Structural studies of ferredoxins

By Kirill Degtyarenko

Last modified: Thu Apr 15 16:50:40 BST 2004


Structures of Fe-S clusters
Some general references
[Fe2S2] ferredoxins
Bacterial-type ferredoxins
HiPIP

Structures of Fe-S clusters

 
                                                      Cys
               Cys                                    |
               |                                      S
               S                                      :    
               :                                  S---Fe···S--Cys
               Fe···S--Cys                       /    /
             ,' `.                     Cys--S···Fe---S
       Cys--S     S--Cys                        :
                                                S
                                                |
                                                Cys

            Fe(Cys4)                         [Fe2S2](Cys4)

          * Rubredoxin                     * Adrenodoxins
          * Desulforedoxin                 * Plant-type ferredoxins


S-----Fe···S--Cys S-----Fe···S--Cys /¦ /¦ ¦ /¦ Cys--S···Fe=====S ¦ ¦ S ¦ | ¦ | ¦ ¦ | ¦ Cys--S·|·Fe---|-S Cys--S···Fe---|-S |/ |/ / |/ S======Fe···S--Cys S======Fe···S--Cys [Fe4S4](Cys4) [Fe3S4](Cys3) * Bacterial ferredoxins: * Bacterial ferredoxins: [4Fe-4S], 7Fe [3Fe-4S], 7Fe * HiPIP * Aconitase * Aconitase
Cys | S : Cys--S···Fe---S O=C--Glu / \ ,' | S Fe O \ / `. Cys--S···Fe---S S--Cys : S | Cys [Fe3S3](Cys5Glu) * This structure has been proposed for three-iron cluster of bacterial ferredoxins but appeared incorrect. Nevertheless it is kept here as one of historical importance

Some general references on iron-sulphur proteins


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