P450s that have appeared since the 1993 P450 nomenclature update.
This is Part B of the P450 bibiographic files.
Sequences covered are CYP3 to CYP9.
This list now includes all Drosophila P450s
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list.
Added 4A23-4A25, 6X1 9J1, 9J2,
4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2
Added all human genes and pseudogenes
Added CYP8B1 pig
Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
Added 25 Aedes and 104 Anopheles sequences
Added CYP9G2
This list was last revised on April 7, 2003.
Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
July 2, 2003 added 4F42, 3A64, 4T6, 4T7
Last revised Aug 19 2003, added 9A12
Last revised Sept 26, 2003 added accessions for some old seqs.
3A Subfamily
4A Subfamily
4B Subfamily
4C Subfamily
4D Subfamily
4E Subfamily
4F Subfamily
4G Subfamily
4H Subfamily
4J Subfamily
4K Subfamily
4L Subfamily
4M Subfamily
4N Subfamily
4P Subfamily
4Q Subfamily
4R Subfamily
4S Subfamily
4T Subfamily
5A Subfamily
6A Subfamily
6B Subfamily
6C Subfamily
6D Subfamily
6E Subfamily
6F Subfamily
7A Subfamily
7B Subfamily
8A Subfamily
8B Subfamily
9A Subfamily
9B Subfamily
9C Subfamily
3A Subfamily
CYP3A1 rat
GenEMBL D13912 (2023bp)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of steroid-
induced cytochrome P450 3A in rats
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: only 11 differences and two missing amino acids with
3A1. All changes are limited to a 113 amino
acid region, probably represents a gene conversion.
CYP3A1 rat
PIR S30378 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
CYP3A1 rat
GenEMBL L24207 (2015bp)
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
Unpublished (1993)
CYP3A1 rat
GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of
steroid-induced cytochrome P450 3A1 in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
CYP3A1 rat
GenEMBL M28452 (897bp)
Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
Demonstration in multiple species of inducible hepatic cytochromes
P-450 and their mRNAs related to the glucocorticoid-inducible
cytochrome P-450 of the rat
Mol. Pharmacol. 28, 312-321 (1985)
Komori,M. and Oda,Y.
PIR JX0334 (502 amino acids)
A major glucocorticoid-inducible P450 in rat liver is not 3A1.
J. Biochem. 116, 114-120 (1994)
Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
CYP3A1 rat
PIR S36137 (30 amino acids)
Ribeiro, V. and Lechner, M.C.
Cloning and characterization of a novel CYP3A1 allelic
variant: Analysis of CYP3A1 and CYP3A2
sex-hormone-dependent expression reveals that the CYP3A2
gene is regulated by testosterone.
Arch. Biochem. Biophys. 293, 147-152 (1992)
This sequence agrees exactly with PIR JX0334, a 3A1 variant
CYP3A1 rat
PIR S27107 (24 amino acids)
PIR S21697 (504 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
CYP3A2 rat
GenEMBL M74443 (4230bp) U09725 to U09734 13 exons
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
U09725-U09734 report corrections to M74443
CYP3A2 rat
Gen EMBL X79319 (8014bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL U09742 (1936bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2:
Comparison of the cDNA with P450PCN2.
unpublished (1994)
CYP3A2 rat
Yamazoe,Y. et al.
Transcriptional elements directing a liver-specific expression of
P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
Arch Biochem Biophys. 318, 71-79 (1995)
CYP3A2 rat
PIR S30379 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
CYP3A2 rat
GenEMBL S45634 (1572bp)
PIR S27108 (36 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
CYP3A3 human
PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
Complete cDNA sequence of a cytochrome P-450 inducible by
glucocorticoids in human liver.
Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
CYP3A4 human
GenEMBL D11131 (1345bp)
Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
Kamataki,T. and Itoh, S.
Gene structure of CYP3A4 an adult-specific form of cytochrome
P450 in human
livers and its transcriptional control.
Eur. J. Biochem. 218, 585-595 (1993)
CYP3A4 human
GenEMBL J04449 (2849bp)
Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and
Guengerich,F.P.
Characterization of mRNA species related to human liver cytochrome
P-450 nifedipine oxidase and the regulation of catalytic activity.
J. Biol. Chem. 264, 910-919 (1989)
nf-10 nifedipine oxidase (IIIA3)
CYP3A5P1 human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
CYP3A5P2 human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
CYP3A5 human
PIR A60558 (29 amino acids)
Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
Identification of a polymorphically expressed member of the
human cytochrome P-450III family.
Mol. Pharmacol. 36, 97-105 (1989)
CYP3A5 human
GenEMBL S74699 (1526bp) S74700 (1667bp)
Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
Sequence of the 5'-flanking region of CYP3A5: comparative analysis
with CYP3A4 and CYP3A7.
Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)
CYP3A5 human
GenEMBL AC005020 genomic sequence 13 exons
Same intron exon structure as CYP3A43 from human
NT_033964.1|Hs7_34119 Homo sapiens chromosome 7
alt exon 1 and 2 upstream of 3A5
239409 MDLIPNLAVETWLLLAVSLVLLYL + ex 1
243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697 + ex2
CYP3A7 human
NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
NT_033964.1|Hs7_34119 chromosome 7 alt exon 1 and 2 upstream of 3A7
186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2
CYP3A8 Macaca fasicularis (monkey)
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP3A8 Macaca fasicularis (monkey)
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A8 Macaca fasicularis (monkey)
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A9 rat
GenEMBL U46118(2101bp)
Wang,H., Kawashima,H. and Strobel,H.W.
cDNA cloning of a novel CYP3A from rat brain
Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)
CYP3A9 rat
GenEMBL U60085(1882bp)
Nef,P.
Hepatic expression and inducibilty of CYP3A9 and other members of
the rat CYP3A subfamily.
unpublished (1996)
CYP3A10 hamster
GenEMBL M73992 (2015bp)
Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequence of a new rat CYP3A form
unpublished (1993)
Cyp3a11 mouse
PIR A60564 (24 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
CYP3A12 dog
PIR S04341 (28 amino acids)
Ciaccio, P.J. and Halpert, J.R.
Characterization of a phenobarbital-inducible dog liver
cytochrome P450 structurally related to rat and human
enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Arch. Biochem. Biophys. 271, 284-299 (1989)
Cyp3a13 mouse
GenEMBL X63023(1881bp)
Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
Molecular cloning and functional expression of a mouse cytochrome
P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
aflatoxin B1 (AFB1).
Biochim. Biophys. Acta 1201 (3), 405-410 (1994)
CYP3A14 Cavia cobaya (guinea pig)
GenEMBL D16363 (1827bp)
Mori,T., Itoh,S. and Kamataki,T.
cDNA and deduced amino acid sequence of a novel cytochrome
P450 from male guinea pig liver mRNA with high homology to
CYP3a family
unpublished (1993)
CYP3A14 Cavia porcellus (guinea pig)
GenEMBL D49731 (2321bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
CYP3A15 Cavia cobaya (guinea pig)
GenEMBL D26487 (2163bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
Cyp3a16 mouse
GenEMBL D26137 (1701bp)
Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning
and expression in fetal liver.
Eur. J. Biochem. 226, 877-882 (1994)
CYP3A17 guinea pig
GenEMBL D28515
Mori,T.
submitted to Nomenclature Committee
Not in Genbank as of 6/26/95
CYP3A18 rat
no accession number
Kiyoshi Nagata
6-beta-C
submitted to Nomenclature Committee
CYP3A18 rat
GenEMBL X79991 (2005bp)
Strotkamp,D., Roos,P.H. and Hanstein,W.G.
A novel CYP3 from female rats.
Biochim. Biophys. Acta 1260, 341-344 (1994)
CYP3A18 rat
GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
Yamazoe,Y. et al.
Isolation and characterization of of a new rat P450 (CYP3A18) cDNA
encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
Pharmacogenetics in press (1995)
CYP3A19 Capra hircus (goat)
GenEMBL X76503 (1084bp)
Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
cDNA and deduced amino acid sequence of a dwarf goat liver
cytochrome P450-fragment belonging to the CYP2C gene subfamily
Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
C-terminal fragment from I-helix to end
CYP3A20 Guinea pig
GenEMBL
T. Mori
unpublished
CYP3A21 Marmoset
GenEMBL
Igarishi, T.
unpublished
CYP3A22 Miniature pig
Shimojima, T.
unpublished
CYP3A23 rat
GenEMBL D13912
Kirita,S. and Matsubara,T.
Cloning and characterization of a novel member of steroid induced
cytochrome P450 3A in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
CYP3A23 rat
GenEMBL D29967
Komori,M. and Oda,Y.
A major glucocorticoid inducible P450 in rat liver is not P4503A1
J. Biochem. 116, 114-120 (1994)
CYP3A24 sheep
GenEMBL U59378(1653bp)
Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
and Morgan,D.J.
