P450s that have appeared since the 1993 P450 nomenclature update.
      This is part A of the list covering CYP1 to CYP2
      This includes references that were incomplete and duplications
      of sequences that were already in the update.  If a sequence 
      is assigned an accession number that was not in the old update
      it is included in this list.  
      This list was last revised on Jan. 31, 2003. 
      Added all human genes and pseudogenes

      Compiled by David R. Nelson

      A new format is being designed to make the entries more useful, with links to 
      Genbank and Medline and access to the protein sequence.  As time permits the   
      entries in the 1993 P450 Nomenclature Update will be added to make the  
      listing more comprehensive.  For the time being, I will leave the old text 
      format in place below the newer table format, but eventually the text version 
      will be deleted.  Any comments are welcome.

1A Subfamily

1B Subfamily

2A Subfamily

2B Subfamily

2C Subfamily

2D Subfamily

2E Subfamily

2F Subfamily

2G Subfamily

2H Subfamily

2J Subfamily

2K Subfamily

2L Subfamily

2M Subfamily

2N Subfamily

2P Subfamily

2Q Subfamily

Updated on March 5, 1999

Cytochrome P450 Data CYP1 to CYP2 (Under Construction)


 

P450 gene

Species

Medline Entry

Comment

Protein Sequence

Genbank Accession

 


 

CYP1A1

human

Kawajiri 1986

none

3' UTR

D12525 D01198

 

CYP1A1

human

Kubota 1991

none

3' UTR

D12525 D01198

 

CYP1A1

human

Hayashi 1991

none

3' UTR

D12525 D01198

 

CYP1A1

human

Kawajiri 1986

none

5' UTR

D10855 D01150

 

CYP1A1

human

Kubota 1991

none

5' UTR

D10855 D01150

 

CYP1A1

Cavia cobaya
(guinea pig)

Ohgiya 1993

none

Get Seq

D11043 PIR S43414

 


 


Return to Cytochrome P450 Homepage

1A Subfamily


CYP1A1      human
            GenEMBL D12525 D01198 (650bp)
            Kawajiri,K., Watanabe,J., Gotoh,O., Tagashira,Y., and Sogawa,K.
            Structure and drug inducibility of the human cytochrome P-450c
            gene.
            Eur. J. Biochem. 159, 219-225 (1986)

            Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
            Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
            Xenobiotic responsive element in the 5'-upstream region
            of the human P-450c gene.
            J. Biochem. 110, 232-236 (1991)
      
            Hayashi,S.-i., Watanabe,J., Nakachi,K. and Kawajiri,K.
            Genetic linkage of lung cancer-associated MspI polymorphisms
            with amino acid replacement in the heme binding region of
            the human cytochrome P450IA1 gene.
            J. Biochem. 110, 407-411 (1991)

CYP1A1      human
            GenEMBL D10855 D01150 (4144bp)
            Kawajiri,K., Watanabe,J., Gotoh,O., Tagashira,Y., and Sogawa,K.
            Structure and drug inducibility of the human cytochrome P-450c
            gene.
            Eur. J. Biochem. 159, 219-225 (1986)

            Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
            Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
            Xenobiotic responsive element in the 5'-upstream region
            of the human P-450c gene.
            J. Biochem. 110, 232-236 (1991)
            Note: these refs are the same as the two earlier accession numbers.

CYP1A1      Cavia Cobaya (guinea pig)
            GenEMBL D11043 (2674bp)
            PIR S43414 (516 amino acids)
            Ohgiya,S. Ishizaki,K. and Shinriki,N.
            Molecular cloning of guinea pig CYP1A1: complete primary structure 
            and fast mobility of expressed protein on electrophoresis.
            Biochim. Biophys. Acta 1216, 237-244 (1993)

CYP1A1      rat
            GenEMBL I00732 (1800bp)
            Oeda,K., Sakaki,T., Ohkawa,H., Yabusaki,Y., Murakami,H.,
            Nakamura,K. and Shimizu,M.
            Cytochrome P-450MC gene, expression plasmid carrying the said gene,
            yeasts transformed with the said plasmid and a process for producing
            cytochrome P-450MC by culturing the said transformant yeasts.
            Patent: US 4766068-A 1 23-AUG-1988

CYP1A1      rat
            PIR A93513 (524 amino acids)
            Yabusaki, Y., Shimizu, M., Murakami, H., Nakamura, K., Oeda,
            K. and Ohkawa, H.
            Nucleotide sequence of a full-length cDNA coding for
            3-methylcholanthrene-induced rat liver cytochrome P-450MC.
            Nucleic Acids Res. 12, 2929-2938 (1984)

CYP1A1      rat
            PIR S45716 (524 amino acids)
            Omata, Y., Robinson, R.C., Gelboin, H.V., Pincus, M.R.,
            Friedman, F.K.
            Specificity of the cytochrome P-450 interaction with
            cytochrome b(5).
            FEBS Lett.  346, 241-245 (1994)

CYP1A1      rat
            PIR D60822 (19 amino acids)
            Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
            Oesch, F.
            Effect of nutritional imbalances on cytochrome P-450 isozymes
            in rat liver.
            Biochem. Pharmacol. 37, 3245-3249 (1988)

CYP1A1      hamster
            GenEMBL D10913 (8700bp) Swiss Q00557 (524 amino acids)
            Sagami,I., Ohmachi,T., Fujii,H., Kikuchi,H. and Watanabe,M.
            Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in
            lung and liver: cDNA cloning and sequence analysis
            J. Biochem. 110, 641-647 (1991)

CYP1A1      hamster
            PIR JS0746 (524 amino acids)
            Ohgiya, S., Goda, T., Ishizaki, K., Morimoto, M., Sakamoto,T.,
            Kamataki, T. and Shinriki, N.
            unpublished (1992)

CYP1A1      rabbit
            PIR A25143 (464 amino acids)
            Okino, S.T., Quattrochi, L.C., Barnes, H.J., Osanto, S.,
            Griffin, K.J., Johnson, E.F. and Tukey, R.H.
            Cloning and characterization of cDNAs encoding 2,3,7,
            8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for
            cytochrome P-450 isozymes 4 and 6.
            Proc. Natl. Acad. Sci. U.S.A. 82, 5310-5314 (1985)

CYP1A1      Macaca irus (crab eating macaque monkey)
            GenEMBL D17575 (2602bp)
            Ohmachi,T., Sagami,I., Kikuchi,H., Fujii,H., Suzaki,Y., Fujiwara,T.
            and Watanabe,M.
            Molecular cloning and sequence analysis of cDNA encoding a
            crab-eating monkey (Macaca irus) cytocrome P-450
            unpublished (1993)

CYP1A1      Macaca fasicularis (crab eating macaque monkey)
            Swiss P33616 (512 amino acids)
            Komori, M. Kikuchi,O. Kitada,M. Kamataki T.
            Molecular cloning of monkey 1A1 cDNA and expression in yeast.
            Biochim. Biophys. Acta 1131, 23-29 (1992)

CYP1A1      Sus scrofa (pig)
            No accession number 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            82% to human  CYP1A1, 74% to human 1A2

CYP1A1       Macropus eugenii (tamar wallaby)
             no accession number
             Ross McKinnon
             submitted to nomenclature committee 9/7/98
             98 amino acid C-terminal fragment is 82% identical to macaque 1A1

CYP1A1         Balaenoptera acutorostrata  (Minke whale)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee

CYP1A1          Phocoenoides dalli (Dall's porpoise)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee

CYP1A1      Eumetopias jubatus (Steller sea lion)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            clone #1
            submitted to nomenclature committee

CYP1A1      Phoca largha (Spotted seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee

CYP1A1      Phoca fasciata (Ribbon seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 6/29/99 revised 2/27/01

CYP1A1      Halichoerus grypus (grey seal, gray seal)
            No accession number
            Rachel Tilley
            Submitted to nomenclature committee 3/19/2001
            Name grey seal 1

CYP1A1      Phoca groenlandica (harp seal)
            No accession number
            Rachel Tilley
            Submitted to nomenclature committee 3/19/2001
            Name harp seal 1

Cyp1a1     mouse
            GenEMBL K02588 (2619bp)
            Kimura,S., Gonzalez,F.J. and Nebert,D.W.
            The murine Ah locus.
            J. Biol. Chem. 259, 10705-10713 (1984)

Cyp1a1     mouse
            GenEMBL M10021 (8809bp)
            PIR A24953 (30 amino acids)
            Gonzalez,F.J., Mackenzie,P.I., Kimura,S. and Nebert,D.W.
            Isolation and characterization of full-length mouse cDNA and
            genomic clones of 3-methylcholanthrene-inducible cytochrome
            P-1-450 and P-3-450
            Gene 29, 281-292 (1984)

Cyp1a1     mouse
            GenEMBL X01681 (6214bp)
            Kimura,S., Gonzalez,F.J. and Nebert,D.W.
            The murine Ah locus: Comparison of the complete cytochrome P1-450
            and P3-450 cDNA nucleotide and amino acid sequences
            J. Biol. Chem. 259, 10705-10713 (1984)

Cyp1a1     mouse
            GenEMBL M11515 (8850bp)
            Kimura,S. and Nebert,D.W.
            Comparison of the mouse P-1-450 gene and flanking sequences from a
            MOPC 41 plasmacytoma and normal liver.
            DNA 4, 365-375 (1985)

Cyp1a1     mouse
            GenEMBL M25623 (410bp)
            Peterson,T.C., Gonzalez,F.J. and Nebert,D.W.
            Methylation differences in the murine P-1-450 and P-3-450 genes in
            wild-type and mutant hepatoma cell culture
            Biochem. Pharmacol. 35, 2107-2114 (1986)

Cyp1a1     mouse
            GenEMBL M33935 (474bp)
            Jones,J.E. and Nebert,D.W.
            Transcriptional start site in the mouse Cyp1a1 (cytochrome P-1-450) gene.
            DNA 8, 527-534 (1989)

Cyp1a1     mouse
            PIR C24406 (24 amino acids) 
            Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
            Gelboin, H.V. and Friedman, F.K.
            Amino-terminal sequence and structure of monoclonal antibody
            immunopurified cytochromes P-450.
            Biochemistry 25, 2397-2402 (1986)

CYP1A1    Ovis aries (sheep)
           GenEMBL S79795 (2585bp)
           Hazinski,T.A., Noisin,E., Hamon,I. and DeMatteo,A.
           Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and
           transcriptional regulation by oxygen tension
           J. Clin. Invest. 96 (4), 2083-2089 (1995)

CYP1A2      human
            GenEMBL M38504 (3149bp)
            Jaiswal,A.K., Nebert,D.W., McBride,W.O. and Gonzalez,F.J.
            Human P-3-450: cDNA and complete protein sequence, repetitive Alu
            sequences in the 3' nontranslated region, and localization of gene
            to chromosome 15
            J. Exp. Pathol. 3, 1-17 (1987)

CYP1A2      human
            GenEMBL U02993 (3293bp)
            Quattrochi,L.C. and Tukey,R.H.
            The human cytochrome Cyp1A2 gene contains regulatory elements
            responsive to 3-methylcholanthrene
            Mol. Pharmacol. 36, 66-71 (1989)

CYP1A2      human
            PIR A25892 (515 amino acids)
            Quattrochi, L.C., Pendurthi, U.R., Okino, S.T., Potenza, C. and
            Tukey, R.H.
            Human cytochrome P-450 4 mRNA and gene: part of a multigene
            family that contains Alu sequences in its mRNA.
            Proc. Natl. Acad. Sci. U.S.A. 83, 6731-6735 (1986)

CYP1A2      human
            PIR A60881 (18 amino acids)
            Wrighton, S.A., Campanile, C., Thomas, P.E., Maines, S.L.,
            Watkins, P.B., Parker, G., Mendez-Picon, G., Haniu, M.,
            Shively, J.E., Levin, W. and Guzelian, P.S.
            Identification of a human liver cytochrome P-450 homologous
            to the major isosafrole-inducible cytochrome P-450 in the rat.
            Mol. Pharmacol. 29, 405-410 (1986)

CYP1A2      rabbit
            PIR B27821 (516 amino acids)
            Kagawa, N., Mihara, K., Sato, R.
            Structural analysis of cloned cDNAs for polycyclic
            hydrocarbon-inducible forms of rabbit liver microsomal
            cytochrome P-450.
            J. Biochem. 101, 1471-1479 (1987) 

CYP1A2      dog
            PIR A60463 (16 amino acids)
            Ohta, K., Motoya, M., Komori, M., Miura, T., Kitada, M. and
            Kamataki, T.
            A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is
            a low spin form of cytochrome P-450 but with catalytic and
            structural properties similar to P-450d.
            Biochem. Pharmacol. 38, 91-96 (1989)

CYP1A2      rat
            PIR B24406 (25 amino acids)
            Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
            Gelboin, H.V. and Friedman, F.K.
            Amino-terminal sequence and structure of monoclonal antibody
            immunopurified cytochromes P-450.
            Biochemistry 25, 2397-2402 (1986)

CYP1A2      rat
            GenEMBL X01031 (1106bp) PIR A44612 (367 amino acids)
            Yabusaki, Y., Murakami, H., Nakamura, K., Nomura, N.,
            Shimizu, M., Oeda, K. and Ohkawa, H.
            Characterization of complementary DNA clones coding for two
            forms of 3-methylcholanthrene-inducible rat liver
            cytochrome P-450.
            J. Biochem. 96, 793-804 (1984)

CYP1A2      rat
            PIR S26822 (19 amino acids)
            Botelho, L.H., Ryan, D.E., Yuan, P.M., Kutny, R., Shively,
            J.E. and Levin, W.
            Amino-terminal and carboxy-terminal sequence of hepatic
            microsomal cytochrome P-450d, a unique hemoprotein from
            rats treated with isosafrole.
            Biochemistry 21, 1152-1155 (1982)

CYP1A2      rat
            PIR D60822 (22 amino acids)
            Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
            Oesch, F.
            Effect of nutritional imbalances on cytochrome P-450 isozymes
            in rat liver.
            Biochem. Pharmacol. 37, 3245-3249 (1988)

CYP1A2      rat
            PIR A61400 (513 amino acids)
            Woelfel, C.; Platt, K.L.; Dogra, S.; Glatt, H.; Waechter, F.;
            Doehmer, J.
            Stable expression of rat cytochrome P450IA2 cDNA and
            hydroxylation of 17beta-estrodiol and 2-aminofluorene in
            V79 Chinese hamster cells.
            Mol. Carcinog. 4, 489-498 (1991) 

CYP1A2      hamster
            GenEMBL D10914 (9719bp)
            Sagami,I., Ohmachi,T., Fujii,H., Kikuchi,H. and Watanabe,M.
            Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in
            lung and liver: cDNA cloning and sequence analysis
            J. Biochem. 110, 641-647 (1991)

CYP1A2        Mesocricetus auratus (hamster)
             GenEMBL M63787 M34446 (1868bp)
             Lai,T.S. and Chiang, J.Y.L.
             Cloning and characterization of two major 3-methylcholanthrene inducible hamster 
             liver cytochrome P-450s.
             Arch. Biochem Biophys. 283, 429-439 (1990)
             clone MC4
             note: M34446 is incorrectly included in the GenBank entry
             for CYP2A8 and CYP2A9. M34446 should only be in the CYP1A2 hamster entry.

CYP1A2      Cavia cobaya (guinea pig)
            GenEMBL D50457 (1760bp)
            Mori,T., Itoh,S., Ohgiya,S., Ishizaki,K. and Kamataki,T.
            Effect of ascorbic acid on expression of several forms of
            cytochrome P-450 of guinea pig
            Unpublished (1995)

CYP1A2      Cavia porcellus (guinea pig)
            GenEMBL U23501 (1757bp)
            Black,V.H.
            unpublished 1995

CYP1A2      chicken
            GenEMBL M64537 (884bp)
            Swiss Q01741 (258 amino acids)
            Murti,J.R., Adiga,P.R. and Padmanaban,G.
            Estradiol-17-Beta induces polyaromatic hydrocarbon-inducible
            cytochrome p-450 in chicken liver
            Biochem. Biophys. Res. Commun. 175, 928-935 (1991)
            Note: previously called 1A2

CYP1A2           Eumetopias jubatus (Steller sea lion)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            clone #2
            submitted to nomenclature committee

CYP1A2      Phoca fasciata (Ribbon seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 6/28/99 revised 2/27/01

CYP1A1/CYP1A2 chimera  Phoca fasciata (Ribbon seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 6/28/99
            on 2/27/01 the authors sent the following message
            "... we believe that the production of the chimera 
            sequence could be the result of a PCR defect."

CYP1A2      Halichoerus grypus (grey seal, gray seal)
            No accession number
            Rachel Tilley
            Submitted to nomenclature committee 3/19/2001
            Name grey seal 2

CYP1A2      Phoca groenlandica (harp seal)
            No accession number
            Rachel Tilley
            Submitted to nomenclature committee 3/19/2001
            Name harp seal 2

Cyp1a2      mouse
            GenEMBL K02589 (1893bp)
            Kimura,S., Gonzalez,F.J. and Nebert,D.W.
            The murine Ah locus.
            J. Biol. Chem. 259, 10705-10713 (1984)

Cyp1a2     mouse
            PIR A93512 (513 amino acids)
            Kimura, S., Gonzalez, F.J. and Nebert, D.W.
            Mouse cytochrome P-3-450: complete cDNA and amino acid
            sequence.
            Nucleic Acids Res. 12, 2917-2928 (1984)

Cyp1a2     mouse
            GenEMBL X01682 (6715bp)
            Kimura,S., Gonzalez,F.J. and Nebert,D.W.
            The murine Ah locus: Comparison of the complete cytochrome P1-450
            and P3-450 cDNA nucleotide and amino acid sequences
            J. Biol. Chem. 259, 10705-10713 (1984)

Cyp1a2     mouse
            GenEMBL M25624 (510bp)
            Peterson,T.C., Gonzalez,F.J. and Nebert,D.W.
            Methylation differences in the murine P-1-450 and P-3-450 genes in
            wild-type and mutant hepatoma cell culture
            Biochem. Pharmacol. 35, 2107-2114 (1986)

Cyp1a2     mouse
            PIR B92495 (513 amino acids)
            Gonzalez, F.J., Kimura, S. and Nebert, D.W.
            J. Biol. Chem. 260, 11884-11889 (1985)
            Erratum

Cyp1a2     mouse
            GenEMBL M10022 (8865bp)
            PIR B24953 (30 amino acids)
            Gonzalez,F.J., Mackenzie,P.I., Kimura,S. and Nebert,D.W.
            Isolation and characterization of full-length mouse cDNA and
            genomic clones of 3-methylcholanthrene-inducible cytochrome
            P-1-450 and P-3-450
            Gene 29, 281-292 (1984)

Cyp1a2     mouse
            PIR A45955 (42 amino acids) PIR B45955 (39 amino acids)
            Peterson, T.C., Gonzalez, F.J. and Nebert, D.W.
            Methylation differences in the murine P-1-450 and P-3-450
            genes in wild-type and mutant hepatoma cell culture.
            Biochem. Pharmacol. 35, 2107-2114 (1986)

Cyp1a2     mouse
            PIR D24406 (25 amino acids) PIR E24406 (25 amino acids)
            Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
            Gelboin, H.V. and Friedman, F.K.
            Amino-terminal sequence and structure of monoclonal antibody
            immunopurified cytochromes P-450.
            Biochemistry 25, 2397-2402 (1986)

Fish Cytochrome P450s are undergoing a revision to their nomenclature.  Initially 
there appeared to be just one fish 1A gene per species, but that is not true as shown 
by Amy Berndtson in trout.  Until an adequate nomenclature can be devised, these fish 
sequences are listed as CYP1A, without a number following the subfamily.  This does 
not affect the mammalian gene designations, though it may affect the chicken 
sequences.

CYP1A1      Oncorhynchus mykiss (trout)
            GenEMBL S69278 (5023bp)
            Berndtson,A.K. and Chen,T.T.
            Two unique CYP1 genes are expressed in response to 
            3-methylcholanthrene treatment in rainbow trout.
            Arch. Biochem. Biophys. 310, 187-195 (1994)
            Note: published as CYP1A2, but it is more similar to Heilmann's sequence
            than Berndtson's 1A1 (97.9% identical).

CYP1A1      Oncorhynchus mykiss (trout)
            GenEMBL U62797(1697bp)
            Bailey,G., You,L. and Harttig,U.
            Cloning, sequencing and functional expression of two trout CYP1A
            cDNAs in yeast
            unpublished (1997)
            incorrectly called 1A2

CYP1A3      Oncorhynchus mykiss (trout)
            GenEMBL U62796(2401bp)
            Bailey,G., You,L. and Harttig,U.
            Cloning, sequencing and functional expression of two trout CYP1A
            cDNAs in yeast
            unpublished (1997)
            incorrectly called 1A1

CYP1A      Oncorhynchus mykiss (trout)
           GenEMBL AF015660
           Bailey,G., You,L. and Harttig,U.
           Cloning,sequencing and aflatoxin B1 metabolism by multiple rainbow
           trout CYP1A cDNAs expressed in yeast
           Unpublished
           8 amino acid differences with U62797

CYP1A3      Oncorhynchus mykiss (trout)
            GenEMBL S69277 (5524bp)
            Berndtson,A.K. and Chen,T.T.
            Two unique CYP1 genes are expressed in response to 
            3-methylcholanthrene treatment in rainbow trout.
            Arch. Biochem. Biophys. 310, 187-195 (1994)
            Note: published as CYP1A1.  This sequence is 96.7% identical to
            Heilmann's 1A1 sequence.

