Last modified: Thu Apr 15 16:58:10 BST 2004
Updated by Kirill Degtyarenko
Last modified: Thu Apr 15 16:58:10 BST 2004
For a list of corresponding EC numbers, click here.
P450 enzymes constitute a superfamily of haem-thiolate proteins, widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds. Usually, they act as terminal oxidases in multicomponent electron transfer chains, called here P450-containing monooxygenase systems.
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
CYP1A1 hum B23585 A24797 P04798 M12079 X04300 X02612 K03191 1210238A
S15803 S16714 D12525 D01198 D10855 D01150
mon S21761 P33616 1814274A
Mir Q29489 D17575
rat A00185 S15584 P00185 K02246 M12170 M14633 M26126 1005262A
M26129 X00469 1010319A
1105202A
1713486A
ham JX0189 Q00557 D10251 D12977 1803390A
gpi F24406 Q06367 D11043 2001208A
rab A27821 B27821 P05176 D00212 M11727 X05685 1109280B
1307202A
Q28716 M19917
cat U82184
dog C37222 1703408B
she S79795
tro P10609 M21310 1410185A
CYP1A1/A3 tro A28789
Cyp1a-1 mou A00184 S15588 P00184 Y00071 M10021 K02588
A23923
Cyp1a-1p mou M11515
CYP1A2 hum S07373 S16718 Q16754 L00383 L00384 L00385 L00386 1210358A
S22433 L00387 L00388 L00389 1918405A
P05177 M12078 M14337 Z00036 M55053
M31664 M31665 M31666 M31667
mon
rat A22562 B24406 P04799 K02422 K03241 M26127 X01031 1009215A
A20963 S16875 1105282A
1005270A
1203207A
ham S13885 JX0190 P24453 M63787 D10252 1803390B
PX0036 1705176C
gpi Q64391 D50457 U23501
rab B27821 P00187 D00213 M11728 X05686 X13853 1008260A
Q29526 M36538 1109280A
1204232A
1307202B
1501250A
dog B37222 1703408C
chi JT0575 Q01741 M64537 1708151A
tro Q92110 S69278
P79830 U62797
Cyp1a-2 mou A00186 B92495 P00186 X00479 M10022 X04283 K02589
A26373 B24953
CYP1A3 tro Q92109 S69277
P79829 U62796
CYP1A4 chi P79760 X99453
CYP1A5 chi P79761 X99454
CYP1A pla S34184 Q92100 X73631
CYP1A Ota Q92095 U14161 2113184A
CYP1A Sch Q92116 U14162 2113184B
CYP1A Chc Q92039 U19855
CYP1A Dla P79716 U78316
CYP1A Mto Q92148 L41886 L41917
CYP1B1 hum Q16678 U03688 2013283A
Q93089 U56438
rat I48130 Q64678 X83867 U09540 2113315A
Cyp1b-1 mou Q64461 X78445 2017226A
Q64429 U03283
Q60593 U02479
CYP2A1 rat A29560 A34272 P11711 J02669 M33312 1604168A
S03981
CYP2A2 rat A31887 S03982 P15149 J04187 M33313 M33325 M34392 1604168B
CYP2A3 rat S15056 A32030 P20812 M33190 J02852 1507164A
S12708
Cyp2a-4 mou A33531 S16067 P15392 M25146 M25147 M26202 M26203 1405272A
S16068 S03979 M26205 M26206 M26207 M26208
J03549 M19319
Cyp2a-5 mou B33531 P20852 M26204 M25205 M25206 M25207
M25208 M25209 M25210 M25211
CYP2A6 hum A00190 S05946 P11509 K03192 M33316 M33318 X06401 1604167A
A34271 B34271 Q16803 X13929 X13897 X13930 1609083A
S04698 1511124A
1509339A
CYP2A6v2 hum Q13120 U22027
CYP2A7 hum C34271 P20853 M33317 1604167B
Q13121 U22029
CYP2A7P hum U22030
CYP2A8 ham S13884 A33293 P24454 M27906 M34446 M34447 M63788 1511056A
