16alpha-Hydroxytestosterone

Last modified: Fri Jul 9 14:30:30 BST 2004

Steroid carbon nomenclature

Trivial name: 16alpha-Hydroxytestosterone
Systematic name: 16alpha,17ß-Dihydroxyandrost-4-en-3-one
Molecular formula: C19H28O3
CAS Number: 63-01-4


Product

Pathway: Testosterone -> 16alpha-Hydroxytestosterone
Reaction: steroid alpha-hydroxylation at C16
Enzyme: P45016alpha (testosterone 16alpha-hydroxylase), CYP2B [1]
EC 1.14.14.1 Enzyme: P45016alpha (testosterone 16alpha-hydroxylase), CYP2D [2]
EC 1.14.14.1 Enzyme: P450NMb, CYP2G1 [3]
EC 1.14.14.1

References

  1. Noshiro, M. Lakso, M., Kawajiri, K. and Negishi, M. (1988) Rip locus: regulation of female-specific isozyme (I-P-45016alpha) of testosterone 16alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry 27, 6434-6443.
  2. Wong, G., Itakura, T., Kawajiri, K., Skow, L. and Negishi, M. (1989) Gene family of male-specific testosterone 16alpha-hydroxylase (C-P-45016alpha) in mice. Organization, differential regulation, and chromosome localization. J. Biol. Chem. 264, 2920-2927.
  3. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.


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