CYP1A1/CYP1A3 chimera      Oncorhynchus mykiss (trout)
            PIR A28789 (522 amino acids)
            Heilmann, L.J., Sheen, Y.Y., Bigelow, S.W. and Nebert, D.W.
            Trout P450IA1: cDNA and deduced protein sequence, expression
            in liver, and evolutionary significance.
            DNA 7, 379-387 (1988)
            Published as CYP1A1
            note:  subsequent analysis has shown that the 5' end of this sequence
            comes from the 1A3 gene and the switch over occurs between base 271 
            and base 435 with base 1 as the A of the ATG start codon.

CYP1A       Pleuronectes platessa (plaice, a fish)
            GenEMBL X73631 (2411bp) PIR S34184 (521 amino acids)
            Leaver,M.J., Pirrit,L. and George,S.G.
            Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) 
            Mol. Marine Biol. Biotechnol. 2, 338-345 (1993)

CYP1A       Opsanus tau ( oyster toadfish)
            GenEMBL U14161 (2352bp)
            Morrison, H.G., Oleksiak, M.F., Cornell, N.W., Sogin,M.L. and 
            Stegeman, J.J.
            Identification of Cytochrome P450 1A genes from two teleost fish, toadfish
            (Opsanus tau) and scup (Stenotomus chrysops), and pyhlogenetic analysis 
            of CYP1A genes.
            Biochem. J. 308, 97-104 (1995)

CYP1A       Stenotomus chrysops (scup, a fish)
            GenEMBL U14162 (1566bp)
            Morrison, H.G., Oleksiak, M.F., Cornell, N.W., Sogin,M.L. and 
            Stegeman, J.J.
            Identification of Cytochrome P450 1A genes from two teleost fish, toadfish
            (Opsanus tau) and scup (Stenotomus chrysops), and pyhlogenetic analysis 
            of CYP1A genes.
            Biochem. J. 308, 97-104 (1995)

CYP1A       Chaetodon capistratus (four-eye butterfly fish)
            GenEMBL U19855 (2552bp)
            Vrolijk,N.H., Lin,C. and Chen,T.T.
            Characterization and expression of a CYP1A gene from the tropical
            teleost, Chaetodon capistratus.
            Unpublished 1995

CYP1A       Dicentrarchus labrax (european sea bass)
            GenEMBL U78316(1563bp)
            Stien,X., Amichot,M., Berge,J.-B. and Lafaurie,M.
            Molecular cloning of a CYP1A cDNA from the teleost fish
            Dicentrarchus labrax.
            Unpublished (1995)

CYP1A1v2    Dicentrarchus labrax (european sea bass)
            No accession number
            Alessandra Salvetti
            Submitted to nomenclature committee 11/26/99
            94% identical to U78316 probably an allele

CYP1A       Microgadus tomcod (Atlantic tomcod)
            GenEMBL L41886 (2497bp) L41917
            Roy,N.K., Konkle,B.A., Kreamer,G.-L., Grunwald,C. and Wirgin,I.I.
            Characterization and prevalence of a polymorphism in the 3'
            untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod
            Arch. Biochem. Biophys. (1995) In press
            probable frameshift detected by O. Gotoh. in the beginning of the sequence.

CYP1A       Microgadus tomcod (Atlantic tomcod)
            GenEMBL  L41917 (6837bp)
            Roy,N.K., Konkle,B. and Wirgin,I.I.
            Functional characterization of Cytochrome P4501A1 regulatory
            sequences in cancer-prone Atlantic tomcod.
            Unpublished (1995)

CYP1A       Pagrus major (wild red sea bream)
            no accession number
            Mizukami,M., Okauchi,M., Ariyoshi,T. and Kito,H.
            The isolation and sequence of cDNA encoding a 3-methylcholanthrene-
            inducible cytochrome P450 from wild red sea bream, Pagrus major.
            Marine Biol. 120, 343-349 (1994)

CYP1A      Sparus aurata (gilthead sea bream)
            GenEMBL AF011223, AF005719

CYP1A       Liza aurata 
            GenEMBL AF022433
            Cousinou,M., Lopez-Barea,J. and Dorado,G.

CYP1A      Liza saliens (leaping mullet)
           GenEMBL AF072899
           Alaattin Sen and Don Buhler
           submitted to nomenclature committee
           96% identical to Liza aurata

CYP1A      Limanda limanda
           GenEMBL AJ001724
           Robertson,F.E., McPhail,M.E., Rankin,R., Stagg,R.M. and Craft,J.A.

CYP1A       Platichthys flesus (European flounder)
            GenEMBL AJ132353
            Williams,T.D., Lee,J.S. and Chipman,J.K.
            The cytochrome P450 1A gene (CYP1A) from European flounder
            (Platichthys flesus), analysis of regulatory regions and
            development of a dual luciferase reporter gene assay.
            Unpublished

CYP1A1      Salmo salar (salmon)
            No accession number
            Christopher Rees Weiming Li
            submitted to nomenclature committee Nov. 9, 2001
            a second gene is being isolated so this is called 1A1 
            rather than just CYP1A.  This does not imply orthology to the 
            mammalian 1A1, 1A2.  The CYP1A gene duplications in fish and mammals 
            occurred independently.

CYP1A4      Gallus gallus (chicken)
            GenEMBL X99453(2098bp)
            Gilday,D.J., Gannon,M., Yutzey,K., Bader,D. and Rifkind,A.
            Molecular cloning and expression of two novel avian cytochrome P450
            1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
            J. Biol. Chem. 271, 33054-33059 (1996)

CYP1A5     Gallus gallus (chicken)
            GenEMBL X99454(1845bp)
            Gilday,D.J., Gannon,M., Yutzey,K., Bader,D. and Rifkind,A.
            Molecular cloning and expression of two novel avian cytochrome P450
            1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
            J. Biol. Chem. 271, 33054-33059 (1996)

CYP1A6       Xenopus laevis (African clawed frog)
            GenEMBL AB022087
            Fujita,Y. and Ohi,H.
            Xenopus laevis mRNA for cytochrome P450, cDNA clone MC1
            unpublished(1999) In press
            clone MC1

CYP1A7       Xenopus laevis (African clawed frog)
            GenEMBL AB022088
            Fujita,Y. and Ohi,H.
            Xenopus laevis mRNA for cytochrome P450, cDNA clone MC2
            unpublished(1999) In press
            clone MC2

CYP1A8P     human
            NT_008580.9 
            Pseudogene 43% identcal to 1A2 human
NT_008580.9|Hs9_8737 chromosome 9 
4822084 MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPY 4822260
4822261 LTLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKS 4822440
4822441 LSFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSK 4822620
4822621 NGSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCL 4822800
4822801 HYLPLKIINAPLEFYQALNGFIALHVQDHLATYGK 4822905 (0)
4824790 DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVSDLFGA 4824912 (1)
4829424 GFETVSTCLCWSFLYLIHYPEIQARIQEEI 4829513 (1)
4829611 RPPRFEDRKILPYTEAFVSEVFRHASFLPFTIPHS 4829715 (2)
4832677 TTADTTLNGYFIPRKTCTFINMYQVNHDE 4832763 (2)
4835676 TIWDNHSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFK 4835858
4835859 LKK*PRAKLDLTPTYGLVMRPKLYQLQAELHPSGSSSA* 4835975

1B Subfamily


CYP1B1      human
            GenEMBL  U03688 (5102bp)
            Sutter,T.R., Tang,Y.M., Hayes,C.L., Wo,Y.-Y.P., Jabs,E.W.,
            Li,X., Yin,H., Cody,C.W. and Greenlee,W.F.
            Complete cDNA sequence of a human dioxin-inducible mRNA
            identifies a new gene subfamily of cytochrome P450 that maps to
            chromosome 2.
            J. Biol. Chem. 269, 13092-13099 (1994)

*** Note The CYP1B1 gene has been linked to primary congenital glaucoma****
See April 97 Human Molecular Genetics

CYP1B1      human
            GenEMBL U56438 (12177bp)
            Tang,Y.M., Wo,Y.-Y.P., Stewart,J., Hawkins,A.L., Griffin,C.A.,
            Sutter,T.R. and Greenlee,W.F.
            Isolation and characterization of the human cytochrome P450 CYP1B1
            gene.
            J. Biol. Chem. 271, 28324-28330 (1996)

CYP1B1       rat
            GenEMBL X83867 (2321bp)
            Battacharyya,K.K., Brake,P.B., Eltom,S.E., Otto,S.A. and Jefcoate,C.R.
            Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon 
            metabolism as a rat CYP1B1.  Demonstration of a unique tissue-specific pattern of 
            hormonal and aryl; hydrocarbon receptor-linked regulation.
            J. Biol. Chem. 270 11595-11602 (1995)

CYP1B1      rat
            GenEMBL U09540(4964bp)
            Nigel Walker
            Walker,N.J., Gastel,J.A., Costa,L.T., Clark,G.C., Lucier,G.W. and
            Sutter,T.R.
            Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent
            expression in livers and kidneys of TCDD-treated animals.
            Carcinogenesis 16 (6), 1319-1327 (1995)

Cyp1b1     mouse
            GenEMBL U02479 (317bp)
            Shen,Z., Wells,R., Liu,J. and Elkind,M.M.
            Identification of a cytochrome P450 gene by reverse transcription-
            PCR using degenerate primers containing inosine.
            Proc. Natl. Acad. Sci. USA 90, 11483-11487 (1993)
            Note: only 104 amino acids by PCR. 

Cyp1b1     mouse
            GenEMBL U03283 (5128bp)
            Shen,Z., Liu,J., Wells,R.L. and Elkind,M.M.
            cDNA cloning, sequence analysis, and induction by aryl hydrocarbons
            of a murine cytochrome P450 gene, Cyp1b1.
            DNA Cell Biol. 13, 763-769 (1994)

Cyp1b1     mouse
           GenEMBL X78445 (2006bp)
           Savas,U., Bhattacharyya,K.K., Christou,M., Alexander,D.L. and 
           Jefcoat,C.R.
           Mouse cytochrome P450EF, representative of a new 1B subfamily of 
           cytochrome P450s. Cloning, sequence determination, and tissue
           expression.
           J. Biol. Chem. 269, 14905-14911 (1994)

CYP1B      Fundulus heteroclitus (killifish)
           No accession number
           Celine Godard, Maya Said and John Stegeman
           Submitted to nomenclature committee Feb. 16, 2000

CYP1B      Danio rerio (zebrafish)
           No accession number
           Celine Godard, Maya Said and John Stegeman
           Submitted to nomenclature committee Feb. 16, 2000

CYP1B1     Stenella coeruleoalba (striped dolphin)
           no accession number
           Celine Godard, Maya Said and John Stegeman
           submitted to nomenclature committee Nov. 20, 1998
           PCR fragment 90% identical to human 1B1 I-helix to PERF motif region

CYP1B1     Pleuronectes platessa (plaice)
           no accession number
           Michael Leaver
           submitted to Nomenclature Committee 3/11/99
           full length seq.

CYP1B2X    Stenotomus chrysops (scup, a fish)
           no accession number
           Celine Godard, Maya Said, and John Stegeman.
           submitted to nomenclature committee full length 4/21/99
           81% identical to scup 1B3 
           renamed CYP1C1 

CYP1B3X    Stenotomus chrysops (scup, a fish)
           no accession number
           Celine Godard, Maya Said, and John Stegeman.
           submitted to nomenclature committee Aug. 26, 1998 full length 4/21/99
           63% identical to human 1B1 over C-terminal PCR fragment 
           I-helix to heme
           formerly 1B1, reaassigned to CYP1C2

CYP1C1     Stenotomus chrysops (scup, a fish)
           no accession number
           Celine Godard, Maya Said, and John Stegeman.
           submitted to nomenclature committee full length 4/21/99
           81% identical to scup 1C2 
           formerly 1B2, reaassigned after consultation with the submitters
           and comparison to the Fugu genomic orthologs (see below)

CYP1C1     Fugu rubripes 
           No accession number
           Scaffold_3008b comp(8676-10253) no introns complete gene
           86% to scup 1C1 75% to scup 1C2
10253 MALDTEFGVKSSSITREWSGQVQPALVASFLFLFCLEACLWVRNLRHKRRL
10100 PGPFAWPVVGNAMQLGQMPHITFAKLAKKYGNVYQIRLGCSNI 9972
9971  VVLNGDQAIHQALIEHSTEFAGRPNFVSFQMISGGRSLTFTNYSKQWKVHRKLAQSSLRA 9792
9791  FSSANKQTKIAFEQHVTAEANELVQAFLRYSTDGRYFDPAHEFTVAAANVMCALCFGKRY 9612
9611  GHDDHEFRCLLKKLNKFGETVGAGSLVDVMPWLQSFPNPVRSLYENFKSLNEEFFNFV 9438
9437  KNKVQEHRESFDPNVTRDMSDAMINVIEERKDGTLSKEFAEATITDLIGAGQDTVS 9270
9269  TVLQWIVLLLVKHPDKQAKLHELMDKVVGQDRLPTTEDRSSLAYLDAFIYETMRFTSFVP 9090
9089  VTIPHSTTSDVTIEGLRIPKDTVVFINQWSVNHDPLKWKDPHVFDPSRFLNENGDLNKDL 8910
8909  TSGVMIFSSGKRRCIGSQIAKVEVFLFAAILLHQCSFESDPSDPLTLDCSYGLTLKP 8739
      LRCFVSAKPRGKLLGLVSPA* 8676

CYP1C2     Stenotomus chrysops (scup, a fish)
           no accession number
           Celine Godard, Maya Said, and John Stegeman.
           submitted to nomenclature committee Aug. 26, 1998 full length 4/21/99
           63% identical to human 1B1 over C-terminal PCR fragment 
           I-helix to heme
           formerly 1B3, reaassigned after consultation with the submitters
           and comparison to the Fugu genomic orthologs (see below)

CYP1C2     Fugu rubripes 
           No accession number
           Scaffold_3008a comp(5208-6770) no introns complete gene
           83% to scup 1C2 78% to scup 1C1
6770 MGXDFGLKXSSSITREWSGHVQPALVAFFVFLFCVEACLWAKNLKRRL
6626 PGPFAWPVVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGCSDI 6498
6497 VVLNGARVIRQALIEHSTEFAGRPNFVSFQNVSGGKSMAFTSYSKQWRMHRKIAQSTIRA 6318
6317 FSSANSQTKKVFEQQIVAEATELVEVFLKLGARGQHFNPAHELTVAAANVICALCFGRRY 6138
6137 GHDDQEFRDVLRRIDKFGQTVGAGSLVDVMPWLQSFPNPVRSMFRSFEALNREFFGF 5967
5966 VQLKVEQHRETFDPEVTRDMSDAIISVLEKSDGETALTKDYTEVTMADLIGAGLDTV 5796
5795 STALHWMLLLLVKHPELQSKLHQLIDRVVGRNRLPSIEDRSSLAYLDAFIYETMRFTSFV 5616
5615 PVTIPHSTTSDVTIEGLRIPKDTVVFINQWSVNQDPLMWKDPHVFDPSRFMDEEGSLDRD 5436
5435 LACNVMIFSAGKRRCIGDQIAKVEVFLFFAVLLHQCSFESSADEDLTLNCSYGLTLKPL 5259
5258 DFSITAKLRGKLLKSP* 5208 
           
2A Subfamily

CYP2A1      rat
            PIR C41425 (12 amino acids)
            Imaoka, S., Kamataki, T. and Funae, Y.
            Purification and characterization of six cytochromes P-450
            from hepatic microsomes of immature female rats.
            J. Biochem. 102, 843-851 (1987)


CYP2A2      rat
            PIR S26821 (27 amino acids)
            Matsumoto, T.,  Emi, Y.,  Kawabata, S. and Omura, T.
            Purification and characterization of three male-specific and
            one female-specific forms of cytochrome P-450 from rat
            liver microsomes.
            J. Biochem. 100, 1359-1371 (1986)

Cyp2a4      mouse
            GenEMBL J04631 (multiple genomic fragments)
            PIR A30499 (494 amino acids) PIR A33531 (494 amino acids)
            Lindberg,R., Burkhart,B., Ichikawa,T. and Negishi,M.
            The structure and characterization of type I P-450-15-alpha gene as
            major steroid 15-alpha-hydroxylase and its comparison with type II
            P-450-15-alpha gene
            J. Biol. Chem. 264, 6465-6471 (1989)

Cyp2a4      mouse
            PIR S16067 (494 amino acids)
            Squires, E.J. and Negishi, M.
            Reciprocal regulation of sex-dependent expression of
            testosterone 15-alpha-hydroxylase (P-450-15-alpha) in liver
            and kidney of male mice by androgen. Evidence for a single gene.
            J. Biol. Chem. 263, 4166-4171 (1987)
            Note: 2a-4 and 2a-5 differ at 11 positions.  This sequence is 2a-4 like at
            9/11 positions.

Cyp2a5      mouse
            GenEMBL J04631 (multiple genomic fragments)
            PIR B30499 (494 amino acids) PIR B33531 (494 amino acids)
            Lindberg,R., Burkhart,B., Ichikawa,T. and Negishi,M.
            The structure and characterization of type I P-450-15-alpha gene as
            major steroid 15-alpha-hydroxylase and its comparison with type II
            P-450-15-alpha gene
            J. Biol. Chem. 264, 6465-6471 (1989)

Cyp2a5      mouse
            PIR S16068 (494 amino acids)
            Squires, E.J. and Negishi, M.
            Reciprocal regulation of sex-dependent expression of
            testosterone 15-alpha-hydroxylase (P-450-15-alpha) in liver
            and kidney of male mice by androgen. Evidence for a single gene.
            J. Biol. Chem. 263, 4166-4171 (1987)
            Note: 2a-4 and 2a-5 differ at 11 positions.  This sequence is 2a-4 like at
            5/11 positions, and 2a-5 like at 6/11 positions
            
Cyp2a4 or 5 mouse
            PIR S03979 (21 amino acids)
            Lang, M.A., Juvonen, R., Jaervinen, P., Honkakoski, P. and
            Raunio, H.
            Mouse liver P450Coh: genetic regulation of the
            pyrazole-inducible enzyme and comparison with other P450
            isoenzymes.
            Arch. Biochem. Biophys. 271, 139-148 (1989)

CYP2A6      human
            PIR S17220 (20 amino acids)
            Maurice, M., Emiliani, S., Dalet-Beluche, I., Derancourt, J.
            and Lange, R.
            Isolation and characterization of a cytochrome P450 of the
            IIA subfamily from human liver microsomes.
            Eur. J. Biochem. 200, 511-517 (1991)

CYP2A6      human
            PIR A61272 (13 amino acids)
            Yun, C.H., Shimada, T. and Guengerich, F.P.
            Purification and characterization of human liver microsomal
            cytochrome P-450 2A6.
            Mol. Pharmacol. 40, 679-685 (1991)

CYP2A6v2    human
            GenEMBL U22027(7215bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)

CYP2A7      human
            GenEMBL U22029(2282bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)

CYP2A7PTX   human (retired name see CYP2A18PN)
            GenEMBL U22030(1192bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)
            There are two human pseudogenes of 2A7 on chromosome 19.  They are 
            Located adjacent to each other.  This one is telomeric.

CYP2A7PCX   human (retired name see CYP2A18PN)
            GenEMBL U22044(1192bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)
            There are two human pseudogenes of 2A7 on chromosome 19.  They are 
            Located adjacent to each other.  This one is centromeric.

CYP2A8       Mesocricetus auratus (hamster)
             GenEMBL M63788 M34446 M34447 (1771bp)
             Lai,T.S. and Chiang, J.Y.L.
             Cloning and characterization of two major 3-methylcholanthrene inducible hamster 
             liver cytochrome P-450s.
             Arch. Biochem Biophys. 283, 429-439 (1990)
             clone MC1 note: M34446 is incorrectly included in this GenBank entry
             and in the 2A9 entry. M34446 should only be in the CYP1A2 hamster entry.

CYP2A9       Mesocricetus auratus (hamster)
             GenEMBL M63789 M34446 M34448 (918bp)
             Lai,T.S. and Chiang, J.Y.L.
             Cloning and characterization of two major 3-methylcholanthrene inducible hamster 
             liver cytochrome P-450s.
             Arch. Biochem Biophys. 283, 429-439 (1990)
             clone MC1-81 3 prime end 
             note: M34446 is incorrectly included in this GenBank entry
             and in the 2A8 entry. M34446 should only be in the CYP1A2 hamster entry.

CYP2A9      Syrian hamster
            GenEMBL D86953
            Kurose,K., Tohkin,M., Ushio,F. and Fukuhara,M.
            Cloning and characterization of syrian hamster testosterone
            7alpha-hydroxylase, CYP2A9
            Arch. Biochem. Biophys. 351, 60-65 (1998)
            clone name P450SH2A-1
            1 amino acid difference with MC1-81 of Lai and Chiang (incomplete seq.)