Ovine foetal liver CYP3A24
unpublished (1996)
Cyp3a25 mouse
GenEMBL AF204959
Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
submitted to Nomenclature Committee 10/18/96
Cloning, sequencing, heterologous expression and characterization
of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
Unpublished
Cyp3a25 mouse
GenEMBL Y11995
Mahnke,A., Roos,P. and Hanstein,W.G.
one amino acid difference with Roses sequence at amino acid 215
unpublished
CYP3A26 dog
no accession number
David Fraser
submitted to Nomenclature Committee
95.6% identical to 3A12 from dog
CYP3A27 Oncorhynchus mykiss (rainbow trout)
GenEMBL U96077
Don R. Buhler
Arch. Biochem. Biophys. 360, 000-000 (1998) in press
56% identical to 3A12
CYP3A28 bovine
GenEMBL Y10214(1870bp)
Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
Witkamp,R.F. and Horbach,G.J.
Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
and its functional expression in V79 cells.
unpublished (1997)
CYP3A29v1 pig
GenEMBL Z93099 (2015bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA
CYP3A29v2 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
2 amino acid diffs with 3A29v1
clone name 3Ac9
CYP3A29v3 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1
clone name 3Ac16
CYP3A29v4 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
clone name 3Ac25
CYP3A29v5 Sus scrofa (mini pig)
GenEMBL AF424780
Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
cDNA of minipig cytochrome P450 3A
Unpublished
75% to 3A4 human 98% to 3A29v1 8 diffs.
3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
4 diffs with 329v2 (Partial seq from 99-328)
CYP3A30 Fundulus heteroclitus
Genbank AF105068
Malin Celander and John J. Stegeman
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the
marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A
genes.
Biochem. Biophys. Res. Commun. 236, 306-312 (1997)
CYP3A31 Syrian hamster
GenEMBL D86951
Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
Nagata,K. and Yamazoe,Y.
cDNA cloning and expression of a novel CYP3A from the Syrian
hamster, CYP3A31
Biochim. Biophys. Acta 1397, 9-13 (1998)
clone name P450SH3A-1
CYP3A32 Balaenoptera acutorostrata (Minke whale)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee
CYP3A33 Phocoenoides dalli (Dall's porpoise)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee
CYP3A34 Eumetopias jubatus (Steller sea lion)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee
CYP3A35 Phoca largha (Spotted seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee
CYP3A36 Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee
CYP3A37 Gallus gallus (chicken)
no accession number
Manuel Baader and Urs Meyer
submitted to nomencalture committee
60% identical to mammalian CYP3A sequences
CYP3A38 Medaka (fish)
no accession number
Seth Kullman
submitted to nomenclature committee 11/6/98
72% identical to CYP3A27 trout
CYP3A39v1 Sus scrofa (pig)
GenEMBL AF109068
Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
Porcine Cytochrome-P450 with high protein homology to human CYP3A4
(Nifedipine oxidase J04449)
Unpublished
88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA
CYP3A39v2 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
clone name 3Ac13
CYP3A39v3 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
clone name 3Ac19
CYP3A39v4 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
clone name 3Ac32
CYP3A40 medaka
no accession number
Seth Kullman
submitted to nomenclature committee 1/12/99
90% identical to CYP3A38 trout
Cyp3a41 mouse
GenEMBL NM_017396 AB033414
Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene
subfamily in the mouse liver
Arch. Biochem. Biophys. 377 (1), 153-162 (2000)
91% identical to 3a11 87% identical to 3a16 69% to 3a25 and
68% to 3a13 90% to 3a44
submitted to nomenclature committee 6/1/99
CYP3A42 Python regius (ball python or royal python, African snake)
No accession number
Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
Submitted to nomenclature committee Oct 22, 1999
59% to mouse 3a
CYP3A43 human
GenEMBL AC011904 8902-46787 13 exons
Gene assembled from genomic sequence by Henry Strobel
and David Nelson on Dec 11, 1999
intron exon boundaries defined by comparison to rat 3A9
and human 3A sequences. GT AG pairs found for all introns
ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
Opposite ends of same clone
67% identical to rat 3A9
Assembled gene * = intron exon boundary ** = EST support for this boundary
MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI*
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*
coding region 504 amino acids
exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787
AC011904 alt exon 1 upstream of 3A43 83% to 3A43 exon 1
MDLIPNFAMEMCVLLATSLVLLYL
Cyp3a44 mouse
GenEMBL AB039380
Tsutomu Sakuma
Submitted to nomenclature committee 2/29/2000
This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)
CYP3A45 Oncorhynchus mykiss (rainbow trout)
No accession number
Su-Jun Lee, Don R. Buhler
96% to 3A27 but different 3 prime and 5 prime ends
CYP3A46v1 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
clone name 3Ac4
CYP3A46v2 Sus scrofa (pig)
No accession number
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
clone name 3Ac28
CYP3A47X Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Renamed CYP3D1
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPPLHDPSTSP (1)
Cannot identify exon 8 in this region
(0) EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3A48 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803
CYP3A49 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124b length 48103 gene runs off end of scaffold
48101 XXXXYEILAQ 48804 frameshift
48084 AIFFIFAGYELPAALLDFANNLATNPKIQKKLQEEIDKTFPGK 47956 (0)
47876 VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQ 47697
47696 RDPVLWPEPEAFKPER 47648 (2)
47492 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCQETD (0) 47331
47246 IPMVLGNEGFVTPKNPIKLKLKLRDVFN* 47160
CYP3A50P Fugu rubripes (pufferfish)
No accession number
Scaffold 10760 probable pseudogene
1847 MNFLPDFFLNTWTFLILVIVLSTT 1918 (2) exon 1
2258 bad boundary MDVLHMSSIKRVGIRRPKTWPIIGTYNRTDG 2350 bad boundary exon 2
cannot identify exons 3-6
3091 XXXXXXXXXXXXXXFSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG 3195 (1) part of exon 7
3268 AIFPFLTPLMD 3300 start of exon 8
Seq gap in scaffold
3919 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNLAVHPQTQTRLQAEIDRTFPGK 3990 exon 10
4078 CLITYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSGVIIPEGVAVAVPIYTLH 4257
4258 RDPTVWPDPDSFKPERFSKDNRDNIDPYGLLTR 4424 frameshift and 7 nuc. deletion
4423 GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM 4527
IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN* 4787
CYP3A51P human
NT_033964.1|Hs7_34119 chromosome 7
lone exon 13 upstream of 3A5
254205 QIPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
CYP3A52P human
AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4
MIKTVLVKECYSVFPNWR
CYP3A53P human
NT_033964.1|Hs7_34119 Homo sapiens chromosome 7
lone exon 6 downstream of 3A43
67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6
CYP3A54P human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A55P human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
CYP3A56 Fundulus heteroclitus (killifish)
No accession number
Tove Hegelund and Malin Celander
64% to 3A48 Fugu 99% to 3A30
submitted to nomenclature committee 6/20/02
Cyp3a57 mouse
GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP
Cyp3a58-ps mouse
See mouse page
Cyp3a59 mouse
See mouse page
Cyp3a60-ps mouse
See mouse page
Cyp3a61-ps mouse
See mouse page
CYP3A62 rat
GenEMBL AB084894
Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
Isolation and characterization of a novel rat CYP3A, CYP3AL1,
predominantly expressed in intestinal tract Unpublished 2003
80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD
Cyp3a63-ps mouse
See mouse page
CYP3A64 Macaca mulatta (rhesus monkey)
No accession number
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
CYP3A65 Danio rerio (zebrafish)
No accession number
Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu,
Jun-Lan Wang-Buhler, and Donald R. Buhler
Submitted to nomenclature committee 10/10/2003
71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias,
69% to 3A30 Fundulus, 69% to 3A56 fundulus,
56% to 3A37 chicken, 58% to 3A48 fugu 59% to 3A49 fugu, 45% to 3B2
CYP3A sheep
PIR A60728 (20 amino acids)
Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
Purification of a sheep liver cytochrome P-450 from the
P450IIIA gene subfamily. Its contribution to the
N-dealkylation of veterinary drugs.
Biochem. Pharmacol. 39, 901-909 (1990)
only one amino acid difference with CYP3A24 (L9K)
CYP3A baboon (Papio sp.)
Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
Purification of two cytochrome P450 isozymes related to CYP2A
and CYP3A gene families from monkey (baboon, Papio papio)
liver microsomes. Cross reactivity with human forms.
Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
Eur. J. Biochem. 204, 641-648 (1992)
CYP3B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213a
6382 MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232 YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052 GIIPFESWCQAEYGDVWG 5999 (2)
Exon 3 not detected may be in small seq. gap
5469 XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259 AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069 FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846 AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011 GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780 APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651 LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416 FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171 IPLEFDWKSQPLKPIKLSFIPRQK* 3097
CYP3B2 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
8214 HKDPRFWSSPEEFRPER 8164 (2)
XXXXXXXXX in sequence gap
IELGTFMX frameshift
8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734
CYP3C1 Danio rerio (zebrafish)
GenEMBL BC052130.1 dated 10/7/2003
Also submitted by Don Buhler 10/2/2003
Jun-Lan W. Buhler, Thuy Hoang, Quan D. Nguyen,
Chin-Hwa Hu, and Donald R. Buhler
52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49
53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout,
54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken,
48% to 3A29 pig (47% to 50% to many mammal 3As)
CYP3D1 Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Formerly CYP3A47
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQGASP (1)
RCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
4A Subfamily
CYP4A1 rat
PIR S21711 (22 amino acids)
Okita, R.T. and Okita, J.R.
