4,4'-Dimethylcholestatrienol

Last modified: Fri Jul 9 14:49:37 BST 2004

Steroid carbon nomenclature

Trivial name: 4,4'-Dimethylcholestatrienol
Systematic name: 4,4'-Dimethylcholesta-8,14,24-trien-3ß-ol
Molecular formula: C29H46O

Product

Pathway: Lanosterol -> 4,4'-Dimethylcholestatrienol + HCOOH
Reaction: sterol 14alpha-demethylase (demethylation of C30 at C14 and desaturation of C14-C15 bond)
Enzyme: P45014DM (lanosterol 14alpha-demethylase), CYP51
EC 1.14.13.70

References

  1. Vanden Bossche, H. (1988) Mode of action of pyridine, pyrimidine and azole antifungals. In Berg, D. and Plempel, M., Eds. Sterol Biosynthesis Inhibitors. Ellis Horwood, Chichester, pp. 79-119.
  2. Yoshida, Y. and Aoyama, Y. (1991) Cytochromes P-450 in the ergosterol biosynthesis. In Ruckpaul, K. and Rein, H., Eds. Frontiers in Biotransformation, vol. 4: Microbial and Plant Cytochromes P-450: Biochemical Characteristics, Genetic Engineering and Practical Implications. Taylor & Francis, London, pp. 127-148.

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