CYP2A10     rabbit
            GenEMBL L10236 (1641bp) Swiss Q05555 (494 amino acids)
            Peng.H.-M., Coon,M.J. and Ding,X.
            Isolation and heterologous expression of cloned cDNAs
            for two rabbit nasal microsomal proteins CYP2A10 and CYP2A11
            that are related to nasal microsomal cytochrome P-450 form a.
            J. Biol. Chem. 268,17253-17260 (1993)

CYP2A10/11  rabbit
            PIR A31944 (23 amino acids)
            Ding, X. and Coon, M.J.
            Purification and characterization of two unique forms of
            cytochrome P-450 from rabbit nasal microsomes.
            Biochemistry 27, 8330-8337 (1988)

CYP2A11     rabbit
            GenEMBL L10237 (2484bp) Swiss Q05556 (494 amino acids)
            Peng.H.-M., Coon,M.J. and Ding,X.
            Isolation and heterologous expression of cloned cDNAs
            for two rabbit nasal microsomal proteins CYP2A10 and CYP2A11
            that are related to nasal microsomal cytochrome P-450 form a.
            J. Biol. Chem. 268, 17253-17260 (1993)

Cyp2a12     mouse
            GenEMBL L06463 (1665bp) PIR S32491 (492 amino acids)
            Iwasaki,M., Juvonen,R., Lindberg,R. and Negishi,M.M.
            Site-directed mutagenesis of mouse steroid 7 alpha-
            hydroxylase cytochrome P-450 (7 alpha): Role of residue
            209 in determining steroid-cytochrome P-450 interaction.
            Biochemical J. 291, 569-573 (1993)
            Note: called 7 alpha hydroxylase, but this sequence is very
            different from CYP7 sequences.  It is actually a 2A sequence.

CYP2A13     human
            GenEMBL U22028(8778bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)

CYP2A14      Cricetulus griseus (Chinese hamster)
             GenEMBL D86954 
             Fukuhara,M., Kurose, K., Aiba, N., Matsunaga, N., Omata, W., Kato, K.,
             and Kimura, M.
             A Major Phenobarbital-Inducible P450 Isozyme, CYP2A14, in the
             Chinese Hamster Liver: Purification, Characterization, and cDNA 
             Cloning"
             Arch. Biochem. Biophys. 359, 241-248 (1998)
             clone P450CH2A-2 85% identical to 2A3 and 2a5

CYP2A15      Cricetulus griseus (Chinese hamster)
             GenEMBL AB022916
             Kouichi Kurose, Emi Isozaki, Masahiro Tohkin, and Morio Fukuhara
             Cloning and expression analysis of a new member of the cytochrome 
             P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-
             Hydroxylase.
             Archives of Biochemistry and Biophysics (1999) Vol. 371 pp270-276
             91% identical to CYP2A9

CYP2A16      Mesocricetus auratus (Syrian hamster)
             GenEMBL D86952
             Masahiro Tohkin, Kouichi Kurose, Emi Isozaki, and Morio Fukuhara
             Molecular cloning, heterologous expression, and characterization of 
             a novel member of CYP2A in Syrian hamster"
             Biochimica et Biophysica Acta (1999) Vol.1446 pp438-442
             94% identical to CYP2A3

CYP2A17      Cricetulus griseus (Chinese hamster)
             No accession number
             Kouichi KUROSE
             86% identical to CYP2A14
             submitted to nomenclature committee 11/29/99

CYP2A18PC   human pseudogene
            AC008537 
            Hoffman S.M.G., Nelson, D.R. and Keeney, D.S.
            Organization, strtucture and evolution of the CYP2 gene cluster
            On human chromosome 19.
            Pharmacogenetics 2001, in press
            C-terminal part of P450 only.  This is the opposite end of the 
            pseudogene CYP2A18PN.  This gene appears to be split by a 2B6, 2B7P 
            insertion. 

CYP2A18PN   human pseudogene
            AC008537 
            Hoffman S.M.G., Nelson, D.R. and Keeney, D.S.
            Organization, strtucture and evolution of the CYP2 gene cluster
            On human chromosome 19.
            Pharmacogenetics 2001, in press
            N-terminal part of P450 only.  This is the opposite end of the 
            pseudogene CYP2A18PC.  This gene appears to be split by a 2B6, 2B7P 
            insertion.  This name replaces the old designations CYP2A7PT
            and CYP2A7PC.  There now seems to be only one copy of this pair
            in the sequenced human genome.

CYP2A18PN   human pseudogene (formerly CYP2A7PT)
            GenEMBL U22030(1192bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)
            There are two human pseudogenes of 2A7 on chromosome 19.  They are 
            Located adjacent to each other.  This one is telomeric.
            Note added 4/10/2001 This gene appears to be split by a 2B6, 2B7P 
            insertion.  This name replaces the old designations CYP2A7PT
            and CYP2A7PC.  There now seems to be only one copy of this pair
            in the sequenced human genome.

CYP2A18PN   human pseudogene (formerly CYP2A7PC)
            GenEMBL U22044(1192bp)
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)
            There are two human pseudogenes of 2A7 on chromosome 19.  They are 
            Located adjacent to each other.  This one is centromeric.
            Note added 4/10/2001 This gene appears to be split by a 2B6, 2B7P 
            insertion.  This name replaces the old designations CYP2A7PT
            and CYP2A7PC.  There now seems to be only one copy of this pair
            in the sequenced human genome.

CYP2A19     Sus scrofa (pig)
            No accession number 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            89% to human CYP2A13
            clone name c7

Cyp2a20p    mouse
            GenEMBL NW_000310 (52646-53186)
      53186 MTLS (frameshift) MLLVAVLTCFIAMITMSVLR*KKLLGK
            MPPGPTPLPFLGNFLELDTKKFYDSFLRVVLGREM (0) 52988
      52810 IREWYGPVFTVHLGTYSAVVPWGYDVVKETLVDQAEQFSGRGEQAFLDWFFKGYG 52646

CYP2A       Macaca fasicularis (monkey)
            PIR S36874 (13 amino acids)
            Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
            Purification and characterization of two forms of hepatic microsomal 
            cytochrome P450 from untreated cynomolgus monkeys.
            Arch. Biochem. Biophys. 305, 405-413 (1993)

CYP2A       baboon (Papio sp.)
            Swiss P80055 (20 amino acids) PIR S21737 (20 amino acids)
            Purification of two cytochrome P450 isozymes related to CYP2A
            and CYP3A gene families from monkey (baboon, Papio papio)
            liver microsomes. Cross reactivity with human forms.
            Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
            Eur. J. Biochem. 204, 641-648 (1992)

CYP2A       bovine
            PIR A35704 (18 amino acids)
            Lazard, D., Tal, N., Rubinstein, M., Khen, M., Lancet, D. and
            Zupko, K.
            Identification and biochemical analysis of novel olfactory-specific
            cytochrome P-450IIA and UDP-glucuronosyl transferase
            Biochemistry 29, 7433-7440 (1990)

2B Subfamily

CYP2B1 or 2 rat
            PIR A92255 (22 amino acids) B92255 (22 amino acids)
            Botelho, L.H., Ryan, D.E. and Levin, W.
            Amino acid compositions and partial amino acid sequences of
            three highly purified forms of liver microsomal cytochrome
            P-450 from rats treated with polychlorinated biphenyls,
            phenobarbital, or 3-methylcholanthrene.
            J. Biol. Chem. 254, 5635-5640 (1979)

CYP2B1 or 2 rat
            PIR A60822 (20 amino acids)
            Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
            Oesch, F.
            Effect of nutritional imbalances on cytochrome P-450 isozymes
            in rat liver.
            Biochem. Pharmacol. 37, 3245-3249 (1988)

CYP2B2      rat
            GenEMBL S51970 (2946bp)
            Hoffmann,M., Mager,W.H., Scholte,B.J., Civil,A. and Planta,R.J.
            Analysis of the promoter of the cytochrome P-450 2B2 gene in the 
            rat.
            Gene Expr. 2, 353-363 (1992)
            promoter region, no coding sequence

CYP2B2      rat
            GenEMBL L28169 (1401bp)
            Shephard,E.E.A.
            unpublished (1993)
            promoter region

CYP2B2      rat
            GenEMBL I00525 (427bp)
            White,P.C., Dupont,B. and New,M.I.
            Genetic probe used in the detection of adrenal hyperplasia
            Patent: US 4720454-A 3 19-JAN-1988
            Includes I-helix region

CYP2B3      rat 
            GenEMBL U16209 to U16214
            Jean,A., Reiss,A., Desrochers,M., Dubois,S., Trottier,E., Trottier,Y.,
            Wirtanen,L., Adesnik,M., Waxman,D.J. and Anderson,A.
            Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and 
            immunological identification of a constitutive P450 2B3-like protein in
            rat liver.
            DNA Cell Biol. 13, 781-792 (1994)

CYP2B4      rabbit
            GenEMBL L10912 (2026bp)
            Ryan,R., Grimm,S.W., Kedzie,K.M., Halpert,J.R. and
            Philpot,R.M.
            Expression and induction of cytochromes P450 2B and P450 4B,
            identification of P450 2B-Bx, and functional comparison of four
            highly related forms of P450 2B.
            unpublished (1993)

CYP2B4      rabbit 
            GenEMBL S64259 (2028bp) PIR S35666 (491 amino acids)
            Ryan,R., Grimm,S.W., Kedzie,K.M., Halpert,J.R. and Philpot,R.M.
            Cloning, sequencing, and functional studies of
            phenobarbital-inducible forms of cytochrome P450 2B and 4B
            expressed in rabbit kidney
            Arch. Biochem. Biophys. 304, 454-463 (1993)

CYP2B4      rabbit
            Swiss P00177 PIR S31277 (491 amino acids) S31278 (491 amino acids)
            PIR S31279 (491 amino acids)
            Gasser R., Negishi M., Philpot R.M.
            Primary structures of multiple forms of cytochrome P-450 isozyme 2
            derived from rabbit pulmonary and hepatic cDNAs.
            Mol. Pharmacol. 32, 22-30 (1988)

CYP2B6      human
            PIR S04579 (139 amino acids) PIR S04580 (170 amino acids)
            Miles, J.S.,Spurr, N.K.,  Gough, A.C., Jowett,T., McLaren, A.W.,
            Brook,J.D. and Wolf, C.R.
            A novel human cytochrome P450 gene (P450IIB): chromosomal
            localization and evidence for alternative splicing.
            Nuc. Acids Res. 16, 5783-5795 (1988)

CYP2B6     human
            GenEMBL M29874
            Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
            Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
            cDNA cloning and sequence and cDNA-directed expression of human
            P450 IIB1: identification of a normal and two variant cDNAs derived
            from the CYP2B locus on chromosome 19 and differential expression
            of the IIB mRNAs in human liver.
            Biochemistry 28, 7340-7348 (1989)
            clone name hIIB1

CYP2B7P     human
            GenEMBL M29873
            Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
            Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
            cDNA cloning and sequence and cDNA-directed expression of human
            P450 IIB1: identification of a normal and two variant cDNAs derived
            from the CYP2B locus on chromosome 19 and differential expression
            of the IIB mRNAs in human liver.
            Biochemistry 28, 7340-7348 (1989)
            clone name hIIB3
            This entry was originally made then discontinued as 2B7PX because an article by      
            Miles et al. Nuc. Acids res. 18, 189 (1990) showed evidence of alternative splicing 
            of CYP2B6.  I thought that this explained the difference.  However, on going back 
            and looking at the sequences and the EST data and mRNAs, there are clearly two 
            different genes in the 2B human subfamily.  M29873 has an in frame stop codon, 
            making it a pseudogene.

Cyp2b9      mouse
            GenEMBL M60267 to M60273
            Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
            Structures and characterization of sex-specific mouse cytochrome
            P-450 genes as members within a large family. Duplication boundary
            and evolution
            Eur. J. Biochem. 195, 477-486 (1991)

Cyp2b10     mouse
            GenEMBL M21856, PIR A60559 (15 amino acids)
            Bornheim, L.M. and Correia, M.A.
            Purification and characterization of a mouse liver cytochrome
            P-450 induced by cannabidiol.
            Mol. Pharmacol. 36, 377-383 (1989)
Note: the genome of mouse has only one sequence for Cyp2b10 and Cyp2b20.   They are derived from the same gene.  The Cyp2b10 mRNA M21856 appears to contain errors in the sequence.  No exact match for it can be found in the mouse genome.
This mRNA has an extra exon called exon 8b (27 nucleotides in the heme binding peptide region).  This appears to be an alternative splice variant of this gene.
The Cyp2b20 sequence matches the genomic sequence and represents the correct 2b10 sequence.  The Cyp2b20 name has been discontinued and Cyp2b10 has been retained
since it is the older of the two names.
GenEMBL M21856 (sequence Cyp2b10 was based on)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLKSLIQ
LREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEY
GVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANVICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQ
MFELFSGFLKYFPGAHRQISKNLQELLDYIGHSVERHKATLDPSVPRDFIDIYLLRMEK
EKSNQNAEFHHQNLMMSVLSLFFVGTETSSTTLHYGFLLMLKYPHVTEKVQKEIDQVIGS
HRLPTLDDRTKMPYSDAVIHEIQRFSDLIPIGVPHRVTKDTLFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDQFLDANGALKKSEAFLPFST
Exon 8b GQIFDQKSV
GKRICLGESIARSELFLFFTSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR

GenEMBL AK028103 from RIKEN (corrected Cyp2b10/Cyp2b20 sequence)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR

CYP2B12     rat 
            GenEMBL S48369 X63545 (2528bp) Swiss P33272 (492 amino acids)
            PIR S27160 (492 amino acids)
            Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P,
            Arand,M., Adesnik,M. and Oesch,F.
            Sequence of a novel cytochrome CYP2B cDNA coding for a 
            protein which is expressed in a sebaceous gland, but not in the liver.
            Biochem. J. 287, 775-783 (1992)

Cyp2b13     mouse
            GenEMBL M60352 to M60358
            Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
            Structures and characterization of sex-specific mouse cytochrome
            P-450 genes as members within a large family. Duplication boundary
            and evolution.
            Eur. J. Biochem. 195, 477-486 (1991)

CYP2B14X    rat 
            discontinued number see CYP2B16P

CYP2B14P    rat
            GenEMBL U33540
            Eric Trottier, Stéphane Dubois, Andréa Jean and Alan Anderson 
            Identification of CYP2B14P and CYP2B16P, two apparent pseudogenes in the rat      
            cytochrome P450 2B (CYP2B) subfamily.
            Biochemical Pharmacology, 52, 963-965 (1996)
            MKPNVLLLLAILLSFLLFLVRGHAKVHGHLPPGPRPLPILGNLLQMDRGGLLQSF

CYP2B15     rat
            GenEMBL D17343 to D17349
            Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-
            Kuriyama, Y. 
            Cloning and sequencing of a novel rat cytochrome P450 2B-encoding 
            gene.
            Gene 136, 333-336 (1993)
            most similar to 2B12, 89% identical
MELGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQ
EKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGE
RWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKALLNPTSIFQSIAANIIC
SIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQE
ILNYIDHSVEKHRATLDPNTPRDFINTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFTGT
ETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFA
DLIPIGLPHRVTNDTMFLGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTL
KKSEAFLPFSTGKRICLGEGIAQNELFIFFTAILQNFSLASPVAPEDIDLSPINSGISKI
PSPYQIHFLSRCVG

CYP2B16P    rat
            GenEMBL U33541 to U33546
            Eric Trottier, Stéphane Dubois, Andréa Jean and Alan Anderson 
            Identification of CYP2B14P and CYP2B16P, two apparent pseudogenes in the rat      
            cytochrome P450 2B (CYP2B) subfamily.
            Biochemical Pharmacology, 52, 963-965 (1996)
            note: previously called CYP2B14 in 1993 update.  This gene has a complete
            coding sequence but there is a defect in the splice junction in intron 1.
Exon 1 MEPSVLLLLAVLLSFLLLLVRGHAKIHGRLPPGPCPVPLLGNLLQMDRRGLLKSFIQLR
Exon 2 EKYGDVFTVHLGLRPVVVLCGTQTIREALVDHAEAFSGRGTIAGLEPVFQDYG
Exon 3 IFFSSGEQWKTLRRFSMATMRDFGMRKKSVEERIKEESQCLVEELKKYQG
Exon 4 APLDPTFLFQCITSNIICSIVFGECFDYTDHQFLHLLDLMYQTFSLLSSIFSQ
Exon 5 VFELFPGVLKYFPGAHRQISRNLHEILDFIGQSVEKHRATLDPNAPRDFIYTYLLHMEK
Exon 6 QKSNHYTEFHHWNLLSSVLSLFFAGTETSSTTLRYGFLIMLKYPHI
Exon 7 EKVQKEIDCVIGSHRLPTLDDRSKMPYTEAVIHEIQRFSDLAPIGTPHRVIKDTIFRGYLLPK
Exon 8 QNTEVFPILSSVLHDPQYFEQPDIFNLQHFLDANGALKIIEAFLPFSTGK
Exon 9 TGKRICLGESIARNELFLFFTTILQNFSVSSPVAPKDIDLTPKESGIGRIPQVYQICFLA

CYP2B17     macaque monkey
            PIR JT0676 (491 amino acids)
            Ohmori, S.; Sakamoto, Y.; Nakasa, H.; Horie, T.; Saito, K.; Kitada, M.
            Nucleotide and amino acid sequences of monkey P450 2B gene
            subfamily.
            unpublished

CYP2B18   guinea pig
            no accession number (437 amino acids)
            Oguri, K. 
            submitted to nomenclature committee

Cyp2b19       mouse
            GenEMBL AF047529
            Diane Keeney, D.S. (1998) The Novel Skin-Specific Cytochrome P450 Cyp2b19 
            Maps to Proximal Chromosome 7 in the Mouse, near a Cluster of Cyp2 Family 
            Genes
            Genomics 53, 417-419.

Cyp2b20X    mouse
            GenEMBL X99715(1416bp)
            Damon,M., Fautrel,A., Marc,N., Guillouzo,A. and Corcos,L.
            Isolation of a new mouse cDNA clone: hybrid form of cytochrome P450
            2b10 and NADPH-cytochrome P450 oxidoreductase
            Biochem. Biophys. Res. Commun. 226 (3), 900-905 (1996)
            This clone has a part of the NADPH cytochrome P450 reductase on the
            opposite strand at the end of the P450 sequence.
            note: this sequence was accidentally given the name Cyp2b19.  That 
            name is assigned to a mouse keratinocyte P450 cloned by Diane Keeney.
            The reductase sequence at the end of this gene seems to be a cloning 
            error, because it cannot be found in the genomic DNA sequence.
            Cyp2b20 has been merged with Cyp2b10.  Though the Cyp2b20 sequence 
            is more like the genomic sequence, the Cyp2b10 name has precedence.

            GenEMBL AF128849
            Marc,N., Damon,M., Fautrel,A., Guillouzo,A. and Corcos,L.
            Isolation of a cyp2b10-like cDNA and of a clone derived from a
            cyp2b10-like pseudogene
            Biochem. Biophys. Res. Commun. 258 (1), 11-16 (1999)
            This sequence is 100% identical to Cyp2b20 and 97% identical to   
            Cyp2b10
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR

Cyp2b20X    mouse  
            GenEMBL AK028103 100% identical to AF128849
            Now renamed Cyp2b10 (the corrected sequence)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR

Cyp2b20p1
            GenEMBL AF129405
            Marc,N., Damon,M., Fautrel,A., Guillouzo,A. and Corcos,L.
            Isolation of a cyp2b10-like cDNA and of a clone derived from a
            cyp2b10-like pseudogene
            Biochem. Biophys. Res. Commun. 258 (1), 11-16 (1999)
            This sequence is 100% identical to Cyp2b20 from amino acid 64 on
            This seq is partial, starting at amino acid 60 with a stop codon
            at amino acid 63.  Full length cDNAs AK028103 and AF128849 do not
            have this stop codon and it is not found in genomic DNA.
            This probably represents a sequence derived from the Cyp2b10 gene.

CYP2B21     rat
            GenEMBL AF159245
            Nicola Brookman Amissah and Peter Swann

CYP2B22     Sus scrofa (pig)
            No accession number 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            78% to rabbit CYP2B4
            clone name c780

Cyp2b23     mouse
            NW_000307 618973-640139
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Next to 2b24p on chr 7

Cyp2b24p    mouse 
            NW_000307 692575-699876
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Next to 2b19 on chr 7

Cyp2b25p    mouse
            NW_000307 195792-195980
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Next to 2b9 on chr 7

Cyp2b26p    mouse
            GenEMBL AC087157 22100-26200
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Between 2b9 and 2b13 on chr 7

Cyp2b27p    mouse
            NW_000303 2122792-2130037
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Between 2b13 and 2b28p on chr 7

Cyp2b28p    mouse
            NW_000303 2064442-2094900
            Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
            Between 2b27p and 2b10 on chr 7

CYP2B29     hamster
            No accession number
            Pedro Dominguez
            Submitted to nomenclature committee Dec. 17, 2002
            77% to cyp2b10

CYP2B       guinea pig
            Swiss P34033 (20 amino acids)
            Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I.,
            Yoshimura H.
            Purification of a cytochrome P450 isozyme belonging to a subfamily of 
            P450IIB from liver microsomes of guinea pigs.
            Biochem. Biophys. Res. Commun. 172, 607-613 (1990)
            PIR S28205 (31 amino acids)
            Yamada, H., Kaneko, H., Takeuchi, K., Oguri, K. and Yoshimura,H.
            Tissue-specific expression, induction, and inhibition through
            metabolic intermediate-complex formation of guinea pig
            cytochrome P450 belonging to the CYP2B subfamily.
            Arch. Biochem. Biophys. 299, 248-254 (1992)
            Note:  These two fragments are identical over the first 20 amino acids.

