5ß-Cholestane-3,7,12,27-tetrol

Last modified: Thu Jun 3 18:53:59 BST 2004

Steroid carbon nomenclature

Systematic name: 5ß-Cholestane-3 alpha ,7 alpha ,12 alpha ,27-tetrol
Molecular formula: C₂₇H₄₈O₄

Substrate

Pathway: 5ß-Cholestane-3 alpha

alpha

alpha

alpha

3

alpha

alpha

alpha

-Trihydroxy-5ß-cholestan-27-oic acid
Reaction: sterol oxidation at C27
Enzyme: P450c27 (sterol 27-hydroxylase), CYP27
EC 1.14.-.-

Product

Pathway: 5ß-Cholestane-3 alpha

alpha

alpha

alpha

5ß-Cholestane-3 alpha

alpha

alpha

alpha

,27-tetrol
Reaction: sterol hydroxylation at C27
Enzyme: P450c27 (sterol 27-hydroxylase), CYP27
EC 1.14.-.-

Reference

Cali, J.J. and Russell, D.W. (1991) Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J. Biol. Chem. 266, 7774-7778.

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