15alpha-Hydroxytestosterone

Last modified: Fri Jul 9 14:29:24 BST 2004

Steroid carbon nomenclature

Trivial name: 15alpha-Hydroxytestosterone
Systematic name: 15alpha,17ß-Dihydroxyandrost-4-en-3-one
Molecular formula: C19H28O3
CAS Number: 2226-70-2


Product

Pathway: Testosterone -> 15alpha-Hydroxytestosterone
Reaction: steroid alpha-hydroxylation at C15
Enzyme: P45015alpha (testosterone 15alpha-hydroxylase), CYP2A [1]
EC 1.14.14.1 Enzyme: P450NMb, CYP2G1 [2]
EC 1.14.14.1

References

  1. Matsunaga, T., Nagata, K., Holsztynska, E.J., Lapenson, D.P., Smith, A., Kato, R., Gelboin, H.V., Waxman, D.J. and Gonzalez, F.J. (1988) Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15alpha-hydroxylase. J. Biol. Chem. 263, 17995-18002.
  2. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.


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