2-Hydroxyestradiol

Last modified: Fri Jul 9 14:32:36 BST 2004

Steroid carbon nomenclature

Trivial name: 2-Hydroxyestradiol
Systematic name: Estra-1,3,5(10)-triene-2,3,17ß-triol
Molecular formula: C18H24O3
CAS Number: 362-05-0


Product

Pathway: Estradiol -> 2-Hydroxyestradiol
Reaction: steroid hydroxylation at C2
Enzyme: P450HP, CYP4B1 [1]
EC 1.14.14.1 Enzyme: P450NMb, CYP2G1 [2]
EC 1.14.14.1

References

  1. Waxman, D.J., Lapenson, D.P., Aoyama, T., Gelboin, H.V., Gonzalez, F.J. and Korzekwa, K. (1991) Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch. Biochem. Biophys. 290, 160-166.
  2. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.


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