Characterization of a cytochrome P450 from Di(2-ethylhexyl)
phthalate-treated rats which hydroxylates fatty acids.
Arch. Biochem. Biophys. 294, 475-481 (1992)
CYP4A1 rat
Aldridge et al.
Biochem. J. 306, 473-479 (1995)
note: identification of far upstream PPAR response element.
CYP4A1 rat
GenEMBL M14972
Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
Isolation, complementary DNA sequence, and regulation of rat
hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
Identification of a new cytochrome P-450 gene family
J. Biol. Chem. 262, 801-810 (1987)
CYP4A1 rat
GenEMBL X07259
Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
Differential splicing in the 3' non-coding region of rat cytochrome
P-452 (P450 IVA1) mRNA
FEBS Lett. 236 (2), 357-361 (1988)
CYP4A1 rat
GenEMBL M33937 M57718
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A2 rat
GenEMBL M33938 M57719
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A3 rat
GenEMBL M33936
Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
coordinate and tissue-specific regulation of the CYP4A genes
DNA 8, 517-525 (1989)
CYP4A4 rabbit
GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
PIR S32423 (64 amino acids)
Palmer,C.N., Griffin,K.J. and Johnson,E.F.
Rabbit prostaglandin omega-hydroxylase (CYP4A4):
Gene structure and expression.
Arch. Biochem. Biophys. 300, 670-676 (1993)
Note: The translation is different from the 4A4 sequence
in the alignment after AALLG. A frameshift occurs between
nucleotides 1201 and 1203, with an extra "G" added. After 1320
P450 similarity stops. 1320-1378 is an intron sequence.
CYP4A4 rabbit
PIR JN0089 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A4 rabbit
GenEMBL J02818
Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
and Kusunose,M.
cDNA cloning and inducible expression during pregnancy of the mRNA
for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
P-450p-2)
J. Biol. Chem. 262, 13366-13371 (1987)
CYP4A5 rabbit
GenEMBL M28655
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A5 rabbit
GenEMBL X57209
Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning and expression of the mRNA for cytochrome P-450kd
which shows a fatty acid omega-hydroxylating activity
Eur. J. Biochem. 196 (3), 531-536 (1991)
CYP4A6 rabbit
PIR S23949 (510 amino acids)
Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
Characterization of a rabbit gene encoding a
clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A6 rabbit
PIR PQ0047 (20 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
CYP4A6 rabbit
GenEMBL M29531 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A6 rabbit
GenEMBL M28656
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A6 rabbit
GenEMBL L04755
Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
Characterization of a rabbit gene encoding a clofibrate-inducible
fatty acid omega-hydroxylase: CYP4A6
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A7 rabbit
PIR JN0090 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A7 rabbit
GenEMBL M29530 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A7 rabbit
GenEMBL M28657
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A8 rat
PIR S08300 (15 amino acids)
Imaoka, S., Nagashima, K. and Funae, Y.
Characterization of three cytochrome P450s purified from
renal microsomes of untreated male rats and comparison with
human renal cytochrome P450.
Arch. Biochem. Biophys. 276, 473-480 (1990)
CYP4A8 rat
GenEMBL M37828
Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
Cloning and characterization of a novel member of the cytochrome
P450 subfamily IVA in rat prostate
DNA Cell Biol. 9 (8), 569-577 (1990)
Cyp4a10 mouse
GenEMBL X69296 (1887bp)
Colin J. Henderson, Theo Bammler & C. Roland Wolf
Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a
protein: developmental and hormonal regulation in liver and kidney
Biochim. Biophys. Acta (1994) 1200, 182-190
Cyp4a10 mouse
GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
GenEMBL Y10221 (exons 10-12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a10 mouse
GenEMBL AB018421
Yasumura,N. and Ikeda,T.
Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
Unpublished (1998)
CYP4A11 human
GenEMBL L04751 (2576bp)
PIR S29845 (519 amino acids)
Palmer,C.N., Richardson,T.H., Griffin,K.J., Hsu,M.-H.,
Muerhoff,A.S., Clark,J.E. and Johnson,E.F.
Characterization of a cDNA encoding a human kidney,
cytochome P450 4A fatty acid omega-hydroxylase and the
cognate enzyme expressed in Escherichia coli.
Biochim. Biophys. Acta 1172, 161-166 (1993)
CYP4A11 human
GenEMBL X71480 (423bp) PIR S35609 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
CYP4A11 human
GenEMBL S67580 (2470bp) and S67581 (2469bp)
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of
CYP4A11, a fatty acid omega-hydroxylase expressed in human
kidney.
DNA Cell Biol. 12, 893-899 (1993)
GenEMBL NM_000778
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a
fatty acid omega-hydroxylase expressed in human kidney
DNA Cell Biol. 12, 893-899 (1993)
CYP4A11 human
GenEMBL D26481 (2382bp) PIR JX0331, PC2194 (519 amino acids)
Kawashima,H., Kusunose,E., Kikuta,Y., Kinoshita,H., Tanaka,S.,
Yamamoto,S., Kishimoto,T. and Kusunose,M.
Purification and cDNA cloning of human liver CYP4A fatty acid
omega hydroxylase.
J. Biochem. 116, 74-80 (1994)
CYP4A11 human kidney
GenEMBL D13705 (1809bp)
Kikuta,Y.
unpublished (1994)
P-450 HVK, fatty acid omega hydroxylase
CYP4A22 human
GenEMBL AL390073.5, AF208532 AL135960 all genomic sequences
new 4A11 like genomic sequence 95% identical to 4A11
three different gene sequences agree so this gene is different from 4A11
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*
Also AF208532
Homo sapiens fatty acid omega-hydroxylase CYP4A11 like gene, complete cds
CDS join(2564..2758,5858..5999,6649..6693,7186..7313,
8347..8471,8840..8994,9435..9541,9628..9818,9915..10048,
10944..11008,11155..11231,13680..13875)
also AL135960 matches new 4A gene not 4A11 gene
Human DNA sequence from clone RP1-18D14 on chromosome 1 Contains genes for SIL (TAL1
(SCL) interrupting locus ), TAL1 (T-cell acute lymphocytic leukemia 1), 17 KD membrane associated protein (DD96 protein), CYP4A11 -like gene
gi|6635875|emb|AL135960.1|AL135960[6635875]
CDS complement(join(129154..129349,131798..131874,
132021..132085,132981..133147,133211..133401,
133488..133594,134035..134189,134558..134682,
135716..135843,136336..136380,137030..137171,
140271..140465))
cyp4a12 mouse
GenEMBL X71479 (423bp) PIR S35610 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
PCR fragment
GenEMBL Y10222 (exon 12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a12 mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee 12/4/96 fax
complete sequence
CYP4A13 Cavia cobaya (guinea pig)
GenEMBL X71481 (423bp)
PIR S32714 (141 amino acids) PIR S35611 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
Cyp4a14 mouse
GenEMBL Y11639 to Y11642 exons 1-12
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Cyp4a14 mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee
complete sequence
CYP4A15 Koala
No accession number
Ieva Stupans
Submitted to nomenclature committee Oct. 20, 1999
69% identical to human 4A11
CYP4A16 Felis cattus (domestic cat)
GenEMBL U91787
Gebremedhin,D.G., Lange,A.R., Narayanan,J., Aebly,M., Jacobs,E. and
Harder,D.R.
Cerebral vascular smooth muscle cells express cytochrome P450 4A2
enzyme and produces 20-HETE which enhances L-type calcium current
Unpublished
CYP4A17 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4ai 90% to mouse Cyp4a10 95% to 4A19
CYP4A18 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aii 88% to rat CYP4A1 88% to 4A19
CYP4A19 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aiii 92% to rat CYP4A1 95% to 4A17
CYP4A20X human
GenEMBL AJ131016 AC026935 161971-176942
Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
Full length seq now available on genomic DNA
52% to 4A11 52% to 4X1
because the sequence is the same percent identity to
4A11 and 4X1 and this is less than 55%
and the sequence does not cluster with CYP4As on a tree
the earlier name of CYP4Z1 is being resurrected.
This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDRS
SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
HLEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV
CYP4A21 pig
GenEMBL AJ278474
Lundell K, Hansson R, Wikvall K.
Cloning and expression of a pig liver taurochenodeoxycholic acid
6 alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily.
J Biol Chem. 276, 9606-12 (2001)
77% to rabbit 4A6
submitted to nomenclature committee July 3, 2000
This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid
CYP4A22 human
GenEMBL AL390073.5, AF208532 AL135960 all genomic sequences
new 4A11 like genomic sequence 95% identical to 4A11
three different gene sequences agree so this gene is different from 4A11
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*
Also AF208532
Homo sapiens fatty acid omega-hydroxylase CYP4A11 like gene, complete cds
CDS join(2564..2758,5858..5999,6649..6693,7186..7313,
8347..8471,8840..8994,9435..9541,9628..9818,9915..10048,
10944..11008,11155..11231,13680..13875)
also AL135960 matches new 4A gene not 4A11 gene
Human DNA sequence from clone RP1-18D14 on chromosome 1 Contains genes for SIL (TAL1
(SCL) interrupting locus ), TAL1 (T-cell acute lymphocytic leukemia 1), 17 KD membrane associated protein (DD96 protein), CYP4A11 -like gene
gi|6635875|emb|AL135960.1|AL135960[6635875]
CDS complement(join(129154..129349,131798..131874,
132021..132085,132981..133147,133211..133401,
133488..133594,134035..134189,134558..134682,
135716..135843,136336..136380,137030..137171,
140271..140465))
CYP4A23 pig
GenEMBL AF384031
Van Es,A., Calleja,C. and Galtier,P.
