Archive of Kirill's P450 Café - 2001

Last modified: Fri Jul 30 17:22:21 BST 2004

14 December 2001.

• Grinberg, A.V. and Bernhardt, R. (2001) Contribution of a salt bridge to the thermostability of adrenodoxin determined by site-directed mutagenesis. Arch. Biochem. Biophys. 396, 25-34.

7 December 2001.

• Takeuchi, K., Tsubaki, M., Futagawa, J., Masuyam F. and Hori, H. (2001) Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: Comparison with the putidaredoxin-cytochrome P450cam system. J. Biochem. (Tokyo) 130, 789-797.

30 November 2001.

Harris, D.L. (2001) High-valent intermediates of heme proteins and model compounds. Curr. Opin. Chem. Biol. 5, 724-735.

This review appears in the Guest section on Computational bioinorganic chemistry (Current Opinion in Chemical Biology vol. 5, no. 6, 2001).

23 November 2001.

• Ogliaro, F., de Visser, S.P., Cohen, S., Kaneti, J. and Shaik, S. (2001) The experimentally elusive oxidant of cytochrome P450: A theoretical “trapping” defining more closely the “real” species. ChemBioChem 2, 848-851.

16 November 2001.

Now it's turn for "major phase II detoxification enzyme":

• Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A. (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem. J. 360, 1-16.

9 November 2001.

• Watanabe, Y. (2001) Alternatives to the oxoferryl porphyrin cation radical as the proposed reactive intermediate of cytochrome P450: two-electron oxidized Fe(III) porphyrin derivatives. J. Biol. Inorg. Chem. 6, 846-856.

2 November 2001.

• Hoffman, S.M. Nelson, D.R. and Keeney, D.S. (2001) Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. Pharmacogenetics 11, 687-698.

26 October 2001.

• Luft, F.C. (2001) Steroidogenesis and CYP enzymes. J. Mol. Med. 79, 549-550.

19 October 2001.

• Dunn, A.R., Dmochowski, I.J., Bilwes, A.M., Gray, H.B. and Crane, B.R. (2001) Probing the open state of cytochrome P450cam with ruthenium-linker substrates. Proc. Natl. Acad. Sci. USA 98, 12420-12425.

12 October 2001.

• Okita, R.T. and Okita, J.R. (2001) Cytochrome P450 4A fatty acid omega hydroxylases. Curr. Drug Metab. 2, 265-281.

5 October 2001.

• Yoshizawa, K., Kamachi, T. and Shiota, Y. (2001) A theoretical study of the dynamic behavior of alkane hydroxylation by a compound I model of cytochrome P450. J. Am. Chem. Soc. 123, 9806-9816. [Supplementary Material]

28 September 2001.

• Rubinstein, E. (2001) Comparative safety of the different macrolides. Int. J. Antimicrob. Agents 18, Suppl. 1, 71-76.

21 September 2001.

• Kupfer, R., Liu, S.Y., Allentoff, A.J. and Thompson, J.A. (2001) Comparisons of hydroperoxide isomerase and monooxygenase activities of cytochrome P450 for conversions of allylic hydroperoxides and alcohols to epoxyalcohols and diols: probing substrate reorientation in the active site. Biochemistry 40, 11490-11501.

14 September 2001.

• Gabriel, W.N., Blumberg, B., Sutton, S., Place, A.R. and Lance, V.A. (2001) Alligator aromatase cDNA sequence and its expression in embryos at male and female incubation temperatures. J. Exp. Zool. 290, 439-448.

7 September 2001.

• Kunic, B., Truan, G., Breskvar, K. and Pompon, D. (2001) Functional cloning, based on azole resistance in Saccharomyces cerevisiae, and characterization of Rhizopus nigricans redox carriers that are differentially involved in the P450-dependent response to progesterone stress. Mol. Genet. Genomics 265, 930-940.

31 August 2001.

• Lieberman, S. and Lin, Y.Y. (2001) Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450_scc. J. Steroid Biochem. Mol. Biol. 78, 1-14.

17 August 2001.

• Lefevre-Groboillot, D., Dijols, S., Boucher, J.-L., Mahy, J.-P., Ricoux, R., Desbois, A., Zimmermann, J.-L. and Mansuy, D. (2001) N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8. Biochemistry 40, 9909-9917.

10 August 2001.

• Cauet, G., Balbuena, D., Achstetter, T. and Dumas, B. (2001) CYP11A1 stimulates the hydroxylase activity of CYP11B1 in mitochondria of recombinant yeast in vivo and in vitro. Eur. J. Biochem. 268, 4054-4062.

3 August 2001.

• Meier, M., Janosik, M., Kery, V., Kraus, J.P. and Burkhard, P. (2001) Structure of human cystathionine ß-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein. EMBO J. 20, 3910-3916.

27 July 2001.

• Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001) Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357, 593-615.

20 July 2001.

Beck, B.W., Xie, Q. and Ichiye, T. (2001) Sequence determination of reduction potentials by cysteinyl hydrogen bonds and peptide dipoles in [4Fe-4S] ferredoxins. Biophys. J. 81, 601-613.

13 July 2001.

• Schoefs, B., Rmiki, N.-E., Rachadi, J. and Lemoine, Y. (2001) Astaxanthin accumulation in Haematococcus requires a cytochrome P450 hydroxylase and an active synthesis of fatty acids. FEBS Lett. 500, 125-128.

6 July 2001.

• Green, A.J., Rivers, S.L., Cheesman, M., Reid, G.A., Quaroni, L.G., Macdonald, I.D.G., Chapman, S.K. and Munro, A.W. (2001) Expression, purification and characterization of cytochrome P450 BioI: a novel P450 involved in biotin synthesis in Bacillus subtilis. J. Biol. Inorg. Chem. 6, 523-533.

29 June 2001.

• Mellado, E., Diaz-Guerra, T.M., Cuenca-Estrella, M. and Rodriguez-Tudela, J.L. (2001) Identification of two different 14-sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species. J. Clin. Microbiol. 39, 2431-2438.

22 June 2001.

• Ekins, S., de Groot, M.J. and Jones, J.P. (2001) MINIREVIEW. Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome P450 active sites. Drug Metab. Dispos. 29, 936-944.

15 June 2001.

• Azeva, T.N., Gilep, A.A., Lepesheva, G.I., Strushkevich, N.V. and Usanov, S.A. (2001) Site-directed mutagenesis of cytochrome P450scc. II. Effect of replacement of the Arg425 and Arg426 residues on the structural and functional properties of the cytochrome P450scc. Biochemistry (Moscow) 66, 564-576.

8 June 2001.

• Wilson, T.G. (2001) Resistance of Drosophila to toxins. Annu. Rev. Entomol. 46, 545-571.

1 June 2001.

Anandatheerthavarada, H.K., Amuthan, G., Biswas, G., Robin, M.A., Murali, R., Waterman, M.R. and Avadhani, N.G. (2001) Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. EMBO J. 20, 2394-2403.

25 May 2001.

• Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B. and Kim, J.-J.P. (2001) NADPH-cytochrome P450 oxidoreductase: structural basis for hydride and electron transfer. J. Biol. Chem. 276, 29163-29170.

18 May 2001.

• Sieber, V., Martinez, C.A. and Arnold, F.H. (2001) Libraries of hybrid proteins from distantly related sequences. Nature Biotechnol. 19, 456-460.

11 May 2001.

• Sigfridsson, E., Olsson, M.H.M. and Ryde, U. (2001) Inner-sphere reorganization energy of iron-sulfur clusters studied with theoretical methods. Inorg. Chem. 40, 2509-2519.

4 May 2001.

• Jung, Y., Kwak, J. and Lee, Y. (2001) High-level production of heme-containing holoproteins in Escherichia coli. Appl. Microbiol. Biotechnol. 55, 187-191.

27 April 2001.

• Mathews, F.S., Mauk, A.G. and Moore, G.R. (2000) Protein-protein complexes formed by electron transfer proteins. In Kleanthous, C., Ed. Protein-Protein Recognition. Oxford University Press, New York, pp. 60-101.

20 April 2001.

• Iametti, S., Bera, A.K., Vecchio, G., Grinberg, A., Bernhardt, R. and Bonomi, F. (2001) GroEL-assisted refolding of adrenodoxin during chemical cluster insertion. Eur. J. Biochem. 268, 2421-2429.

6 April 2001.

• Leroux, A., Vieira, L.M. and Kahn, A. (2001) Transcriptional and translational mechanisms of cytochrome b₅ reductase isoenzyme generation in humans. Biochem. J. 355, 529-535.

30 March 2001.

• Furukawa, Y. and Morishima, I. (2001) The role of water molecules in the association of cytochrome P450cam with putidaredoxin. An osmotic pressure study. J. Biol. Chem. 276, 12983-12990.

23 March 2001.

• Wu, Y., Wang, Y., Qian, C., Lu, J., Li, E., Wang, W., Lu, J., Xie, Y., Wang, J., Zhu, D., Huang, Z. and Tang, W. (2001) Solution structure of cytochrome b₅ mutant (E44/48/56A/D60A) and its interaction with cytochrome c. Eur. J. Biochem. 268, 1620-1630.

16 March 2001.

• Jones, J.P., O'Hare, E.J. and Wong, L.-L. (2001) Oxidation of polychlorinated benzenes by genetically engineered CYP101 (cytochrome P450_cam). Eur. J. Biochem. 268, 1460-1467.

9 March 2001.

• Novikova, L.A., Nazarov, P.A., Saveliev, A.S., Drutsa, V.L., Sergeev, V.N., Miller, W.L. and Luzikov, V.N. (2000) Interaction of catalytic domains in cytochrome P450scc-adrenodoxin reductase-adrenodoxin fusion protein imported into yeast mitochondria. Biochemistry (Moscow) 65, 1362-1366.

2 March 2001.

• Lee, D.-S., Park, S.-Y., Yamane, K., Obayashi, E., Hori, H. and Shiro, Y. (2001) Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam. Biochemistry 40, 2669-2677.

23 February 2001.

• Omdahl, J.L., Bobrovnikova, E.A., Choe, S., Dwivedi, P.P. and May, B.K. (2001) Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway. Steroids 66, 381-389.

16 February 2001.

A bunch of interesting papers from the latest Biochemistry:

• Tsao, C.-C., Wester, M.R., Ghanayem, B., Coulter, S.J., Chanas, B., Johnson, E.F. and Goldstein, J.A. (2001) Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9. Biochemistry 40, 1937-1944.
• Munro, A.W., Noble, M.A., Robledo, L., Daff, S.N. and Chapman, S.K. (2001) Determination of the redox properties of human NADPH-cytochrome P450 reductase. Biochemistry 40, 1956-1963.
• Gutierrez, A., Lian, L.-Y., Wolf, C.R., Scrutton, N.S. and Roberts, G.C.K. (2001) Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains. Biochemistry 40, 1964-1975.
• Naito, N.R., Hui, H.L., Noble, R.W. and Hoffman, B.M. (2001) Determination of the hemoglobin surface domains that react with cytochrome b₅. Biochemistry 40, 2060-2065.

9 February 2001.

• Kurisu, G., Kusunoki, M., Katoh, E., Yamazaki, T., Teshima, K., Onda, Y., Kimata-Ariga, Y. and Hase, T. (2001) Structure of the electron transfer complex between ferredoxin and ferredoxin-NADP⁺ reductase. Nature Struct. Biol. 8, 117-121.

2 February 2001.

• Kao, Y.-C., Korzekwa, K.R., Laughton, C.A. and Chen, S. (2001) Evaluation of the mechanism of aromatase cytochrome P450: a site-directed mutagenesis study. Eur. J. Biochem. 268, 243-251.

26 January 2001.

• Fretland, A.J. and Omiecinski, C.J. (2000) Epoxide hydrolases: biochemistry and molecular biology. Chem. Biol. Interact. 129, 41-59.

19 January 2001.

• Zakhariev, O., Trautwein, A.X. and Veeger, C. (2000) Porphyrin-Fe(III)-hydroperoxide and porphyrin-Fe(III)-peroxide anion as catalytic intermediates in cytochrome P450-catalyzed hydroxylation reactions: a molecular orbital study. Biophys. Chem. 88, 11-34.

12 January 2001.

• Green, E.L., Taoka, S., Banerjee, R. and Loehr, T.M. (2001) Resonance Raman characterization of the heme cofactor in cystathionine ß-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme. Biochemistry 40, 459-463.

5 January 2001.

• Dokoh, T., Suzuki, N., Higuchi, T., Urano, Y., Kikuchi, K. and Nagano, T. (2000) A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site. J. Inorg. Biochem. 82, 127-132.

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