Steroid 16ß-hydroxylation

Last modified: Fri Jul 9 14:30:29 BST 2004

Steroid
NADPH
16ß-Hydroxysteroid

Steroid carbon nomenclature

Pathway:

Reaction: steroid ß-hydroxylation at C16
Enzyme: P45016ß (steroid 16ß-hydroxylase), CYP2B [1]
EC 1.14.14.4 Enzyme: P450NMb, CYP2G1 [2]
EC 1.14.14.1

References

  1. Szklarz, G.D., He, Y.Q., Kedzie, K.M., Halpert, J.R. and Burnett, V.L. (1996) Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. Arch. Biochem. Biophys. 327, 308-318.
  2. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.

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