Cloning of a new member of the cyp4a subfamily in the pig renal
cell line LLC-PK1
Unpublished
Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene
CYP4A24 pig
GenEMBL AJ318096
Kerstin Lundell
97% to pig 4A25, 97% to pig 4A23 AF384031, 90% to pig 4A21 AJ278474
77% to rabbit 4A6, 75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene
CYP4A25 pig
GenEMBL AJ318097
Kerstin Lundell
97% to pig 4A24, 96% to pig 4A23, 91% to pig 4A21, 78 % to rabbit 4a6,
75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene
CYP4A26P human
AL731892.5
76% to 4A11 C-term
SAWLRTCIGKKFAMNEL 135092
135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
CYP4A27P human
AL731892.5
67% to 4A11 C-term
168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
Cyp4a28p mouse
AJ297131
lower case = 4a10, same contig as 4x1
4.112000001-113000000 from Ensembl mouse version 3 chr 4 add 112 million to numbers
943832 MSISALSPTRFLECVSGFLQVVSLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 943647
939707 QFKEDEELRWVLRYVEKFPSAFLHWIWGN 939621 frameshift
939621 *VFIKIYDPDYMKVILGRA 939565
939009 SDPKAGLYRFLTPWL 938965
938111 GHGLFILNGHKWFQHRRMLTSAFHYDILKPYVGTMADSVQVIL 937983
930960 DKWEQIACQDITLEIFHPISLMMLETIMKCAFSYQGSVQLDRS 930832
930514 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 930359
929925 DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 929809
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 929542
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 929424
(missing exon 10)
927997 VFDPSRFAMNSVQHSHAFLPFSGGS 927923
926387 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHL 926238
exact duplicate of exons 6-12
925899 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT
DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 925195
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 924927
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 924809
923831 IESTVSCFIFSSAWKAFDKPE
923372 VFDPSRFAMNSVQHSHAFLPFSGGS 923298
922002 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHLHLRKL 921838
>Cyp4a29 mouse
4.113000001-114000000 chr 4 from mouse Ensembl version 3 add 113 million to numbers
91% to 4A28p
47095 MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 47280
53123 QFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRA 53266
53824 SDPKASLYRFLTPWL 53868
54675 GHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVML 54803
55849 EKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRS 55977
56295 RSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 56450
56880 DRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRVSS 56996
57075 DDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITW 57263
57362 DHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKG 57378
58567 IESTVSCFIFFSAWKAFDKPE
59045 VFDPSRFAMNSVQHSHAFLPFSGGS 59119
60585 RNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKL 60749
CYP4A rabbit
PIR PQ0048 (25 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
This fragment has 2 differences with 4A7
4B Subfamily
CYP4B1 human
GenEMBL NM_000779 J02871
Nhamburo,P.T., Gonzalez,F.J., McBride,O.W., Gelboin,H.V. and
Kimura,S.
Identification of a new P450 expressed in human lung: Complete cDNA
sequence, cDNA-directed expression and chromosome mapping
Biochemistry 28, 8060-8066 (1989)
CYP4B1 human
GenEMBL X16699
Yokotani,N., Sogawa,K., Matsubara,S., Gotoh,O., Kusunose,E.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA
library of human placenta. Gene structure and expression
Eur. J. Biochem. 187 (1), 23-29 (1990)
CYP4B1 rat
GenEMBL M29853
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL M29852
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL AF176914
Mastyugin,V., Aversa,E., Bonazzi,A., Vafaes,C., Mieyal,P. and
Schwartzman,M.L.
Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal
epithelium: involvement of a cytochrome P-4504B1 isoform
J. Pharmacol. Exp. Ther. 289 (3), 1611-1619 (1999)
Cyp4b1 mouse
GenEMBL D50834 (1871bp)
Imaoka,S., Hiroi,T., Tamura,Y., Yamazaki,H., Shimada,T., Komori,M.,
Degawa,M. and Funae,Y.
Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal
cytochrome P450, CYP4B1: Cloning and characterization of mouse
Cyp4b1.
Arch. Biochem. Biophys. 321, 255-262 (1995)
CYP4B1 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B2
73% to mouse Cyp4b1
CYP4B1 Bos taurus cattle
GenEMBL AW347853
Differs from 4B2 shown below
3 DGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRHPFAFLPFSAGPRNC 179
CYP4B2 Capra hircus (goat)
No accession number
Garold Yost
Submitted to nomenclature committee August 2002
82% to human 4B1, 94% to bovine 4B2 (partial)
CYP4B2 Bos taurus cattle
GenEMBL BF602740
94% to goat 4B2 only 82% to human 4B1
3 AISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKWDDLAEMTYLTMCIKESFRLYPPVPQ 182
183 VYRQLSQPVNFVDGRSLPEGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENVARRHSFA 362
363 FIPFSAGPRNCIGQQFAMAEVKVVTALCLLRFEFAPDP 476
CYP4B3 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B1
69% to mouse Cyp4b1
4C Subfamily
CYP4C1 Blaberus discoidalis (cockroach)
GenEMBL M63798 Swiss P29981 (511 amino acids)
Bradfield,J.Y., Lee,Y.-H. and Keeley,L.L.
Cytochrome P450 family 4 in a cockroach: Molecular cloning and
regulation by hypertrehalosemic hormone
Proc. Natl. Acad. Sci. U.S.A. 88, 4558-4562 (1991)
CYP4C2 Anopheles albimanus (mosquito)
GenEMBL L38678 (379bp) PIR PC2257 (126 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4c3 Drosophila melanogaster
GenEMBL U34323(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4c3 Drosophila melanogaster
AC014779 73845-80196 also AC008219
CYP4C4 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071073
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C4
Unpublished
CYP4C5 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071074
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C5
Unpublished
CYP4C6 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071075
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C6
Unpublished
CYP4C7 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071072
Andersen,J.F. and Feyereisen,R.
CYP4C7, a P450 from cockroach corpora allata
Unpublished
CYP4C8 Mastotermes darwiniensis (Australian termite)
GenEMBL U77126(432bp)
Falckh,P.H.J., Balcombe,W.M., Haritos,V.S. and Ahokas,J.T.
Isolation, identification and sequence of a cytochrome P450 in an
Australian termite, Mastotermes darwiniensis.
unpublished (1996)
note: 92 amino acid C-terminal fragment
CYP4C9 Coptotermes acinaciformis (termite)
GenEMBL AF046008
Patrick Falckh
C4-8_9-A
CYP4C10 Coptotermes acinaciformis (termite)
GenEMBL AF046009
Patrick Falckh
C4-8_9-I
CYP4C11 Mastotermes darwiniensis (Australian termite)
no accession number
Quoc Wu
M4-150.4
CYP4C12 Mastotermes darwiniensis (Australian termite)
no accession number
Quoc Wu
M4-100-8
CYP4C13 Mastotermes darwiniensis (Australian termite)
no accession number
Quoc Wu
M4-240-2
CYP4C14 Coptotermes acinaciformis (termite)
no accession number
Quoc Wu
4F-22_24
CYP4C15 Orconectes limosus (crayfish)
GenEMBL AF091117
Chantal Dauphin-Villemant
submitted to nomenclature committee
this is a tentative assignment, this sequence may require its own
subfamily
50% identical to 4C1 over full length, 58% identical over C-terminal
CYP4C16 Penaeus setiferus (shrimp)
GenEMBL AF072854
Mark Snyder
submitted to nomenclature committee
CYP4C17 Haliotis rufescens (red abalone)
GenEMBL AF072853
Mark Snyder
submitted to nomenclature committee
CYP4C18 Homarus americanus (lobster)
GenEMBL AF072852
Mark Snyder
submitted to nomenclature committee
CYP4C19 Lytechinus anamesis (sea urchin)
GenEMBL AF072850
Mark Snyder
submitted to nomenclature committee
first sequence from sea urchin
CYP4C20 Lytechinus anamesis (sea urchin)
GenEMBL AF072851
Mark Snyder
submitted to nomenclature committee
second sequence from sea urchin
CYP4C21 Blattella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee Dec. 30, 1998
CYP4C22v1 Culex pipiens pallens (mosquito)
GenEMBL AF157093
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 150 amino acids
clone name NYDR2 81% identical to 4C2
this sequence has one frameshift
CYP4C22v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDS6 PCR fragment 97% identical to 4C22v1
Submitted to nomenclature committee 9/30/99
CYP4C23 Culex pipiens pallens (mosquito)
GenEMBL AF157090
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 167 amino acids
clone name NYDS1 84% identical to AF117650 at C-terminal 44 amino acids
this sequence has numerous frameshifts and insertions/deletions it may
be a pseudogene
CYP4C24 Orconectes limosus (crayfish)
no accession number
C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bcking
submited to nomenclature committee 6/15/99
CYP4C25 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Q
CYPb1x3 on chromosome 1
91% identical to 4C2
CYP4C25 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x3
CYP4C26 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450S
CYPb1x1 on chromosome 1
73% identical to 4C2
CYP4C26 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x1
CYP4C27 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450I
CYPo3r3 on chromosome 3
58% identical to 4C6
CYP4C27 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r3
CYP4C28 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450R
CYPs3l1 on chromosome 3
61% identical to 4C2
CYP4C28 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3l1
CYP4C29 Cherax quadricarinatus (crayfish)
No accession number
Moshe Tom
Submitted to nomenclature committee May 4, 2000
Clusters with the other crayfish sequence 4C24 on trees
CYP4C30 Coscinasterias muricata Australian sea star (11 armed starfish)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
63% to 4C19 partial seq. from I-helix to heme
CYP4C31 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.5 203 aa
65% to 4C24 crayfish 65% to 4C16 shrimp 69% to 4C18 lobster
68% to 4C17 abalone 82% to 4C33
CYP4C32 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.6 149 aa
95% to 4C34
CYP4C33 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.14 200 aa
62% to 4C24 crayfish 61% to 4C16 shrimp 66% to 4C18 lobster
66% to 4C17 abalone 82% to 4C31
CYP4C34 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.16 206 aa
61% to 4C24 crayfish 63% to 4C16 shrimp 64% to 4C18 lobster
65% to 4C17 abalone 95% to 4C32
CYP4C35 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r1
CYP4C36 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r2
CYP4C37 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x2
CYP4C38 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.4
CYP4C39 Carcinus maenas (shore crab)
GenEMBL AY328467
Kim Rewitz
submitted to nomenclature committee 6/18/2003
59.5% to 4C15
4D Subfamily
Cyp4d1 Drosophila melanogaster
GenEMBL X67645 (1675bp) Swiss P33269 (511 amino acids)
PIR S25707 (511 amino acids)
Gandhi,R., Varak,E. and Goldberg,M.L.