Cyp2b       mouse
            PIR A21630 (25 amino acids)
            Stupans, I., Ikeda, T., Kessler, D.J. and Nebert, D.W.
            Characterization of a cDNA clone for mouse
            phenobarbital-inducible cytochrome p-450b.
            DNA 3, 129-137 (1984)
            This fragment has one amino acid difference with 2b-9, 2b-10 and 2b-13

Cyp2b       mouse
            GenEMBL M60359 (997bp)
            Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
            Structures and characterization of sex-specific mouse cytochrome
            P-450 genes as members within a large family. Duplication boundary
            and evolution.
            Eur. J. Biochem. 195, 477-486 (1991)
            N-terminal 57 amino acid fragment very similar to Cyp2b-13.

CYP2b      scup (fish Stenotomus chrysops)
            N-terminal fragment (20 amino acids)
            Klotz et al. Arch. Biochem. Biophys.  249, 326-338 (1986)

2C Subfamily

CYP2C1      rabbit 
            GenEMBL D26152 (1695bp)
            Noshiro,M., Ishida, H. and Okuda, K.
            unpublished (1993)

CYP2C5      rabbit
            GenEMBL M55664 (2340bp)
            Pendurthi,U.R., Lamb,J.G., Nguyen,N., Johnson,E.F. and Tukey,R.H.
            Characterization of the CYP2C5 gene in 21L III/J rabbits: Allelic
            variations affects the expression of P450IIC5
            J. Biol. Chem. 265, 14662-14668 (1990)

CYP2C5      rabbit
            PIR S16715 (143 amino acids) PIR S20227 (145 amino acids)
            Zhao, J., Leighton, J.K. and Kemper, B.
            Characterization of rabbit cytochrome P450IIC4 cDNA and
            induction by phenobarbital of related hepatic mRNA levels.
            Biochem. Biophys. Res. Commun. 146, 224-231 (1987)

CYP2C6      rat
            PIR A41425 (17 amino acids)
            Imaoka, S., Kamataki, T. and Funae, Y.
            Purification and characterization of six cytochromes P-450
            from hepatic microsomes of immature female rats.
            J. Biochem. 102, 843-851 (1987)

CYP2C7      rat
            GenEMBL X12595 (1179bp)
            Stroem,A., Nilsson,A.G. and Zaphiropoulos,P.
            5' flanking sequence of the gene for rat cytochrome p-450f
            Nucleic Acids Res. 0, 0-0 (1988)

CYP2C7      rat
            PIR S24582 (66 amino acids)
            Stroem, A.
            unpublished

CYP2C7      rat
            PIR A60563 (56 amino acids)
            Westin, S., Stroem, A., Gustafsson, J.A., and Zaphiropoulos, P.G.
            Growth hormone regulation of the cytochrome P-450IIC
            subfamily in the rat: inductive, repressive, and
            transcriptional effects on P-450f (IIC7) and P-450-PB1
            (IIC6) gene expression.
            Mol. Pharmacol. 38, 192-197 (1990)

CYP2C7      rat
            PIR A27425 (23 amino acids)
            Favreau, L.V., Malchoff, D.M., Mole, J.E. and Schenkman, J.B.
            Responses to insulin by two forms of rat hepatic microsomal
            cytochrome P-450 that undergo major (RLM6) and minor
            (RLM5b) elevations in diabetes.
            J. Biol. Chem. 262, 14319-14326 (1987)

CYP2C8      human
            PIR S15075 (56 amino acids)
            Ged, C. and Beaune, P.
            Isolation of the human cytochrome P-450 IIC8 gene: multiple
            glucocorticoid responsive elements in the 5' region.
            Biochim. Biophys. Acta 1088, 433-435 (1991)

CYP2C8      human
            GenEMBL Y00498 (1866bp)
            Kimura,S., Pastewka,J., Gelboin,H.V. and Gonzalez,J.
            cDNA and amino acid sequences of two members of the human P450IIC
            gene subfamily
            Nucleic Acids Res. 15, 10053-10054 (1987)

CYP2C8      human
            PIR S16902 (349 amino acids)
            Shephard, E.A., Phillips, I.R., Santisteban, I., Palmer,
            C.N.A. and Povey, S.
            Cloning, expression and chromosomal localization of a member
            of the human cytochrome P450IIC gene sub-family.
            Ann. Hum. Genet. 53, 23-31 (1989)

CYP2C8      human
            no accession number
            D.C. Zeldin, R.N. Dubois, J.R. Falck, and J.H. Capdevila. 
            Molecular Cloning, Expression, and Characterization of an Endogenous Human
            Cytochrome P450 Arachidonic Acid Epoxygenase Isoform.
            Arch. Biochem. Biophys. 322: 76-86 (1995)

CYP2C9      human
            GenEMBL S46963 (1814bp) PIR A48390 (477 amino acids)
            B48390 (475 amino acids)
            Ohgiya,S., Komori,M., Ohi,H., Shiramatsu,K., Shinriki,N. and
            Kamataki,T.
            Six-base deletion occurring in messages of human cytochrome P-450
            in the CYP2C subfamily results in reduction of tolbutamide
            hydroxylase activity.
            Biochem. Int. 27, 1073-1081 (1992)

CYP2C9      human
            GenEMBL L16877 to L16883
            Goldstein,J.A., Raucy,J.L., Blaisdell,J.A., Faletto,M.B. 
            and Romkes,M.
            Cloning and expression of complementary DNAs for multiple 
            members of the human cytochrome P450IIC subfamily.
            Biochemistry 30, 3247-3255 (1991)

            de Morais,S.M., Schweikl,H., Blaisdell,J.A. and Goldstein,J.A.
            Gene structure and upstream regulatory regions of human 
            CYP2C9 and CYP2C18.
            Biochem. Biophys. Res. Commun. 194, 194-201 (1993)

CYP2C9      human
            PIR B61265 (225 amino acids)
            Srivastava, P.K., Yun, C.H., Beaune, P.H., Ged, C. and
            Guengerich, F.P.
            Separation of human liver microsomal tolbutamide hydroxylase
            and (S)-mephenytoin 4'-hydroxylase cytochrome P-450
            enzymes.
            Mol. Pharmacol. 40, 69-79 (1991)
            2C10 has D at position 417 while 2C9 has G.  This sequence does not 
            include position 417.  The only other amino acid difference between 2C9 
            and 2C10 is at position 358 where 2C9 has Y and 2C10 has C.  This 
            sequence has Y at 358.

CYP2C9       human
            PIR S26634 (29 amino acids) PIR S23777 (25 amino acids)
            Shimada, T., Misono, K.S. and Guengerich, F.P.
            Human liver microsomal cytochrome P-450 mephenytoin
            4-hydroxylase, a prototype of genetic polymorphism in
            oxidative drug metabolism.
            J. Biol. Chem. 261, 909-921 (1986)

CYP2C9      human
            PIR S39377 (20 amino acids)
            Sandhu, P., Baba, T. and Guengerich, F.P.
            Expression of modified cytochrome P450 2C10 (2C9) in
            Escherichia coli, purification, and reconstitution of
            catalytic activity.
            Arch. Biochem. Biophys. 306, 443-450 (1993)

CYP2C10X     human
            PIR A61265 (79 amino acids)
            Srivastava, P.K., Yun, C.H., Beaune, P.H., Ged, C. and
            Guengerich, F.P.
            Separation of human liver microsomal tolbutamide hydroxylase
            and (S)-mephenytoin 4'-hydroxylase cytochrome P-450
            enzymes.
            Mol. Pharmacol. 40, 69-79 (1991)
            2C10 has D at position 417 while 2C9 has G.  This sequence shows the D at 
            position 417.  The only other amino acid difference between 2C9 and 2C10
            is at position 358 where 2C9 has Y and 2C10 has C.  This sequence does 
            not include the 358 region.
            The 2C10 gene is in some doubt.  Others have searched 100 samples looking for it 
            and have not found it.  This gene may not exist.

CYP2C11     rat
            GenEMBL S68251 (139bp)
            Habib,S.L., Srikanth,N.S., Scappaticci,F.A., Faletto,M.B.,
            Maccubbin,A., Farber,E., Ghoshal,A.K. and Gurtoo,H.L.
            Altered expression of cytochrome P450 mRNA during chemical-induced
            hepatocarcinogenesis and following partial hepatectomy
            Toxicol. Appl. Pharmacol. 124, 139-148 (1994)

CYP2C11     rat
            PIR A60782 (500 amino acids)
            Stroem, A., Mode, A., Zaphiropoulos, P., Nilsson, A.G.,
            Morgan, E., Gustafsson, J.A.
            Cloning and pretranslational hormonal regulation of
            testosterone 16alpha-hydroxylase (P-450-16alpha) in male
            rat liver.
            Acta Endocrinol. 118, 314-320 (1988)

CYP2C11     rat
            PIR A60783 (500 amino acids)
            Zaphiropoulos, P.G., Mode, A., Stroem, A., Husman, B.,
            Andersson, G., Gustafsson, J.A.
            Sequence and regulation of two growth-hormone-controlled,
            sex-specific isozymes of cytochrome P-450 in rat liver,
            P-450-15beta and P-450-16alpha.
            Acta Med. Scand. Suppl.  723, 161-167 (1988)

CYP2C11     rat
            GenEMBL X79081 (2140bp) PIR S44310 (56 amino acids)
            Strom,A., Equchi,H., Mode,A., Tollet,P., Stromstedt,P.E. and
            Gustafson,J.
            Characterization of the proximal promoter and two silencer elements
            in the CYP2C gene expressed in rat liver.
            DNA Cell Biol. 13, 805-819 (1994)

CYP2C11     rat
            PIR S26818 (500 amino acids)
            Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
            J. Biochem. (1986) 100, 1359-1371
            Purification and characterization of three male-specific and
            one female-specific forms of cytochrome P-450 from rat
            liver microsomes.

CYP2C11     rat
            GenEMBL U33173(1856bp)
            Yoshioka,H., Morohashi,K., Sogawa,K., Miyata,T., Kawajiri,K.,
            Hirose,T., Inayama,S., Fujii-Kuriyama,Y. and Omura,T.
            Structural analysis and specific expression of microsomal
            cytochrome P-450(M-1) mRNA in male rat livers.
            J. Biol. Chem. 262 (4), 1706-1711 (1987)
            Erratum:[J Biol Chem 1986 Jun 15;262(17):8438]]

            Biagini,C. and Celier,C.
            cDNA-directed expression of two allelic variants of cytochrome P450
            2C11 using COS1 and SF21 insect cells.
            Arch. Biochem. Biophys. 326 (2), 298-305 (1996)

CYP2C12     rat
            Swiss B60783 (490 amino acids)
            Zaphiropoulos, P.G., Mode, A., Stroem, A., Husman, B.,
            Andersson, G., Gustafsson, J.A.
            Sequence and regulation of two growth-hormone-controlled,
            sex-specific isozymes of cytochrome P-450 in rat liver,
            P-450-15beta and P-450-16alpha.
            Acta Med. Scand. Suppl. 723, 161-167 (1988) 

CYP2C12     rat
            PIR S26819 (490 amino acids)
            Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
            J. Biochem. (1986) 100, 1359-1371
            Purification and characterization of three male-specific and
            one female-specific forms of cytochrome P-450 from rat
            liver microsomes.

CYP2C12     rat
            PIR B41425 (19 amino acids)
            Imaoka, S., Kamataki, T. and Funae, Y.
            Purification and characterization of six cytochromes P-450
            from hepatic microsomes of immature female rats.
            J. Biochem. 102, 843-851 (1987)

CYP2C13     rat
            GenEMBL X79810 (1944bp)
            Legraverend,C., Eguchi,H., Strom,A., Lahuna,O., Mode,A.,
            Tollet,P., Westin,S. and Gustafsson,J.A.
            Transactivation of the rat CYP2C13 gene promoter involves HNF-1, 
            HNF-3 and members of the orphan receptor subfamily. 
            Biochemistry 33, 9889-9897 (1994)

CYP2C13     rat
            PIR S26820 (30 amino acids)
            Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
            Purification and characterization of three male-specific and
            one female-specific forms of cytochrome P-450 from rat
            liver microsomes.
            J. Biochem. 100, 1359-1371 (1986)

CYP2C17X
            discontinued number     See CYP2C18/19

CYP2C18     human
            GenEMBL L16869 to L16876 Swiss P33260 (490 amino acids)
            Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and 
            Goldstein,J.A.
            Cloning and expression of complementary DNAs for multiple 
            members of the human cytochrome P450IIC subfamily.
            Biochemistry 30, 3247-3255 (1991)

            de Morais,S.M., Schweikl,H., Blaisdell,J.A. and Goldstein,J.A.
            Gene structure and upstream regulatory regions of human 
            CYP2C9 and CYP2C18.
            Biochem. Biophys. Res. Commun. 194, 194-201 (1993)

            Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and 
            Goldstein,J.A.
            Correction: Cloning and expression of complementary DNAs 
            for multiple members of the human cytochrome P450IIC subfamily.
            Biochemistry 32, 1390-1390 (1993)

CYP2C18     human
            GenEMBL S63419 S63421 S63424 S63426 
            X56452 (multiple genomic fragments) PIR S45369 (56 amino acids)
            Ged,C. and Beaune,P.
            Partial sequence and polymerase chain reaction-mediated analysis of
            expression of the human CYP2C18 gene
            Pharmacogenetics 2, 109-115 (1992)

CYP2C18     human
            PIR A61269 (490 amino acids)
            Furuya, H., Meyer, U.A., Gelboin, H.V. and Gonzalez, F.J.
            Polymerase chain reaction-directed identification, cloning,
            and quantification of human CYP2C18 mRNA.
            Mol. Pharmacol. 40, 375-382 (1991)

CYP2C18/19  human
            GenEMBL M61858 J05326 (1276bp) Swiss P33259 (270 amino acids)
            Goldstein,J.A., Raucy,J.L., Blaisdell,J.A., Faletto,M.B. and
            Romkes,M.
            Cloning and expression of complementary DNAs for multiple members
            of the human cytochrome P450IIC subfamily
            Biochemistry 30, 3247-3255 (1991)
            This sequence named 2C17 was later found to be a splice of 2C18 amd 
            2C19.  Therefore, there is no 2C17 sequence.

CYP2C18/19  human
            GenEMBL L07093 (2395bp)
            Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
            Goldstein,J.A.
            Correction: Cloning and expression of complementary cDNAs for
            multiple members of the human cytochrome P450IIC subfamily
            Biochemistry 32, 1390-1390 (1993)

CYP2C19     human
            Swiss P33261 (490 amino acids)
            Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and 
            Goldstein,J.A.
            Cloning and expression of complementary DNAs for multiple 
            members of the human cytochrome P450IIC subfamily.
            Biochemistry 30, 3247-3255 (1991)

CYP2C19     human
            GenEMBL L31506 (129bp)
            GenEMBL L31507 (129bp)
            De Morais,S.M.F., Wilkinson,G.R., Blaisdell,J.A., Nakamura,K.,
            Meyer,U.A. and Goldstein,J.A.
            The major genetic defect responsible for the polymorphism of
            S-mephenytoin metabolism in humans
            J. Biol. Chem. 269, 15419-14522 (1994)

CYP2C19     human
            GenEMBL L32982 (329bp) wild type exon 4
            GenEMBL L32983 (329bp) mutant exon 4
            De Morais,S.M.F., Wilkinson,G.R., Blaisdell,J.A., Meyer,U.A.,
            Nakamura,K. and Goldstein,J.A.
            Identification of a new genetic defect responsible for the
            polymorphism of S-mephenytoin metabolism in Japanese
            Mol. Pharmacol. 46, 594-598 (1994)

CYP2C19     human
            PIR S38753 (16 amino acids)
            Wrighton, S.A., Stevens, J.C., Becker, G.W., and van den Branden,M.
            Isolation and characterization of human liver cytochrome P450
            2C19: correlation between 2C19 and S-mephenytoin
            4'-hydroxylation.
            Arch. Biochem. Biophys. 306, 240-245 (1993)

CYP2C20     Macaca fasicularis (monkey)
            GenEMBL S53046 (1901bp) Swiss P33262 (490 amino acids)
            PIR S28166 (490 amino acids)
            Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
            and Kamataki,T.
            Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450.
            Biochim. Biophys. Acta 1171, 141-146 (1992)

CYP2C20     Macaca fasicularis (monkey)
            PIR A60466 (22 amino acids)
            Ohi, H., Toratani, S., Komori, M., Miura, T., Kitada, M. and
            Kamataki, T.
            Comparative study of cytochrome P-450 in liver microsomes. A
            form of monkey cytochrome P-450, P-450-MK1,
            immunochemically cross-reactive with antibodies to rat
            P-450-male.
            Biochem. Pharmacol. 38, 361-365 (1989)

CYP2C23     rat
            GenEMBL U04733 (1919bp)
            Karara,A., Makita,K., Jacobson,H.R., Falck,J.R.,
            Guengerich,F.P., DuBois,R.N.and Capdevila,J.H.
            Molecular cloning, expression, and enzymatic characterization of the 
            rat kidney cytochrome P-450 arachidonic acid epoxygenase.
            J. Biol. Chem. 268, 13565-13570 (1993)

CYP2C23     rat
            GenEMBL S67064 (265bp)
            Imaoka,S., Wedlund,P.J., Ogawa,H., Kimura,S., Gonzalez,F.J. 
            and Kim,H.Y.
            Identification of CYP2C23 expressed in rat kidney as an arachadonic 
            acid epoxygenase.
            J. Pharmacol. Exp. Ther. 267, 1012-1016 (1993)

CYP2C23     rat
            PIR S29817 (20 amino acids)
            Marie, S.; Roussel, F.; Cresteil, T.
            Age- and tissue-dependent expression of CYP2C23 in the rat.
            Biochim. Biophys. Acta 1172, 124-130 (1993) 
            note: This sequence is diiferent from GenEMBL U04733 and S67064
            by one amino acid. PIR S13101, SwissProt P24470 and GenEMBL 
            X55446 are all equivalent, but they have a frame shift in the sequence 
            in the region of this 20 amino acid fragment. Amino acids 38-54 are affected.

