14alpha-Hydroxyprogesterone

Last modified: Tue Jul 6 11:47:42 BST 2004

Steroid carbon nomenclature

Trivial name: 14alpha-Hydroxyprogesterone
Systematic name: 14alpha-Hydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O3

Substrate [1]

14alpha-Hydroxyprogesterone -> 7alpha,14alpha-Dihydroxyprogesterone
Reaction: steroid alpha-hydroxylation at C7
Enzyme: Cochliobolus lunatus P450C.l. (progesterone 7alpha-hydroxylase)

Product [1]

Progesterone -> 14alpha-Dihydroxyprogesterone
Reaction: steroid alpha-hydroxylation at C14
Enzyme: Cochliobolus lunatus P450C.l. (progesterone 14alpha-hydroxylase)

Reference

  1. Vitas, M., Rozman, D., Komel, R. and Kelly, S.L. (1995) P450 mediated progesterone hydroxylation in Cochliobolus lunatus. J. Biotechnol. 42, 145-150.

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