Archive of Kirill's P450 Café - 2009

by Kirill Degtyarenko

Last modified: Fri Jul 10 10:11:12 GMT 2009

3 July 2009.

• Grobe, N., Zhang, B., Fisinger, U., Kutchan, T.M., Zenk, M.H. and Guengerich, F.P. (2009) Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. J. Biol. Chem., in press.

26 June 2009.

• Namazi, M.R. (2009) Cytochrome-P450 enzymes and autoimmunity: expansion of the relationship and introduction of free radicals as the link. J. Autoimmune Dis. 6, 4.

19 June 2009.

• Robin, A., Roberts, G.A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., Turner, N.J. and Flitsch, S.L. (2009) Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme. Chem. Commun., 2478-2480.

12 June 2009.

• Lamb, D.C., Lei, L., Warrilow, A.G., Lepesheva, G.I., Mullins, J.G., Waterman, M.R. and Kelly, S.L. (2009) The first virally encoded cytochrome P450. J. Virol., in press.

5 June 2009.

• Guelker, M., Stagg, L., Wittung-Stafshede, P. and Shamoo, Y. (2009) Pseudosymmetry, high copy number and twinning complicate the structure determination of Desulfovibrio desulfuricans (ATCC 29577) flavodoxin. Acta Crystallogr. D 65, 523-534.

22 May 2009.

• Spector, A.A. (2009) Arachidonic acid cytochrome P450 epoxygenase pathway. J. Lipid Res. 50, S52-S56.

15 May 2009.

• Meslamani, J.E., André, F. and Petitjean, M. (2009) Assessing the geometric diversity of cytochrome P450 ligand conformers by hierarchical clustering with a stop criterion. J. Chem. Inf. Model. 49, 330-337.

1 May 2009.

• Anandatheerthavarada, H.K., Sepuri, N.B. and Avadhani, N.G. (2009) Mitochondrial targeting of cytochrome P450 proteins containing NH₂-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. J. Biol. Chem., in press.

24 April 2009.

• Mašek, V., Anzenbacherová, E., Machová, M., Brabec, V. and Anzenbacher, P. (2009) Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. Anti-Cancer Drugs 2, 305-311.

17 April 2009.

• Hong, C., Bell, S.G., Yang, W., Wang, H., Hao, Y., Li, X., Zhou, W., Bartlam, M. and Wong, L.-L. (2009) Purification, crystallization and preliminary X-ray analysis of cytochrome P450 219A1 from Novosphingobium aromaticivorans DSM 12444. Acta Crystallogr. F65, 364-367.

27 March 2009.

• McDonald, M.G., Rieder, M.J., Nakano, M., Hsia, C.H. and Rettie, A.E. (2009) CYP4F2 is a vitamin K₁ oxidase: an explanation for altered warfarin dose in carriers of the V433M variant. Mol. Pharmacol., in press.

20 March 2009.

• Brodhun, F., Göbel, C., Hornung, E. and Feussner, I. (2009) Identification of PSI-factor producing oxygenase A (PpoA) from A. nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450. J. Biol. Chem., in press.

13 March 2009.

• Van Aken, B. (2009) Transgenic plants for enhanced phytoremediation of toxic explosives. Curr. Opin. Biotechnol., in press.

6 March 2009.

• Rabe, K.S., Spengler, M., Erkelenz, M., Müller, J., Gandubert, V.J., Hayen, H. and Niemeyer, C.M. (2009) Screening for cytochrome P450 reactivity by harnessing catalase as reporter enzyme. ChemBioChem 10, 751-757.

27 February 2009.

• Hennemann, M., Friedl, A., Lobell, M., Keldenich, J., Hillisch, A., Clark, T. and Göller, A.H. (2009) CypScore: quantitative prediction of reactivity toward cytochromes P450 based on semiempirical molecular orbital theory. ChemMedChem, in press.

20 February 2009.

• Yunt, Z., Reinhardt, K., Li, A., Engeser, M., Dahse, H.-M., Gütschow, M., Bruhn, T., Bringmann, G. and Piel, J. (2009) Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore. J. Am. Chem. Soc. 131, 2297-2305.

13 February 2009.

• Vetter, S.W., Terentis, A.C., Osborne, R.L., Dawson, J.H. and Goodin, D.B. (2009) Replacement of the axial histidine heme ligand with cysteine in nitrophorin 1: spectroscopic and crystallographic characterization. J. Biol. Inorg. Chem. 14, 179-191.

6 February 2009.

• Hessenauer-Ilicheva, N., Franke, A., Meyer, D., Woggon, W.-D. and van Eldik, R. (2009) Mechanistic insight into formation of oxo-iron(IV) porphyrin π-cation radicals from enzyme mimics of cytochrome P450 in organic solvents. Chem. Eur. J., in press.

30 January 2009.

• Hamdane, D., Xia, C., Im, S.-C., Zhang, H., Kim, J.-J.P. and Waskell, L. (2009) Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J. Biol. Chem., in press.

23 January 2009.

• Hall, C.N., Keynes, R.G. and Garthwaite, J. (2009) Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain. Biochem J., in press.

16 January 2009.

• Kirby, J. and Keasling, J.D. (2009) Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu. Rev. Plant Biol., in press.

9 January 2009.

• Li, S., Ouellet, H., Sherman, D.H. and Podust, L.M. (2009) Analysis of transient and catalytic desosamine binding pockets in cytochrome P450 PikC from Streptomyces venezuelae. J. Biol. Chem., in press.

2 January 2009.

• Sauveplane, V., Kandel, S., Kastner, P.E., Ehlting, J., Compagnon, V., Werck-Reichhart, D. and Pinot, F. (2008) Arabidopsis thaliana CYP77A4 is the first cytochrome P450 able to catalyze the epoxidation of free fatty acids in plants. FEBS J. 276, 719-735.

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