CYP2C24     rat
            GenEMBL S59647 (226bp)
            GenEMBL S59648 (187bp)
            GenEMBL S59652 (380bp)
            Zaphiropoulos,P.G.
            Differential expression of cytochrome P450 2C24 and transcripts
            in rat kidney and prostate: evidence indicative of alternative
            and possibly trans splicing events.
            Biochem. Biophys. Res. Commun. 192, 778-786 (1993)

CYP2C24     rat
            Swiss P33273 (434 amino acids) PIR PT0435 (302 amino acids)
            PIR JH0451 (434 amino acids)
            Zaphiropoulos,P.G.
            cDNA cloning and regulation of a novel rat cytochrome P450 of the 2C 
            gene sufamily (P450IIC24).
            Biochem. Biophys. Res. Commun. 180, 645-651 (1991)

CYP2C25      Mesocricetus auratus (Syrian hamster)
            GenEMBL X63022 (1829bp, incorrectly given as X60322 in Table 3
            of the 1993 nomenclature update)
            Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
            Sex-related difference in the expression of cytochrome P450 in
            hamsters: cDNA cloning and examination of the expression of three 
            distinct CYP2C cDNAs.
            Molec. Pharmacol. 45, 228-236 (1994)

CYP2C26     Mesocricetus auratus (Syrian hamster)
            GenEMBL D11435 (1808bp) Swiss P33263 (490 amino acids)
            Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
            Sex-related difference in the expression of cytochrome P450 in
            hamsters: cDNA cloning and examination of the expression of three 
            distinct CYP2C cDNAs.
            Molec. Pharmacol. 45, 228-236 (1994)

CYP2C27     Mesocricetus auratus (Syrian hamster)
            GenEMBL D11436 (1784bp) Swiss P33264 (490 amino acids)
            Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
            Sex-related difference in the expression of cytochrome P450 in
            hamsters: cDNA cloning and examination of the expression of three 
            distinct CYP2C cDNAs.
            Molec. Pharmacol. 45, 228-236 (1994)

CYP2C28     Mesocricetus auratus (Syrian hamster)
            GenEMBL D11437 (1556bp) Swiss P33265 (490 amino acids)
            Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
            Sex-related difference in the expression of cytochrome P450 in
            hamsters: cDNA cloning and examination of the expression of three 
            distinct CYP2C cDNAs.
            Molec. Pharmacol. 45, 228-236 (1994)

Cyp2c29    mouse
            GenEMBL D17674 (1751bp)
            Matsunaga,T., Watanabe,K., Yamamoto,I., Negishi, M.,
            Gonzalez,F.J. and Yoshimura, H. 
            cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2,
            a microsomal aldehyde oxygenase.
            Biochim. Biophys. Acta 1184, 299-301 (1994) 

Cyp2c29     mouse
            PIR A61268 (16 amino acids)
            Bornheim, L.M. and Correia, M.A.
            Purification and characterization of a mouse liver cytochrome
            P-450 induced by cannabidiol.
            Mol. Pharmacol. 36, 377-383 (1989)

Cyp2c29v2    mouse
            no accession number
            Gang Luo and Joyce A. Goldstein
            clone M2c9k
            submitted to Nomenclature Committee

CYP2C30     rabbit
            GenEMBL D26153
            Noshiro,M., Ishida,H. and Okuda,K. 
            unpublished (1993)

CYP2C31     Capra hircus (dwarf goat)
            GenEMBL X76502 (1185bp) PIR JC2199 (284 amino acids) 
            PIR S39314 (284 amino acids)
            Zeilmaker,W.M., Van't Klooster,G.A.E., Gremmels-Gerhmann,F.J.
            Van Miert,A.S.J. and Horbach,G.J.M.J.
            cDNA and deduced amino acid sequence of a dwarf goat liver 
            cytochrome P450-fragment belonging to the CYP2C gene subfamily.
            Biochem. Biophys. Res. Commun. 200, 120-125 (1994)

CYP2C32     pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            most similar to 2C24
            Clone name CL1

CYP2C33v1   pig
            GenEMBL U35837 (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name CL7

CYP2C33v2   pig
            GenEMBL U35838 (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name CL8

CYP2C33v3   pig
            GenEMBL U35839 (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name PF1

CYP2C33v4   Sus scrofa (pig)
            No accession number 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            2 amino acids diffs with 2C33v1 and v2
              clone name c296

CYP2C34v1   pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name PF15

CYP2C34v2   pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name CL6

CYP2C34v3   pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name Cl12

CYP2C34v4   pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name Cl13

CYP2C35     pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name PF11/14

CYP2C36     pig
            no accession number (681bp)
            Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
            Cytochrome P450 genes expressed in porcine ovaries: identification of novel 
            forms, evidence for gene conversion, and evolutionary relationships.
            Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
            Clone name PF13

CYP2C37     macaque [name conflict, reassigned to CYP2C43]
            no accession number
            S. Ohmori
            submitted to Nomenclature Committee

Cyp2c37     mouse
            AF047542 NM_010001
            Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
            Cloning and expression of murine CYP2Cs and their ability to 
            metabolize arachidonic acid.
            Arch Biochem Biophys. 357, 45-57 1998.
            clone M2c10b
            submitted to Nomenclature Committee

Cyp2c38     mouse
            AF047725
            Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
            Cloning and expression of murine CYP2Cs and their ability to 
            metabolize arachidonic acid.
            Arch Biochem Biophys. 357, 45-57 1998.
            clone M2c13f
            submitted to Nomenclature Committee

Cyp2c39     mouse
            AF047726 NM_010003
            Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
            Cloning and expression of murine CYP2Cs and their ability to 
            metabolize arachidonic acid.
            Arch Biochem Biophys. 357, 45-57 1998.
            clone M2c9d
            submitted to Nomenclature Committee

Cyp2c40     mouse
            AF047727 NM_010004 NW_000147 exons 2-6 only
            Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
            Cloning and expression of murine CYP2Cs and their ability to 
            metabolize arachidonic acid.
            Arch Biochem Biophys. 357, 45-57 1998.
            Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
            CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C 
            in murine intestinal tract.
            Mol Pharmacol. 58, 279-87 2000
            clone M2c9h
            submitted to Nomenclature Committee

CYP2C41     dog
            no accession number
            Stephen R. Bai and Joyce A. Goldstein
            clone M2c9h
            submitted to Nomenclature Committee

CYP2C42     pig
            GenEMBL Z93098 (1307bp)
            Nissen,P.H., Winteroe,A.K. and Fredholm,M.
            Characterization and mapping of three porcine genes belonging to
            the cytochrome P450 superfamily
            Unpublished
            clone 10b03

CYP2C42P1   pig
            GenEMBL Z93100 (1758bp)
            Nissen,P.H., Winteroe,A.K. and Fredholm,M.
            Characterization and mapping of three porcine genes belonging to
            the cytochrome P450 superfamily
            Unpublished
            clone 15d09 (pseudogene)

CYP2C43     macaque 
            no accession number
            S. Ohmori
            submitted to Nomenclature Committee
            [name conflict, formerly CYP2C37 reassigned to CYP2C43]

Cyp2c44    mouse
           no accession number 
           Christian Helvig and Jorge H. Capdevila
           submitted to nomenclature committee Oct. 2, 1998
           most similar to CYP2C23 (87% identical)

CYP2C45    gallus gallus (chicken)
           No accession number
           Manuel Baader
           Submitted to nomenclature committee Nov. 22, 1999
           57% identical to CYP2C9

CYP2C46     rat 
            No accession number 
            Lars von Buchholtz
            Submitted to nomenclature committee March 6, 2000 
            91% to 2C24

CYP2C47     Phascolarctos cinereus (koala) 
            No accession number 
            Ross McKinnon
            Submitted to nomenclature committee May 25, 2000
            60% identical to many 2C sequences

CYP2C48     Phascolarctos cinereus (koala) 
            No accession number 
            Brett Jones and Ross McKinnon
            Submitted to nomenclature committee Nov. 6, 2000
            92% identical to 2C47 

CYP2C49     Sus scrofa (pig)
            No accession number 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            92% to 2C35 and 2C34v1, v3, v4
            clone name c195

Cyp2c50     mouse
            No accession number GSS AZ589908 one exon only
            ESTs AI118193 ue34e02.x1, opposite end = AI098787 ue34e02.y1 
            AI097740 AI117011 AI119501 AI314482 BF385641 AI528254
            AA968308 AI876138 AI097678 AI226027 BF384486 BF659471 AI529923
            AI266900 uj08d09.x1, opposite end AI226027 uj08d09.y1,
            Joyce Golstein and Cheng-Chung Tsao
            submitted to nomenclature committee 3/1/2001
            94% to 2c37; 75% 2c39,2c29v2; 74% 2c38; 68% 2c40; 53% 2c44
            name 2C heart

Cyp2c51X?   mouse
            No accession number
            Joyce Golstein and Cheng-Chung Tsao
            submitted to nomenclature committee 3/1/2001
            69% to 2c29v2; 69% 2c37; 68% 2c38; 67% 2c39; 67% 2c40
            no exact hits in nr, htgs, est, gss or sts on 3/5/01
            name 2C aorta
            note: this seq appears to be a combination between 2c52p and 2c69
            it may not be a real gene

Cyp2c52p    mouse
            No accession number
            Joyce Golstein and Cheng-Chung Tsao
            submitted to nomenclature committee 3/1/2001
            78% to 2c51, 70% to 2c29v2, 2c38; 67% to 2c39, 2c37; 61% to 2c40
            missing PYTD in K-helix
            no exact hits in nr, htgs, est, gss or sts on 3/5/01
            name 2C kidney, 2C eye

Cyp2c53p    mouse
            AC078913.5 seq b assembled from parts 74% to 2c39 
            Old assembly included some N- and C-term parts not from this gene
TNFSKVYGPVFTLYLGMKPTVVLHGYEAVKEALIDHGEEFAVKGIFPLAEKNSK

FTLMTLKNLGMGKRNIEDRVQEEAQCLVEELRKTNG
SLCDPTFILGCAPCNVTCSIIFQNHFDYKDQDFLSLMEKINENTKIVSTPWIQ
LIVYCPGSHKTVPENAYYIEIYILKKIKEHQESLDVTNPLDFIDYYLIKCKQ
GAGTETSTTLRYALLLLMTYPEVT

Cyp2c53p    mouse 
            AY227735 NW_000145
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c66 and Cyp2c29 on chr 19
            Temp name 2CN6
            74% to 2c29
            note: this may be a pseudogene.  There are two stop codons 
            near the C-helix and the WXXXR motif is missing
            this is being checked now in the cloned cDNA.

Cyp2c54     mouse
            No accession number
            Darryl Zeldin
            submitted to nomenclature committee 3/18/2002
            clone name N1
            92% to 2c50 91% to 2c37 76% to 2c29 73% to 2c38 74% to 2c39 
            70% to 2c40 67% to 2c55 66% to 2c53p 59% to 2c44 67% to 2c52p 
            68% to 2c51

Cyp2c55     mouse
            No accession number
            Darryl Zeldin
            submitted to nomenclature committee 3/18/2002
            clone name N3
            71% to 2c29 70% to 2c39 70% top 2c38 69% to 2c37 69% to 2c50 
            65% to 2c40 58% to 2c44 53% to 2c53p 59% to 2c52p 67% to 2c54
            67% to 2c51

CYP2C56P    human
            NT_022154.9|Hs2_22310 
            2C pseudogene fragment chr 2
1768949 LSSKVQEETDHAVGRHWRPCMQDRSHMPYTEAMVHEVQRH*PHPTNVPHALTSDIKFRN 1769125
1769126 YLLPK 

CYP2C57P    human
            AC022650 41% to 2C9 pseudogene 2 in frame stops 
GIAFSHGETWKTMRRFSLTTLRNFGMGEWIIEDTIIEECQNLIQ
NMFLVLGFLLKSHKTILRNRDELFSFIRMAFLDHHHKLDKNDPRNFTDVFLVTQQE
ENDTFADYFSDKKLVTLVNNLFTTGTETTASTLHWGILLVMRYPEVQS
KVHNEITKVVVSAQS*LAHRTQMTHTDAVI*EVQRFANILPTSLSHATTTNIFKNYCIPK
GTEVIILLASVARDQAQWEKPDTFNPEHFLNSKEKFIKREAFLPF

CYP2C58P    human
            NT_008769.11|Hs10_8926 
            lone exons 1,2,3 between 2C19 and 2C9 
            same as AL133513.12
8303126 LDLAAVLMLCLSCLLLLSL*TQISGRGKLPSDSTPLQVIESILQMADKDICKSSSNLSTLY 8302944 
8296311 SLYFDMKLVLVLHGYEVLKKALIHHGEEFSGKGIFPVSKK 8296192
8295999 IIFSNRKPCKEIWPFLLMTLWNCGVVKRS 8295913
8295911 LGKHVQVEAHCIVWELRRTK 8295852

CYP2C59P    human
            NT_008769.11|Hs10_8926 
            lone exons 2,3 between 2C9 and 2C8
8437561 LSQFSKVYVPVFTVYFDIKLVLELHGYEVVKEALIDHGEEFSGKGIFPVSKKS**G 8437394
8437211 FRIIFSNGKRCKDIWLFLLMTLWNCRMVKRS 8437119
8437115 MEKHVQGEAQCLRQELRRTK 8437058

CYP2C60P    human
            NT_008769.11|Hs10_8926 
            lone exon 6 between 2C9 and 2C8
8439669 EKDNQPLKFTIENLVGNVPDLFVAGTEMTSTTLRYGLLLLLKHPELTGR 8439815

CYP2C61P    human
            NT_008583.11|Hs10_8740 
            chromosome 10 pseudogene frag parts of exons 1 and 2
1832658 KGKLPHDLTSFLFVGNILQLNSKNLSKSITMLAKDYGPGFTVYFGIKPTVVV 1832813

CYP2C62P    human
            AL138921 NT_030059 chromosome 10 50% to 2C8
LAMCVTCLIFFLVWKKSPSPTPLPTIGNRLQRNPKD
CISFQLAKEYSSVYTLYFGSWPTMVFHGYKAVKEALIDQGDKSLGRGHIPIIDDAQKRY
TSAQPFDSTFILASAPCNL
CSFLFKECFQYKNETFLSLMGLLNENVK
TTVLPLLSLVLFSYKQFP
GHFLDKNGCFNKTDYFLPFSLGK

CYP2C63P    human
            NT_011512.5|Hs21_11669 
            chromosome 21 51% to 2C9
12398358 CPSCLILLFLWNGSYAKGKLLPGPIPLPIV*NILPLRSMNTSKSISMVS 12398212

CYP2C64P    human
            NT_011602.7|HsX_11759 
            2C pseudogene fragment chr X 57% to 2C8
435396 ASVDLAAVLVLFLSHFLFLSLWKQSSEREKLLPGPTPIRIIGNILELDLKDICKSLSDVN 435575
435576 MLYAPL 435593

Cyp2c65     mouse 
            AY227733 NW_000145
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c55 and Cyp2c66 on chr 19
            Temp name 2CN4
            93% to Cyp2c66 73% to 2c29

Cyp2c66     mouse 
            AY227734 NW_000145
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c65 and Cyp2c53p on chr 19
            Temp name 2CN5
            93% to Cyp2c65 73% to 2c29

Cyp2c67     mouse 
            GenEMBL NW_030157.1 (aa 1-274 exons 1-5 minus strand)
            GenEMBL NW_022459.1 (aa 275-320 exon 6 plus strand)
            GenEMBL NW_021833.1 (aa 321-431 exons 7-8 plus strand)
                                Part of exon 9 not found
            GenEMBL NW_020256.1 (aa 469-491 end of exon 9 plus strand)
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c39 and Cyp2c68 on chr 19
            Temp name 2CN7
            95% to Cyp2c40

Cyp2c68     mouse 
            GenEMBL NW_034810.1 (aa 1-161 exons 1-3 plus strand)
                                          Exon 4 not found
            GenEMBL NW_012728.1 (aa 215-273 exon 5 minus strand)
                                            Exon 6 not found
            GenEMBL NW_024952.1 (aa 321-383 exon 7, 2 copies on this contig)
            GenEMBL NW_012306.1 (aa 356-431 part of exon 7 and exon 8)
                                            Exon 9 not found
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c67 and Cyp2c40 on chr 19
            Temp name 2CN8
            96% to Cyp2c40

Cyp2c69     mouse 
            GenEMBL NW_024021.1 (aa 1-56 exon 1 plus strand)
            GenEMBL NW_009479.1 (aa 57-160 exon 2-3 minus strand)
            GenEMBL NW_014461.1 (aa 161-214 exon 4 plus strand)
                                            Exon 5 not found
            GenEMBL NW_024085.1 (aa 276-320 exon 6 plus strand)
            GenEMBL NW_021729.1 (aa 321-491 exons 7-9 plus strand)
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between Cyp2c40 and Cyp2c37 on chr 19
            Temp name 2CN9
            95% to Cyp2c40

Cyp2c70     mouse 
            AY227736 NW_000148 NP_663474 LOC226105
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            50kb downstream of Cyp2c50 on chr 19
            Temp name 2CN10
            59% to Cyp2c29

Cyp2c71p    mouse 
            NW_000148 
            Between 2c69 and 2c37 on chr 19
            69% to Cyp2c69
8628 MGPFVVLVLRLSFLLLLSL*RQRSGRGKLPPGLTPCSINGNFLQIDMKDTHQSLTNVSMP 8449
8448 YAPQVY 8431 exon 1 (in opposite orientation to other exons)
14397 CP*SYNIFF*-IIHVLSYLLEKIKENEELMDVTNP*DFIDYFLIQRHQVKG 14546 exon 5
32761 GTTVLTPLSSVLHDSKEFPNPEMFDPDHFLDGNGNFK*SDYFMPFSAGNR 32910 exon 8
39003 GKFS*TEHSL-FPIRKWMCMGESLALMELILFLTTILQNF*LKSLVDLKDNNITPVYSGL 39179
39180 F*VPPTFLVCFI 39215 exon 9

Cyp2c72p    mouse 
            NW_000145
            Hong Wang, Joyce Goldstein, Darryl Zeldin
            Between 2c29and 2c38
            Temp name 2CN11
            88% to 2c38, 87% to 2c39
       1  MDLITFLVLT LSSLILLLLW RQRSGRGRLP PGPTPFPIIG NFLQIDGKNF 
      51  SQSLTNFSKA YGPMFTLYLG SQPIAVLHGY EAVKEALIDH GEEFSGRRNI 
     101  PMAEKINNSL GVIFSNGNRW KEIRHFTLTI LRNLGMGKRN IEDRVQEEAQ 
     151  CLVEELRKTN

CYP2C       rat
            no accession number (639bp)
            Zaphiropoulos,P.
            submitted to nomenclature committee
            82% amino acid identity to exon 2 of 2C24

CYP2C       rat
            no accession number (397bp)
            Zaphiropoulos,P.
            submitted to nomenclature committee
            similar to exon 3 of 2C7 
            possible pseudogene, with stop codon at location of conserved trp.

CYP2C       rat
            PIR B60822 (19 amino acids)
            Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
            Oesch, F.
            Effect of nutritional imbalances on cytochrome P-450 isozymes
            in rat liver.
            Biochem. Pharmacol. 37, 3245-3249 (1988)

CYP2C       dog
            PIR A60465 (33 amino acids)
            Komori, M., Shimada, H., Miura, T. and Kamataki, T.
            Interspecies homology of liver microsomal cytochrome P-450. A
            form of dog cytochrome P-450 (P-450-D1) crossreactive with
            antibodies to rat P-450-male.
            Biochem. Pharmacol. 38, 235-240 (1989)
            Note: probable N-terminal of 2C21 which is missing the N-terminal region

CYP2C       horse
            PIR PN0659 (16 amino acids)
            Komori, M., Higami, A., Imai, Y., Imaoka, S. and Funae, Y.
            Purification and characterization of a form of P450 from
            horse liver microsomes.
            J. Biochem. 114, 445-448 (1993)

2D Subfamily

CYP2D1      rat
            PIR A30495 (19 amino acids)
            Gonzalez, F.J., Matsunaga, T., Nagata, K., Meyer, U.A.,
            Nebert, D.W., Pastewka, J., Kozak, C.A., Gillette, J.,
            Gelboin, H.V. and Hardwick, J.P.
            Debrisoquine 4-hydroxylase: characterization of a new P450
            gene subfamily, regulation, chromosomal mapping, and
            molecular analysis of the DA rat polymorphism.
            DNA 6, 149-161 (1987)

CYP2D1      rat
            PIR S39761 (13 amino acids)
            Ohishi, N., Imaoka, S., Suzuki, T. and Funae, Y.
            Characterization of two P-450 isozymes placed in the rat
            CYP2D subfamily.
            Biochim. Biophys. Acta 1158, 227-236 (1993)

CYP2D6      human
            GenEMBL M24499 (1195bp)
            Manns,M.P., Johnson,E.F., Griffin,K.J., Tan,E.M. and Sullivan,K.F.
            Major antigen of liver kidney microsomal autoantibodies in
            idiopathic autoimmune hepatitis is cytochrome P450db1
            J. Clin. Invest. 83, 1066-1072 (1989)

CYP2D6      human
            GenEMBL A20907 (1768bp)
            Genetic assay for cytochrome p450
            Patent: WO 9110745-A 13 25-JUL-1991;

CYP2D6      human
            GenEMBL M33189 (5503bp)
            Gonzalez,F.J.
            unpublished (1990)

CYP2D7AP    human
            GenEMBL X58467 (13,278bp)
            Heim,M.H. and Meyer,U.A.
            Evolution of a highly polymorphic human gene locus for 
            a drug metabolizing enzyme.
            Genomics 14,49-58 (1992)
            Note: CYP2D7AP is 94.7% identical to CYP2D7P, both are 
            pseudogenes.

CYP2D8BP    human
            GenEMBL X58468 (13,677bp)
            Heim,M.H. and Meyer,U.A.
            Evolution of a highly polymorphic human gene locus for 
            a drug metabolizing enzyme.
            Genomics 14,49-58 (1992)
            Note: CYP2D8P is a chimeric gene composed of part of 
            CYP2D7AP and part of CYP2D6.  There are only 14 base 
            changes in 13,677 base pairs relative to these parents.
            This gene is different from CYP2D8P.  It is a pseudogene.

Cyp2d9     mouse
            GenEMBL J04471 M24262 (846bp) M24267 (3367bp)
            Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
            Gene family of male-specific testosterone 16-alpha-hydroxylase
            (C-P-450-16-alpha) in mice: Organization, differential regulation,
            and chromosome location
            J. Biol. Chem. 264, 2920-2927 (1989)

Cyp2d10    mouse
            GenEMBL J04471 M24263 M24265 M24268 (4828bp)
            Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
            Gene family of male-specific testosterone 16-alpha-hydroxylase
            (C-P-450-16-alpha) in mice: Organization, differential regulation,
            and chromosome location
            J. Biol. Chem. 264, 2920-2927 (1989)
            
Cyp2d11    mouse
            GenEMBL J04471 M24264 M24266 (5661bp)
            Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
            Gene family of male-specific testosterone 16-alpha-hydroxylase
            (C-P-450-16-alpha) in mice: Organization, differential regulation,
            and chromosome location
            J. Biol. Chem. 264, 2920-2927 (1989)
            
Cyp2d12     mouse
            no accession number
            Negishi,M.
            submitted to nomenclature committee in 1990, but never published.
            ESTs AI116003 ue25f10.x1 (295-end 2 diffs, 1fs) AI785325 uj40c11.x1 
            (326-end 1 diff) AI527869 uj30b05.y1 (1-241 4 diffs, 2fs) AA986388 
            uc82e10.x1 (307-end 4 diffs)
Public Cyp2d12 from EST sequences.  Places where ESTs do not match Negishi's 
sequence are shown in ().  The EST seq is given. In these sites Y, G, N, A and R
are observed in multiple ESTs and they are probably the correct amino acids
F at the last variable site is seen twice and S is seen twice so this may be a 
polymorphic site
MELLTGTDLWSVAIFTVIFILLVDLM (Y) RRQSWTSCYPPGPVPWPVL (G) NLLQVDL (N) NMPYSL
YKLQNRYGDVFSLQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHLGFKPRSQGMIFAPYGPEWREQ
RRFSLSSLRNFGLGRKSLEEWVIKEAGHLCDAFTTQAGQYINPNTMLKK (A) TCNVIASLIFARRFEYED
PYLIRMLKVLEDSLTELSGLIPEVINTFPILLHIPRLAD 
(53 amino acid gap)
ENLRMVVIDLFTAGILTTSTTLSWALLLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIPKGTILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFSAG (R) RSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPQPSDHRVF (F) IMVAPSPYQLCAVIREQGH*


Cyp2d13     mouse
            no accession number
            Negishi,M.
            submitted to nomenclature committee in 1990, but never published.
            no exact matches in the Genbank EST database as of 10/20/97
            sequence may be erroneous, or a rare transcript.

