Archive of Kirill's P450 Café - 2007

by Kirill Degtyarenko

Last modified: Mon Jan 7 15:38:44 GMT 2008

21 December 2007.

• Ouellet, H., Podust, L.M. and Ortiz de Montellano, P.R. (2007) Mycobacterium tuberculosis CYP130: Crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J. Biol. Chem., in press.

14 December 2007.

• Gillam, E.M. (2007) Engineering cytochrome P450 enzymes. Chem. Res. Toxicol., in press.

7 December 2007.

• Craven, R.J., Mallory, J.C. and Hand, R.A. (2007) Regulation of iron homeostasis mediated by the heme-binding protein DAP1 (damage resistance protein 1) via the P450 protein ERG11/CYP51. J. Biol. Chem. 282, 36543-36551.

30 November 2007.

• Troncoso, C., Cárcamo, J., Hedden, P., Tudzynski, B. and Rojas, M.C. (2007) Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases. Phytochemistry, in press.

23 November 2007.

• Li, Y.-C., Chiang, C.-W., Yeh, H.-C., Hsu, P.-Y., Whitby, F.G., Wang, L.-H. and Chan, N.-L. (2007) Structures of prostacyclin synthase and its complexes with substrate-analog and inhibitor reveal a ligand-specific heme conformation change. J. Biol. Chem., in press.

16 November 2007.

• Reipa, V., Holden, M.J. and Vilker, V.L. (2007) Association and redox properties of the putidaredoxin reductase-nicotinamide adenine dinucleotide complex. Biochemistry 46, 13235-13244.

9 November 2007.

• Kijac, A.Z., Li, Y., Sligar, S.G. and Rienstra, C.M. (2007) Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4. Biochemistry 46, 13696-13703.

2 November 2007.

• Xu, F., Bell, S.G., Rao, Z. and Wong, L.-L. (2007) Structure-activity correlations in pentachlorobenzene oxidation by engineered cytochrome P450_cam. PEDS 20, 473-480.

26 October 2007.

• Wang, L., Cowley, A.B. and Benson, D.R. (2007) Enhancing the thermal stability of mitochondrial cytochrome b₅ by introducing a structural motif characteristic of the less stable microsomal isoform. PEDS 20, 511-520.

19 October 2007.

• Chowdhary, P.K., Alemseghed, M. and Haines, D.C. (2007) Cloning, expression and characterization of a fast self-sufficient P450: CYP102A5 from Bacillus cereus. Arch. Biochem. Biophys. 468, 32-43.

12 October 2007.

• Stamer, U.M. and Stüber, F. (2007) The pharmacogenetics of analgesia. Expert Opinion on Pharmacotherapy 8, 2235-2245.

5 October 2007.

• Li, S., Podust, L.M. and Sherman, D.H. (2007) Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J. Am. Chem. Soc. 129, 12940-12941.

28 September 2007.

• Huang, W.-C., Westlake, A.C.G., Maréchal, J.-D., Joyce, M.G., Moody, P.C.E. and Roberts, G.C.K. (2007) Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency. J. Mol. Biol. 373, 633-651.

14 September 2007.

• Hirakawa, H., Kamiya, N., Tanaka, T. and Nagamune, T. (2007) Intramolecular electron transfer in a cytochrome P450cam system with a site-specific branched structure. PEDS 20, 453-459.

7 September 2007.

This week's Café has on the coffee table a special issue of Drug Metabolism Reviews dedicated to Ron Estabrook (Drug Metabolism Reviews, vol. 39, no. 2 & 3, 2007).

24 August 2007.

• Howard-Jones, A.R. and Walsh, C.T. (2007) Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin. J. Am. Chem. Soc. 129, 11016-11017.

17 August 2007.

• Luoma, P.V. (2007) Cytochrome P450 - physiological key factor against cholesterol accumulation and the atherosclerotic vascular process. Ann. Med. 39, 359-370.

10 August 2007.

• Yasutake, Y., Imoto, N., Fujii, Y., Fujii, T., Arisawa, A. and Tamura, T. (2007) Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105). Biochem. Biophys. Res. Commun. 361, 876-882.

3 August 2007.

• Liu, X., Wang, Y. and Han, K. (2007) Systematic study on the mechanism of aldehyde oxidation to carboxylic acid by cytochrome P450. J. Biol. Inorg. Chem. 12, 1073-1081.

27 July 2007.

• Bloom, J.D., Lu, Z., Chen, D., Raval, A., Venturelli, O.S. and Arnold, F.H. (2007) Evolution favors protein mutational robustness in sufficiently large populations. BMC Biology 5, 29.

20 July 2007.

• de Rosa, M., Pennati, A., Pandini, V., Monzani, E., Zanetti, G. and Aliverti, A. (2007) Enzymatic oxidation of NADP⁺ to its 4-oxo derivative is a side-reaction displayed only by the adrenodoxin reductase type of ferredoxin-NADP⁺ reductases. FEBS J. 274, 3998-4007.

13 July 2007.

• Grunau, A., Geraki, K., Grossmann, J.G. and Gutierrez, A. (2007) Conformational dynamics and the energetics of protein-ligand interactions: Role of interdomain loop in human cytochrome P450 reductase. Biochemistry 46, 8244-8255.

6 July 2007.

• Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H. and Nagano, S. (2007) Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc. Natl. Acad. Sci. USA 104, 11591-11596.

29 June 2007.

• Yao, H., McCullough, C.R., Costache, A.D., Pullela, P.K. and Sem, D.S. (2007) Structural evidence for a functionally relevant second camphor binding site in P450cam: Model for substrate entry into a P450 active site. Proteins 69, 125-138.

