Last modified: Thu Apr 15 16:58:10 BST 2004
Updated by Kirill Degtyarenko
Last modified: Thu Apr 15 16:58:10 BST 2004
For a list of corresponding EC numbers, click here.
P450 enzymes constitute a superfamily of haem-thiolate proteins, widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds. Usually, they act as terminal oxidases in multicomponent electron transfer chains, called here P450-containing monooxygenase systems.
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
CYP7A1 hum S29818 JH0659 P22680 X56088 M89803 M93133 L07951 1908212A
L04629 L04630 L04631 L04632
L04633 L04634 M89647
L20569 L20570
rat A35376 P18125 J05460 J05509 M59184 M59185
M59186 M59187 M59188 M59189
J02926 J05430 X17595 Z14108
Z18860 U01962
rab P51542 L10754 S67315
bov
ham S39399 P46634 L04690
Cyp7a-1 mou A54779 L23754
CYP7B1 rat Q63688 U36992 2205302A
Cyp7b-1 mou Q60991 U36993 2205302B
CYP8 bov JC2350 A53658 Q29626 L34208 D30718 S67757 2017321A
PC2016 2018151A
hum JC2231 Q16647 D38145 S70440 D83402 2012205A
D83393 D83394 D83395 D83396
D83397 D83398 D83399 D83400
D83401 U88977
rat Q62969 U53855
CYP9A1 Hvi U23506
CYP9B1 Dme Q24122 U34324
CYP9B2 Dme Q24123 U34325
CYP9C1 Dme Q24124 U34326
CYP10 Lst JX0225 P48416 S46130 1817288A
CYP11A1 hum A25922 S08081 P05108 D00161 D00162 D00163 D00164 1204185A
S16716 D00165 D00166 D00167 D00168 1305284A
D00169 M14565 M60421 1301351A
X05367 X05368 X05369 X05370
X05371 X05372 X05373 X05374
X58981
Q16805 M28253
Q15081 X14257
rat A27321 A34164 P14137 M63125 M63126 M63127 M63128 1313255A
A23688 M63129 M63130 M63131 M63132 1602215A
M63133 J05156 M22615 1703304A
rab A49189 Q28827 S59219
bov A00189 S04947 P00189 K02130 M25920 M25921 1009264A
1111204A
1207198A
1208259A
Q28152 J05245
pig S03188 PN0018 P10612 X13768
she P79202 D50057 S65754
got P79153 D50058
chi S11144 1616432A
O13254 D49803
tro S32197 Q07217 S57305 1912185A
Dam Q92045 U63299
Cyp11a-1 mou J05511
CYP11B1 hum A34181 S11338 P15538 M24667 X55764 X55765 1602198A
M32863 M32878 M32879 D10169 1614284A
D16153 D16154 D16155
bab Q29527 U52081 U52082 U52083 U52084
U52085
rat B34281 P15393 X15431 S58858 D10107 S63899 1515238A
D14086 D14087 D14088 D14089 1909237A
D14090 D14091 1909237B
1909237C
gpi Q64408 Z69785
bov A28415 B28860 P15150 D00185 D00186 D00361 1311298A
JX0050 JX0071 Q29457 D00449 D00450 D00451 D00452 1508213A
S15805 A38819 D00453 D00454 D00455 D00456 1705242A
D00457 1414286A
M17843 M17844 M36535
ham P97720 S82228
pig Q29552 D38590
she P51663 L34337 L47569 2105192A
Cyp11b-1 mou B41552 P15539 J04451
CYP11B2 hum JX0151 B34181 P19099 X54741 M32864 M32880 M32881 1602198B
A37088 S78399 S78400 D10170 1702153A
Q16726 D13752
rat A35342 B35342 P30099 D00567 S58859 S64136 1918169A
S09736 D14092 D14093 D14094 D14095 1609125A
D14096 D14097
bov
ham Q64658 S73810 U71280
fro Q92104 D10984 2110250A
Cyp11b-2 mou A41552 Q64661 S85260
CYP11B3 rat A34281 S09736 P30100 D14098 D14099 D14100 D14101
B35342 JX0253 D14102 D14103 D00568 X52766
Q64546 U17082 2105269A
U14907 2202323A
CYP11B4 bov cf.CYP11B1, different flanking regions
CYP11B5P bov
CYP11B6P bov
CYP11B7P bov D00458 D00459
CYP11B8P rat D14104 D14105 D14106 D14107
D14108
CYP13A1 Cel Q27520 Z48717