Cyp2d13     mouse
            No accession number
            Brian Libby
            partial Cyp2d13 gene sequence
            The top half of the sequence below is from Brian Libby
            This sequence matches Negishi's except at one amino acid
            shown in parentheses.  The bottom half is from EST BF533324
            Dr. Negishi's sequence called "ce" is complete, but still 
            unpublished. (see note to Cyp2d26)
Public Cyp2d13 seq from BF533324 EST and Brian Libby. One extra amino acid 
seen in EST BF533324 is shown as [D].  Two amino acids that do not agree 
are shown in ().  The EST sequence is given at the T and G sites.
MELLTGTGLWPVAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYKL
QNRYGDVFSLQMAWKPVVVISGLKAVREVLVTCGEDTADRPEMPIFQHLGYGEKAKGVVF
APYGPEWRELRRFSVSTLRNLGLGKKSLEQWVTEEAGHLCDAFTAQAGSPLDPYTLLNKAVCNV
IASLIYARRFEYGDPDFIKMLKILKENMGENTGLFPE
(15 amino acid gap)
DKVFPGQKTFLTLVNKLVTEHKRTWDP [D] QPPRDLTDAFLAEMEKAKGNPKSSFNEANLRL
VVFDLFGAGIVTSSITLTWALLLMILHPDVQRRVQEEIDEVIGQVRCPEMADQAHMPYTNAVIH
EVQRFADIVPMNLPHKTSHDIEVQGFLIPKGTTLIPNLSS (T) LKDETVWEKPLRFHPEHFL
DAQGHFVKPEAFMPFSAGRRACLGEPL (G) RMELFLFFTCLLQRFSFLVPAGQPQPSDYGIF
TFLVSPSPYQLCAFTRDQATN*

CYP2D14     bovine
            GenEMBL S45538 X68013 (1538bp) Swiss Q01361 (487 amino acids)
            PIR S29295 S37284 (500 amino acids) PIR S29862 (500 amino acids)
            Tsuneoka,Y., Matsuo,Y., Higuchi,R. and Ichikawa,Y.
            Characterization of the cytochrome P-450IID subfamily in
            bovine liver.  Nuceotide sequences and microheterogeneity.
            Eur. J. Biochem. 208, 739-746 (1992).

CYP2D15     dog
            GenEMBL D17397 (1665bp)
            Sakamoto,K., Kirita,S., (Aoyama,J., Baba,T. and Matsubara,T.)
            cDNA cloning and characterization of dog P-450 2D.
            Arch. Biochem. Biophys. 319, 372-382 (1995)
            check authors on paper

CYP2D15      dog
             no accession number (1640bp)
             Tasaki,T., Ito,S., Kamataki,T. and Fujita,S.
             unpublished

CYP2D16      guinea pig
             GenEMBL U21486 (1666bp)(500 amino acids)
             Jiang,Q. Voigt,J.M. and Colby,H.
             Molecular Cloning and sequencing of a guinea pig cytochrome P4502D     
             (CYP2D16): high level expression in adrenal microsomes.
             Biochem. Biophys. Res. Commun. 209, 1149-1156 (1995)

CYP2D17     Macaca fasicularis ( cynomolgus monkey)
            GenEMBL U38218(1494bp)
            Laddison,K.J., Speirs,A., Mankowski,D.C., Tweedie,D. and Lawton,M.
            Cloning, Sequencing and expression of the cynomolgus monkey liver cytochrome     
            P450 that is orthologous to human CYP2D6.
            ISSX abstracts number 367 (1995)
            94% identity to human 2D6

CYP2D18     rat
            GenEMBL U48219, S77859
            Kawashima,H. and Strobel,H.W.
            cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D 
            subfamily.
            Biochem Biophys Res. Commun. 209, 535-540 (1995)
            Kawashima,H., Sequeira, D.J., Nelson, D.R. and Strobel,H.W.
            Protein expression and catalytic activity toward imipramine N-
            demethylation of
            a novel rat brain cytochrome P450 CYP2D18.
            Biochem Biophys Res. Commun. submitted
            note: this gene was cloned and sequenced from two independent 
            libraries.
            This appears to be a distinct gene from CYP2D4.

CYP2D19     Callithrix jacchus (white-tufted-ear marmoset)
            GenEMBL D29822
            Igarashi,T., Sakuma,T., Isogai,M., Nagata,R. and Kamataki,T.
            Marmoset liver cytochrome P450s: study for expression and molecular
            cloning of their cDNAs
            Arch. Biochem. Biophys. 339 (1), 85-91 (1997)

CYP2D20     hamster
            T. Sakuma 
            95% identical to CYP2D27

CYP2D20     Syrian hamster
            no accession number
            Kouichi Kurose
            submitted to nomenclature committee 7/13/99
            clone name SH2D3
            1 amino acid diff with Sakumas sequence

CYP2D21     miniature pig

Cyp2d22     mouse
           no accession number
           J. Leonard and N. Blume
           submitted to nomenclature committee
           88% identical to rat 2D4

CYP2D23     rabbit
           no accession number
           Yukio Yamamoto 
           submitted to nomenclature committee
           Clone name rabbit 2D/Clone I

CYP2D24     rabbit
           no accession number
           Yukio Yamamoto 
           submitted to nomenclature committee
           Clone name rabbit 2D/Clone II

CYP2D25     Sus scrofa (pig)
           GenEMBL Y16417
           Postlind, H., Axen, E., Bergman, T. and Wikvall, K. (1997)
           Cloning, structure and expression of a cDNA encoding vitamin D3 25-hydroxylase.
           Biochem. Biophys. Res. Commun. 241, 491-497.
           note: this is a microsomal emzyme different from the mitochondrial CYP27
           which also has vitamin D3 25-hydroxylase activity.

Cyp2d26      mouse 
           GenEMBL ESTs only (68 ESTs see UNIGENE Mm.29064)
MGLLVGDDLWAVVIFTAIFLLLVDLVHRRQRWTACYPPGPVPFPGLGNLLQVDFENIPYS
FYKLQNRYGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHIGYGHKSK
GVILAPYGPEWREQRRFSVSTLRDFGLGKKSLEQWVTEEAGHLCDAFTKEAEHPFNPSPL
LSKAVSNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEVLNAIPMLLHIPGLP
DKAFPKLNSFIALVNKMLIEHDLTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDKNLRI
VVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPYTN
AVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYP
EHFLDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSD
YGIYTMPVTPEPYQLCAVAR

Note: Brian Libby (bjl@jax.org) at The Jackson Laboratory has given his 
permission to post sequence data he has on the 2d26 gene and a partial Cyp2d13 
gene from mouse.  He will make the BAC clone available to anyone who wants it.  
The BAC has at least two and maybe more P450 sequences.  I am putting a link to 
a pdf version of the 2D26 gene sequence file here.  It is color coded with 
additional information, such as sequencing primers and restriction sites. 
CYP2D26 gene sequence

CYP2D27    syrian hamster
           no accession number
           Kouichi Kurose
           95% identical to CYP2D20
           submitted to nomenclature committee 6/29/99

CYP2D28    syrian hamster
           no accession number
           Kouichi Kurose
           71% identical to CYP2D27 73% to CYP2D20
           clone name SH2D2
           submitted to nomenclature committee 7/13/99

CYP2D29    Macaca fuscata (Japanese monkey)
           GenEMBL AF301911 (release date March 1, 2001)
           Shizuo Narimatsu, Hiroyuki Hichiya, Shigeo Yamamoto, Kazuo Asaoka
           Submitted to nomenclature committee Oct. 16, 2000
           95% to CYP2D6

CYP2D30    Callithrix jacchus (white-tufted-ear marmoset)
           GenEMBL AY082602 (to be released April 1, 2003) bankit450928 Mar. 5 2002
           Hichiya,H., Yamamoto,S., Asaoka,K. and Narimatsu,S.
           Complementary DNA cloning and characterization of a cytochrome P450
           2D enzyme from Marmoset monkey liver
           Unpublished
           submitted to nomenclature committee 3/5/02
           33 diffrerences to 2D19 also from marmoset.

CYP2D31P   human
           NT_022676.10|Hs3_22832 chromosome 3 
           2D6 pseudogene fragment I-helix
899650 NQENLV*VVIDLFLGGTDTTATTLCWALIHMIQHGAVQ 899537


2E Subfamily

CYP2E1      human
            PIR A60554 (18 amino acids)
            Robinson, R.C., Shorr, R.G.L., Varrichio, A., Park, S.S.,
            Gelboin, H.V., Miller, H. and Friedman, F.K.
            Human liver cytochrome P-450 related to a rat
            acetone-inducible, nitrosamine-metabolizing cytochrome
            P-450: identification and isolation.
            Pharmacology 39, 137-144 (1989)

CYP2E1      Macaca fasicularis (monkey)
            GenEMBL S55205 (1508bp) Swiss P33266 (449 amino acids)
            PIR S28167 (449 amino acids)
            Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
            and Kamataki,T.
            Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450.
            Biochim. Biophys. Acta 1171, 141-146 (1992)

CYP2E1      Mesocricetus auratus (hamster)
            GenEMBL D17449 (2512bp)
            Sakuma,T., Takai,M., Yokoi,T. and Kamataki,T.
            Molecular cloning and sequence analysis of hamster CYP2E1
            Biochim. Biophys. Acta 1217, 229-231 (1993)

CYP2E1      hamster
            PIR S27176 (34 amino acids)
            Puccini, P., Menicagli, S., Longo, V., Santucci, A. and Gervasi,P.G.
            Purification and characterization of an acetone-inducible
            cytochrome P-450 from hamster liver microsomes.
            Biochem. J. 287, 863-870 (1992)

CYP2E1      rat
            GenEMBL S48325 (1093bp)
            Richardson,T.H., Schenkman,J.B., Turcan,R., Goldfarb,P.S.
            and Gibson,G.G.
            Molecular cloning of a cDNA for rat diabetes-inducible
            cytochrome P450RLM6:hormonal regulation and similarity to 
            the cytochrome P4502E1 gene.
            Xenobiotica 22, 621-631 (1992)

CYP2E1      rat
            PIR B27425 (34 amino acids)
            Favreau, L.V., Malchoff, D.M., Mole, J.E. and Schenkman, J.B.
            Responses to insulin by two forms of rat hepatic microsomal
            cytochrome P-450 that undergo major (RLM6) and minor
            (RLM5b) elevations in diabetes.
            J. Biol. Chem. 262, 14319-14326 (1987)

CYP2E1      rat
            GenEMBL AF061442
            Yoo,M. and Shin,S.W.
            The complete coding sequence of the rat brain cytochrome P450 2E1
            Unpublished

Cyp2e1      mouse
            GenEMBL L11650 (1827bp) Swiss Q05421 (493 amino acids)
            Davis,J.F. and Felder,M.R.
            Mouse ethanol-inducible cytochrome P450 (P450IIE1).
            Characterization of cDNA clones and testosterone 
            induction in kidney tissue.
            J. Biol. Chem. 268, 24933-24939 (1993)

Cyp2e1      mouse
            PIR A21231 (39 amino acids)
            Ryskov, A.P., Ivanov, P.L., Kramerov, D.A. and Georgiev, G.P.
            Mouse ubiquitous B2 repeat in polysomal and cytoplasmic poly
            (A)+RNAs: uniderectional orientation and 3'-end localization.
            Nucleic Acids Res. 11, 6541-6558 (1983)
            C-terminal 39 amino acids

CYP2E1v1    dog
            no accession number
            Susan M. Lankford and Stephen A. Bai
            submitted to nomenclature committee

CYP2E1v2    dog
            no accession number
            Susan M. Lankford and Stephen A. Bai
            submitted to nomenclature committee
            note: only one amino acid difference with 2E1v1

CYP2E2      rabbit
            GenEMBL J03726 (multiple genomic fragments)
            GenEMBL M19162 (multiple genomic fragments)
            GenEMBL M19163 (multiple genomic fragments)
            Khani,S.C., Porter,T.D., Fujita,V.S. and Coon,M.J.
            Organization and differential expression of two highly similar
            genes in the rabbit alchol-inducible cytochrome P-450 subfamily
            J. Biol. Chem. 263, 7170-7175 (1988)

CYP2E1      sus scrofa (pig)
            GenEMBL AB000885.1
            Kimura,M., Kawakami,K., Suzuki,H. and Hamasima,N.
            Cloning of the pig cytochrome P-450-j gene
            Unpublished

CYP2E1      sus scrofa (pig)
            No accession number 
            Misaki Kojima
            2 amino acid differences with AB000885.1
            Submitted to nomenclature committee Oct. 27, 2000
            clone name c469

CYP2E1      Bos taurus (bovine)
            GenEMBL AJ001715
            van Raak,M., Natsuhori,M., Ligtenberg,M., Kleij,L., ten Berghe,D.,
            de Groene,E.M., Van Miert,A.S., Witkamp,R.F. and Horbach,G.J.
            Isolation of a full length cytochrome P450 (CYP2E) cDNA sequence
            and its functional expression in V79 cells
            Unpublished

2F Subfamily

CYP2F1      human
            GenEMBL J02906
MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLL
LLCSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYP
AFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLADVRKT
EGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYD
ILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASSPRDFIQCFLTKMAEEK
EDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGR
ARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLL
NTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGELLARMELFLYL
TAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRPR

CYP2F1P     human
            AC008537.3 93% identical to 2F1
            Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. and Gonzalez, F.J.
            A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles.
            Am. J. Hum. Genet. 57, 651-660 (1995)
            There are two 2F1 genes, and one pseudogene of 2F1 on chromosome 19.  
GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGE
LYDIFPSLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLTKMAE
KKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQ
AHVQEEINLVVGHVRLPALKDRAAMPYTDMVIHEVQRFADIIPMNLPHRITRDTAFHGFLIPK
GTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG
HRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLHPR

Cyp2f2      mouse
            Swiss P33267 (491 amino acids)
            Ritter J.K., Owens I.S., Negishi M., Nagata K., Sheen Y.Y.,
            Gillette J.R. and Sasame H.A.
            Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA 
            cloning, sequence and expression in Saccharomyces cerevisiae.
            Biochemistry 30, 11430-11437(1991)

CYP2F3      goat
            GenEMBL AF016293
            Huifen Wang, Diane L. Lanza, and Garold S. Yost.  
            Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates  
            The selective pneumotoxins 3-methylindole and naphthalene
            submitted

CYP2F4      rat
            GenEMBL AF017393
            R. Michael Baldwin and Alan Buckpitt
            submitted to nomenclature committee

2G Subfamily

CYP2G1      human
            GenEMBL S80997, S80998, S80999
            Sheng J, Ding X
            Biochem. Biophys. Res. Commun.  218, 570-574 (1996)
            Identification of human genes related to olfactory-specific CYP2G1.
            2 PCR fragments for a human 2G1 are presented and 2 more PCR 
            fragments from two possible 2G1 pseudogenes are also shown.
            86% identical to rat 2G1

CYP2G1      human
            GenEMBL AC008537 genomic DNA in 93 fragments
            Sequence is assembled from fragments and it may need to be revised
            The * indicate intron locations except the last one that is a stop 
            codon. The sequence is 78% identical to rat 2G1.  Two exons are missing
            from AC008537 and these have been taken from AC008962 which is probably
            a pseudogene. There is a frameshift after YMGP on the second line.
            CYP2G1 is 58-59% identical to some CYP2A sequences so it may actually 
            Be a CYP2A sequence.  The 2G subfamily might be absorbed by CYP2A.

MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK*

LREKYSPVFTVYMGPRPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG*

VALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK*

GAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQ*

LYDMYSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMH*

QEEKNPNTEFYLKNLVLTTLNLFVGGTETVSTTLHYGFLLLMKHPEVE*

AKIHEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK*

GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGRGK*

RICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR*

CYP2G1P revised seq AC008537 missing exons 4, 5 and 6 
MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK
LREKYSPVFTVYMGPRPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG
VALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK
AKIHEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGRGK
RICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR


CYP2G1      rat 
            GenEMBL M33296

CYP2G1      rabbit
            PIR B31944 (50 amino acids)
            Ding, X. and Coon, M.J.
            Purification and characterization of two unique forms of
            cytochrome P-450 from rabbit nasal microsomes.
            Biochemistry 27, 8330-8337 (1988)

Cyp2g1       mouse 
            GenEMBL L81171
            Hua, Z., Zhang, Q.Y., Su, T., Lipinskas, T.W., Ding, X.
            cDNA cloning, heterologous expression, and characterization of
            mouse CYP2G1, an olfactory-specific steroid hydroxylase.
            Arch. Biochem. Biophys. 340, 208-214 (1997) 
            94.9% identical to rat CYP2G1

CYP2G2P     human
            AC008962 comp(28700-40696) seq of gene has two in frame stop codons
MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK
LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGHG
VALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK
GAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQ
LYDMYSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMH
QDKNNPRTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVE
AKIHEEINQVIGPHRLPRVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNLIRDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR
GKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKLSGFGNIPPTYELCLVAR*

2H Subfamily

CYP2H1      chicken
            PIR D44107 (22 amino acids)
            Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
            Beta-naphthoflavone induction of a cytochrome P-450
            arachidonic acid epoxygenase in chick embryo liver distinct
            from the aryl hydrocarbon hydroxylase and from
            phenobarbital-induced arachidonate epoxygenase.
            J. Biol. Chem. 267, 19503-19512 (1992)

CYP2H2      chicken
            PIR E44107 (25 amino acids)
            Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
            Beta-naphthoflavone induction of a cytochrome P-450
            arachidonic acid epoxygenase in chick embryo liver distinct
            from the aryl hydrocarbon hydroxylase and from
            phenobarbital-induced arachidonate epoxygenase.
            J. Biol. Chem. 267, 19503-19512 (1992)

2J Subfamily

CYP2J1      rabbit 
            GenEMBL D90405 
            Kikuta, Y., Sogawa, K., Haniu, M., Kinosaki, M., Kusunose, E., Nojima, Y.,   
            Yamamoto, S., Ichihara, K., Kusunose, M. and Fujii-Kuriyama, Y. 
            A novel species of cytochrome P-450 (P-450ib) specific for the small intestine 
            of rabbits.
            J. Biol. Chem. 266, 17821-17825 (1991)

CYP2J2      human
            GenEMBL U37143 (1876bp)
            Wu, S., Moomaw, C., Tomer, K.B., Capdevila, J.H., Falck, J.R., 
            and Zeldin, D.C. 
            Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450  
            Arachidonic Acid Epoxygenase Highly Expressed in Heart. 
            J. Biol. Chem., 271: 3460-3468 (1996)

CYP2J3     rat
            GenEMBL U39943 (1778bp)
            Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J., 
            Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C. 
            Molecular Cloning, Expression, and Functional Significance of a Cytochrome 
            P450 Highly Expressed in Rat Heart Myocytes. submitted.

CYP2J3P1    rat
            GenEMBL U40000 (1909bp)
            Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J., 
            Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C. 
            Molecular Cloning, Expression, and Functional Significance of a Cytochrome 
            P450 Highly Expressed in Rat Heart Myocytes. submitted.

CYP2J3P2    rat
            GenEMBL U40004
            Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J., 
            Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C. 
            Molecular Cloning, Expression, and Functional Significance of a Cytochrome 
            P450 Highly Expressed in Rat Heart Myocytes. submitted.

CYP2J4       rat
            GenEMBL L81170 (1826bp)
            Zhang,Q.-Y., Ding,X., Kaminsky,L.S.
            cDNA cloning, heterologous expression, and characterization of rat
            intestinal CYP2J4
            Arch. Biochem. Biophys. 340, 270-278 (1997)

Cyp2j5      mouse
            GenEMBL U62294 (1886bp)
            J. Ma and D.C. Zeldin, unpublished.
            clone JM-6

Cyp2j6      mouse
            GenEMBL U62295 (2046bp)
            J. Ma and D.C. Zeldin, unpublished.
            clone JM-15

Cyp2j7      mouse
            GenEMBL
            D.C. Zeldin, unpublished.

