7alpha-Hydroxycholesterol

Last modified: Tue Jul 6 10:48:28 BST 2004

Steroid carbon nomenclature

Trivial name: 7alpha-Hydroxycholesterol
Systematic name: Cholest-5-ene-3ß,7alpha-diol
Molecular formula: C27H46O2

Product

Pathway: Cholesterol -> 7alpha-Hydroxycholesterol
Reaction: steroid alpha-hydroxylation at C7
Enzyme: P4507alpha (cholesterol 7alpha-monooxygenase), CYP7A
EC 1.14.13.17

Reference

  1. Jelinek, D.F., Andersson, S., Slaughter, C.A. and Russell, D.W. (1990) Cloning and regulation of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265, 12012-12019.

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