Archive of Kirill's P450 Café - 1998

Last modified: Thu Apr 15 13:42:51 BST 2004

25 December 1998.

• Louërat-Oriou, B., Perret, A. and Pompon, D. (1998) Differential redox and electron-transfer properties of purified yeast, plant and human NADPH-cytochrome P-450 reductases highly modulate cytochrome P-450 activities. Eur. J. Biochem. 258, 1040-1049.

18 December 1998.

• Grinberg, A.V. and Bernhardt, R. (1998) Effect of replacing a conserved proline residue on the function and stability of bovine adrenodoxin. Protein Engineering 11, 1057-1064.

11 December 1998.

• Hart-Davis, J., Battioni, P., Boucher, J.-L. and Mansuy, D. (1998) New catalytic properties of iron porphyrins: Model systems for cytochrome P450-catalyzed dehydration of aldoximes. J. Am. Chem. Soc. 120, 12524-12530.

4 December 1998.

• Walsh, M.A., McCarthy, A., O'Farrell, P.A., McArdle, P., Cunningham, P.D., Mayhew, S.G. and Higgins, T.M. (1998) X-ray crystal structure of the Desulfovibrio vulgaris (Hildenborough) apoflavodoxin-riboflavin complex. Eur. J. Biochem. 258, 362-371.

27 November 1998.

• Aissaoui, H., Bachmann, R., Schweiger, A. and Woggon, W.-D. (1998) On the origin of the low-spin character of cytochrome P450cam in the resting state - Investigations of enzyme models with pulse EPR and ENDOR spectroscopy. Angew. Chem. Int. Ed. 37, 2998-3002. (163 Kb PDF file)

20 November 1998.

• Kuroda, R., Ikenoue, T., Honsho, M., Tsujimoto, S., Mitoma, J.-y. and Ito, A. (1998) Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b₅. J. Biol. Chem. 273, 31097-31102.

13 November 1998.

• Naito, N.R., Huang, H., Sturgess, A.W., Nocek, J.M. and Hoffman, B.M. (1998) Binding and electron transfer between cytochrome b₅ and the hemoglobin - and ß-subunits through the use of [Zn, Fe] hybrids. J. Am. Chem. Soc. 120, 11256-11262.

6 November 1998.

• Anzenbacher, P., Hudecek, J., Lange, R. and Bancel, F. (1998b) Accessibility of tyrosine residues in cytochrome P­450scc (CYP11A1). Collect. Czechoslovak Chem. Commun. 63, 1678-1682.

30 October 1998.

• McIver, L., Leadbeater, C., Campopiano, D.J., Baxter, R.L., Daff, S.N., Chapman, S.K. and Munro, A.W. (1998) Characterisation of flavodoxin NADP⁺ oxidoreductase and flavodoxin - Key components of electron transfer in Escherichia coli. Eur. J. Biochem. 257, 577-585.

23 October 1998.

• Betlach, M.C., Kealey, J.T., Betlach, M.C., Ashley, G.W. and McDaniel, R. (1998) Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin. Biochemistry 37, 14937-14942.

16 October 1998.

• Furchgott, R.F., Ignarro, L.J. and Murad, F. The Nobel Prize in Physiology or Medicine 1998 "for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system".

• Howlett, R. (1998) Nobel award stirs up debate on nitric oxide breakthrough. Nature 395, 625-626.

9 October 1998.

• Fawcett, S.E.J., Davis, D., Breton, J.L., Thomson, A.J. and Armstrong, F.A. (1998) Voltammetric studies of the reactions of iron-sulphur clusters ([3Fe-4S] or [M3Fe-4S]) formed in Pyrococcus furiosus ferredoxin. Biochem. J. 335, 357-368.

2 October 1998.

• Chen, Z. and Banerjee, R. (1998) Purification of soluble cytochrome b₅ as a component of the reductive activation of porcine methionine synthase. J. Biol. Chem. 273, 26248-26255.

25 September 1998.

• Peterson, J.A. and Graham, S.E. (1998) A close family resemblance: the importance of structure in understanding cytochromes P450. Structure 6, 1079-1085.

18 September 1998.

• Babu, B.R. and Griffith, O.W. (1998) Design of isoform­selective inhibitors of nitric oxide synthase. Curr. Opin. Chem. Biol. 2, 491-500.

11 September 1998.

A good bit of theoretical P450-logy from JACS:

• Roitberg, A.E., Holden, M.J., Mayhew, M.P., Kurnikov, I.V., Beratan, D.L. and Vilker, V.L. (1998) Binding and electron transfer between putidaredoxin and cytochrome P450cam. Theory and experiments. J. Am. Chem. Soc. 120, 8927-8932.
• Harris, D.L. and Loew, G.H. (1998) Theoretical investigation of the proton assisted pathway to formation of cytochrome P450 compound I. J. Am. Chem. Soc. 120, 8941-8948.