PX0037 1705176A
CYP2A9 ham P24455 M34448 M63789 1705176B
CYP2A10 rab Q05555 L10236 1920322A
CYP2A11 rab Q05556 L10237 1920322B
Cyp2a-12 mou S32491 L06463 1912175A
CYP2A13 hum Q16696 U22028
CYP2A bov A35704 P22779
CYP2A mon 1905232B
CYP2B1 rat A00176 S03854 P00176 M11251 L00313 L00314 L00315 0805305A
A22363 S19172 L00316 L00317 L00318 L00319 0904267A
L00320 D00250 M19972 M21412 0904321A
M26854 M26855 M37134 1108237A
J00719 J00720 J00721 J00722
J00723 J00724 J00725 J00726
J00727 J00728
CYP2B2 rat A00177 A21872 P04167 J00720 J00721 J00722 J00723 0907261A
S15589 B00176 J00724 J00725 J00726 J00727 0910215A
S03855 A32736 J00728 K00996 K01626 S51970 1002217A
A21162 K01721 K02427 K02428 M13234
M15947 M19972 M27076
Y00410 M21403 M13650
Q64579 M34452
Q03738 M26853
CYP2B1 or 2B2 A34259
CYP2B3 rat A25459 A29818 P13107 M20406 M19973 U16209 U16210 1407136A
U16211 U16212 U16213 U16214
CYP2B4 rab A00178 A00179 P00178 M20856 M20857 0911310A
B27717 C27717 0905212A
E27717 0901269A
1403250A
1404379A
1919216A
Q29532 S64259
Q29515 L10912
CYP2B5 rab D27717 A27717 P12789 M20855
Q29516 M18820
CYP2B6 hum S04578 A32969 P20813 J02864 M29874 X06399 X06400 1601463A
S07598 S04579 X13494 1515189A
1515189B
Q14096 X16864
CYP2B7P hum Q14097 M29873 J02864
CYP2B8 rat J04808
Cyp2b-9 mou A31047 P12790 M21855
Cyp2b-10 mou B31047 P12791 M21856
Q62397 U48732
+ CPR X99715
CYP2B11 dog S11305 P24460 M33575 M92447 1614241A
CYP2B12 rat S27160 P33272 X63545 S48369 X63545 1901199A
Cyp2b-13 mou K02409
CYP2B14P rat U33540
CYP2B15 rat Q63140 D17343 2004298A
Q62802 D17344
Q64583 D17345 D17346 D17347 D17348
D17349
CYP2B16P rat U33541 U33542 U33543 U33544
U33545 U33546
CYP2B gpi A36154 S15135
CYP2C1 rab A00181 A34257 P00180 K01522 M76597 1002188A
Q00172 M74199
Q29509 D26152
CYP2C2 rab A00182 A27718 P00181 K01521 M14955 M19137 M76596 1002188B
S15587 1403251A
CYP2C3 rab A00183 A22606 Q29525 M31245 M31246 M31247 M31248 1002188C
A34534 M31249 M31250 M31251 M31252 1106190A
M31253 M31254
P00182 K01523 J02901
CYP2C4 rab A26731 B34257 P11371 M74200 M74201 M74202 M74203 1306327A
J02716
CYP2C5 rab A00180 A37828 P00179 J05575 M11299 1111272A
S20227 M74204 M74205 M74206 1614312A
Q29507 M17026
Q29511 M55664
CYP2C6 rat A25954 B25585 P05178 J04466 K03501 M13711 M18336 1209242A
A28516 S00955 Q64614 M24237 M24238 M24239 1302146B
M36848 X06712 M14776
CYP2C7 rat B28516 P05179 M14775 M18774 M31031 M18335 1209242B
1302146A
CYP2C8 hum A29782 S06306 P10632 J03472 M17397 M17398 M21941 1314226A
E28951 C28951 X51535 X54807 M21942 1412182A
S12688 S21423 1412182B
2121231A
Q16743 X65962
CYP2C9 hum A28530 S06863 P11712 J05326 M21940 1819194A
C38462 B38462 M61855 M61857 1313295A
A28951 B28951 L16877 L16878 L16879 L16880 1402324A
L16881 L16882 L16883 1709170A
1501199A
Q16872 S46963
Q16756 D00173
CYP2C10 hum D28951 A27541 P11713 J02832 M15331 M21939 1304180A
