Steroid 21-hydroxylation

Steroid
	NADPH
21-Hydroxysteroid

Steroid carbon nomenclature

Pathways:

• 11ß-Hydroxyprogesterone Corticosterone
• 17-Hydroxyprogesterone 11-Deoxycortisol
• Progesterone 11-Deoxycorticosterone

CPS1_BOVIN
CPS1_HUMAN
CPS1_MOUSE
CPS1_PIG
CPS3_PIG

CPC4_RABIT
CPC5_RABIT
CPCG_RABIT
CPCJ_HUMAN

CPBB_CANFA

Reference

1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.
2. Richardson, T.H., Jung, F., Griffin, K.J., Wester, M., Raucy, J.L., Kemper, B., Bornheim, L.M., Hassett, C., Omiecinski, C.J. and Johnson, E.F. (1995) A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli. Arch. Biochem. Biophys. 323, 87-96.
3. Born, S.L., John, G.H., Harlow, G.R. and Halpert, J.R. (1995) Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis. Drug Metab. Dispos. 23, 702-707.

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