Cyp2j8      mouse
            GenEMBL
            D.C. Zeldin, unpublished.
            clone WQ4-1

Cyp2j9      mouse
            GenEMBL
            D.C. Zeldin, unpublished.
            clone WQ24-1

Cyp2j10     rat
            GenEMBL
            Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL.
            Mol Pharmacol 2000 May;57(5):1011-20
            Increased CYP2J expression and epoxyeicosatrienoic acid formation in 
            spontaneously hypertensive rat kidney.

Cyp2j11     mouse
            GenEMBL XM_131521, AC091461.3 Unigene Mm.26915
            Joan Graves, Hong Wang, and Darryl Zeldin
            Clone name CYP2JA

Cyp2j12     mouse
            GenEMBL XM_143892 (genbank entry missing part of exon 4)

Cyp2j13     mouse
            Map view locus LOC230459
            Joan Graves, Hong Wang, and Darryl Zeldin
            Clone name CYP2JC

Cyp2j13de1  mouse
            Detritus exon 1 7kb downstream of 2j13 (exon 8)

Cyp2jzzp    mouse 
            Map view locus LOC230460 
            3 C-term fragments ABOUT 19KB APART
            temporary placeholder name

Cyp2jbbp    mouse 
            XM_143896 
            Map view locus LOC230464 
            exons 3-4 and exon 9
            temporary placeholder name

2K Subfamily

CYP2K1      Onchorhynchus mykiss (rainbow trout)
            GenEMBL L11528 (1853bp) PIR S45644 (504 amino acids)
            Buhler,D.R., Yang,Y.-H., Dreher,T.W., Miranda,C.L. and 
            Wang,J.-L.
            Cloning and sequencing of the major rainbow
            trout constitutive cytochrome P450 (P450 2K1): Identification
            of a new P450 gene subfamily and its expression in mature 
            rainbow trout liver and trunk kidney.
            Arch. Biochem. Biophys. 312, 45-51 (1994)

CYP2K1v2    Onchorhynchus mykiss (rainbow trout)
            GenEMBL AF045052
            Buhler,D.R.
            note: 98.6% identical to 2K1 may be an allele (5L1FL)
            submitted to nomenclature committee

CYP2K1v3    Onchorhynchus mykiss (rainbow trout)
            GenEMBL AF045053
            Buhler,D.R.
            note: 98.4% identical to 2K1 may be an allele (5L6FL)
            submitted to nomenclature committee

CYP2K2      Fundulus heteroclitus (killifish)
            John Stegeman
            submitted to nomenclature committee

CYP2K3      Onchorhynchus mykiss (rainbow trout)
            GenEMBL AF043551
            Buhler,D.R.
            (5L7FL) 96.5% identical to 2K1

CYP2K4      Onchorhynchus mykiss (rainbow trout)
            GenEMBL AF043296
            Yang,Y.-H., Andersson,T.B., Ryu,B.-W., Wang,J.-L. and Buhler,D.R.
            CYP2K4: A New Cytochrome P450 Isoform from Male Trunk Kidney of
            Post-Spawning Rainbow Trout.
            Unpublished
            kid8 from kidney

CYP2K5      Onchorhynchus mykiss (rainbow trout)
            GenEMBL AF151524
            Buhler,D.R.
            80% identical to 2K1
            clone name KM2-2 from sexually mature male trunk kidney library

CYP2K6      Danio rerio (zebrafish)
            No accession number
            Wang-Buhler, J.L., Yang, Y.H., Lee, S.J. and Buhler, D.R.
            Submitted to nomenclature committee 6/16/2000

CYP2K7      Danio rerio (zebrafish)
            GenEMBL AI722500 EST 88% to CYP2K6
Full length translation of this EST allowing framshifts
INNLFGAGXDTTVTTLRWGLLLFAKYPEIQAKVHDEIDSVIGERQPVPDDRKNLPYTDAVIHEIQRFADILPIG
LLRQTSCDVHLNGYLIKKGTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGES
LARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKRF*

CYP2K7      Danio rerio (zebrafish)
            No accession number
            Donald R. Buhler
            EST AI722087 fd19b07.y1, AI722500 fd19b07.x1, BF157099 fl60g01.y1
            Submitted to nomenclature committee 2/10/2001
            503 amino acids, 76% to 2K6, 59% to CYP2K4, CYP2K5 

CYP2K8      Danio rerio (zebrafish)
            No accession number
            Yea-Huey Yang, Jun-Lan Wang-Buhler and Donald R. Buhler
            EST 78% to CYP2K5 clone name F2R
            Submitted to nomenclature committee 7/1/2000

CYP2K9      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_12487
3037 MIEDLFESSTSGFLMVAIVSLLLLQ
     LCFSFISREKRKDLPGPEALPLLGNLHQLDLKRLDCHLVQ 3231 (0)
3299 LSQKYGPIFRVYLASKKVVVLAGYTAVKQALVNQAEDFGEREIFPIFHDFNKGN 3460 (1)
3527 GILFTNGDQWKEMRRFALMTLKDFGMGKRTIEEKIIKECQYLIEAFEQHQ 3676 (1)
     GEAFSNAQVISYATSNIISAIMYGRRFDYKDPTFQAMIERDHEVIHLTGSPSIQ (0)
     IYNIFPWLGPFLKTWRYIMKKVEINIESTRRIIGEMKETRNP
     GTCRCFVDAFLIHKENQE (0)
4483 ESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQ 4623 (1)
4692 DGVQEELRRVVGNRQVRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTS*DTFQGYVIKK (0?)
     GTMVIPLLTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSA 5095 (1)
5164 GRRMCLGEGLARMELFLFFASLLQHFRFKPAPGVSEDSLDLTPVVGITLNPLTHKLRAISRF* 5352


CYP2K10     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_19693
296  SKKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNAEQFGDRDISPIFYDMNQGHG 457 LKU76565.x1
     missing exon 3 and part of exon 4
2727 YATSNIISSIVYGSRFDYDDPRFINMVNRVNEVIRLTGSAPIQ (0)
     LYNIFPGLANWIKNRQLLLKQVAMNLRDMTDLIQQLKDTLNPGVCRGFVDCFLLRKQKAV (0)
2184 DSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQG
     QVQQELSMVVGNRRVCVEDRKNLPYVDAV 1813
1812 IHEIQRLGNIAPMAVPHKTARDVEFRGYFIEK 1717
1286 GTTVFPLLTSVLYDENEWETPHTFNPSHFLDKDGKFIKRDAFMPFSA 1146
1063 GRRLCLGEGLAKMEIFLFFTSLLQQFRFTPPPGVGEDELDLTPVVGFTLSPSPHKLCAIPRQ* 


CYP2K11     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_10791
missing exons 1-4 about 176 aa
5891 VYDLFPWIGPLVNNKKLFQSLFAANKKQNLQLFAAAKEMLNPQMCRSFVDSFLARQQILE 5721 (0)
4989 KSGTNVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQ (1?)
4750 DQVQEELRRVIGSRQVQVEDRKSLPFTDAVIHETQRLANIVPMALPHKTSQDVTLQGFFIEK 4571 (0)
     GTTVYPLLTSVLYDETEWEKPLNFYPAHFLDKDGKFVKREAFLPFSA 4355 (1)
4287 GRRICLGEGLAKMELFIFFSTLLQHFRFRPPPGVSEDHLDLTPRVGLTLNPSAHKLCAVSCL* 3999

CYP2K12P    Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3103 Length = 27036 59% to scaf 10791 
Heme junction missing the conserved Gly, no uspstream seq found 
With these defects and a frameshift this is probably a pseudogene 
LKB99171.x1 50% TO 2C37
17897 DQVQEELSRVIG 17862 frameshift
17860 SRQVQEGDRKNLSFTNAVIHETQSGHVALTSLPHVTNQDIIFRGHFLKKG 17711 (1)
17388 NYMEDTASVASVLLEETEWEHPHTFYPSHFLEKDRKFVKRDAFLPFSA 17242 (1)
17176 ISRACPGETLARVELFIFLVTLLQHFCFTLAPGVSPDELHVTPSIGSNHSPVAYRLCTVSCM* 16988

CYP2K13P    Fugu rubripes (pufferfish)
            No accession number
            Scaffold_12487 
pseudogene frag of 2K9
660 VRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSXX frameshift
    RHLPGIRHQK 

CYP2K14P    Fugu rubripes (pufferfish)
            No accession number
            Scaffold_13436b Length = 4942 
pseudogene of 2K9
= LGW56404.x1 50% to 2A7 
two partial genes in this contig both on minus strand
Scaffold_13436b pseudogene of Scaffold_12487 (fs) = frameshift
3958 VRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSRD (fs) RHLLX (fs) GIRH (fs) QK (1?)
     alternative frame                  RDTSFSGDTSSKRFTALFELAHVYV
     GTMVIPL (fs) LTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSA (1)
     GRRMCLGE (deletion 3 nuc) RMELF (insertion 12 nuc) LFF (deletion 33 nuc)
     VSVDSLDLTPVVGITLNPLTHNLRAISRF* 3368

CYP2K15P    Fugu rubripes (pufferfish)
            No accession number
            Scaffold_13758
pseudogene 
41% to LKB99171.x1 50% TO 2C37 Length = 5303
FC:C094J16aF1, FC:C007E01aF1 pseudogene
740 KGRITQRHFHDEKLMMTVSSHLAAGTHLDTYTALRQEPLVMAK*PEVQ 883 exon 6 (1) 52% to 2K11
    Exons 7 and 8 deleted
1284 (1) GLRSCPGEG*SRMKLFIFIVILLQHLCFSSSPVLMEEDLELKTVLGSILNPINCVLFVGRER* 1472 exon 9 48% to 2K9

2L Subfamily

CYP2L1      Panulirus argus (spiny lobster)
            GenEMBL U44826 (1601bp)
            James, M.O., Boyle, S.M., Trapido-Rosenthal, H., Carr, W.E.
            and Shiverick K.T.
            cDNA and protein sequence of a major form of P450, CYP2L,
            in the hepatopancreas of the spiny lobster Panulirus argus.
            Arch. Biochem. Biophys. 329, 31-38 (1996)

CYP2L2      spiny lobster
           no accession number
           Sean Boyle and Margaret O. James
           submitted to nomenclature committee

2M Subfamily

CYP2M1      Onchorhynchus mykiss (rainbow trout)
            GenEMBL U16657
            Yang,Y.H., Wang,J.L. and Buhler,D.R.
            cDNA cloning and characterization of a novel cytochrome P450 from rainbow 
            trout.
            Abstracts of the VII International Congress of Toxicology, 
            Vol. 7, No. 1, 10-P-2 (1995)

            Yang,Y.H., Wang,J.L., Miranda, C.L. and Buhler,D.R.
            CYP2M1: cloning, sequencing, and expression of a new
            cytochrome P450 from rainbow trout liver with fatty acid
            (omega-6)-hydroxylation activity.
            Arch. Biochem. Biophys. 352, 271-280 (1998)
            Note: 42% identical to CYP2K1

2N Subfamily

CYP2N1      Fundulus heteroclitus (killifish)
            John Stegeman
            submitted to nomenclature committee

CYP2N2      Fundulus heteroclitus (killifish)
            John Stegeman
            submitted to nomenclature committee

CYP2N3      Stenotomus chrysops (scup)
            No accession number
            Agnes Knorr, Andrew McArthur John Stegeman
            Submitted to nomenclature committee Nov. 3, 2000
            73% to 2N1

CYP2N4      Chaetodon mertensii (butterfly fish)
            No accession number
            Bryan DeBusk
            Submitted to nomenclature committee July 19, 2001

CYP2N5      Chaetodon punctatofasciatus (butterfly fish)
            No accession number
            Bryan DeBusk
            Submitted to nomenclature committee July 19, 2001

CYP2N6      Chaetodon auriga (butterfly fish)
            No accession number
            Bryan DeBusk
            Submitted to nomenclature committee July 19, 2001

CYP2N7      Chaetodon xanthurus (butterfly fish)
            No accession number
            Bryan DeBusk
            Submitted to nomenclature committee July 19, 2001

CYP2N8      Chaetodon plebius (butterfly fish)
            No accession number
            Bryan DeBusk
            Submitted to nomenclature committee July 19, 2001

CYP2N9      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3261a
9342 MWLWDLVLWLRLTGFLLPVLIVLLIIMYSLRQKDPPNFPPGPPALPLLGNIFNIEAKQPHLYLTK 9148 (0)
     LADVYGSVFCIRLGRHKTVFVSGWKMVKEAIVTQADSFVDRPYSPMATRIYSGNS LKG95403.y1
     AGLFFSNGHVWRKQRRFAMATLRSFGLANGSMELSICEESRHLQEAMESQK LKG95403.y1
8235 GEPFDPVPLLNNAVANIICQIVFGRRFDYTDHMFQRMLHHLTEMAYLEGSIWAL 8074 (0)
7991 LYDSFPALMKHLPGPHNGIFSSSSSLQGFIWREIQRHKSDLDPSNPRDYIDAFLIEEG 7818 (0)
7743 NGNNQLGFEERNLVLCCLDLFLAGSETTSKTLQWGLIYLIRKPHIQ 7606 (1)
     EKVQVEIDRPIGRTRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNGPSNGCQGTRPWRGYFIPK (0)
     GTSVMPNLTSVLFDKNEWETPDTFNPEHFLDAEGKFVRREAFLPFSA 7246 (1)
7162 GRRACLGEGLARMELLLFFVSLCQRFHFSTLDRVELSTEGITGATRTPYPFKIYAQVR* 6986

CYP2N10     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3261b
13883 MWLYSVLSWDFTSLLLFFFVLILFANYLKNRDPPNFPPGPFAFPIVGNFFTMDSKNLHLYFNK 13695 (0)
12557 LADVHGNVFSFRLGGDKMVCVSGHKMVKEAIVTQADNFVDRPYDPISARVYGGQT 12393 (1)
      DGLFQSNGEVWKRQRRFALSTLRNFGLGKNILEQSICEEAQHLLEEMRSHG 12153 (1)
      GKPFNPARLFNNTVSNIICQLVMGKRFEYSDHKFQMLLKYLSEVLVLEGSFWGQ 11913 (0)
11814 LYEAFPSVMKHLPGPHNKVFSHFNHLKDFMNEEIQNHKKDLDHNNPRDYIDAFIIEMEK 11638 (0)
      NKDTNLGFTETNLAMCSLDLFIAGTETTATTLLWDLVYLINNPDIQ 11413 (1)
11290 GKVQAEIDQVIGQNRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNGPRMAAKDTTLGGYFIPK 11102 (0)
11018 GTSLMPILTSVLFDKNEWETPDKFNPGHFLDAEGKFKKREALLPFSA (1)
      GKRVCLGEGLAKMELFLFFVSLFQNFTFFVPGGAELNTEGITGTTRVPHPFEILARPR* 10619

CYP2N11     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3261c
      MWPLQLLLDFDIRALLLFISVLLLIGDYFRYKNPPNFPPGPMSLPFVGSFFSVDSKHPHNYFIQ (0)
18495 MAELYGKLFSIRLGSGKIVFACGYKMVKEAIVTQADNFVDRPFNAFGDRIYMGQR 18331 (1)
18251 DGLFQNNGEVWKRQQHFALSTLRNFGLGKNILEQSICEEAQHLLEEMRSHG (1)
      GKPFDPASLFTRAVSNIICQLVMGKRFEYSDHKFQMLLKYLSELLVLEGSFWGQ 17859 (0)
      LYQAFPSVMKHLPGPHNKVFSHYNHLKDFMNEEIQNHKKNLNHNNPRDYIDAFIIEMEK (0)
17498 NKDTNLGFTETNLVLCSLDLFLAGTQTTATTLLWALVYLINNPDIQ 17364 (1)
16988 EKVQAEIDQVIGQTRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNASRMAAKDTTLGGYFIPK 16800 (0)
      GTSLLPILTSVLFDKNEWETPDKFNPGHFLDAEGKFKKREAFLPFSA (1)
16492 GKRVCLGEGLVKMELFLFFVSLFQKFSYSVSGGAELSTEGITGITRVPHPFEIHTRPRSF* 16310

CYP2N12     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3261d
22960 XCLNIHTGIALSNGYMWKKQRKFAHTHLRYFGEGQKLLENHIQMESKFMCEAFKDEQ 22811 (1? Bad boundary)
22727 GKPFDPQYTITNAVGNIISALVFGHRFEYSDASFRRILELDNEAVVLAGSARTQ 22566 (0)
22482 LYDSFPSLMKHLPGPHQTVHANYGKITDFLKKEVDKHMEEWNPEDPRDYVDTYLSEMEK 22306 (0)
21959 MNQDPQGGFNVETLLICILDLIEAGTESAATTLRWGLVFILNYPDVQ 21819 (1)
21739 EKVQEEIDRVIGQSRQPAMADRPNMPYTDAVIHEIQRFANVVPAGFPKMATKDTTVGGYFIPK 21551 (0)
21462 GLAITTMLSSVLFDKNEWETPDVFNPNHFLDSEGRFRKRDAFIPFSA 21322 (1)
21218 GKRVCIGENLAKMELFLFFTSILQHFNLSPVPGQMPSLEGILGFTYSPQPFRMIVAPR* 21042

2P Subfamily

CYP2P1      Fundulus heteroclitus (killifish)
            John Stegeman
            submitted to nomenclature committee

CYP2P2      Fundulus heteroclitus (killifish)
            GenEMBL AF117342
            John Stegeman
            submitted to nomenclature committee

CYP2P3      Fundulus heteroclitus (killifish)
            GenEMBL AF117343
            John Stegeman
            submitted to nomenclature committee

CYP2P4      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_3261e
      MEAILSTLGLEWMDGRTILIFLLVFVLLADYIKNRVPSNFPPGPWPLPLIGDLHRINPSRLHLQFAE (0)
24760 FAGKYGNIFSLRLFGGRVVVLNGYKTVREALVEKGENFVDRPLIPLFEAFAGNR 24924 (1)
24994 GLVISNGNPWKHQRRFALHTLRNFGIGKKSLEPSIQQECHYLAEAFAQHKG 25156
      gap missing exon 4
26236 VYNTFPWLLKWLPGTHQTIFSEIKTVINFVDLKIQEHKRNFDPSSLRDYIDCFLAEMGE 26412 (0)
26493 KEDVESGFDMKNLSICTMDLFGAGTETTTTTLQWGLLYMIYYPHIQ 26630 (1)
seq runs off end of contig missing exons 7,8 and 9

>CYP2P fragment Fugu rubripes (pufferfish)
                No accession number
probably exon 7 of 2P4 
Fc:c161F04y1 LPC.61739.y1 Fc:c161E03y1 LPC.61451.y1 60% to 2J9 
71% to 2P1
KVYAEISAVIGSSREPSITDRDNMPYTNAVIHEMQRMANIIPLNVVHMASSDTTIxxxxxxx

>CYP2P fragment Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2841 probably exons 8 and 9 of 2P4
80% to LPC61680  66% to 2D9 Length = 29344
LPC61680.x1 LPC22842.y1 LPC61776.x1 LPC61672.x1 Fc:c161P11x1 Fc:c161P09x1 
66% to 2D9 LPC61488.x1 64% to 2d9 Fc:c161O11x1 93% to LPC61680 
probably same gene 67% to CYP2K, upstream sequence runs off scaffold
62% to 2Z2 over 106 aa 59% to 2K10 over 108 aa 60% to 2N12 over 100 aa 
80% to 2P2
179 GTIIMPTLNSVLHDESMWETPHSFNPQHFLDQDGKFRKREAFLPFSA 319
442 GKRVCLGEQLARMELFLFFTSLLQRFSFSMADGEQPSLDFQLGGARFPKPYRLRAILR* 618

>CYP2P5P    Fugu rubripes (pufferfish)
            No accession number
pseudogene fragment Fc:c060E24y1 LPC.22843.y1 
56% TO 2W1 PKG TO HEME 70% to scaf 2841 exon 8
GTIVVPTLNSVLPDESVWETPHSLDPPLFLDL*RXFRVREAFLPFFA

2Q Subfamily

CYP2Q1      Xenopus laevis (african clawed frog)
            GenEMBL D50560 (2237bp)
            Ohi, H., Sugata, E., Fujita, Y., Saito, H., Saguchi, K., Murayama, N.
            and Higuchi, S.
            Cloning and expression analysis of a cDNA coding for a
            dexamethasone-inducible cytochrome P450 in Xenopus laevis
            Biochem. Mol. Biol. Internatl., 45, 689-697 (1998).
            Saito, H., Ohi, H., Sugata, E., Murayama, N., Fujita,Y. and Higuchi,S.
            Purification and characterization of a cytochrome P450 from liver
            microsomes of Xenopus laevis
            Arch. Biochem. Biophys., 345, 56-64 (1997)

CYP2R1     human
           AC018795.4 also AC025730 AC025748
           Mikael Oscarson
           submitted to nomencalture committee 9/4/98
           missing N-terminal (approximately 80 amino acids)
           Unigene entry Hs.16846
           ESTs AA058765 zk65e06.r1, AA099882 zl90c08.r1, AA115448 zl04h11.r1
           AI280096 qh85e09.x1, AA732048 nz87c04.s1, AA449325 zx06e11.s1,
           AI221745 qg93e12.x1, AA088847 zl90c08.s1, AA235247 zs37b03.s1,
           AA115449 zl04h11.s1, AI431661 tg74h07.x1, AI376519 te59a09.x1,
           T83549 yd44f12.r1, T91507 ye20c08.s1, R11612 yf47e10.r1,
           T91536 ye20c08.r1, AA449583 zx06e11.r1, T83719 yd65h05.r1
           AA663042
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIY
SLAASSELPHVYMRKQSQVYGE 
IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR
YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS
NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR
NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI
IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV
LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS
SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT
LQPQPYLICAERR 

