Last modified: Fri Jul 9 14:29:24 BST 2004
Steroid carbon nomenclature
Trivial names: 11-Deoxycorticosterone; Deoxycorticosterone;
11-Desoxycorticosterone; Desoxycortone; DOC;
21-Hydroxyprogesterone; Kendall's desoxy compound B
Systematic name: 21-Hydroxypregn-4-ene-3,20-dione
Molecular formula: C21H30O3
CAS Number: 64-85-7
Merck Index (11th Ed) Number: 2882
Reaction: steroid ß-hydroxylation at C11
Enzyme: P450c11 (steroid 11ß-hydroxylase), CYP11B
Reaction: steroid hydroxylation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B2
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B3
Reaction: steroid hydroxylation at C19
Enzyme: P450c19 (steroid 19-hydroxylase), CYP11B
Reaction: steroid hydroxylation at C21
Enzyme: P450c21 (steroid 21-hydroxylase), CYP21A
Enzyme: progesterone 21-hydroxylase, CYP2C
Enzyme: progesterone 21-hydroxylase, CYP2B11
- Ruckpaul, K. and Rein, H., Eds. (1990)
Frontiers in Biotransformation, vol. 3:
Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation
Taylor & Francis, London.
Richardson, T.H., Jung, F., Griffin, K.J., Wester, M., Raucy, J.L.,
Kemper, B., Bornheim, L.M., Hassett, C., Omiecinski, C.J. and Johnson, E.F.
A universal approach to the expression of human and rabbit cytochrome
P450s of the 2C subfamily in Escherichia coli.
Arch. Biochem. Biophys. 323, 87-96.
Born, S.L., John, G.H., Harlow, G.R. and Halpert, J.R. (1995)
Characterization of the progesterone 21-hydroxylase activity of canine
cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous
expression, and site-directed mutagenesis.
Drug Metab. Dispos. 23, 702-707.
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