11-Deoxycortisol

Last modified: Tue Jul 6 15:32:55 BST 2004

Steroid carbon nomenclature

Trivial names: 11-Deoxycortisol; 11-Desoxycortisone; Cortexolone; 11-Deoxy-17-hydroxycorticosterone; Reichstein's substance S
Systematic name: 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O4
CAS Number: 152-58-9
Merck Index (11th Ed) Number: 2912

Substrate

Pathway: 11-Deoxycortisol -> Cortisol
Reaction: steroid ß-hydroxylation at C11
Enzyme: P450c11 (steroid 11ß-hydroxylase), CYP11B
EC 1.14.15.4

Product

Pathway: 17alpha-Hydroxyprogesterone -> 11-Deoxycortisol
Reaction: steroid hydroxylation at C21
Enzyme: P450c21 (steroid 21-hydroxylase), CYP21A
EC 1.14.99.10

Reference

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.

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