism of conversion of androgens to estrogens
by aromatase.
Biochemistry 30, 6155-6162.
-
Korzekwa, K.R., Trager, W.F., Mancewicz, J. and Osawa, Y. (1993)
Studies on the mechanism of aromatase and other cytochrome P450 mediated
deformylation reactions.
J. Steroid Biochem. Mol. Biol. 44, 367-373.
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