Archive of Kirill's P450 Café - 2001
By Kirill Degtyarenko
Last modified: Fri Jul 30 17:22:21 BST 2004
14 December 2001.
7 December 2001.
30 November 2001.
23 November 2001.
- Ogliaro, F., de Visser, S.P., Cohen, S., Kaneti, J. and Shaik, S. (2001)
The experimentally elusive oxidant of cytochrome P450:
A theoretical trapping defining more closely the real
ChemBioChem 2, 848-851.
16 November 2001.
Now it's turn for "major phase II detoxification enzyme":
9 November 2001.
- Watanabe, Y. (2001)
Alternatives to the oxoferryl porphyrin cation radical as the proposed reactive
intermediate of cytochrome P450: two-electron oxidized Fe(III) porphyrin
J. Biol. Inorg. Chem. 6, 846-856.
2 November 2001.
- Hoffman, S.M. Nelson, D.R. and Keeney, D.S. (2001)
Organization, structure and evolution of the CYP2 gene cluster on human
Pharmacogenetics 11, 687-698.
26 October 2001.
19 October 2001.
12 October 2001.
5 October 2001.
28 September 2001.
- Rubinstein, E. (2001)
Comparative safety of the different macrolides.
Int. J. Antimicrob. Agents 18, Suppl. 1, 71-76.
21 September 2001.
- Kupfer, R., Liu, S.Y., Allentoff, A.J. and Thompson, J.A. (2001)
Comparisons of hydroperoxide isomerase and monooxygenase activities of
cytochrome P450 for conversions of allylic hydroperoxides and alcohols to
epoxyalcohols and diols: probing substrate reorientation in the active site.
Biochemistry 40, 11490-11501.
14 September 2001.
7 September 2001.
Analysis of the subcellular localization and function of the
R. nigricans <NADPH-cytochrome P450> reductase in yeast
indicated that the CPR1-FL cDNA and a derivative (CPR1-S) truncated at the
first ATG codon gave rise to functionally equivalent products that were found
in both cytosolic and microsomal fractions
Kunic, B., Truan, G., Breskvar, K. and Pompon, D. (2001)
Functional cloning, based on azole resistance in Saccharomyces
cerevisiae, and characterization of Rhizopus nigricans redox
carriers that are differentially involved in the P450-dependent response to
Mol. Genet. Genomics 265, 930-940.
31 August 2001.
The paper indicates that the generally held view of the process
<see, for example, here> most likely does not
describe the true mechanism
17 August 2001.
Lefevre-Groboillot, D., Dijols, S., Boucher, J.-L., Mahy, J.-P., Ricoux, R.,
Desbois, A., Zimmermann, J.-L. and Mansuy, D. (2001)
N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance
Raman studies of the interaction of various compounds bearing a C=NOH function
Biochemistry 40, 9909-9917.
10 August 2001.
3 August 2001.
The structure of this unique haem-thiolate protein is solved.
The sulfhydryl group of Cys52 and the
N2 atom of His65 axially
coordinate the iron in the haem.
- Meier, M., Janosik, M., Kery, V., Kraus, J.P. and Burkhard, P. (2001)
Structure of human cystathionine ß-synthase: a unique pyridoxal
5'-phosphate-dependent heme protein.
EMBO J. 20, 3910-3916.
27 July 2001.
- Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001)
Nitric oxide synthases: structure, function and inhibition.
Biochem. J. 357, 593-615.
20 July 2001.
- Beck, B.W., Xie, Q. and Ichiye, T. (2001)
Sequence determination of reduction potentials by cysteinyl hydrogen bonds
and peptide dipoles in [4Fe-4S] ferredoxins.
Biophys. J. 81, 601-613.
13 July 2001.
6 July 2001.
- Green, A.J., Rivers, S.L., Cheesman, M., Reid, G.A., Quaroni, L.G.,
Macdonald, I.D.G., Chapman, S.K. and Munro, A.W. (2001)
Expression, purification and characterization of cytochrome P450 BioI: a novel
P450 involved in biotin synthesis in Bacillus subtilis.
J. Biol. Inorg. Chem. 6, 523-533.
29 June 2001.
"This is the first report of the existence of two homologue genes coding for
14-sterol demethylase in the fungal
22 June 2001.
15 June 2001.
Azeva, T.N., Gilep, A.A., Lepesheva, G.I., Strushkevich, N.V. and Usanov, S.A.
Site-directed mutagenesis of cytochrome P450scc. II. Effect of replacement of
the Arg425 and Arg426 residues on the structural and functional properties of
the cytochrome P450scc.
Biochemistry (Moscow) 66, 564-576.
8 June 2001.
1 June 2001.
Anandatheerthavarada, H.K., Amuthan, G., Biswas, G., Robin, M.A.,
Murali, R., Waterman, M.R. and Avadhani, N.G. (2001)
Evolutionarily divergent electron donor proteins interact with P450MT2 through
the same helical domain but different contact points.
