Archive of Kirill's P450 Café - 2003
by Kirill Degtyarenko
Last modified: Fri Oct 6 12:33:53 BST 2006
26 December 2003.
"Heme in CYP154A1 is in a 180° flipped orientation compared with most
other structurally determined CYPs."
Podust, L.M., Bach, H., Kim, Y., Lamb, D.C., Arase, M., Sherman, D.H.,
Kelly, S.L. and Waterman, M.R. (2004)
Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces
coelicolor A3(2) with the closely related CYP154C1 and CYPs from
antibiotic biosynthetic pathways.
Protein Science 13, 255-268.
19 December 2003.
12 December 2003.
Bentley, E.A., Astier, Y., Ji, W.M., Bell, S.G., Wong, L.-L. and Hill, H.A.O. (2003)
The electrochemistry and scanning tunnelling microscopy of the flavoprotein
putidaredoxin reductase on alkanethiol-modified gold.
Inorg. Chim. Acta 356, 343-348.
5 December 2003.
28 November 2003.
The first CYP enzyme to be detected on acrosomal membranes.
21 November 2003.
This review appears in
Proceedings of the VI International Aromatase Conference 'AROMATASE
2002', 26-30 October 2002, Kyoto, Japan
(The Journal of Steroid
Biochemistry and Molecular Biology vol. 86, nos. 3-5,
14 November 2003.
Petryk, A., Warren, J.T., Marqués, G., Jarcho, M.P., Gilbert, L.I.,
Kahler, J., Parvy, J.-P., Li, Y., Dauphin-Villemant, C. and O'Connor, M.B.
Shade is the Drosophila P450 enzyme that mediates the hydroxylation
of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone.
Proc. Natl. Acad. Sci. USA 100, 13773-13778.
7 November 2003.
Roberts, G.A., Çelik, A., Hunter, D.J.B., Ost, T.W.B., White, J.H.,
Chapman, S.K., Turner, N.J. and Flitsch, S.L. (2003)
A self-sufficient cytochrome P450 with a primary structural organisation
that includes a flavin domain and a [2Fe-2S] redox center.
J. Biol. Chem. 278, 48914-48920.
31 October 2003.
Wiseman, A. (2003)
Replacement of immobilised cell bioreactors by smaller immobilised enzyme
bioreactors: unique-outcome predictability for cytochromes P450 isoforms?
Biotechnol. Lett. 25, 1581-1590.
24 October 2003.
17 October 2003.
Finally, structure of CYP2B4 (aka P450 LM2) is here!
Scott, E.E., He, Y.A., Wester, M.R., White, M.A., Chin, C.C., Halpert,
J.R., Johnson, E.F. and Stout, C.D. (2003)
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å
Proc. Natl. Acad. Sci. USA 100, 13196-13201.
10 October 2003.
Craft, D.L., Madduri, K.M., Eshoo, M. and Wilson, C.R. (2003)
Identification and characterization of the CYP52 family of Candida
tropicalis ATCC 20336, important for the conversion of fatty acids and
Appl. Environ. Microbiol. 69, 5983-5991.
Eschenfeldt, W.H., Zhang, Y., Samaha, H., Stols, L., Eirich, L.D., Wilson, C.R.
and Donnelly, M.I. (2003)
Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase
enzymes of Candida tropicalis.
Appl. Environ. Microbiol. 69, 5992-5999.
3 October 2003.
26 September 2003.
19 September 2003.
12 September 2003.
Baudry, J., Li, W., Pan, L., Berenbaum, M.R. and Schuler, M.A. (2003)
Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1,
an insect cytochrome P450 monooxygenase.
Protein Engineering 16, 577-587.
5 September 2003.
- Chapman, S.K., Daff, S. and Ost, T.W.B. (2003)
Haem-thiolate redox enzymes: cytochrome P450 BM3 versus nitric oxide
synthase. Power versus control.
Biochemist 25, 20-23.
29 August 2003.
22 August 2003.
15 August 2003.
Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D.,
and Jhoti, H. (2003)
Crystal structure of human cytochrome P450 2C9 with bound warfarin.
Nature 424, 464-468.
Coordinates are available: PDB
8 August 2003.
The major iron-binding compound of T. foetus hydrogenosomes was
identified as adrenodoxin-type [2Fe2S] protein.
Suchan, P., Vyoral, D., Petrák, J., ut'ák, R., Rasoloson, D.,
Nohýnková, E., Dolezal, P. and Tachezy, J. (2003)
Incorporation of iron into Tritrichomonas foetus cell compartments
reveals ferredoxin as a major iron-binding protein in hydrogenosomes.
Microbiology 149, 1911-1921.
