17alpha-Hydroxyprogesterone

Last modified: Fri Jul 9 14:31:35 BST 2004

Steroid carbon nomenclature

Trivial name: 17alpha-Hydroxyprogesterone
Systematic name: 17alpha-Hydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O3
CAS Number: 68-96-2
Merck Index (11th Ed) Number: 4773
COMPOUND: C01176

Substrate

Pathway: 17alpha-Hydroxyprogesterone -> 11-Deoxycortisol
Reaction: steroid hydroxylation at C21
Enzyme: P450c21 (steroid 21-hydroxylase), CYP21A
EC 1.14.99.10

Substrate

Pathway: 17alpha-Hydroxyprogesterone -> Androstenedione + Acetate
Reaction: cleavage of steroid C17-C20 bond
Enzyme: P450c17 (steroid 17alpha-hydroxylase/17,20-lyase), CYP17
EC 1.14.99.9

Product

Pathway: Progesterone -> 17alpha-Hydroxyprogesterone
Reaction: steroid alpha-hydroxylation at C17
Enzyme: P450c17 (steroid 17alpha-hydroxylase/17,20-lyase), CYP17
EC 1.14.99.9

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.

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