4 September 1998.

• Banci, L., Bertini, I., Cavazza, C., Felli, I.C. and Koulougliotis, D. (1998) Probing the backbone dynamics of oxidized and reduced rat microsomal cytochrome b₅ via ¹⁵N rotating frame NMR relaxation measurements: Biological implications. Biochemistry 37, 12320-12330.

28 August 1998.

• Perret, A. and Pompon, D. (1998) Electron shuttle between membrane-bound cytochrome P450 3A4 and b₅ rules uncoupling mechanisms. Biochemistry 37, 11412-11424.

14 August 1998.

• Toy, P.H., Newcomb, M. and Hollenberg, P.F. (1998) Hypersensitive mechanistic probe studies of cytochrome P450-catalyzed hydroxylation reactions. Implications for the cationic pathway. J. Am. Chem. Soc. 120, 7719-7729.

7 August 1998.

• Lehnerer, M., Schulze, J., Pernecky, S.J., Lewis, D.F.V., Eulitz, M. and Hlavica P. (1998) Influence of mutation of the amino-terminal signal anchor sequence of cytochrome P450 2B4 on the enzyme structure and electron transfer processes. J. Biochem. (Tokyo) 124, 396-403.

31 July 1998.

• Perry, J.M., Moon, N., Zhao, Y., Dunham, W.R. and Marletta, M.A. (1998) The high-potential flavin and heme of nitric oxide synthase are not magnetically linked: implications for electron transfer. Chemistry & Biology 5, 355-364.

24 July 1998.

• Wong, L.-L. (1998) Cytochrome P450 monooxygenases. Curr. Opin. Chem. Biol. 2, 263-268.

17 July 1998.

• Siddhanta, U., Presta, A., Fan, B., Wolan, D., Rousseau, D.L. and Stuehr, D.J. (1998) Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer. J. Biol. Chem. 273, 18950-18958.

10 July 1998.

• Druhan, L.J. and Swenson, R.P. (1998) Role of methionine 56 in the control of the oxidation-reduction potentials of the Clostridium beijerinckii flavodoxin: Effects of substitutions by aliphatic amino acids and evidence for a role of sulfur-flavin interactions. Biochemistry 37, 9668-9678.

3 July 1998.

• Vidakovic, M., Sligar, S.G., Li, H. and Poulos, T.L. (1998) Understanding the role of the essential Asp251 in cytochrome P450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect. Biochemistry 37, 9211-9219.

26 June 1998.

• Shimoji, M., Yin, H., Higgins, L. and Jones, J.P. (1998) Design of a novel P450: A functional bacterial-human cytochrome P450 chimera. Biochemistry 37, 8848-8852.

19 June 1998.

• Shikama, K. (1998) The molecular mechanism of autoxidation for myoglobin and hemoglobin: A venerable puzzle. Chem. Rev. 98, 1357-1374.

12 June 1998.

• Meyer, K., Shirley, A.M., Cusumano, J.C., Bell-Lelong, D.A. and Chapple, C. (1998) Lignin monomer composition is determined by the expression of a cytochrome P450-dependent monooxygenase in Arabidopsis. Proc. Natl. Acad. Sci. USA 95, 6619-6623.

5 June 1998.

• Imai, T., Yamazaki, T. and Kominami, S. (1998) Kinetic studies on bovine cytochrome P450_11ß catalyzing successive reactions from deoxycorticosterone to aldosterone. Biochemistry 37, 8097-8104.

29 May 1998.

• Lee-Robichaud, P., Akhtar, M.E. and Akhtar, M. (1998) Control of androgen biosynthesis in the human through the interaction of Arg³⁴⁷ and Arg³⁵⁸ of CYP17 with cytochrome b₅. Biochem. J. 332, 293-296.

22 May 1998.

Ueyama, N., Nishikawa, N., Yamada, Y., Okamura, T., Oka, S., Sakurai, H. and Nakamura, A. (1998) Synthesis and properties of octaethylporphinato(arenethiolato)iron(III) complexes with intramolecular NH···S hydrogen bond: Chemical function of the hydrogen bond. Inorg. Chem. 37, 2415-2421.

15 May 1998.

• Higgins, L., Bennett, G.A., Shimoji, M. and Jones, J.P. (1998) Evaluation of cytochrome P450 mechanism and kinetics using kinetic deuterium isotope effects. Biochemistry 37, 7039-7046.

8 May 1998.

• Lvov, Yu.M., Lu, Z., Schenkman, J.B., Zu, X. and Rusling, J.F. (1998) Direct electrochemistry of myoglobin and cytochrome P450_cam in alternate layer-by-layer films with DNA and other polyions. J. Am. Chem. Soc. 120, 4073-4080.