1 August 2003.
Pylypenko, O., Vitali, F., Zerbe, K., Robinson, J.A. and Schlichting, I. (2003)
Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C
coupling reaction during vancomycin biosynthesis.
J. Biol. Chem. 278, 46727-46733.
25 July 2003.
Lewis, D.F.V. (2003)
Human cytochromes P450 associated with the phase 1 metabolism of drugs and
other xenobiotics: a compilation of substrates and inhibitors of the CYP1, CYP2and CYP3 families.
Curr. Med. Chem. 10, 1955-1972.
27 June 2003.
20 June 2003.
13 June 2003.
Vermeulen, N.P. (2003)
Prediction of drug metabolism: the case of cytochrome P450 2D6.
Curr. Top. Med. Chem. 3, 1227-1239.
6 June 2003.
3-D structure available (PDB code
Wester, M.R., Johnson, E.F., Marques-Soares, C., Dansette, P.M., Mansuy, D. and
Stout, C.D. (2003)
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3
Å resolution: Evidence for multiple substrate binding modes.
Biochemistry 42, 6370-6379.
23 May 2003.
16 May 2003.
9 May 2003.
2 May 2003.
25 April 2003.
11 April 2003.
4 April 2003.
28 March 2003.
Kirchheiner, J. (2003)
Concise guide to the cytochrome P450 system:drug interaction principles for
Acta Psychiatr. Scand. 107, 319.
21 March 2003.
14 March 2003.
And now for some herbal medicine...
Zhou, S., Gao, Y., Jiang, W., Huang, M., Xu, A. and Paxton, J.W. (2003)
Interactions of herbs with cytochrome P450.
Drug Metab. Rev. 35, 35-98.
7 March 2003.
Iwuoha, E.I. and Smyth, M.R. (2003)
Reactivities of organic phase biosensors: 6. Square-wave and differential
pulse studies of genetically engineered cytochrome P450cam (CYP101)
bioelectrodes in selected solvents.
Biosens. Bioelectron. 18 237-244.
28 February 2003.
Lambard, S., Galeraud-Denis, I., Bouraïma, H., Bourguiba, S., Chocat, A.
and Carreau, S. (2003)
Expression of aromatase in human ejaculated spermatozoa: a putative marker of
Mol. Hum. Reprod. 9, 117-124.
21 February 2003.
Schwab, W. (2003)
Metabolome diversity: too few genes, too many metabolites?
Phytochemistry 62, 837-849.
14 February 2003.
Faro, M., Schiffler, B., Heinz, A., Nogues, I., Medina, M., Bernhardt, R. and
Gómez-Moreno, C. (2003)
Insights into the design of a hybrid system between Anabaena
ferredoxin-NADP+ reductase and bovine adrenodoxin.
Eur. J. Biochem. 270, 726-735.
7 February 2003.
Does smoking help the elimination of ethanol, and vice versa?
Schoedel, K.A. and Tyndale, R.F. (2003)
Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing
CYP2E1 by nicotine: summary and implications.
Biochim. Biophys. Acta 1619, 283-290.
31 January 2003.
24 January 2003.
Green, A.J., Munro, A.W., Cheesman, M.R., Reid, G.A., von Wachenfeldt, C. and
Chapman, S.K. (2003)
Expression, purification and characterisation of a Bacillus subtilis
ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.
J. Inorg. Biochem. 93, 92-99.
17 January 2003.
Bell, S.G., Chen, X., Sowden, R.J., Xu, F., Williams, J.N., Wong, L.-L. and
Rao, Z. (2003)
Molecular recognition in (+)--pinene
oxidation by cytochrome P450cam.
J. Am. Chem. Soc. 125, 705-714.
10 January 2003.
Not one, but two new P450 crystal structures.
Lee, D.-S., Yamada, A., Sugimoto, H., Matsunaga, I., Ogura, H., Ichihara, K.,
Adachi, S.-i., Park, S.-Y. and Shiro, Y. (2003)
Substrate recognition and molecular mechanism of fatty acid hydroxylation by
cytochrome P450 from Bacillus subtilis: Crystallographic, spectroscopic
and mutational studies.
J. Biol. Chem. 278, 9761-9767.
Podust, L.M., Kim, Y., Arase, M., Neely, B.A., Beck, B.J., Bach, H.,
Sherman, D.H., Lamb, D.C., Kelly, S.L. and Waterman, M.R. (2003)
The 1.92 Å structure of Streptomyces coelicolor A3(2) CYP154C1:
A new monooxygenase that functionalizes macrolide ring systems.
J. Biol. Chem. 278, 12214-12221.
3 January 2003.
Nelson, D.R. (2003)
Comparison of P450s from human and fugu: 420 million years of vertebrate P450
Arch. Biochem. Biophys. 409, 18-24.
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