CYP2C11 rat A26685 P08683 J02657 X79081 1402198A
M18356 M18357 M18358 M18359 1303289A
M18360 M18361 M18362 M18363
U33173
CYP2C12 rat A32140 P11510 J03786 1409383A
Q64648 M33544 M33545 M33546 M33547 1605163A
M33548 M33549 M33656 M33550
CYP2C13 rat A32470 A36122 P20814 J02861 J05352 M32277 M33994 1511061A
S15586 Q64587 M82846 M82848 M82849 M82850 1604157A
M82851 M82852 M82853 M82854
M82855 M81311 X79810
CYP2C14 rab A26921 P17666 D00190 D00191 1306317A
CYP2C15 rab B27718 P11372 M19234
CYP2C16 rab S12765 A27479 P15123 M18376 M29968 M29661
CYP2C17 hum G38462 P33259 M61858 L07093
CYP2C18 hum D38462 E38462 P33260 M61853 1801333A
Q16751 M61856
Q16703 L16869 L16870 L16871 L16872
L16873 L16874 L16875 L16876
S63421 S63424 S63426 X54808
CYP2C19 hum F38462 P33261 M61854 L31506 L31507
CYP2C20 mon S28166 P33262 S53046 1905232A
CYP2C21 dog A37222 1703408A
CYP2C22 rat A39257 S11160 P19225 M58041 X53477 1703477A
1615337A
CYP2C23 rat S13101 P24470 X55446 1704329A
Q64534 U04733
P97716 S80125
CYP2C24 rat JH0451 P33273 M86677 M86678 1718168A
Q63853 S59652 S59647
Q63854 S59652
Q63855 S59652
CYP2C25 ham Q08078 X63022 2009386A
CYP2C26 ham P33263 D11435
CYP2C27 ham P33264 D11436
CYP2C28 ham P33265 D11437 2112203A
Cyp2c-29 mou Q64458 D17674 2009209A
CYP2C30 rab Q29510 D26153
CYP2C31 got JC2199 Q29478 X76502 2010191A
CYP2C32 pig Q28971 U35733
CYP2C33v1 pig Q28972 U35837 2117161A
CYP2C33v2 pig Q28973 U35838
CYP2C33v3 pig Q28974 U35839
CYP2C34v1 pig Q28975 U35840 2117161B
CYP2C34v2 pig Q28976 U35841
CYP2C34v3 pig Q28977 U35842
CYP2C34v4 pig Q28978 U35843
CYP2C35 pig Q28979 U35844
CYP2C36 pig Q28980 U35845
CYP2C42 pig P79402 Z93098
CYP2C42P1 pig Z93100
CYP2C hum Q16750 X56452
CYP2C pig Q29565 F14781
CYP2C rat B60822
CYP2C dog A60465
CYP2C hor PN0659
Cyp2c mou A23739
CYP2D1 rat A31579 A26822 P10633 J02867 M16654 M22328 1306261A
1414200A
CYP2D2 rat C31579 B26822 P10634 M16655 M22330 X52027 X52455 1306261B
S16871 1414200B
1701403A
CYP2D3 rat E32970 S16872 P12938 J02868 X52028 X52456 1701403B
CYP2D4 rat D31579 S16873 P13108 M22331 X52029 X52457 1414200D
1701403C
CYP2D5 rat B31579 S09611 P12939 J02869 M22329 M25143 X52030 1414200C
S16874 X52458 1701403D
1513478A
CYP2D6 hum A30335 S01199 P10635 M19697 M20403 1506410A
A33629 X07618 X07619 X07620 X08006
X16865 X16866 X16867 Y00300
X90927
Q16752 M33388
Q16804 M24499
Q16753 M33189
CYP2D7P hum M33387 X58467
CYP2D8P hum M33387 X58468
Cyp2d-9 mou A27384 B27384 P11714 M23998 M23997 M24262 M24267 1403249A
S15806 Q64529 U20087 U26265 2116358B
Q64489 M27168 2116358C
Cyp2d-10 mou A30247 S19168 P24456 M24263 1509206A
Q64530 U20088
Q64490 M27167
Cyp2d-11 mou S19169 P24457 M24264
Cyp2d-12 mou
Cyp2d-13 mou
CYP2D14 bov S29295 S37284 Q01361 X68013 S45538 1819257A
Q29454 X68481
CYP2D15 dog D17397 2114248A
CYP2D16 gpi Q64403 U21486 2111231A
CYP2D17 mon Q29488 U38218
CYP2D18 rat Q64680 U48219 U48220 2110198A
