Archive of Kirill's P450 Café - 2006

by Kirill Degtyarenko

Last modified: Fri Jan 5 10:51:32 GMT 2007

15 December 2006.

• Sun, Y., Hong, H., Samboskyy, M., Mironenko, T., Leadlay, P.F. and Haydock, S.F. (2006) Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin. Microbiology 152, 3507-3515.

"The meridamycin modular polyketide synthase consists of 14 extension modules distributed between three giant multienzyme proteins. The terminal module is flanked by a highly unusual cytochrome P450-like domain."

8 December 2006.

• Nebert, D.W. and Dalton, T.P. (2006) The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nature Rev. Cancer 6, 947-960.

1 December 2006.

• Kumar, S., Sun, L., Liu, H., Muralidhara, B.K. and Halpert, J.R. (2006) Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. PEDS 11, 903-916.

24 November 2006.

• Qi, X., Bakht, S., Qin, B., Leggett, M., Hemmings, A., Mellon, F., Eagles, J., Werck-Reichhart, D., Schaller, H., Lesot, A., Melton, R. and Osbourn, A. (2006) A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense. Proc. Natl. Acad. Sci. USA 11, 903-916.

17 November 2006.

• Dodhia, V.R., Fantuzzi, A. and Gilardi, G. (2006) Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego. J. Biol. Inorg. Chem. 11, 903-916.

10 November 2006.

• Sanderson, J.T. (2006) The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals. Toxicol. Sci. 94, 3-21.

3 November 2006.

• Girvan, H.M., Seward, H.E., Toogood, H.S., Cheesman, M.R., Leys, D. and Munro, A.W. (2006) Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets: New heme ligation states influence conformational equilibria in P450 BM3. J. Biol. Chem., in press.

27 October 2006.

• Olsen, L., Rydberg, P., Rod, T.H. and Ryde, U. (2006) Prediction of activation energies for hydrogen abstraction by cytochrome P450. J. Med. Chem. 49, 6489-6499. [Supplementary Material]

20 October 2006.

• Zurek, J., Foloppe, N., Harvey, J.N. and Mulholland, A.J. (2006) Mechanisms of reaction in cytochrome P450: hydroxylation of camphor in P450cam. Org. Biomol. Chem. 4, 3931-3937.

13 October 2006.

• Franke, A., Hessenauer-Ilicheva, N., Meyer, D., Stochel, G., Woggon, W.-D. and van Eldik, R. (2006) Thermodynamic and kinetic studies on the binding of nitric oxide to a new enzyme mimic of cytochrome P450. J. Am. Chem. Soc. 128, 13611-13624.

6 October 2006.

• Chiang, C.-W., Yeh, H.-C., Wang, L.-H. and Chan, N.-L. (2006) Crystal structure of the human prostacyclin synthase. J. Mol. Biol. 364, 266-274.

29 September 2006.

• Ekroos, M. and Sjögren, T. (2006) Structural basis for ligand promiscuity in cytochrome P450 3A4. Proc. Natl. Acad. Sci. USA 103, 13682-13687.

22 September 2006.

• Hannemann, F., Bichet, A., Ewen, K.M. and Bernhardt, R. (2006) Cytochrome P450 systems - biological variations of electron transport chains. Biochim. Biophys. Acta, in press.

15 September 2006.

• Nakanishi, N., Takeuchi, F., Okamoto, H., Tamura, A., Hori, H. and Tsubaki, M. (2006) Characterization of heme-coordinating histidyl residues of cytochrome b₅ based on the reactivity with diethylpyrocarbonate: a mechanism for the opening of axial imidazole rings. J. Biochem., in press.

8 September 2006.

• Cojocaru, V., Winn, P.J. and Wade, R.C. (2006) The ins and outs of cytochrome P450s. Biochim. Biophys. Acta, in press.

25 August 2006.

• Zhao, J., Das, A., Zhang, X., Schatz, G.C., Sligar, S.G. and Van Duyne, R.P. (2006) Resonance surface plasmon spectroscopy: Low molecular weight substrate binding to cytochrome P450. J. Am. Chem. Soc. 128, 11004-11005.

28 July 2006.

• Ctrnacta, V., Ault, J.G., Stejskal, F. and Keithly, J.S. (2006) Localization of pyruvate:NADP⁺ oxidoreductase in sporozoites of Cryptosporidium parvum. J. Eukaryot. Microbiol. 53, 225-231.

21 July 2006.

• Dulos, J. and Boots, A.H. (2006) DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad. Ann. N. Y. Acad. Sci. 1069, 401-413.

14 July 2006.

• Pourahmad, J., Ghashang, M., Ettehadi, H.A. and Ghalandari, R. (2006) A search for cellular and molecular mechanisms involved in depleted uranium (DU) toxicity. Environ. Toxicol. 21, 349-354.

7 July 2006.

• Funhoff, E.G., Bauer, U., García-Rubio, I., Witholt, B. and van Beilen, J.B. (2006) CYP153A6, a soluble P450 oxygenase catalyzing terminal-alkane hydroxylation. J. Bacteriol. 188, 5220-5227.

30 June 2006.

• Komen, J.C. and Wanders, R.J.A. (2006) Identification of the cytochrome P450 enzymes responsible for the -hydroxylation of phytanic acid. FEBS Lett. 580, 3794-3798.