CYP13A2 Cel Q27518 Z48717
CYP13A3 Cel Q27517 Z48717
CYP13A4 Cel Q27513 Z48717
CYP13A5 Cel Q27514 Z48717
CYP13A6 Cel Q27515 Z48717
CYP13A7 Cel Q27519 Z48717
CYP13A8 Cel Q27516 Z48717
CYP13A9P Cel Z48717
CYP13A10 Cel Q09653 Z46934
CYP14A1 Cel Q27506 Z50742
CYP14A2 Cel Q27505 Z50742
CYP14A3 Cel Q27507 Z50742
CYP14A4 Cel Q27510 Z70212
CYP14A? Cel Q27508 Z50742
CYP14A? Cel Q27531 U64847
CYP14? Cel Z83121
CYP14? Cel O02627 U97008
CYP14? Cel O02628 U97008
CYP14? Cel O02651 Z81127
CYP16A1 Cel Q27491 Z54269
CYP17A1 hum A29587 A26366 P05093 M14564 M19489 M63871 1302320A
A40908 A40921 M31146 M31147 M31148 M31149 1313220A
M31150 M31151 M31152 M31153
Z19875 Z20209 S85459 S51705
rat A27659 A30828 P11715 M21208 M22204 M27282 M31681 1502195A
A33980 S16719 X14086 Z11902 S40343 1409199A
1613401A
1816175B
2103157A
ham P70687 U66494
gpi D28860 Q64410 X82878 S75277 2104182A
bov S04346 A26289 P05185 M12547 1203301A
1509192A
hor Q95328 D88184
Q29483 D30688
she Q29497 L40335
tro S21125 P30437 X65800 1809207A
Ola P70085 D87121
P70086 D87122
pig B26366 S22339 P19100 M63507 Z11854 Z11855 Z11856 1809168A
S40340 S40341 S40342 1816175A
U41519 U41520 U41521 U41522
U41523 U41524 U41525
chi JT0318 P12394 M21406 1409257A
Sqa Q92113 S77384 2118305A
Cyp17a-1 mou A39072 P27786 M64863 S41708 1711346A
CYP17A2 bov X59613
CYP18 Dme Q95078 U44753
Q27767 S66112
CYP19 bov P46194 S66248 Z32741 e18447 1924225A
hum S03962 A31255 P11511 J04127 J05105 M28420 S52034 1310327A
A31580 A29480 M30795 M30796 M30797 M30798 1501399A
A23546 A34451 M30799 M30800 M30801 M30802 1507200A
A24344 D24344 M30803 M30804 M74714 X55983 1516307A
B24344 E24344 Y07508 M18856 X13589 S52789 1922320A
C24344 S22908 S52793 S52794 D14473 1922320B
A40142 D29757 D21240 D21241 D13391 1922320C
L21982 S58866 S67203 S67206 1922320D
S67207 S67210 S67214 S85075 1922320E
S96437 S41951 M32245 S71536
Q16731 M22246
Q16449 S85356
rab Q29605 Z68271
Q28684 Z70302
rat A36121 S16901 P22443 M33986 Z11815 S59505
hor Q28373 U37313
pig Q29624 L15471 2122348A
U37309 U37310 U37311 U37312 2122348B
P79286 U52141 2210279A
U57511 U57512 U57513 U57514
U57515 U57516 U57510
P79430 U57517 U57518 U57519 U52142
P79304 U57522 U57520 U57521
O02847 U92245 U92246
chi A31916 P19098 J04047 1414320A
Q03737 M73277 M73278 M73279 M73280
M73281 M73282 M73283 M73284
M73285
M73286 M73287 M73288 M73289
M73290 M73291 M73292 M73293
M73294
M73295 M73296 M73297 M73298
M73299 M73300 M73301 M73302
M73303
jqu Q92150 S46949
P79699 D50336
Pog Q92112 S75898
tro 1806325A
Ipu Q92111 S75715 2017254A
Ola Q92087 D82968 D82969
Tni P70091 U72071
gol P79690 U18974
Cyp19 mou S13912 P28649 D00659 1707124A
CYP19P bov Z32813
CYP21A1 bov A00192 A24101 P00191 K01333 M11267 M12918 M13461 1207187A
A27555 A21181 M13545 1207312A
C28860 1204233A
pig A32525 P15540 M83939 1306214A
she A43349 M92836 M92837 1818301A
Cyp21a-1 mou A00193 A26660 P03940 K03234 M64933 M73820 M15009 1108302A
CYP21A1P hum A21889 A25446 P08686 M12793 M12792 M26857 1513491A
A27865 A32715 M25813 M13936 S38953
Q16746 X58898
Q16747 X58899
Q16874 X58900 X58902 X58901 X58903
Q16748 X58904
X58905 X58906
Q93071 X58907
Q16755 X58908
CYP21A2 hum A00191 P04033 K02771 M25813
Q16806 M17252
Q01204 M26856
X54940 S38953 M19711
