18-Hydroxydeoxycorticosterone

Last modified: Tue Jul 6 11:47:36 BST 2004

Steroid carbon nomenclature

Trivial name: 18-Hydroxydeoxycorticosterone
Systematic name: 18,21-Dihydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O4

Substrate

Pathway: 18-Hydroxydeoxycorticosterone -> 18-Hydroxycorticosterone
Reaction: steroid ß-hydroxylation at C11
Enzyme: P450c11 (steroid 11ß-hydroxylase), CYP11B
EC 1.14.15.4

Substrate

Pathway: 18-Hydroxydeoxycorticosterone -> 18,19-Dihydroxydeoxycorticosterone
Reaction: steroid hydroxylation at C19
Enzyme: P450c19 (steroid 19-hydroxylase), CYP11B
EC 1.14.15.4

Product

Pathway: 11-Deoxycorticosterone -> 18-Hydroxydeoxycorticosterone
Reaction: steroid hydroxylation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B
EC 1.14.15.4 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B2
EC 1.14.15.5 Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B3
EC 1.14.15.4

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.

Back to the Directory of P450-containing Systems home page: