Archive of Kirill's P450 Café

Archive of Kirill's P450 Café - 1999

By Kirill Degtyarenko

Last modified: Thu Apr 15 13:36:46 BST 2004

24 December 1999.

Repa, J.J. and Mangelsdorf, D.J. (1999) Nuclear receptor regulation of cholesterol and bile acid metabolism. Curr. Opin. Biotechnol. 10, 557-563.

Merry Christmas and a Happy Year 2000

17 December 1999.

Ma, D., Wu, Y., Qian, C., Tang, W., Wang, Y.-H., Wang, W.-H., Lu, J.-X., Xie, Y. and Huang, Z.-X. (1999) Effects of some charged amino acid mutations on the electron self-exchange kinetics of cytochrome b₅. Inorg. Chem. 38, 5749-5754.

10 December 1999.

Contzen, J. and Jung, C. (1999) Changes in secondary structure and salt links of cytochrome P450cam induced by photoreduction: a Fourier transform infrared spectroscopic study. Biochemistry 38, 16253-16260.

3 December 1999.

Boutaud, O. and Brash, A.R. (1999) Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. J. Biol. Chem. 274, 33764-33770.

Note that this allene oxide synthase is not a P450.

26 November 1999.

Gelboin, H.V., Krausz, K.W., Gonzalez, F.J. and Yang, T.J. (1999) Current Awareness. Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery. Trends Pharm. Sci. 20, 432-438.

19 November 1999.

Davydov, R.M., Macdonald, I.D.G., Makris, T.M., Sligar, S.G. and Hoffman, B.M. (1999) EPR and ENDOR of catalytic intermediates in cryoreduced native and mutant oxy-cytochromes P450cam: Mutation-induced changes in the proton delivery system. J. Am. Chem. Soc. 121, 10654-10655.

12 November 1999.

Tudzynski, B. (1999) Biosynthesis of gibberellins in Gibberella fujikuroi: biomolecular aspects. Appl. Microbiol. Biotechnol. 52, 298-310.

5 November 1999.

Payne, V.A., Chang, Y.-T. and Loew, G.H. (1999a) Homology modeling and substrate binding study of human CYP2C9 enzyme. Proteins 37, 176-190.
Payne, V.A., Chang, Y.-T. and Loew, G.H. (1999b) Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes. Proteins 37, 204-217.

29 October 1999.

Sawada, N., Sakaki, T., Kitanaka, S., Takeyama, K.-i., Kato, S. and Inouye, K. (1999) Enzymatic properties of human 25-hydroxyvitamin D₃ 1-hydroxylase: Coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli. Eur. J. Biochem. 265, 950-956.

22 October 1999.

Deng, T.-j., Proniewicz, L.M., Kincaid, J.R., Yeom, H., Macdonald, I.D.G. and Sligar, S.G. (1999) Resonance Raman studies of cytochrome P450BM3 and its complexes with exogenous ligands. Biochemistry 38, 13699-13706.

15 October 1999.

Roberts, G.C.K. (1999) The power of evolution: accessing the synthetic potential of P450s. Chemistry & Biology 6, R269-R272.

8 October 1999.

Akashi, T., Matsumura, T., Ideguchi, T., Iwakiri, K.-i., Kawakatsu, T., Taniguchi, I. and Hase, T. (1999) Comparison of the electrostatic binding sites on the surface of ferredoxin for two ferredoxin-dependent enzymes, ferredoxin-NADP⁺ reductase and sulfite reductase. J. Biol. Chem. 274, 29399-29405.

1 October 1999.

Schröder, G., Unterbusch, E., Kaltenbach, M., Schmidt, J., Strack, D., De Luca, V. and Schröder, J. (1999) Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase. FEBS Lett. 458, 97-102.

24 September 1999.

Zhu, Q.-s., von Dippe, P., Xing, W. and Levy, D. (1999) Membrane topology and cell surface targeting of microsomal epoxide hydrolase. Evidence for multiple topological orientations. J. Biol. Chem. 274, 27898-27904.

17 September 1999.

Bertini, I., Luchinat, C., Parigi, G. and Walker, F.A. (1999) Heme methyl ¹H chemical shifts as structural parameters in some lowspin ferriheme proteins. J. Biol. Inorg. Chem. 4, 515-519.

10 September 1999.

Sigman, J.A., Pond, A.E., Dawson, J.H. and Lu, Y. (1999) Engineering cytochrome c peroxidase into cytochrome P450: A proximal effect on heme-thiolate ligation. Biochemistry 38, 11122-11129. [Supplementary Material]

3 September 1999.

Humphreys, J.M., Hemm, M.R. and Chapple, C. (1999) New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. USA 96, 10045-10050.