1 May 1998.

• Jenkins, C.M. and Waterman, M.R. (1998) NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: Characteristics as a soluble microsomal P450 reductase. Biochemistry 37, 6106-6113.

24 April 1998.

• Tschirret-Guth, R.A., Hui Bon Hoa, G. and Ortiz de Montellano, P.R. (1998) Pressure-induced deformation of the cytochrome P450_cam active site. J. Am. Chem. Soc. 120, 3590-3596.

17 April 1998.

• Armengaud, J. and Timmis, K.N. (1998) The reductase RedA2 of the multi-component dioxin dioxygenase system of Sphingomonas sp. RW1 is related to class-I cytochrome P₄₅₀-type reductases. Eur. J. Biochem. 253, 437-444.

10 April 1998.

• Vaz, A.D.N., McGinnity, D.F. and Coon, M.J. (1998) Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. Proc. Natl. Acad. Sci. USA 95, 3555-3560.

3 April 1998.

• Chin, K.-K. and Chang, S.-F. (1998) The -104 G nucleotide of the human CYP21 gene is important for CYP21 transcription activity and protein interaction. Nucleic Acids Res. 26, 1959-1964.

27 March 1998.

• Cane, D.E. and Graziani, E.I. (1998) Methymycin biosynthesis. Isolation of P450 monooxygenase activity in a cell-free system from Streptomyces venezuelae. J. Am. Chem. Soc. 120, 2682-2683.

20 March 1998.

• Xia, B., Volkman, B.F. and Markley, J.L. (1998) Evidence for oxidation-state-dependent conformational changes in human ferredoxin from multinuclear, multidimensional NMR spectroscopy. Biochemistry 37, 3965-3973.

13 March 1998.

• Honkakoski, P. and Negishi, M. (1998) Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem. J. 330, 889-895.

6 March 1998.

• Tavares, P., Pereira, A.S., Krebs, C., Ravi, N., Moura, J.J.G., Moura, I. and Huynh, B.H. (1998) Spectroscopic characterization of a novel tetranuclear Fe cluster in an iron-sulfur protein isolated from Desulfovibrio desulfuricans. Biochemistry 37, 2830-2842.

27 February 1998.

• Shaik, S., Filatov, M., Schröder, D. and Schwarz, H. (1998) Electronic structure makes a difference: Cytochrome P-450 mediated hydroxylations of hydrocarbons as a two-state reactivity paradigm. Chem. Eur. J. 4, 193-199.

20 February 1998.

• Venkateswarlu, K., Lamb, D.C., Kelly, D.E., Manning, N.J. and Kelly, S.L. (1998) The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. J. Biol. Chem. 273, 4492-4496.

13 February 1998.

• Rivera, M., Seetharaman, R., Girdhar, D., Wirtz, M., Zhang, X., Wang, X. and White, S. (1998) The reduction potential of cytochrome b₅ is modulated by its exposed heme edge. Biochemistry 37, 1485-1494.

6 February 1998.

• Iametti, S., Uhlmann, H., Ragg, E., Sala, N., Grinberg, A., Beckert, V., Bernhardt, R. and Bonomi, F. (1998) Cluster-iron substitution is related to structural and functional features of adrenodoxin mutants and to their redox states. Eur. J. Biochem. 251, 673-681.

30 January 1998.

• Anandatheerthavarada, H.K., Addya, S., Mullick, J. and Avadhani, N.G. (1998) Interaction of adrenodoxin with P4501A1 and its truncated form P450MT2 through different domains: Differential modulation of enzyme activities. Biochemistry 37, 1150-1160.

23 January 1998.

• Sopková-de Oliveira Santos, J., Smith, J.C., Delaforge, M., Virelizier, H. and Jankowski, C.K. (1998) Oxidation of tetrahydro-ß-carboline by cytochrome P-450_cam. Determination and rationalisation of product distribution. Eur. J. Biochem. 251, 398-404.

16 January 1998.

• Kisselev, P., Wessel, R., Pisch, S., Bornscheuer, U., Schmid, R.-D. and Schwarz, D. (1998) Branched phosphatidylcholines stimulate activity of cytochrome P450SCC (CYP11A1) in phospholipid vesicles by enhancing cholesterol binding, membrane incorporation, and protein exchange. J. Biol. Chem. 273, 1380-1386.

9 January 1998.

• Guengerich, F.P. and Parikh, A. (1997) Expression of drug-metabolizing enzymes. Curr. Opin. Biotechnol. 8, 623-628.

2 January 1998.

• Oinonen, T. and Lindros, K.O. (1998) Zonation of hepatic cytochrome P-450 expression and regulation. Biochem. J. 329, 17-35.

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