Steroid 16alpha-hydroxylation

Last modified: Tue Jul 6 10:55:00 BST 2004

Steroid
NADPH
16alpha-Hydroxysteroid

Steroid carbon nomenclature

Pathways:

Reaction: steroid alpha-hydroxylation at C16
Enzyme: P45016alpha (steroid 16alpha-hydroxylase), CYP2B [1]
EC 1.14.14.4 Enzyme: steroid 16alpha-hydroxylase, CYP3A [2]
EC 1.14.14.1 Enzyme: P450NMb, CYP2G1 [3]
EC 1.14.14.1 Enzyme: P45016alpha (testosterone 16alpha-hydroxylase), CYP2B [4]
EC 1.14.14.1 Enzyme: P45016alpha (testosterone 16alpha-hydroxylase), CYP2D [5]
EC 1.14.14.1

References

  1. Szklarz, G.D., He, Y.Q., Kedzie, K.M., Halpert, J.R. and Burnett, V.L. (1996) Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. Arch. Biochem. Biophys. 327, 308-318.
  2. Waxman, D.J., Lapenson, D.P., Aoyama, T., Gelboin, H.V., Gonzalez, F.J. and Korzekwa, K. (1991) Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch. Biochem. Biophys. 290, 160-166.
  3. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.
  4. Noshiro, M. Lakso, M., Kawajiri, K. and Negishi, M. (1988) Rip locus: regulation of female-specific isozyme (I-P-45016alpha) of testosterone 16alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry 27, 6434-6443.
  5. Wong, G., Itakura, T., Kawajiri, K., Skow, L. and Negishi, M. (1989) Gene family of male-specific testosterone 16alpha-hydroxylase (C-P-45016alpha) in mice. Organization, differential regulation, and chromosome localization. J. Biol. Chem. 264, 2920-2927.

Back to the Directory of P450-containing Systems home page: