Steroid 7-hydroxylation

Steroid
	NADPH
7-Hydroxysteroid

Steroid carbon nomenclature

Pathways:

• Cholesterol 7-Hydroxycholesterol [1]
• 14-Hydroxyprogesterone 7,14-Dihydroxyprogesterone [2]
• Testosterone 7-Hydroxytestosterone [3]

7

CP70_CRIGR
CP70_HUMAN
CP70_RAT

Enzyme: testosterone 7-hydroxylase, CYP2A1 [3]
EC 1.14.14.1

CPA1_RAT

References

1. Jelinek, D.F., Andersson, S., Slaughter, C.A. and Russell, D.W. (1990) Cloning and regulation of cholesterol 7-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265, 12012-12019.
2. Vitas, M., Rozman, D., Komel, R. and Kelly, S.L. (1995) P450 mediated progesterone hydroxylation in Cochliobolus lunatus. J. Biotechnol. 42, 145-150.
3. Nagata, K., Matsunaga, T., Gillette, J., Gelboin, H.V. and Gonzalez, F.J. (1987) Rat testosterone 7-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. J. Biol. Chem. 262, 2787-2793.

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