20 August 1999.

Ivanov, I.V., Groza, N.V. and Myagkova, G.I. (1999) Cytochrome P450-dependent metabolism of arachidonic acid. Biochemistry (Moscow) 64, 725-737.

13 August 1999.

Posti, K., Leinonen, S., Tetri, S., Kottari, S., Viitala, P., Pelkonen, O. and Raunio, H. (1999) Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases. Eur. J. Biochem. 264, 19-26.

6 August 1999.

Fahnenschmidt, M., Rau, H.K., Bittl, R., Haehnel, W. and Lubitz, W. (1999) Characterization of a de novo designed heme protein by EPR and ENDOR spectroscopy. Chem. Eur. J. 5, 2327-2334.

30 July 1999.

Drapier, J.-C. and Ducrocq, C. [Coordinators] (1999) Multi-author Review: Molecular and functional modifications by nitric oxide and its derivatives. Cell. Mol. Life Sci. 55, 1001-1112.

23 July 1999.

Whitlock, J.P., Jr. (1999) Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol. 39, 103-125.

16 July 1999.

Primus, J.-L., Boersma, M.G., Mandon, D., Boeren, S., Veeger, C., Weiss, R. and Rietjens, I.M.C.M. (1999) The effect of iron to manganese substitution on microperoxidase 8 catalysed peroxidase and cytochrome P450 type of catalysis. J. Biol. Inorg. Chem. 4, 274-283.

"For the peroxidase type of conversions the Fe to Mn replacement resulted in a less than 10-fold decrease in the activity at optimal pH, whereas the aniline para-hydroxylation is reduced at least 30-fold."

9 July 1999.

Lamb, D.C., Kelly, D.E., Venkateswarlu, K., Manning, N.J., Bligh, H.F.J., Schunck, W.-H. and Kelly, S.L. (1999) Generation of a complete, soluble, and catalytically active sterol 14-demethylase-reductase complex. Biochemistry 38, 8733-8738.

2 July 1999.

Nam, W., Goh, Y.M., Lee, Y.J., Lim, M.H. and Kim, C. (1999) Biomimetic alkane hydroxylations by an iron(III) porphyrin complex with H₂O₂ and by a high-valent iron(IV) oxo porphyrin cation radical complex. Inorg. Chem. 38, 3238-3240. [Electronic Supplementary Material]

25 June 1999.

Zaphiropoulos, P.G. (1999) RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver. Nucleic Acids Res. 27, 2585-2590.

18 June 1999.

Ziegler, G.A., Vonrhein, C., Hanukoglu, I. and Schulz, G.E. (1999) The structure of adrenodoxin reductase of mitochondrial P450 systems: Electron transfer for steroid biosynthesis. J. Mol. Biol. 289, 981-990.

11 June 1999.

Zhukov, A. and Ingelman-Sundberg, M. (1999) Relationship between cytochrome P450 catalytic cycling and stability: Fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. Biochem. J. 340, 453-458.

4 June 1999.

Chang, F.-C. and Swenson, R.P. (1999) The midpoint potentials for the oxidized-semiquinone couple for Gly57 mutants of the Clostridium beijerinckii flavodoxin correlate with changes in the hydrogen-bonding interaction with the proton on N(5) of the reduced flavin mononucleotide cofactor as measured by NMR chemical shift temperature dependencies. Biochemistry 38, 7168-7176.

28 May 1999.

Lees, N.D., Bard, M. and Kirsch, D.R. (1999) Biochemistry and molecular biology of sterol synthesis in Saccaromyces cerevisiae. Crit. Rev. Biochem. Mol. Biol. 34, 33-47.

14 May 1999.

Ito, S., Matsuoka, T., Watanabe, I., Kagasaki, T., Serizawa, N. and Hata, T. (1999) Crystallization and preliminary X-ray diffraction analysis of cytochrome P450_sca-2 from Streptomyces carbophilus involved in production of pravastatin sodium, a tissue-selective inhibitor of HMG-CoA reductase. Acta Crystallogr. D55, 1209-1211.

7 May 1999.

Maldotti, A., Andreotti, L., Molinari, A. and Carassiti, V. (1999) Photochemically driven models of oxygenases based on the use of iron porphyrins. J. Biol. Inorg. Chem. 4, 154-161.

30 April 1999.

Parikh, A., Josephy, P.D. and Guengerich, F.P. (1999) Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry 38, 5283-5289 .