22 June 2007.

• Goldberg, D.P. (2007) Corrolazines: new frontiers in high-valent metalloporphyrinoid stability and reactivity. Acc. Chem. Res. 40, 626-634.

15 June 2007.

• Peng, Y., Xu, F., Bell, S.G., Wong, L.-L. and Rao, Z. (2007) Crystallization and preliminary X-ray diffraction studies of a ferredoxin reductase from Rhodopseudomonas palustris CGA009. Acta Crystallogr. F63, 422-425.

8 June 2007.

• Gillam, E.M.J. (2007) Extending the capabilities of nature's most versatile catalysts: Directed evolution of mammalian xenobiotic-metabolizing P450s. Arch. Biochem. Biophys. 464, 176-186.

1 June 2007.

• Menzel, R., Yeo, H.L., Rienau, S., Li, S., Steinberg, C.E.W. and Stürzenbaum, S.R. (2007) Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. J. Mol. Biol. 370, 1-13.

25 May 2007.

• Rosales-Hernández, M., Kispert, L., Torres-Ramírez, E., Ramírez-Rosales, D., Zamorano-Ulloa, R. and Trujillo-Ferrara, J. (2007) Electron paramagnetic resonance analyses of biotransformation reactions with cytochrome P-450 immobilized on mesoporous molecular sieves. Biotechnol. Lett. 29, 919-924.

18 May 2007.

• Dürr, U.H.N., Yamamoto, K., Im, S.-C., Waskell, L. and Ramamoorthy, A. (2007) Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome b₅. J. Am. Chem. Soc. 129, 6670-6671.

4 May 2007.

• Shoji, O., Fujishiro, T., Nakajima, H., Kim, M., Nagano, S., Shiro, Y. and Watanabe, Y. (2007) Hydrogen peroxide dependent monooxygenations by tricking the substrate recognition of cytochrome P45_BSβ. Angew. Chem. Int. Ed. Engl. 46, 3656-3659.

27 April 2007.

• Klein, K., Tatzel, S., Raimundo, S., Saussele, T., Hustert, E., Pleiss, J., Eichelbaum, M.F. and Zanger, U.M. (2007) A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab. Dispos. 35, 1247-1250.

20 April 2007.

• Chang, M.C.Y., Eachus, R.A., Trieu, W., Ro, D.-K., and Keasling, J.D. (2007) Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nature Chem. Biol. 3, 274-277.

30 March 2007.

• Chen, S. and Li, X. (2007) Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol. Biol. 7, 46.

23 March 2007.

• Bichet, A., Hannemann, F., Rekowski, M. and Bernhardt, R. (2007) A new application of the yeast two-hybrid system in protein engineering. PEDS 20, 117-123.

16 March 2007.

• Gerisch, B., Rottiers, V., Li, D., Motola, D.L., Cummins, C.L., Lehrach, H., Mangelsdorf, D.J. and Antebi, A. (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104, 5014-5019.

9 March 2007.

• Milani, M., Balconi, E., Aliverti, A., Mastrangelo, E., Seeber, F., Bolognesi, M. and Zanetti, G. (2007) Ferredoxin-NADP⁺ reductase from Plasmodium falciparum undergoes NADP⁺-dependent dimerization and inactivation: Functional and crystallographic analysis. J. Mol. Biol. 367, 501-513.

2 March 2007.

• Feenstra, K.A., Starikov, E.B., Urlacher, V.B., Commandeur, J.N.M. and Vermeulen, N.P.E. (2007) Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants. Protein Science 16, 420-431.

23 February 2007.

• Frank, B., Knauber, J., Steinmetz, H., Scharfe, M., Blöcker, H., Beyer, S. and Müller, R. (2007) Spiroketal polyketide formation in Sorangium: identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes. Chemistry & Biology 14, 221-233.

16 February 2007.

• Shen, Z., Yan, H., Parl, F.F., Mernaugh, R.L. and Zeng, X. (2007) Recombinant antibody piezoimmunosensors for the detection of cytochrome P450 1B1. Anal. Chem. 79, 1283-1289.

9 February 2007.

• Bonifacio, A., Keizers, P.H.J., Vermeulen, N.P.E., Commandeur, J.N.M., Gooijer, C. and van der Zwan, G. (2007) Surface-enhanced resonance Raman scattering of cytochrome P450-2D6 on coated silver hydrosols. Langmuir 23, 1860-1866.

2 February 2007.

• Pechurskaya, T.A., Harnastai, I.N., Grabovec, I.P., Gilep, A.A. and Usanov, S.A. (2007) Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s. Biochem. Biophys. Res. Commun. 353, 598-604.

26 January 2007.

• Liu, Y., Dettin, L., Folmer, J., Zirkin, B. and Papadopoulos, V. (2007) Abnormal morphology of spermatozoa in cytochrome P450 17α-hydroxylase/17, 20-lyase (CYP17) deficient mice. J. Androl. 28, 453-460.

19 January 2007.

• Henderson, M.P.A., Hwang, Y.T., Dyer, J.M., Mullen, R.T. and Andrews, D.W. (2007) The C-terminus of cytochrome b₅ confers endoplasmic reticulum specificity by preventing spontaneous insertion into membranes. Biochem. J. 401, 701-709.

12 January 2007.

• Taira, Z., Yamase, D. and Ueda, Y. (2007) A new technique for assaying cytochrome P450 enzyme activity in a single cell. Cell Biol. Toxicol. 23, 143-151.

5 January 2007.

• Frick, S., Kramell, R. and Kutchan, T.M. (2007) Metabolic engineering with a morphine biosynthetic P450 in opium poppy surpasses breeding. Metab. Eng. 9, 169-176.

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