Steroid 15-hydroxylation

Steroid
	NADPH
15-Hydroxysteroid

Steroid carbon nomenclature

Pathways:

• Androstenedione 15-Hydroxyandrostenedione [1]
• Testosterone 15-Hydroxytestosterone [2, 3]

15

CPB5_RABIT

15

CPA2_RAT
CPA4_MOUSE

CPG1_RABIT
CPG1_RAT

References

1. Szklarz, G.D., He, Y.Q., Kedzie, K.M., Halpert, J.R. and Burnett, V.L. (1996) Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. Arch. Biochem. Biophys. 327, 308-318.
2. Matsunaga, T., Nagata, K., Holsztynska, E.J., Lapenson, D.P., Smith, A., Kato, R., Gelboin, H.V., Waxman, D.J. and Gonzalez, F.J. (1988) Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15-hydroxylase. J. Biol. Chem. 263, 17995-18002.
3. Ding, X. and Coon, M.J. (1994) Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch. Biochem. Biophys. 315, 454-459.

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