23 June 2006.

• Harvey, J.N., Bathelt, C.M. and Mulholland, A.J. (2006) QM/MM modeling of compound I active species in cytochrome P450, cytochrome c peroxidase, and ascorbate peroxidase. J. Comput. Chem. 27, 1352-1362.

16 June 2006.

• Otey, C.R., Landwehr, M., Endelman, J.B., Hiraga, K., Bloom, J.D. and Arnold, F.H. (2006) Structure-guided recombination creates an artificial family of cytochromes P450. PLoS Biol. 4, e112.

9 June 2006.

• Cryle, M.J., Espinoza, R.D., Smith, S.J., Matovic, N.J. and De Voss, J.J. (2006) Are branched chain fatty acids the natural substrates for P450_BM3? Chem. Commun. (Cambridge) (22), 2353-2355.

26 May 2006.

• Phillips, I.R. and Shephard, E.A. (Eds.) Cytochrome P450 Protocols. 2nd Ed. Humana Press, Totowa, 2006.

19 May 2006.

• de Leon, J. (2006) AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry. Expert Rev. Mol. Diagn. 6, 277-286.

12 May 2006.

• Yoshioka, H., Kasai, N., Ikushiro, S., Shinkyo, R., Kamakura, M., Ohta, M., Inouye, K. and Sakaki, T. (2006) Enzymatic properties of human CYP2W1 expressed in Escherichia coli. Biochem. Biophys. Res. Commun. 345, 169-174.

5 May 2006.

• Goldstone, H.M.H. and Stegeman, J.J. (2006) A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection. J. Mol. Evol. 62, 708-717.

28 April 2006.

• Cornette, R., Koshikawa, S., Hojo, M., Matsumoto, T. and Miura, T. (2006) Caste-specific cytochrome P450 in the damp-wood termite Hodotermopsis sjostedti (Isoptera, Termopsidae). Insect Mol. Biol. 15, 235-244.

21 April 2006.

• Skaanild, M.T. (2006) Porcine cytochrome P450 and metabolism. Curr. Pharm. Des. 12, 1421-1427.

7 April 2006.

• Bu, H.-Z. (2006) A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: Structure-kinetics relationship assessment. Curr. Drug Metab. 7, 231-249.

31 March 2006.

• Kawaide, H. (2006) Biochemical and molecular analyses of gibberellin biosynthesis in fungi. Biosci. Biotechnol. Biochem. 70, 583-590.

24 March 2006.

• Rodriguez-Antona, C. and Ingelman-Sundberg, M. (2006) Cytochrome P450 pharmacogenetics and cancer. Oncogene 25, 1679-1691.

17 March 2006.

• Haarmann, T., Ortel, I., Tudzynski, P. and Keller, U. (2006) Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways. ChemBioChem 7, 645-652.

10 March 2006.

• Nazor, J. and Schwaneberg, U. (2006) Laboratory evolution of P450 BM-3 for mediated electron transfer. ChemBioChem 7, 638-644.

3 March 2006.

• Bell, S.G., Hoskins, N., Xu, F., Caprotti, D., Rao, Z. and Wong, L.-L. (2006) Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris. Biochem. Biophys. Res. Commun. 342, 191-196.

24 February 2006.

Zhao, Y., White, M.A., Muralidhara, B.K., Sun, L., Halpert, J.R. and Stout, C.D. (2006) Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: Insight into P450 conformational plasticity and membrane interaction. J. Biol. Chem. 281, 5973-5981.
PDB code: 2BDM

17 February 2006.

• Teoh, K.H., Polichuk, D.R., Reed, D.W., Nowak, G. and Covello, P.S. (2006) Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett. 580, 1411-1416.

10 February 2006.

• Hughes, R.K., Belfield, E.J., Muthusamay, M., Khan, A., Rowe, A., Harding, S.E., Fairhurst, S.A., Bornemann, S., Ashton, R., Thorneley, R.N.F. and Casey, R. (2006) Characterisation of Medicago truncatula hydroperoxide lyase (CYP74C3), a water-soluble detergent-free cytochrome P450 monomer whose biological activity is defined by monomer-micelle association. Biochem. J. 395, 641-652.

3 February 2006.

• Fang, Z. and Breslow, R. (2006) Metal coordination-directed hydroxylation of steroids with a novel artificial P-450 catalyst. Org Lett. 8, 251-254.

27 January 2006.

• Nohl, H., Staniek, K. and Kozlov, A.V. (2005) The existence and significance of a mitochondrial nitrite reductase. Redox Rep. 10, 281-286.

20 January 2006.

• Halavaty, A., Muller, J.J., Contzen, J., Jung, C., Hannemann, F., Bernhardt, R., Galander, M., Lendzian, F. and Heinemann, U. (2006) Light-induced reduction of bovine adrenodoxin via the covalently bound ruthenium(II) bipyridyl complex: Intramolecular electron transfer and crystal structure. Biochemistry 45, 709-718.

13 January 2006.

• Lamb, D.C., Kim, Y., Yermalitskaya, L.V., Yermalitsky, V.N., Lepesheva, G.I., Kelly, S.L., Waterman, M.R. and Podust, L.M. (2006) A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases. Structure 14, 51-61.

6 January 2006.

• Leal, S.S. and Gomes, C.M. (2005) Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins. Biol. Chem. 386, 1295-1300.

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