Sterol 27-hydroxylation

Last modified: Thu Jun 3 18:22:49 BST 2004

Sterol
NADPH
27-Hydroxysterol


Steroid carbon nomenclature

Pathway:

Reaction: sterol hydroxylation at C27
Enzyme: P450c27 (sterol 27-hydroxylase), CYP27
EC 1.14.-.-

References

  1. Cali, J.J. and Russell, D.W. (1991) Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J. Biol. Chem. 266, 7774-7778.
  2. Usui, E., Noshiro, M., Ohyama, Y. and Okuda, K. (1990) Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation. FEBS Lett. 274, 175-177.


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