CYP2D rat A28702
CYP2E1 hum A31949 P05181 D10014 J02625 J02843 M77918 1301294B
1503130A
Q16868 S77873
mon S28167 P33266 S55205
rat A28145 A25341 P05182 J02627 M20131 S48325 1301294A
S09072 1911515A
1405281A
rab A26579 A27750 P08682 M15061 M18770 M19235 1303357A
1403251C
ham S27176 P51581 D17449 2007232A
pig P79383
Cyp2e-1 mou S18037 S19657 Q05421 X62595 L11650 1919337A
1802364A
1806181A
CYP2E2 rab B27750 B27680 M18771 1407213A
M21351 M21349 M21350 M21358
M21359 M21360 M21361 M21362
M21363
Q29508 M21364 M21365 M21366 M21367
M21368 M21369 M21370 M21371
M21372
CYP2F1 hum A36036 B36036 P24903 J02906 1611209A
1611209B
Cyp2f-2 mou A39302 P33267 M77497 1802218A
CYP2G1 rat A35551 P10610 M31923 M31924 M31925 M31926 1604337A
M31927 M31928 M31929 M31930 1507263A
M31931 M33296 M34444
rab S13907 B31944 P24461 1706166A
CYP2H1 chi A24814 P05180 M13454 1208339A
1507184A
CYP2H2 chi A31418 S10683 P20678 M25469
CYP2J1 rab A40938 P52786 D90405 1717296A
CYP2J2 hum P51589 U37143
CYP2J3 rat P51590 U39943
CYP2J3P1 rat U40000
CYP2J3P2 rat U40004
CYP2J pig P79316 Z84061
CYP2K1 tro S45644 L11528 2015199A
CYP2L1 Paa Q27712 U44826
CYP2M1 tro U16657
CYP2Q Xla D50560
CYP2(EST) Cel M89049
CYP3A1 rat A22631 P04800 M10161 X62086 D13912 1107256A
S39797 D29967 L24207 2002214A
Q64580 X64401
Q64590 M28452
CYP3A2 rat A25222 P05183 M13646 X62087 M74443 1208360A
U09725 U09726 U09727 U09728
U09729 U09730 U09731 U09732
U09733 U09734 X79319 X79320
CYP3A1 or 3A2 B26997 A26997 M86850
C26997
CYP3A3 hum A25170 A29410 P05184 D00003 M13785 X12387 1208395A
2108280A
CYP3A4 hum A25517 A29815 P08684 M14096 M18907 X12387 D11131 1212387A
A32199 S16900 Q16757 J04449 1404264A
S03851
CYP3A5 hum S06491 A34101 P20815 J04813 L35912 1510260A
1602106A
CYP3A5P hum L26985
CYP3A6 rab A29487 A34236 P11707 M19139 U40569 1403281A
Q29506 J05034 1515287A
CYP3A7 hum S04983 S02152 P24462 D00408 1504252A
JX0062
CYP3A8 mon S28168 P33268 S53047 1905232C
S04509 P25231
CYP3A9 rat P51538 U60085
Q64557 U46118
CYP3A10 ham A40843 M73992 S79317
Cyp3a-11 mou S22334 Q64459 X60452 D28565 1813172A
CYP3A12 dog S14275 P24463 X54915 1707145A
Cyp3a-13 mou S18155 Q64464 X63023 2105184A
CYP3A14 gpi Q64417 D16363
Q64407 D49731
CYP3A15 gpi Q64406 D26487
Cyp3a-16 mou Q64481 D26137 2104197A
CYP3A17 gpi Q64409 D28515
CYP3A18 rat S47471 Q64581 X79991 2106148A
CYP3A19 got P79152 X76503
CYP3A23 rat JX0334 Q06884 X96721 2015293A
CYP3A24 she A60728 Q29496 U59378
CYP3A25 mou O09158 Y11995
CYP3A29 pig P79401 Z93099
CYP3A pig Q29598 F14604
CYP3A rat PX0033
CYP3A bab S21176 P80056
CYP3A bov P79102 Y10214
CYP4A1 rat S01336 B32965 P08516 M14972 M33937 M57718 X07259 1516169A
CYP4A2 rat A32965 P20816 M33938 M57719 1516169B
CYP4A3 rat A27700 A32966 P20817 M33936 1516170A
CYP4A2 or 4A3 A26380 S09074
CYP4A4 rab A29368 P10611 J02818 1908184A
Q02927 L04758
CYP4A5 rab A34260 S14761 P14579 M28655 X57209 1709201A
