Sterol 14
-demethylase reaction
Last modified: Fri Jul 9 14:49:42 BST 2004
Substrate |
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 |
NADPH
30-hydroxylation |
 |
|
 |
NADPH
30-hydroxylation |
|
 |
|
 |
|
 |
NADPH |
 |
|
 |
oxidative elimination
desaturation of C14-C15 bond |
 +
Product |
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Steroid carbon nomenclature
Pathway:
Lanosterol
4,4'-Dimethylcholestatrienol +
HCOOH
Reaction: sterol
14
-demethylase
(demethylation of C30 at C14 and desaturation of C14-C15 bond)
Enzyme: P45014DM (lanosterol 14-demethylase), CYP51
EC 1.14.13.70
References
- Vanden Bossche, H. (1988)
Mode of action of pyridine, pyrimidine and azole antifungals.
In Berg, D. and Plempel, M., Eds.
Sterol Biosynthesis Inhibitors.
Ellis Horwood, Chichester, pp. 79-119.
- Yoshida, Y. and Aoyama, Y. (1991)
Cytochromes P-450 in the ergosterol biosynthesis.
In Ruckpaul, K. and Rein, H., Eds.
Frontiers in Biotransformation, vol. 4:
Microbial and Plant Cytochromes P-450: Biochemical Characteristics, Genetic
Engineering and Practical Implications.
Taylor & Francis, London, pp. 127-148.
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