17alpha-Hydroxypregnenolone

Last modified: Fri Jul 9 14:31:34 BST 2004

Steroid carbon nomenclature

Trivial name: 17alpha-Hydroxypregnenolone
Systematic name: 3ß,17alpha-Dihydroxypregn-5-en-20-one
Molecular formula: C21H32O3
CAS Number: 387-79-1

Substrate

Pathway: 17alpha-Hydroxypregnenolone -> Dehydroepiandrosterone + Acetate
Reaction: cleavage of steroid C17-C20 bond
Enzyme: P450c17 (steroid 17alpha-hydroxylase/17,20-lyase), CYP17
EC 1.14.99.9

Product

Pathway: Pregnenolone -> 17alpha-Hydroxypregnenolone
Reaction: steroid alpha-hydroxylation at C17
Enzyme: P450c17 (steroid 17alpha-hydroxylase/17,20-lyase), CYP17
EC 1.14.99.9

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.

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