EC numbers for P450 enzymes

Compiled by Kirill Degtyarenko

Last modified: Mon May 10 11:13:17 BST 2004

The P450 enzymes constitute a large superfamily of haem-thiolate proteins involved in the metabolism of a wide variety of both exogenous and endogenous compounds (for a list of relevant papers, click here). Usually, they act as terminal oxidase in multicomponent electron transfer chains, called here P450-containing monooxygenase systems. Most of P450s currently are classified, often misleadingly, as unspecific monooxygenases (EC 1.14.14.1). Majority (marked by *) of the reaction equations and systematic names in the EC entries for P450s contain NADPH. Therefore, these reactions are true for the entire system (consisting of P450 and NADPH:ferrihemoprotein reductase, EC 1.6.2.4), but not for P450 alone.


List of relevant EC numbers

EC Recommended name Family/gene
1.3.3.9 * secologanin synthase CYP72A1
1.14.13.11 * trans-cinnamate 4-monooxygenase CYP73
1.14.13.12 * benzoate 4-monooxygenase CYP53
1.14.13.13 * calcidiol 1-monooxygenase CYP27
1.14.13.15 * cholestanetriol 26-monooxygenase CYP27
1.14.13.17 * cholesterol 7alpha-monooxygenase CYP7
1.14.13.21 * flavonoid 3'-monooxygenase CYP75
1.14.13.28 * 3,9-dihydroxypterocarpan 6a-monooxygenase CYP93A1
1.14.13.30 * leukotriene-B4 20-monooxygenase CYP4F
1.14.13.37 * methyltetrahydroprotoberberine 14-monooxygenase CYP93A1
1.14.13.41 * tyrosine N-monooxygenase CYP79
1.14.13.42 * hydroxyphenylacetonitrile 2-monooxygenase
-
1.14.13.47 * (-)-limonene 3-monooxygenase
-
1.14.13.48 * (-)-limonene 6-monooxygenase
-
1.14.13.49 * (-)-limonene 7-monooxygenase
-
1.14.13.52 * isoflavone 3'-hydroxylase
-
1.14.13.53 * isoflavone 2'-hydroxylase
-
1.14.13.55 * protopine 6-monooxygenase
-
1.14.13.56 * dihydrosanguinarine 10-monooxygenase
-
1.14.13.57 * dihydrochelirubine 12-monooxygenase
-
1.14.13.60 * 27-hydroxycholesterol 7alpha-monooxygenase
-
1.14.13.70 * sterol 14-demethylase CYP51
1.14.13.71 * N-methylcoclaurine 3'-monooxygenase CYP80B1
1.14.13.73 * tabersonine 16-hydroxylase CYP71D12
1.14.13.74 * 7-deoxyloganin 7-hydroxylase
-
1.14.13.75 * vinorine hydroxylase
-
1.14.13.76 * taxane 10beta-hydroxylase CYP725A1
1.14.13.77 * taxane 13alpha-hydroxylase CYP725A2
1.14.13.78 * ent-kaurene oxidase CYP701
1.14.13.79 * ent-kaurenoic acid oxidase CYP88A
1.14.14.1 unspecific monooxygenase multiple
1.14.15.1 camphor 5-monooxygenase CYP101
1.14.15.3 alkane 1-monooxygenase CYP4A
1.14.15.4 steroid 11beta-monooxygenase CYP11B
1.14.15.5 corticosterone 18-monooxygenase CYP11B
1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) CYP11A
1.14.21.1 * (S)-stylopine synthase
-
1.14.21.2 * (S)-cheilanthifoline synthase
-
1.14.21.3 * berbamunine synthase CYP80
1.14.21.4 * salutaridine synthase
-
1.14.21.5 * (S)-canadine synthase
-
1.14.99.9 steroid 17alpha-monooxygenase CYP17
1.14.99.10 steroid 21-monooxygenase CYP21
1.14.99.22 ecdysone 20-monooxygenase
-
1.14.99.28 linalool 8-monooxygenase CYP111
4.2.1.92 hydroperoxide dehydratase CYP74
5.3.99.4 prostaglandin-I synthase CYP8
5.3.99.5 thromboxane-A synthase CYP5

* : reaction equations and systematic names contain NADPH.


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