18-Hydroxycorticosterone

Last modified: Tue Jul 6 11:38:55 BST 2004

Steroid carbon nomenclature

Trivial name: 18-Hydroxycorticosterone
Systematic name: 11ß,18,21-Trihydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O5
CAS Number: 561-65-9


Substrate

Pathway: 18-Hydroxycorticosterone -> Aldosterone
Reaction: steroid oxidation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B
EC 1.14.15.5

Product

Pathway: Corticosterone -> 18-Hydroxycorticosterone
Reaction: steroid hydroxylation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B1
EC 1.14.15.4 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B2
EC 1.14.15.5 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B3
EC 1.14.15.4

Product

Pathway: 18-Hydroxydeoxycorticosterone -> 18-Hydroxycorticosterone
Reaction: steroid ß-hydroxylation at C11
Enzyme: P450c11 (steroid 11ß-hydroxylase), CYP11B
EC 1.14.15.4

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.


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