CYP2R1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_7138
            69% to human 2R1
      MVPAQSPPLVPPSRDQALLGLACLTVAFLAVLLVRQLVK
      QRRPPGFPPGPSPIPIIGNIMSLATEPHVFLKKQSEVHGQ (0)
      IFSIDLGGILTVVLNGYDCIRECLYNQSEVFADRPSLPLFKKMTKMG 12808
12701 GLLNCKYSKGWIEHRKLACNSFRYFGSGQRLFERKISEECMFLVDAIDQHKGKAFNPKHL 12522
12521 VTNAVSNITNLIIFGQRFTYDDHNFQHMIELFSENVELAVSGWALLYNAFPWIEYLPFGK 12342
12341 HQKLFFNAAEVYDFLLRVTKEFSQGRVPHMPRHYVDAYLDELERNAGDPNSSFSYENLIY 12162
12161 SVGELIIAGTETTTNTLRWAMLYMALYPNIQG
      RVHREIDSVLANGRMPTLEDKQKMPYVEAVLHEVLRFCNIVPLGIFRATSQDA 11802
11801 NVNGYTIPKGTMVITNLYSVHFDEKYWSDPGVFSPQRFLDANGNFVRREAFLPFSLG 11631
11535 GRRQCLGEQLARMEMFLFFTTLLQRFHLQFPVGTIPTIAPKLGMTLQPKPYSICAVRR 11362
      HQKSLISVTTPCHK* 11317

CYP2R2P     Fugu rubripes (pufferfish)
            No accession number
Fc:c104I03x1 LPC.39565.x1 77% to fugu 2R1 MAY BE PSEUDOGENE OF scaf 7138 exon 8
201 DSVLANGRMPTLEDKQKMPYVEAVLHEVLRFCNIVPLGIFRATS*DANVNGYTIPKGTM 220
221 VITNLYSWHFYEKNWSKTGAFSHPKCLWDAHGHFCEWLMASMPGSFG 518

CYP2R3P     Fugu rubripes (pufferfish)
            No accession number
Fc:c068L08y2 LPC.26046.y2 67% to fugu 2R1 exon 8 possible pseudogene fragment
LYYTKIXTVLARVEIPTLEDKQKMPYLEAVLPEVLRFCDIVPLGLFRATSAGADVNGFTIPGGAVLIAILCSGRF

CYP2S1     human
           GenEMBL AF335278 AC011510
           ESTs T84852, AA315278, AA300981 and AA301039
           AA316621, AA496320, AA422150
           Rylander, T., Neve, E.P.A., Ingelman-Sundberg, M. and Oscarson, M
           Identification and tissue distribution of the novel human cytochrome 
           P450 2S1 (CYP2S1)
           Biocem. Biophys. Res. Commun. 281, 529-535 2001
           There is no UNIGENE entry for any of these ESTs
           52% identical to CYP2B subfamily members and 50% with CYP2A 
           members 50% with CYP2G1.
AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13
MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMR
LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH
GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE
GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQ
TYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ
EEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ
KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ
GTEVFPLLGSILHEPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSL
GKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR

Cyp2s1         mouse
            GenEMBL AA967201 ua50f06.r1 80% IDENTICAL TO HUMAN CYP2S1

AA967201 ua50f06.r1 80% IDENTICAL TO HUMAN CYP2S1
AA562979 vl64a09.r1
AA543966 vj69d06.r1
AA472776 vg94b11.r1
AI481433 vg94b11.x1
HUMAN (TOP) MOUSE (BELOW)
human LMTVIYXLFAGTMTVSTTVGYTLLLXMKYPHVQKWVRXELNRELGAGQAPSLGDRT
           Y LFAGTMT   T  Y LLL   YP VQ  VR EL  ELG G APSL DR
mouse VRIQPYLLFAGTMTIGATIRYALLLLLRYPQVQQRVRGELIQELGPGRAPSLSDRV

RLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHEPNIFKHPEEFNPDRFLDADGRFRKHEAFLP
RLPYTDAVLHEAQRLLALVPMG+P T+ RTT FRGYTLPQGTEVFPL+GSILH+P +F++P EF+P RFLD DGR RKHEAFLP
RLPYTDAVLHEAQRLLALVPMGMPHTITRTTCFRGYTLPQGTEVFPLIGSILHDPAVFQNPGEFHPGRFLDEDGRLRKHEAFLP

FSLGKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR*
+SLGKRVCLGEGLA+AE++LFFT+ILQAFSLE+PCPP  LSLKP +SGLFNIPP FQL+V PT
YSLGKRVCLGEGLARAELWLFFTSILQAFSLETPCPPGDLSLKPAISGLFNIPPDFQLRVWPTGDQSR*

CYP2T1    rat
          No accession number
          Lars von Buchholtz
          Submitted to nomenclature committee 3/6/2000 
          73% to CYP2T2P

CYP2T2P   human
          GenEMBL AC008537
RAQMRGSLPPRPRPLPLLGNL
QLQSGGLDRALHSLSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADA 
VSGRGSMAVFERFTRGNGILFSNRPCWWTLRNFALGALKKFGLGTRTVEA 
RVLEEAACLLDEFQATIGAPFDPVRLLDNAVSNVICSLVFGNRYRYGDPE 
FLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRIFRNFSE 
LRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHGQQDPESHFQE*TSVM 
TTHFFFGVTETTSTTLCYGLLILLKYLEVAAKVQELDPVVGWRPAPSL 
DYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCLPKGTFVIP 
LLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFAPAKQMCLG 
TGLAHSGIFLFLTATLQRFCLLPVVRPGTINLTQCTGLGSVPPDFQLQPVAC

CYP2T3P   human
          GenEMBL AC008962 C-terminal missing
RAQMRGSLPPRPRLLPLLGNLQLQSGGLDRALHS
LSGRWGRVFTVRLGPRPAVVLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN
GILFSNRPCWWTLRNFALGAPKKFGLDTRTIEARVLDEAACLLDEFQATI
GAPFDPVRLLGNAVSSVTCSCLREPLWLRGPGVPEVLNLLSDNFRIMSSKWGE  
SLMDWLPGPHHQIFQNFSELQVFISEQIQQHWHMRQPAEPRDFIDCLARWVRHG
QQDPESHFQEETLVMTMQLFFFFFFGGTETTSTTLC
AKGQELDPVVGQRPVPSPD
DHVQWPYTNAVLLEIQRFISVVPRTLTLDTHLHSHCLAKG

CYP2U1    human
AC025090, (AC000016 has C-term) 41% to 2N1 new CYP2 subfamily

MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGI
77036 PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSI 76863
76862 FSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT 76734
105008 GPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPF 105160
105161 SIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPF 105340
105341 GPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEE 105517
105518 YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ 105622
107396 KVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENT 107554
109370 LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIG 109540
KRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR

CYP2U1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_8899
            56% to human 2U1
MMSLSWLQSLSSSILTLVIMIILHHLFKCYQKRHGFANIPPGPKPWPVVGNFGGFL (0) 
NAAAVLTELAKVYGNVYSIYVGSQLVVVLNGYKVVRDALSNHPDVFSDRPDIPA 
ISIMTKISGIVFAPYGPLWQKHRRFCLSTLRNFGLGRLGLEPCIVEGLTNIKTELLRLE 
EESGGAGVDPAPVISNAVSNVICSLVLGHRFNHDDQEFRSMLRLMDRGLEICVNSPAVLI 
NVFPLLYHLPFGVFRELRQVERDITAFL
KRFIANHQETLDPNNPRDLTDMYLKEISARREAGDVDSGFTED
YLFYIIGDLFIAGTDTTANSVLWVILYMASYPDIQ
KVQAEIDGVVGPLRTPSLSDKGKLPFTEAAIMEVQRLTTVVPLAIPHMTSET
EFMGYTIPKGTVVLPNLWSVHRDPTEWDDPDSFDPTRFLDEDGTLLRKECFIPFGIG
RRVCMGAQLAKMELFLTVTNLLQTFHFRLPEGAPRPPLQGRFGLTLAPCPYTVCINPR

CYP2V1   Danio rerio (zebrafish)
         GenEMBL AB026158
         Ohta,M., Saitou,T., Yoshizaki,G. and Otsuki,A.
         Identification of a Cytochrome P450(CYP2) cDNA for Zebrafish
         Also found as an EST from Yea-Huey Yang, Jun-Lan Wang-Buhler and 
         Donald R. Buhler Submitted to nomenclature committee 7/1/2000

CYP2W1   human
         GenEMBL AC073957.3 chromosome 7 
         clone RP11-449P15 40% to 2F1
MALLLLLFLGLLGLWGLLCACAQDPSPAARWAPGLRPLPLVGNLHLLRLSQQDRSLME 
LSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRP
PIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQL
DGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL
FNVHPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQG
DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP
GRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLT
SVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSA
GRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRPRALCAVPRP*

The following cDNA AK000366.1 has been reported from Japan in a project to 
identify Full length cDNAs.  This is a part of the 2W1 gene.  The reported 
sequence shown below is not full length.  It is missing the N-terminal 
exon and the C-terminal exon. If one translates the sequence upstream of 
the ATG shown below, one finds the N-terminal exon sequence as shown 
above, however, there are only about 7 amino acids worth before the 
sequence runs out and stops. Similarly, if the genomic clone is searched 
downstream of the end of the cDNA, a clear heme binding sequence is 
found and another exon is identified.  The last exon has a problem.  It 
is too long if allowed to run until it hits a natural stop codon.  
However, in another frame there is a sequence LCAVPRP* that is identical 
to the end of CYP2D6 and this sequence is at the right location for this 
to be the end of the 2W1 gene.  I suspect there is a frameshift between 
the heme binding region and the LCAVPRP* sequence.  I have shown the 2W1 
gene with this frameshift, though the exact location is uncertain.

CYP2X1   Ictalurus punctatus (catfish)
         GenEMBL AF315346.1
         Schlenk,D., Furnes,B. and Zhou,X.
         Isolation and cloning of a new P450 2 family gene from Ictalurus
         Punctatus.
         Unpublished
         42% to 2N2

CYP2X2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_4007
      MVTSVILLCLGVVVLVLLLRSQRPKNFPPGPPVLPLLGSILELALDNPLQDFER (0)
12453 LRKKYGNVYSLFLGTRPAVVISGLKNIKEALVTKGSDFSGRPQDMILSI 12629
      possible frameshift DAIKTN (1)
13208 VIMQDYNLVWKEHRRFALTTMRNFGMGKTSMEDRIHGEIEYIVNTLEKNN (1)
      GKTLSPHLMFHNAASNIICQVLFGTRYEYDDHFIREIVRCFTENAKISNGPWAM (0)
      LYDSIPLVRYLPLPFKNAFKNVE (0)
      TAENLVKDLFVEHKKTRMSGDPRDFVDCYFDELDK (0)
      RGKDRSSFSENMLTMYALDLHFAGTDTTSNTLLTGFLYLMNYPHIQ (1)
      ERCHQEIDKVLQDNETVTYDARNQMPYMQ (0)
15630 AVIHEVQRVANTVPLSVFHCTTKDTEFMGYSIPK 15731 (0)
15853 GTLIIPHLASVLKEEGQWKFPNEFNPDNFLNDDGEFVKPEAFMP 15984 (frameshift) XST (1)
16100 GPRVCLGEGLARMELFLIIVTLLHKFQFIWPEDAGEPDYTPIFGATQTPKPYRMKIQLRK* 16282

CYP2X3      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_10845
missing exons 1-4 off the end of the scaffold
7527 LYDSFPAVRYLPLPFKRGFEMFK 7450 (0)
7381 MSHERYLEMFVETKKTRVPGKPRHFVDAYMDELEK 7277 (0)
7193 RGDEAFFSEDQLCAIILDLHFAGTDTTANTLLSGLLYLMKYPHIQ 7057 (1)
6289 EYCQQEIDKVMQGKNEVSFEDRVQMPYVQ 6203 (0)
6105 AVIHEIQRTANTVPLSVFHCTTRDTELMGYSIPK 6004 (0) exon 9
5617 GTLIIPNLSSVLNEKGQWKSSHEFNPENFLNENGEFVQPEAFMPFST 5477 (1)
5244 GPRVCLGEGLARMELFIILVSLLRKFRFIWPEDAEEPDLTPVFGVTQTPKPYSLKVQVRSRC* 5056

CYP2X4      Fugu rubripes (pufferfish)
            No accession number
FE:EFRy002apsE4 EST exons 10 and 11
Length = 458 395-496 51% to 2D6 87% to Scaffold_10845 (CYP2X3)
SSPKGTIIIPNLSSVLNEKGQWKCPHEFHPGNFLNENGEFVKPEAFVPFST
GPRVCLGEGLARMELFIILVTLLRRFKFIWPEDAEEPDLTPIFGLTQTPKPYRLKVQIRSSFK*

CYP2X5P     Fugu rubripes (pufferfish)
            No accession number
Scaffold_3538 57% to FE:EFRy002apsE4 51% to 2D6 Length = 26272 
61% to 2X2 59% to scaf 10845 (CYP2X3)
first 8 exons missing off end of scaffold
E in EXXR motif missing, one bad boundary, no exon 11 found
Possible pseudogene
25728 (0) PGIHKVQRIANTVPLNVQYCTMKETQLMAHLLPR 25627 exon 9 bad boundary
25349 (0) ETLIIQNLNSRQNEEGQWKFPHKSRPENFLNDQGEFVKTEDFMLFSA 25209 (1) exon 10

CYP2X fragment a    Fugu rubripes (pufferfish)
               No accession number 
               Scaffold_9193  Length = 9721 51% to scaf 4007
possible exon 1 of 2X3 or 2X4 
LGL47087.y1 Length = 725 2 family N-term exon 1
333 MLVSLALLLAAAFGLWVFFQIQRPKNFPPGPPPIPLFGNLLEIQLDNPIADLER 172 (0)

CYP2X fragment b     Fugu rubripes (pufferfish)
                     No accession number 
possible exon 2 of 2X3 or 2X4 
LED83776.x1 75% to scaf 4007 exon 2 not in new version of fugu databases
LAKRYGNVYGLFLGSRPAVVINGVSAL

CYP2Y1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_39a 
12087 MDLTVMLLTATLLLVVLWILNAHTRKHTRLPPGPRGIPVLGNLLQLDKKAPFKSLLK 11917 (0)
11768 LSENYGPVLTVALGPQRTVVLVGYEAVKDALVDHADDFTGRGPVPFLMKVTRGY 11607 (1)
11166 GLAISNGERWRQLRRFTLTTLRDFGMGRKGMEEWIQEESKHLVTRIKSTE 11011 (1)
10937 GAPFDPTFFLSCTVSNVICCLVFGQ 10869 frameshift
10867 GFSYDDEHFLSLLHIISETIQFGSSASGL 10781 (0) 
10700 MYNLFPRLMEWLPGRHREMFGKIEKVRAFTMEKIEEHQDTLDPSSPRDYIDCFLMRLQQ 10524 (0)
10452 EKPQPNTEFNYDNLVSTVLNLYLAGTETTSSTIRYALNVLIRHPKIQ 10312 (1)
10187 EKMQEDIDSVIGQGRCPYVEDRKSLPFTDAVLHEIQRYLDMIPFSIPHYALQDISFRGYTIPK 9999 (0)
9924  DTLIIPLLHSVLKDDKMWETPGSFN 9850 frameshift
9850  PLQHFVDGNGSFKKNPAFLPFSAG 9779 (1)
9687  GKRACVGESVARHGDIPSLSSHLVQHFTLSX 9595 frameshift
9593  PGGPDSVDLTPEYSSFANVPRKYKIIATPRCNKRLCIVI* 9471

CYP2Y2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_39b
15595 MEFSVTLILAGLVLAFFWFILQKRKYNLPPGPTTLPLVGNLPQLDKKQPFKSFTE 15431 (0)
15356 LSKSYGPVMTLYLGWQRTVVLTGYEVVKEALVDQAEDFTGRGPLPFLLKATNGY 15195 (1)
15078 GLGISNGERWRQLRRFTLSTLRDFGMGRKGMEEWIQEESKHLTARIKTLK 14944 (1)
14815 VKPFDPTFLLGCTVSNVICCMVFGERFSYDDKQFLELLRVIAEVLRFNSSFLGQ 14654 (0)
14549 MYNVFPWILEHLPGPQHTMFSHVNFLREFIKKKIQEHKESLDPSSPRDYIDTFLIRMEQ 14373 (0)
14282 EKNLPNTEFHYENLVSTVLNLFLAGTETTSSTLRYALGVLIKHPNVQ 14142 (1)
14046 EEMQREIDNVVRQDQCPKMEDRKSLPFTDAVIHEVQRFLDIVPFGLPHYALKDITFRGYSIPK 13858 (0)
13775 GTVIIPLLHSVLKGDQWETPWAFNPKHFLDQNGSFKKNSAFLPFSA 13638 (1)
13390 GKRSCVGESLARMELFIFLVTLLKDFTFSCIEGPDSISLNPQYSGFANLPRNYEIVATPR* 13208

CYP2Z1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2993a
      MGLIVSVFGSHADWSISTLLLFTAVFILMVNWIRNRRPPSFPPGPWTLPVVGNMHNLAHHRMHLNLME (0)
16293 LAETYGNVFSIQLGQEWMVVLNGPTILKEALVNQGDSVADRPNLQLIIDSCHGL (1)
16785 GLGFSSGHLWKQQRQFAISTLRYFGSGSKSLEPVVLEEFAHCAKQFSEFK 16937 (1)
17023 GKPFAPQLMFYNIVTNIICSLVFGHRFEYGDKNFEKLMNSFGRCLQIEASVCAQ 17184 (0)
17262 LYNSFPRLMGCLPGPHQTVKRIYQNIRDFIREEMKEHKKGLDPSTPRDYIDCYLNKIKK 17435 (0)
      XXXXXXXXXXXNL (fs) VIX (fs) VWNX (fs) FVPX (fs) TNT (fs) TTFTYRWLFLFMA 
      (fs) KYPEMQ (1)
17899 EKVQAEIDEVIGQSRRATMDDCVNMPYTNAVIHESLRMGNVVPLSLLHATGRDIQLEGYTIPK 18087 (0)
18158 GTTVIANLTSALFDKNEWETPFAFNPGHFLDEEGRFRKRTAFLPFSA (1)
18388 GRRLCLGENLARMMLFLFFTSFMQDFTISFPAGVSPAMEYHHFGVTLAPHPFDICAVSR* 18567

CYP2Z2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2993b
      MHWIFDLIGSFLAGDFKSLLFFLLIFILTADYLRNRRSGSFPPGPMAIPIIGNMLSLDRSRTHESLTQ (0)
21437 LAETYGNVYSLRTGQTWMVVVNSFKVVREALVTHGESVSDRPDLPLQDEIAHGK 21273 (1)
20946 GVISSNGHLWKQQRRFALSTLRLFGFGKKSLEPFITDEFTHCANIFRSYK 20815 (1)
20726 GKPLPPHLILNNVVSNIICSLVFGHRFEYGDKNFKNLIKLFDQSLQIEASVWAE 20565 (0)
20473 LYNSFPLLMKHVPGPHQTVKKIWNEVKDFVRNELKEHRKNWDPSDPRDYIDCYLREIQX 20300 (?) gap at boundary
19990 SGQSDSTFDEENLVICVMDLFVPGSETTSTTLRWAFLYMAKYPEIQ (1)
19748 EKVQAEIDRVVGQSRPLTMDDRVNLPYTDAVLHEIQRFGNIVPLSLPHVTNKAIQLEGYNIPK 19560 (0)
19470 GIMIIPNLTSALFDKNEWETPCTFNPGHFLDNEGKFRKRAAFIPFSA 19330 (1)
19220 GKRLCLGENLARMELFLFFTSFMQHFTFSMPAGVKPDMSFRFGVTLAPKPYEICAIPR* 19044

CYP2AA1     Danio rerio (zebrafish)
            No accession number
            Afonso Bainy and John Stegeman
            74% to 2AA2 (only known from ESTs)
            submitted to nomenclature committee 4/5/02

CYP2AA2     Danio rerio (zebrafish)
            AI657973 fc19c11.y1, AI958603 fc94a10.y1, AI544967 fb69h12.y1
            BI887677 AI444248 fb40e01.y1
            zfishC-a1385b03.q1c zfishC-a2172h09.q1c zfishG-a67c10.q1c
            these last three are from the zebrafish blast server
            48% to 2J1 74% to CYP2AA1
            intron phases from closely related zebrafish genomic sequences
MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL (0) exon 1
MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPAIDWTSNGC (1) exon 2
GIIMATFNNSWKQQRRFALHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE (1) exon 3
GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ (0) exon 4
IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK (0) exon 5
QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ (1) exon 6
ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ (0) exon 7
GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV (1) exon 8
GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFSIICCSRDTKE* exon 9