X58901 X58902 X58904 X58905
X58906 X58907 X58908
Cyp21a-2p mou K03234 M15008
CYP21A3 pig Q02390 M83939
CYP21B hum Q16741 M31022 M23224 M21544 M21545
M21546 M23225 M21547 M21548
M21549 M21550
Q16742 M28548
CYP22A1 Cel Q27523 U39648
CYP23A1 Cel Q27465 U39472
CYP24 hum A47436 Q07973 L13286 S67623
rat A45228 Q09128 L04608 L04609 L04610 L04611
L04612 L04613 L04614 L04615
L04616 L04617 L04618 L04619
X59506 Z28351 D17792 U03112
Cyp24 mou Q64441 D49438
CYP25A1 Cel Q27476 Z66495
CYP25A2 Cel Q27477 Z66495
CYP25A3 Cel Q27478 Z66495
CYP25A4 Cel Q27479 Z66495
CYP25? Cel Q21262 U50072
CYP27 hum A39740 Q02318 M62401 S62709 X59812
rat A36239 S09198 P17178 M38566 Y07534 1702186A
A33406 U17363 U17369 U17370 U17371
U17372 U17373 U17374 U17375
U17376
rab A30293 A33813 P17177 J04717 1508224A
CYP29A1 Cel Q27480 Z69787
CYP29A2 Cel Z74040
CYP30 Mem
CYP31A1 Cel Q27466 Z68213
CYP31A2 Cel Z68336
CYP32 Cel Q27472 U53148
CYP33A1 Cel Q27470 U55365
CYP33B1 Cel Q27471 U50311
CYP33E1 Cel Q27482 U61945
CYP33E2 Cel Q27499 U61952
CYP33E3P Cel Q20315 U61952
CYP33? Cel O02641 AF003385
CYP35C1 Cel Z77652
CYP35D1 Cel Z83105
CYP36A1 Cel O02645 Z83220
CYP51 hum Q16784 U23942 D55653
Q99868 U51684 U51685 U51686 U51687
U51688 U51689 U51690 U51691
U51692
rat JC2334 Q64654 D55681 U17697
CYP51P1 hum U36926
CYP51P2 hum U40053
CYP51P rat D78370 D87997
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
hum S14367
hum S08282 (2C like or 2A like)
rat S09073
CYP2?P rab M12280 M12281 M12282 M12283
M12284 M12285 M12286 M12287
M12288
pig S11471
pig S15850
Cel M88882
Cel Q09660 U21321
chi S10680
chi S10681 S13263
chi S10682
Dre U68234
We use combined listing of GenBank, EMBL and DDBJ accession numbers because they use common numbering.
Some sequences can be identified from N-terminal sequences as belonging to a subfamily. These have been included in the listing of the subfamily even though it is premature to assign a specific number to these sequences.
Aal = Anopheles albimanus (mosquito) bab = baboon (Papio species) Bld = Blaberus discoidalis (cockroach) bov = bovine Cel = Caenorhabditis elegans (nematode worm) Chc = Chaetodon capistratus chi = chicken Dam = Dasyatis americana (southern stingray) Dme = Drosophila melanogaster (fruit fly) dog = dog Dre = Danio rerio (zebrafish) fro = bullfrog (Rana catesbeiana) gol = goldfish got = goat gpi = guinea pig ham = hamster Har = Helicoverpa armigera hor = horse hum = human Hvi = Heliothis virescens Ipu = Ictalurus punctatus (channel catfish) jqu = japanese quail Lst = Lymnaea stagnalis (pond snail) Mdo = Musca domestica (house fly) Mem = Mercenaria mercenaria (northern quahog) mon = monkey mou = mouse Mse = Manduca sexta (tobacco hornworm) Mto = Microgadus tomcod Ola = Oryzias latipes (medaka), teleost fish Ota = Opsanus tau (toadfish) pig = pig pla = Pleuronectes platessa (plaice) Pog = Poephila guttata (zebra finch) Ppx = Papilio polyxenes (black swallowtail butterfly) rab = rabbit rat = rat Rcu = Romanomermis culicivorax (nematode) Sch = Stenotomus chrysops (scup) she = sheep Sqa = Squalus acanthias (spiny dogfish shark) Tni = Tilapia nilotica tro = trout
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