Last modified: Fri Jul 9 14:49:37 BST 2004

Steroid carbon nomenclature

Trivial name: 4,4'-Dimethylcholestatrienol
Systematic name: 4,4'-Dimethylcholesta-8,14,24-trien-3ß-ol
Molecular formula: C29H46O


Pathway: Lanosterol -> 4,4'-Dimethylcholestatrienol + HCOOH
Reaction: sterol 14alpha-demethylase (demethylation of C30 at C14 and desaturation of C14-C15 bond)
Enzyme: P45014DM (lanosterol 14alpha-demethylase), CYP51


  1. Vanden Bossche, H. (1988) Mode of action of pyridine, pyrimidine and azole antifungals. In Berg, D. and Plempel, M., Eds. Sterol Biosynthesis Inhibitors. Ellis Horwood, Chichester, pp. 79-119.
  2. Yoshida, Y. and Aoyama, Y. (1991) Cytochromes P-450 in the ergosterol biosynthesis. In Ruckpaul, K. and Rein, H., Eds. Frontiers in Biotransformation, vol. 4: Microbial and Plant Cytochromes P-450: Biochemical Characteristics, Genetic Engineering and Practical Implications. Taylor & Francis, London, pp. 127-148.

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