Steroid 17,20-lyase reaction

Substrate
	NADPH Cytochrome b5
+ Product	Carboxylic acid

Steroid carbon nomenclature

Pathways:

• 17-Hydroxypregnenolone Dehydroepiandrosterone + Acetate
• 17-Hydroxyprogesterone Androstenedione + Acetate

CPT7_BOVIN
CPT7_CHICK
CPT7_HUMAN
CPT7_MOUSE
CPT7_ONCMY
CPT7_PIG
CPT7_RAT

References

1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.
2. Lee-Robichaud, P., Shyadehi, A.Z., Wright, J.N., Akhtar, M.E. and Akhtar, M. (1995) Mechanistic kinship between hydroxylation and desaturation reactions: Acyl-carbon bond cleavage promoted by pig and human CYP17 (P450 17; 17-hydroxylase-17,20-lyase). Biochemistry 34, 14104-14113.

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