23 April 1999.

Noble, M.A., Miles, C.S., Chapman, S.K., Lysek, D.A., Mackay, A.C., Reid, G.A., Hanzlik, R.P. and Munro, A.W. (1999) Roles of key active-site residues in flavocytochrome P450 BM3. Biochem. J. 339, 371-379.

16 April 1999.

Renodon-Cornière, A., Boucher, J.-L., Dijols, S., Stuehr, D.J. and Mansuy, D. (1999) Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase. Biochemistry 38, 4663-4668.

Results of the study "suggest a possible implication of NOSs in the oxidative metabolism of certain classes of xenobiotics".

9 April 1999.

Shimada, H., Nagano, S., Ariga, Y., Unno, M., Egawa, T., Hishiki, T., Ishimura, Y., Masuya, F., Obata, T. and Hori, H. (1999) Putidaredoxin-cytochrome P450_cam interaction. Spin state of the heme iron modulates putidaredoxin structure. J. Biol. Chem. 274, 9363-9369.

1 April 1999.

Poulos, T.L., Li, H. and Raman, C.S. (1999) Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase. Curr. Opin. Chem. Biol. 3, 131-137.

This review appears in Bio-inorganic Chemistry issue of Current Opinion in Chemical Biology.

26 March 1999.

Ueno, T., Nishikawa, N., Moriyama, S., Adachi, S., Lee, K., Okamura, T.-a., Ueyama, N. and Nakamura, A. (1999) Role of the invariant peptide fragment forming NH···S hydrogen bonds in the active site of cytochrome P-450 and chloroperoxidase: Synthesis and properties of Cys-containing peptide Fe(III) and Ga(III) (octaethylporphinato) complexes as models. Inorg. Chem. 38, 1199-1210.

19 March 1999.

Haining, R.L., Jones, J.P., Henne, K.R., Fisher, M.B., Koop, D.R., Trager, W.F. and Rettie, A.E. (1999) Enzymatic determinants of the substrate specificity of CYP2C9: Role of B'-C loop residues in providing the -stacking anchor site for warfarin binding. Biochemistry 38, 3187-3196.

12 March 1999.

Wang, P.-F., Arscott, L.D., Gilberger, T.-W., Müller, S. and Williams, C.H., Jr. (1999) Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol. Biochemistry 38, 3187-3196.

5 March 1999.

Grigoryev, D.N., Kato, K., Njar, V.C.O., Long, B.J., Ling, Y.-Z., Wang, X., Mohler, J. and Brodie, A.M.H. (1999) Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17-hydroxylase-C_17,20-lyase inhibitors. Anal. Biochem. 267, 319-330.

26 February 1999.

Koenigs, L.L., Peter, R.M., Hunter, A.P., Haining, R.L., Rettie, A.E., Friedberg, T., Pritchard, M.P., Shou, M., Rushmore, T.H. and Trager, W.F. (1999) Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9. Biochemistry 38, 2312-2319.

19 February 1999.

Roberts, G.C.K. (1999) NMR spectroscopy in structure-based drug design. Curr. Opin. Biotechnol. 10, 42-47.

12 February 1999.

Huang, L., Abu-Soud, H.M., Hille, R. and Stuehr, D.J. (1999) Nitric oxide-generated P420 nitric oxide synthase: Characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion. Biochemistry 38, 1912-1920.

5 February 1999.

Tan, H.-M. (1999) Bacterial catabolic transposons. Appl. Microbiol. Biotechnol. 51, 1-12.

28 January 1999.

Jung, Y.-S., Roberts, V.A., Stout, C.D. and Burgess, B.K. (1999) Complex formation between Azotobacter vinelandii ferredoxin I and its physiological electron donor NADPH-ferredoxin reductase. J. Biol. Chem. 274, 2978-2987.

22 January 1999.

Macdonald, I.D.G., Sligar, S.G., Christian, J.F., Unno, M. and Champion, P.M. (1999) Identification of the Fe-O-O bending mode in oxycytochrome P450cam by resonance Raman spectroscopy. J. Am. Chem. Soc. 121, 376-380.

15 January 1999.

Audergon, C., Iyer, K.R., Jones, J.P., Darbyshire, J.F. and Trager, W.F. (1999) Experimental and theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the P450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl. J. Am. Chem. Soc. 121, 41-47.

8 January 1999.

Oesterheld, J.R. (1998) A review of developmental aspects of cytochrome P450. J. Child Adolesc. Psychopharmacol. 8, 161-174.

1 January 1999.

Tian, Y., Ke, S., Denison, M.S., Rabson, A.B. and Gallo, M.A. (1999) Ah Receptor and NF-B interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem. 274, 510-515.

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