CYP4A6 rab B34260 A34160 P14580 M28656 M29531 L04755 1602211A
CYP4A7 rab C34260 B34160 P14581 J05150 M29530 M28657 1602211B
CYP4A8 rat A36304 P24464 M37828 1701272A
CYP4A9 hum
Cyp4a-10 mou S35608 Q06772 X69296 X71478 2017209A
CYP4A11 hum S29845 S35609 Q02928 L04751 S67580 D26481 1908216A
Q16802 D13705 S67581 2003235A
Q06766 X71480
Cyp4a-12 mou S35610 Q06767 X71479
CYP4A13 gpi S32714 S35611 Q06768 X71481
Cyp4a-14 mou Y11638 Y11639 Y11640 Y11641
Y11642
CYP4A rab PQ0048
CYP4A cat O02845 U91787
Cyp4a mou Y10221 Y10222
CYP4B1 hum S07765 P13584 J02871 X16699 1515193A
1605167A
rat PQ0092 B40164 P15129 M29853 1509332B
rab A40164 P15128 M29852 1509332A
Cyp4b-1 mou D50834 2119162A
CYP4C1 Bld A39381 P29981 M63798 1711468A
CYP4C2 Aal PC2257 Q16903 L38678 2102220A
CYP4C3 Dme Q24121 U34323
CYP4C8 Mda P91762 U77126
CYP4C? Cel Z74043
CYP4D1 Dme S25707 P33269 X67645 1814309A
CYP4D2 Dme S41192 S34291 Q27588 Z23005 2015216A
Q27589 X75955
CYP4D5 Aal PC2270 Q16904 L38679
CYP4D6 Aal PC2271 Q16905 L38680
CYP4D7 Aal PC2272 Q16906 L38681
CYP4D8 Dme Q24127 U34329
CYP4E1 Dme K00045
CYP4E2 Dme Q27606 U56957
Q24291 X86076
Q24130 U34332
CYP4E3 Dme Q24128 U34330
CYP4E4 Dme Q24129 U34331
CYP4F1 rat S29723 P33274 M94548 S53039 1907136A
CYP4F2 hum Q16677 U02388
P78329 D26480
CYP4F3 hum A46661 Q08477 D12620 D12621 S63604 1914182A
CYP4F4 rat P51869 U39206 2205230A
CYP4F5 rat P51870 U39207 2205230B
CYP4F6 rat P51871 U39208 2205230C
CYP4G1 Dme Q24126 U34328
CYP4H1 Aal PC2261 Q16907 L38682
CYP4H2 Aal PC2262 Q16908 L38683
CYP4H3 Aal PC2263 Q16909 L38684
CYP4H4 Aal PC2264 Q16910 L38685
CYP4H5 Aal PC2265 Q16911 L38686
CYP4H6 Aal PC2266 Q16912 L38687
CYP4H7 Aal PC2267 Q16913 L38688
CYP4H8 Aal PC2268 Q16914 L38689
CYP4H9 Aal PC2269 Q16915 L38690
CYP4J1 Aal PC2258 Q16916 L38691
CYP4J2 Aal PC2259 Q16917 L38692
CYP4J3 Aal PC2260 Q16918 L38693
CYP4K1 Aal PC2273 Q16919 L38694
CYP4L1 Mse Q25505 L38668 2119160A
CYP4L2 Mse Q25506 L38669 2119160B
CYP4M1 Mse Q25507 L38670 2119160C
CYP4M2 Mse Q25508 L38671
CYP4M3 Mse Q25509 L38672
CYP4P1 Dme Q24125 U34327
CYP4T1 tro P79835 U82983
CYP4(EST) Cel M89401
CYP4(EST) Cel M80176
CYP5A1 hum A41766 S10750 P24557 M74055 M80646 M80647 S60133 1715147A
Q16844 D34613 D34614 D34615 D34616 1805282A
D34617 D34618 D34619 D34620 1805282B
D34621 D34622 D34623 D34624 2019278A
D34625 S51388 U88978
rat S42404 P49430 D28773 S69335 2007255A
pig P47787 L13128 2008200A
Cyp5a-1 mou JN0683 P36423 L18868 1919229A
U41326 U41327 U41328 U41329
U41330 U41331 U41332 U41333
U41334 U41335 U41336 U41337
U41397
CYP6A1 Mdo A32157 P13527 M25367 1505396A
Q27703 L27241 L27242 2019323A
CYP6A2 Dme A45378 A47198 P33270 M88009 S51248 S81983 1812334A
P91669 U78088
CYP6A3 Mdo Q27691 U09231
CYP6A4 Mdo Q27692 U09232
CYP6A5 Mdo Q27694 U09343
CYP6A6 Mdo Q27695 U09344
CYP6A Dme Q27592 L46858
CYP6A8 Dme Q27593 L46859
CYP6A9 Dme Q27594 L46860
Dgr