EMBO J. 20, 2394-2403.
25 May 2001.
18 May 2001.
11 May 2001.
- Sigfridsson, E., Olsson, M.H.M. and Ryde, U. (2001)
Inner-sphere reorganization energy of iron-sulfur clusters studied with
Inorg. Chem. 40, 2509-2519.
4 May 2001.
27 April 2001.
- Mathews, F.S., Mauk, A.G. and Moore, G.R. (2000)
Protein-protein complexes formed by electron transfer proteins.
In Kleanthous, C., Ed.
Oxford University Press, New York, pp. 60-101.
20 April 2001.
Iametti, S., Bera, A.K., Vecchio, G., Grinberg, A., Bernhardt, R. and
Bonomi, F. (2001)
GroEL-assisted refolding of adrenodoxin during chemical cluster insertion.
Eur. J. Biochem. 268, 2421-2429.
6 April 2001.
- Leroux, A., Vieira, L.M. and Kahn, A. (2001)
Transcriptional and translational mechanisms of cytochrome b5
reductase isoenzyme generation in humans.
Biochem. J. 355, 529-535.
30 March 2001.
23 March 2001.
- Wu, Y., Wang, Y., Qian, C., Lu, J., Li, E., Wang, W., Lu, J., Xie, Y.,
Wang, J., Zhu, D., Huang, Z. and Tang, W. (2001)
Solution structure of cytochrome b5 mutant (E44/48/56A/D60A)
and its interaction with cytochrome c.
Eur. J. Biochem. 268, 1620-1630.
16 March 2001.
- Jones, J.P., O'Hare, E.J. and Wong, L.-L. (2001)
Oxidation of polychlorinated benzenes by genetically engineered CYP101
Eur. J. Biochem. 268, 1460-1467.
9 March 2001.
Novikova, L.A., Nazarov, P.A., Saveliev, A.S., Drutsa, V.L., Sergeev, V.N.,
Miller, W.L. and Luzikov, V.N. (2000)
Interaction of catalytic domains in cytochrome P450scc-adrenodoxin
reductase-adrenodoxin fusion protein imported into yeast mitochondria.
Biochemistry (Moscow) 65, 1362-1366.
2 March 2001.
- Lee, D.-S., Park, S.-Y., Yamane, K., Obayashi, E., Hori, H. and Shiro, Y.
Structural characterization of n-butyl-isocyanide complexes of
cytochromes P450nor and P450cam.
Biochemistry 40, 2669-2677.
23 February 2001.
16 February 2001.
A bunch of interesting papers from the latest Biochemistry:
- Tsao, C.-C., Wester, M.R., Ghanayem, B., Coulter, S.J., Chanas, B.,
Johnson, E.F. and Goldstein, J.A. (2001)
Identification of human CYP2C19 residues that confer S-mephenytoin
4'-hydroxylation activity to CYP2C9.
Biochemistry 40, 1937-1944.
- Munro, A.W., Noble, M.A., Robledo, L., Daff, S.N. and Chapman, S.K. (2001)
Determination of the redox properties of human NADPH-cytochrome P450 reductase.
Biochemistry 40, 1956-1963.
- Gutierrez, A., Lian, L.-Y., Wolf, C.R., Scrutton, N.S. and Roberts, G.C.K.
Stopped-flow kinetic studies of flavin reduction in human cytochrome P450
reductase and its component domains.
Biochemistry 40, 1964-1975.
- Naito, N.R., Hui, H.L., Noble, R.W. and Hoffman, B.M. (2001)
Determination of the hemoglobin surface domains that react with cytochrome
Biochemistry 40, 2060-2065.
9 February 2001.
- Kurisu, G., Kusunoki, M., Katoh, E., Yamazaki, T., Teshima, K., Onda, Y.,
Kimata-Ariga, Y. and Hase, T. (2001)
Structure of the electron transfer complex between ferredoxin and
Nature Struct. Biol. 8, 117-121.
2 February 2001.
- Kao, Y.-C., Korzekwa, K.R., Laughton, C.A. and Chen, S. (2001)
Evaluation of the mechanism of aromatase cytochrome P450: a site-directed
Eur. J. Biochem. 268, 243-251.
26 January 2001.
- Fretland, A.J. and Omiecinski, C.J. (2000)
Epoxide hydrolases: biochemistry and molecular biology.
Chem. Biol. Interact. 129, 41-59.
19 January 2001.
12 January 2001.
- Green, E.L., Taoka, S., Banerjee, R. and Loehr, T.M. (2001)
Resonance Raman characterization of the heme cofactor in cystathionine
Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme.
Biochemistry 40, 459-463.
5 January 2001.
Dokoh, T., Suzuki, N., Higuchi, T., Urano, Y., Kikuchi, K. and Nagano, T.
A new thioether-ligated iron porphyrin as a model of a protonated form of P450
J. Inorg. Biochem. 82, 127-132.
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