Molecular analysis of a cytochrome P450 gene of family 4 on the
Drosophia X chromosome.
DNA Cell Biol. 11, 397-404 (1992)
note: X67645 has a probable frameshifts at the C-terminal
see Z98269 and AF016992 to AF017004 for correct end
Cyp4d1 Drosophila melanogaster
GenEMBL AC017770 49988-51720
Alternative splice AC017770 48817-51720
Cyp4d2 Drosophila melanogaster
GenEMBL Z23005 (1481bp) X75955 (1883bp) PIR S41192 (496 amino acids)
Frolov,M.V. and Alatortsev,V.E.
Cluster of cytochrome P450 genes on the X-chromosome of
Drosophila melanogaster
DNA Cell Biol. 13, 663-668 (1994)
probable frameshift at C-terminal
see Al009194 and AF017006 to AF017019 for correct end
Cyp4d2 Drosophila melanogaster
GenEMBL AC017770 comp(32267-34028)
CYP4D3 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4D4 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4D5 Anopheles albimanus (mosquito)
GenEMBL L38679 (382bp) PIR PC2270 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D6 Anopheles albimanus (mosquito)
GenEMBL L38680 (446bp) PIR PC2271 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D7 Anopheles albimanus (mosquito)
GenEMBL L38681 (447bp) PIR PC2272 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4d8 Drosophila melanogaster
GenEMBL U34329(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Dro-G453 (formerly called 4N3)
Cyp4d8 Drosophila melanogaster
GenEMBL AC017388 comp(37292-39859)
also AC010557 AC010112 AC010113
CYP4D9 Musca domestica
Rene Feyereisen
no accession number
6-full
submitted to nomenclature committee
CYP4D10 Drosophila mettleri
GenEMBL U91634
Jim Fogleman
full length sequence 288mt
submitted to nomenclature committee (one of 109 sequences)
CYP4D11 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD60 PCR of C-terminal
CYP4D12 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD5 PCR of C-terminal
CYP4D13 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD84 PCR of C-terminal
Cyp4d14 Drosophila melanogaster
GenEMBL AL009194 comp(10685-12421)
also submitted by Michael Goldberg
55% identical to Cyp4d2
Cyp4d14 Drosophila melanogaster
GenEMBL AC017770 35699-37438
CYP4D15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450E
77% identical to 4D6
CYP4D15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r3
CYP4D16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450F
84% identical to 4D6
CYP4D16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r5
CYP4D17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450H
79% identical to 4D5
CYP4D17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r4
CYP4D18v1 Culex pipiens
GenEMBL AF190775
Changliang Zhu
Clone NYDS2 PCR fragment 95% identical to 4D18v2, 66% to 4D6
Submitted to nomenclature committee 9/30/99
CYP4D18v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDR16 PCR fragment 95% identical to 4D18v1
Submitted to nomenclature committee 9/30/99
CYP4D19v1 Culex pipiens
No accession number
Changliang Zhu
Clone NYDR11 PCR fragment 3 diffs with 4D19v2
Submitted to nomenclature committee 9/30/99
CYP4D19v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDR14 PCR fragment 3 diffs with 4D19v1
Submitted to nomenclature committee 9/30/99
CYP4D19v3 Culex pipiens
GenEMBL AF190777
Changliang Zhu
Clone NYDS4 PCR fragment 95% identical to 4D19v2, 54% to 4D5
Submitted to nomenclature committee 9/30/99
Cyp4d20 Drosophila melanogaster
GenEMBL AC019509 comp(19731-21636)
Cyp4d21 Drosophila melanogaster
GenEMBL AC020004 55466-57280
CYP4D22 Anopheles gambiae (malaria mosquito)
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450O
50% identical to 4H5, 4H7
note the 4H subfamily might really be considered two differernt
subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.
4H20 falls between these. Revised seq now groups with CYP4Ds
formerly CYP4H20
CYP4D22 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r6
CYP4D23v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.8
CYP4D23v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.3
CYP4D23v3 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.1
CYP4D24 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.6
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4I1.3
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.6
4E Subfamily
Cyp4e1 Drosophila melanogaster
GenEMBL AC020402 44580-46698
CYP4E1 HAS INSERT AT C-TERM VSKDGYISTTLGLQPAEKKSRDAHNHK
Cyp4e2 Drosophila melanogaster
no accession number
Amichot, M., Brun, A., Cuany, A., Helvig, C., Salaun, J. P., Durst, F.
and Berge, J. B.
Expression study of CYP genes in drosophila strains
resistant or sensitive to insecticides. In: Cytochrome P450
Lechner M.C. ed. John Libbey Eurotext, Paris.pp. 689-692 (1994)
(PCR fragment) 144 amino acid region
Cyp4e2 Drosophila melanogaster
GenEMBL X86076(1408bp)
Amichot,M., Brun,A., Cuany,A., LeMouel,T. and Berge,J.
Cloning and expression study of CYP4E2 a novel P450 gene in
drosophila.
unpublished (1995)
Cyp4e2 Drosophila melanogaster
GenEMBL U56957(1458bp) U34332(373bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4e2 Drosophila melanogaster
GenEMBL AC020402 41848-44099
Cyp4e3 Drosophila melanogaster
GenEMBL U34330(370bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
DroG4-2
Cyp4e3 Drosophila melanogaster
GenEMBL AC020324 73117-75125
Cyp4e4x Drosophila melanogaster
GenEMBL U34331(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
formerly called 4N4
note: this sequence is pretty far out in the 4E subfamily
it has been reassigned as Cyp4ae1
CYP4E5 Drosophila mettleri
GenEMBL U78486
Phil Danielson
Mt1
CYP4E6 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD21 PCR of C-terminal
CYP4E7 Musca domestica (house fly)
no accession number (530 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee
4F Subfamily
CYP4F1 rat
GenEMBL S53039 M94548 (1977bp) Swiss P33274 (524 amino acids)
PIR S29723 (524 amino acids)
Chen,L. and Hardwick,J.P.
Identification of a new P450 subfamily, CYP4F1, expressed
in rat hepatic tumors.
Arch. Biochem. Biophys. 300, 18-23 (1993)
CYP4F2 human
GenEMBL U02388 (2368bp)
Chen,L. and Hardwick,J.P.
The human liver CYP4F2 cDNA sequence and expression in
baculovirus-infected cells.
unpublished (1993)
CYP4F2 human
GenEMBL D26480 (2227bp)
Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
Kusunose,M.
Cloning and expression of a novel form of leukotriene B4
omega-hydroxylase from human liver
FEBS Lett. 348, 70-74 (1994)
CYP4F3 human
GenEMBL D12620 (2073bp) D12621 (1185bp) S63604 (2073bp)
Swiss Q08477 (520 amino acids)
Kikuta,Y., Kusunose,E., Endo,K., Yamamoto,S., Sogawa,K,
Fujii-Kuriyama,Y. and Kusunose,M.
A novel form of cytochrome P-450 family 4 in human
polymorphonuclear leukocytes. cDNA cloning and expression of
leukotriene B4 omega-hydroxylase.
J. Biol. Chem. 268, 9376-9380 (1993)
Note: three overlapping clones F-22, A-4 and M-6 are identical.
Clone S-8 is different at 4 nucleotides and one amino acid.
CYP4F3v2 human
GenEMBL AF054821
Kanga Morgan
alternative splice variant of 4F3 with a cryptic exon at amino acids
67-114 this exon resembles the region in 4F2.
CYP4F3 human
GenEMBL AD000685 12 exons from 26660-44629
CYP4F4 rat
GenEMBL U39206
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F5 rat
GenEMBL U39207
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F6 rat
GenEMBL U39208
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F7 Dicentrarchus labrax (European sea bass)
GenEMBL AF045925
Sabourault C, Amichot M, Pauron D, Berge JB, Lafaurie M, Girard JP
Cloning of CYP4F7, a kidney-specific P450 in the sea bass Dicentrarchus
labrax.
Biochem Biophys Res Commun 258, 155-61 1999
62% identical to human 4F3
authors name CYP4Dl2
Query: 1 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKES 60
GHDTTAS + W LY+LA+H +YQE+CRQEV EL++ R+ EIEW+DL+ LPF TMCI+ES
Sbjct: 1 GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES 180
Query: 61 LRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPK 120
LRLH PV AV+R TQD+ LP +PKG ICL+S++GTHHNP VW +P + P RFDP
Sbjct: 181 LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT 360
Query: 121 NIKERSPLAFIPFSAGPRNCIGQAFAMAE 149
N + + AFIPFS+GPRNCIGQ FA+AE
Sbjct: 361 NKEGLAAHAFIPFSSGPRNCIGQKFALAE 447
Sequence of reported protein may have 2 frameshifts at the end
See alignment below to human 4F3 as query
Possible corrected sequence
GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES
LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT
NKEGLAAHAFIPFSSGPRNCIGQKFALAELRVVVALTLLRFRLTLGVNPEVGPSSGEVRR
LPQLVLRAEGGMWLQVEPL
Score = 85 (29.9 bits), Expect = 6.3e-62, Sum P(2) = 6.3e-62
Identities = 23/59 (38%), Positives = 31/59 (52%), Frame = +2
Query: 132 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVL--------PDHTEPRRKPELVLRAEG 182
PF P + ++ ++VV+ LTLL FR+ P E RR P+LVLRAEG
Sbjct: 395 PFPQAPGTALVRSSPWQRLRVVVALTLLRFRLTLGVNPEVGPSSGEVRRLPQLVLRAEG 571
Score = 54 (19.0 bits), Expect = 1.2e-58, Sum P(2) = 1.2e-58
Identities = 10/18 (55%), Positives = 12/18 (66%), Frame = +3
Query: 174 PELVLRAEGGLWLRVEPL 191
P L GG+WL+VEPL
Sbjct: 546 PSLSCVQRGGMWLQVEPL 599
CYP4F8 human
GenEMBL AD000685 13 exons from 862-14599
GenEMBL AF133298
Bylund, J., Finnstrm, N. and Oliw, E. H. (1999) Gene Expression of a
Novel Cytochrome P450 of the CYP4F subfamily in Human Seminal Vesicles.
Biochem. Biophys. Res. Commun. 261, 169-174.
submitted to nomenclature committee 10/30/98
81.2% identity with CYP4F2 and 76.7% with CYP4F3.
EST AI401776, AI349730
CYP4F9P HUMAN
GenEMBL AC004609 complement(13903-33104 region)
pseudogene N-terminal not on this cosmid, may be on adjacent cosmid
missing 71 amino acids at N-terminal
69% identical to 4F3 67% identical to 4F8
EGMRVLTQLVATYPQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKD
EAFYKFLKPWLGDGLLVNASDKWSCHRQMLMPAFHFNMLKPYMKFFTDSV
NIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQKCVFSFDSHCQEKPSQYIATI
LELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVHDFTEAIIQEQRH
TLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXXXXXX
GHNTTASGLSWVLYYLARHPEYQEHCWQEVQKLLKDHEPKEIEX
DDLAQLPFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLF
SNFETHHNPTVWLDPEVYDPFRFDPENSKERSPLAFIPFSAGSX
NCIGQAFAMAEMKVVLALTLLCFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS
CYP4F10P human
GenEMBL AD000685 exons 3-6 (cosmid ends in middle of exon 6)
49350 to end of cosmid. Cannot recognize exons 1 and 2 after 4F3 gene
ends at 44623 and before exon 3 starts at 49350. May be a pseudogene
(No ESTs)
SATIAPKDKVFYSFLKPWLG
DGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNIMH
AKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQE
KPSEYIASVLELSSLVAKRNQQ
CYP4F11 human
GenEMBL AC005336 cosmid F20129 end of cosmid
ESTs T56269 and T56204 opposite ends of clone yb89b03
ESTs T69576 and T69645 opposite ends of clone yc44c03
EST AA991369 and EST W23003
N-terminal up though C helix and C-terminal from I helix to end is
Present middle region is not present. The rest of this gene should be
on cosmid R28342 this is not in the database yet. About 22 amino acids
missing at N-terminal
N-terminal is on AC011517 rest is on AC020950
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQC
FPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLI
LCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRML
TPAFHFNLKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDS
LQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQR
FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD
EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEV
QELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG
RVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGP
RNCIGQAFAMAEMKVVLALTLLHFRILPTHIEPRRKPELILRAEGGLWLRVEPLGANSQ
CYP4F12 human
GenEMBL AC004523 missing N-terminal
UNIGENE entry Hs.110130 (12 ESTs)
UNIGENE Hs.168862 R08175 and R08229 (opposite end)
Complete cDNA sequence submitted by Johan Bylund June 16, 2000
mRNA for cytochrome P450, complete cds. AB035130
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNN
CRRLQCFPQPPKRNWFWGHLGL
ITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLC
HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
EGGLWLRVEPLNVGLQ
Cyp4f13 mouse
GenEMBL ESTs AI304244 ui64h08.y1, AA277579 va77c04.r1
AA238458 my34d11.r1, AA277631 va81d08.r1
AI265156 uj03h07.y1, AI120320 ub69c04.r1
AI327511 mb31b06.y1, AA245188 mx09e08.r1
AA799238 vx69h12.r1, AA797204 vw22d08.r1
AI196488 ui64h08.x1, AI196852 ui67e09.x1
AA511038 vh55g04.r1,AI323999 mb31b06.x1
W64560 md70f05.r1, AI121221 ud70e01.x1
Unigene Mm.22045
89% identical to rat CYP4F6 probable ortholog
CONSENSUS
MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWF
WGHLALMKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKP
WLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLD
MFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQP
FLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLD
FIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILYNXXXXXXXXXXXXX
EVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAI
PKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFA
MSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ*
Cyp4f14 mouse
GenEMBL ESTs
AI098768 ue38c01.y1
AI047403 ud65h03.y1
AI099192 ue40b11.y1
AA237519 mx10h12.r1
AA793220 vl85g08.r1
AA869706 vq44d03.r1
AI118365 ue40b11.x1 chimeric clone contains a-L-Fucosidase
AA880205 vx39b01.r1
consensus N-terminal to 370
MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWL
MGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALK
DVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQR
VISDGSAPLDMFEHVSLMTLDSLQKCVVFSFDSNCQEKSSEYIAAILELSALVAK
KDQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD
FIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQE
VQELLRGREPEE
gap of 69 amino acids
Cyp4f14 Cterminal 439-524
AI046446 ud65h03.x1 C-term
AA274495 vb07d01.r1 C-term
AI121221 ud70e01.x1 C-term
consensus
VYDXFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVE
PLSAGAH*
UNIGENE entry Mm.10976 (C-terminal part only)
92% identical to rat CYP4F1 probable ortholog
Cyp4f15 mouse
GenEMBL ESTs
AI315840 uj47c01.y1
AI046615 ud70e01.y1
AI048594 ud61g02.y1 this clone skips over exons
MPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWF
LGHLGMITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALK
EVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQH
LALGGSARLDVFENISLMTLD
AI048594 ud61g02.y1 407-480
AI121221 ud70e01.x1 C-term this fragment also is an exact match to 4f13 and 4f14
There may have been gene conversion at the C-terminal of these three genes.
LLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPR
NCIGQTFAMNEMXVXXXXXXXXXXXXPDDKEPRRKPELILRAEGGLWLRVEPLSTQ
No UNIGENE entry for these ESTs
92% identical to rat CYP4F4 probable ortholog
Cyp4f16 mouse
GenEMBL ESTs AA059667 mj77a08.r1
AA863889 vx15d11.r1, AA673923 vo83a09.r1
AA798644 vw34b12.r1, AA896484 vx63d12.r1
MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWF
SGHLGMIQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWL
GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMF
EHISLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSXXXXXXXXXXXXXXX
Cyp4f fragment a 93% identical to 4F5 88% to 4F6, 86% to 4F1 83% to 4F4
This fragment belongs to Cyp4f16
AA671839 vl02c09.r1
AA755081 vu02b08.r1
LYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVL
LLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQRVQE
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDXXXXXXX
Cyp4f fragment c 91% identical to 4F6, 86% to 4F1 and 4F5, 85% to 4F4
This fragment is part of Cyp4f16
AA688499 vq53e04.r1
AA791143 vv91d10.r1
AI036012 vz68a09.r1
AA794692 vu63c06.r1
DIVLXXXXXXPKGNICVISIFGIHHNPSVWPDPEXXX
PFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEM
KVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ*
92% identical to rat CYP4F5 probable ortholog
Cyp4f17 mouse
GenEMBL ESTs AA387122 vc22e06.r1, AA386914 vc23b12.r1
AA387149 vc22f06.r1
MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWF
WGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQASAAVAPK
EMIFYGFLKPWLGDGLLVSAGEKWSRH
66% to CYP4F6 but 81% identical to a rat EST AI030199
The rat homolog to this gene has not been cloned yet.
Cyp4f18 frag.b mouse
GenEMBL ESTs AA716998 vu61b04.r1 AI006742 ua82h10.r1
frag. d AI006742 ua82h10.r1
PKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKXVVLA
frag. b AA716998 vu61b04.r1
LLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRD
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVIS
RISIFGTHHNPAVWPDPEV
Cyp4f18 fragments b and d 90% identical to 4F6, 89% to 4F4, 88% to 4F5, 87% to 4F1
complete sequence known but confidential (Henry Strobel)
CYP4F19 rat
GenEMBL AI030199
probable rat ortholog to 4f17 81% identical
opposite end of this clone = BF554573 N-terminal
4f17 1 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPS 56
MLQL LS LG GP PWQLL +VG SL LARIL WI AFYDNYCRLRCFP+PPS
4f19 1 MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS 56
4f17 53 EPPSRHWFWGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQA 113
+P SRHWFWGH+++VKNNEEGLQLL E SHQF D+HLCWIG FYPILRLIHPKFIG ILQA
4F19 53 QPLSRHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA 113
* one amino acid difference in overlap
sequence = MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS
RHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA
Cacgaggcattaacagagaagagcggaagtctctgggactcctgagaaaagg (start met)
atgctacagctgagcctg tcctgcctgg gccgggggcc agtgactgtc tccccatggc agcttctgct
ggtggttggg acctccttgc ttctggctcg aattctgggc tggatcagtg ctttctatga
caactactgc cgtctccgct gcttccctca gcccccttca
CGG CAC TGG TTT TGG GGT CAC TTG AAC TTG GTC AAG AAC AAT GAA GAA GGC CTG CAG TTG TTG GCT GAA ATG AGC CAC CAG TTC CAG GAT ATC CAC CTC TGT TGG ATT GGG ATC TTC TAC CCC ATC CTG AGG CTT ATC CAC CCC AAG TTT ATT GGC CCC ATA CTC CAG GCC
CYP4F20X starfish
Quoc Wu
Given its own subfamily renamed CYP4FA1
CYP4F21 sheep
no accession number
Johan Bylund
submitted to nomenclature committee 8/3/99
CYP4F22 human
GenEMBL AC011492
assembled gene 13 exons 114537-140651 66% to 4F3, 65% to 4F11, 63% to 4F2,
59% to 4F8, 64% to 4F12, 57% to AC011537 exact intron boundaries need checking no ESTs
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMVS
PNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGAS
AAIAPKDDLFYGFLKPWLG
DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMH
AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQE
KMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRR
ALRQQGAEAWLKAKQGKTLDFIDVLLLAR
DEDGKELSDEDIRAEADTFMFEG
HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW
DDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK
GIICLVSIYGTHHNPTVWPDSK
VYNPYRFDPDNPQQRSPLAYVPFSAGPR
NCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRPELILRTENGLWLKVEPLPPRA*
CYP4F23P human
GenEMBL AC011492
assembled gene 76% to 4F3, 76% to 4F8, 76% to 4F11, 73% to 4F2, 75% to 4F12,
77% to 4F11, 60% to other 4F on this accession no ESTs also on AD000091
MSLLSLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYAFYDNCHRLQCFQQPPKRNCF*GHLSLVS
GNEEDMRLMEDLGHYFRDVQLWWLGSFYPVLHLVHPTFTAPVLQAS AAVALKDMSFYGFLKPWLG
DGLLISAGDKWRWHRHLLTPAFHFKILKPYVKIFNESTNIMH
AKWQRLALEGSVRLEMFEHISLMTLDSLQKCIFSFDSNCQE
KPSEYIDAILELSALSLKRHQHIFLLTDFLYFLTPNGRRFCRACDIVHNFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLAK DENGKKLSDENIRAEADTFMSG
GHDTTASGLSWVLYNLARYPEYQEHCRQEVQELLKNGDPKEIEW
DDLAQLPFLTMCLKESLRLHSPVSRIHRCCPQDGVLPDGRVIPK GNTCTISIFGIHHNPSVWPDPEV
YDPFRFDPENLQKTSPLAFIPFSAVPR
NCIGQTFAMAEMKVVLALTLLRFRVLPDHAEPRRKLELIVRAEDGLWLRVEPLSADLQ*
CYP4F24P human
GenEMBL AC011537.4
77% to 4F11 missing last exon two in frame stops and a gap.
24346 MPQLSLSWLGLGQVAAFPWLLLLLAGASRLLAGFLAWTYAFYDNCRRLQYFPQPPKQKWF 24167
24166 WGQPGX 24152
6633 IIATEEGLKNLTQMSATYPQGFRIWLGPIFPFIVLCHPDIVRSITNAS 6788
8837 AAIAPKDDLSIRFLKPWLGEGILLSGGDK 9016
9017 WSRHRRMLTPAFHFNILKPYIKIFNRSVNIMH 9112
11018 DKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 11140
11921 RPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGWRFRRACRLVHDFTDAVIQERRH 12100
12101 TLPTQGI 12121
12115 CDFLKNKAKS*TLDFIDVLLLSKXXXXXXXXXXXXXXXXXXXXXX 12189
13460 GHDTTASGLSWVLYNLARHPEYQEHCRQEVQELLKDRDPKEIEWX 13591
21804 DLAQLPFLTMCVKESLRLHPPVPYTSRHRIWDIVLPDGRVIPK 21932
22019 GIICIINIIGIHHNPTV*PDPEV 22165
22263 YNPFRFNSENSKERSPLAFIPFSAGPR 22361
CYP4F25P HUMAN
GenEMBL AC018949
62% to 4F3 pseudogene
95242 LWRCFLSPTSPCRNPSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDL 95066
95065 VHNF 95054
95052 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 94936
CYP4F26P Human
GenEMBL AL139008
Homo sapiens chromosome 9 clone RP11-255A11 81% TO 4F25P
SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF FRAME SHIFT
DTIILEQHCTLTSQSVDILKARATFKTLDFIDALVLSK
CYP4F27P human
GenEMBL AC018804.2
Homo sapiens clone RP11-397H17 62% TO CYPF25P
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
CYP4F28 Fugu rubripes (pufferfish)
No accession number
Scaffold_2425
76% to 4F7
8381 MSVLQLALSWTSVCPLLAVLAAAPVALLTFWTAKLLVRHAWYTHRMACFSKPHARSWLLGHLGQ 8190 (0)
7561 MQSTEEGLLQVDELVQMFTYCCSWFIGPFYHLVRVFHPDYVKPLLMAP 7418 (1)
7238 ASITVKDELIYDHLRPWL 7185 (1)
7049 GNSLLLSNGEAWSRRRRLLTPAFHFDILKNYVTKFNTSTNTLH 6921 (0)
6727 DKWHRLLVEGTTNIEVFEHFTLMTLDSLLKCAFSYDSDCQQ 6605 (2)
6527 SSSEYASAIIELSDLIIERRQRILHHWDWIYWRTQQGKRFKKALSIVHK 6381 (2)
6307 FTRDVVQKRLALISQKGVAELAAHRKRDFVDIILLTK 6197 (0)
6115 DEDGKGLTDEELQAEANTFMFA 6050 (1)
5813 GHDTTASAICWSLYNLAHHNHYQEQCRQEVMDLMEGRDVDEIKW 5682 (2)
5607 EDLSSLPFTTMCIRESLRLHSPVQAVTRRYIQDVKLPGERTVPK 5476 (1)
5248 GAICLVSIYGTHHNPAVWTNPH 5183 (0)
5101 DFDPLRFDPKNQEGLSSHAFIPFSSGPR 5018 (2)
4948 NCIGQKFALAELRVVVALTLLRFRLLPGNDPKRETPFEKVRRLPQLVLRAEGGLWLQIKPVTQTQ* 4751
CYP4F29P human
AL109748 chr 21
designated CYP4F3LP pseudogene Nature 405, 311-319 2000
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW
CYP4F30P human
NT_022140.9|Hs2_22296 Homo sapiens chromosome 2
270169 RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLTSQGVDDFLKAKATFKA 269990
269989 SDFIDALVLSK 269957
CYP4F31P human
NT_019306.9|Hs2_19462 Homo sapiens chromosome 2
2940797 PEG*CFYKACDLVHNF 2940844
CYP4F32P human
NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to 4F25P
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
CYP4F32P human
NT_022300.8|Hs2_22456 chromosome 2 88% to 4F25P
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
CYP4F33P human
NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
CYP4F34P human
NT_009799.9|Hs13_9956 Homo sapiens chromosome 13
343178 DTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
CYP4F35P human
NT_010859.8|Hs18_11016 chromosome 18 4F pseudogene 84% to 4F12
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
CYP4F36P human
NT_011281.4|Hs19_11438 chromosome lone last exon 75% TO 4F11
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448
Cyp4f37 mouse
AC073754 comp(28012-47256)
93% identical to 4f16
MLRLSVSGLDLGSVVTLSWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGM
IEHNEEGMQLMTEAGQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLA TALVAPKDTTFHTFVKPWL
GDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH
AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE
SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR
ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK
DEHGKELSDEDIRAEADTFMFGG
HDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW
DDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VYDPFRFDPENAHKRPPLAFIPFSAGP
RNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLS
Cyp4f38p mouse
AC073754 comp(9555-20475)
partial pseudogene 52% to 4f14
AHILIQVYAAYGNYPHIPKWNWLMGHVSM
PQRRARRMLLNW*GNYP*GFIL*MIPLVSILKPCHPGIAKSV
VSAGDKWSHHCHMLTPAFHFNILKLYVKIFNDSTNIVH
LNISDHVILMTLGNFQKCIFSFDSNCQD
AIMELSMLISRRNKEPLLHMDLLGHLTPDGMCCCKACSMMHGLDDAVI
QERGHILSRQGLDGFFKDKVKFKPLNFIAVLLLTK
DDMSQLPFLTMCISLWLHPPDLLISYYCI*DVVLPDGWIIPKG
Cyp4f39 mouse
AC073754 range 185296-209241
minus strand 62% to 4F14
MLPLTDYLLQLLGLEKTAFRVYV
VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMVS
PNEKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGAS
AAIAPKDEFFYSFLKPWLG
DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMH
AKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVFSYNSDCQE
SMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDTVHNFTTEVI
QERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAK
DEEGKELSDEDIRAEADTFMFEG
HDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDW
DDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPK
GIICLVSIYGTHHNPIVWPDSK
VYNPYRFDPDTPQQRSPLAFVPFSAGP
RNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWLNVEPLPSRA*
Cyp4f40 mouse
AC073754 range <1-3688
minus strand two N-terminal exons no ESTs
continues on AC073720 comp(118300-137027) 79% to 4F14
MRYLDLSWLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMVS
PTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSAS
SAAVAPKDDIFYSFLKPWL
GDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMH
AKWLRLASGGSTRLNMFENISLMTLDTLQKCVFSFNSNCQE
KPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDF
TDAVIQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTK
DEDGKELSDEDIRAEADTFMFRG
HDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEW
DDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPK
GVICIINIFGTHHNPTVWRDPE
VYDPFRFDPENIQARSPLSFIPFSAGP
RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSTQA
Cyp4f41-ps mouse
Pseudogene (more details later)
CYP4F42 Xenopus laevis
No accession number
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
64% to 4F22 in humans (full length)
CYP4FA1 see bottom of Cyp4 family entries
4G Subfamily
Cyp4g1 Drosophila melanogaster
no accession number
Waters,L.C. personal communication (1993)
Note: called P450-A1 starts at amino acid 192 and goes to
the end.
Cyp4g1 Drosophila melanogaster
GenEMBL U34328(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4g1 Drosophila melanogaster
GenEMBL AL009188 comp (26402-24747) region genomic
Cyp4g1 Drosophila melanogaster
GenEMBL AC020093 comp(33262-34932) no introns
CYP4G2 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen.
1996. Cytochrome P450 gene clusters in Drosophila
melanogaster. Mol. Gen. Genetics 251: 290-297.
Dta1
corrected from error, previously listed as 4G6
CYP4G2 Musca domestica (house fly)
no accession number (559 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee
CYP4G3 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen. 1996.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251: 290-297.
Dt6-139
corrected from error, previously listed as 4G5
CYP4G4 Manduca
Rene Feyereisen
submitted to nomenclature committee
CYP4G5 Heliothis virescens(tobacco budworm)
no accession number (382bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G2
Hv-13a
CYP4G6 Heliothis virescens(tobacco budworm)
no accession number (386bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G3
Hv-1
CYP4G7 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R39
submitted to nomenclature committee
CYP4G8 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp24
submitted to nomenclature committee
CYP4G8v2 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp433
submitted to nomenclature committee
CYP4G8v3 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp477g
submitted to nomenclature committee
CYP4G8v4 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp73g
submitted to nomenclature committee
CYP4G9 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp60
submitted to nomenclature committee
CYP4G10 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp5g
submitted to nomenclature committee
CYP4G11 Apis mellifera (honey bee)
GenEMBL AF207948
S. Tares, J.B. Berg and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacĪciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 18Am
CYP4G11v2 Apis mellifera mellifera (honeybee)
No accession number
S. Tares, J.B. Berg and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacĪciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 9Am only 2 amino acid differences, one in EXXR motif, possible PCR
errors
CYP4G12 Trichogramma cacĪciae (a parasitoid wasp)
GenEMBL AF207949
S. Tares, J.B. Berg and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacĪciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 3Tc 76% identical to CYP4G8
clone 6Tc is identical to 3Tc in the coding region but not in a short
intron this probably represents a recent gene duplication rather than an
allele
CYP4G13 Musca domestica (house fly)
no accession number
Xiaohua Shen, Gary Blomquist
68% identical to 4G1 full length, but different from 4G2 fragment (75%)
and 4G3 fragment (71%)
submitted to nomenclature committee 10/9/98
CYP4G13v2 Musca domestica (house fly)
no accession number
Nannan Liu
98% identical to 4G13, may be same gene with some errors between the
two
submitted to nomenclature committee 7/29/99
CYP4G14 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S19
submitted to nomenclature committee
Cyp4g15 Drosophila melanogaster
no accession number
M. Mabche, D. Bcking, S. Aragon and C. Dauphin-Villemant.
submitted to nomenclature committee 6/15/99
ESTs AI134510, AI388987, AI403684
Cyp4g15 Drosophila melanogaster
GenEMBL AC013897 comp(8972-10574 and 5306-6643) two pieces
CYP4G16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450A
79% identical to 4G8
CYP4G16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x5
CYP4G17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450L
69% identical to 4G9
CYP4G17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x3
CYP4G18 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF243507
Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
Insecticide Resistance Associated Cytochrome P450 Gene Fragments
from D. v. virgifera
Unpublished
DvP450-2
CYP4G19 Blattella germanica (German cockroach)
No accession number
Nannan Liu
Submitted to nomenclature committee 9/24/02
About 65% identical to Cyp4g15
CYP4G20 Mamestra brassicae (moth)
GenEMBL deposited but not released yet
Martine Maibeche
73% to 4G16
submitted to nomenclature committee Sept. 12, 2003
4H Subfamily
CYP4H1 Anopheles albimanus (mosquito)
GenEMBL L38682 (382bp) PIR PC2261 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H2 Anopheles albimanus (mosquito)
GenEMBL L38683 (382bp) PIR PC2262 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H3 Anopheles albimanus (mosquito)
GenEMBL L38684 (382bp) PIR PC2263 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H4 Anopheles albimanus (mosquito)
GenEMBL L38685 (382bp) PIR PC2264 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H5 Anopheles albimanus (mosquito)
GenEMBL L38686 (382bp) PIR PC2265 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H6 Anopheles albimanus (mosquito)
GenEMBL L38687 (452bp) PIR PC2266 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H7 Anopheles albimanus (mosquito)
GenEMBL L38688 (382bp) PIR PC2267 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H8 Anopheles albimanus (mosquito)
GenEMBL L38689 (461bp) PIR PC2268 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H9 Anopheles albimanus (mosquito)
GenEMBL L38690 (406bp) PIR PC2269 (135 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H10 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R26
submitted to nomenclature committee
CYP4H11 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R18
submitted to nomenclature committee
CYP4H12v1 Culex pipiens pallens (mosquito)
GenEMBL AF157091
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 125 amino acids
clone name NYDR1 73% identical to 4H7
this sequence has three frameshifts and some poor quality sequence at
the 5 prime end
CYP4H12v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDR19 PCR fragment 98% identical to 4H12v1
Submitted to nomenclature committee 9/30/99
CYP4H13 Culex pipiens pallens (mosquito)
GenEMBL AF160259
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 151 amino acids
clone name NYDR3 74% identical to 4H5
This sequence has a retained intron
CYP4H14 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450P
94% identical to 4H8
CYP4H14 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r1
CYP4H15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450B
77% identical to 4H3
CYP4H15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r2
CYP4H15v2 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Y
one amino acid difference with 4H15, DNA is 95% identical
CYP4H16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450C
78% identical to 4H6
CYP4H16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r1
CYP4H17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450D
83% identical to 4H16
CYP4H17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r3
CYP4H18 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450G
77% identical to 4H16
CYP4H18 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r2
CYP4H19 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450K
78% identical to 4H7
CYP4H19 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.