Accession numbers for animal P450 sequences. Families CYP7 through CYP51

Compiled by David R. Nelson [Nelson et al. (1996) Pharmacogenetics 6, 1-42]

Updated by Kirill Degtyarenko

Last modified: Thu Apr 15 16:58:10 BST 2004

For a list of corresponding EC numbers, click here.

Unidentified sequences

Species abbreviations

P450 enzymes constitute a superfamily of haem-thiolate proteins, widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds. Usually, they act as terminal oxidases in multicomponent electron transfer chains, called here P450-containing monooxygenase systems.

 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   
CYP7A1    hum  S29818  JH0659  P22680  X56088  M89803  M93133  L07951  1908212A
                                       L04629  L04630  L04631  L04632 
                                       L04633  L04634  M89647         
                                       L20569  L20570 
          rat  A35376          P18125  J05460  J05509  M59184  M59185 
                                       M59186  M59187  M59188  M59189 
                                       J02926  J05430  X17595  Z14108 
                                       Z18860  U01962                 
          rab                  P51542  L10754  S67315                 
          ham  S39399          P46634  L04690                         
Cyp7a-1   mou  A54779                  L23754                          

CYP7B1    rat                  Q63688  U36992                          2205302A
Cyp7b-1   mou                  Q60991  U36993                          2205302B

CYP8      bov  JC2350  A53658  Q29626  L34208  D30718  S67757          2017321A
               PC2016                                                  2018151A
          hum  JC2231          Q16647  D38145  S70440  D83402          2012205A
                                       D83393  D83394  D83395  D83396
                                       D83397  D83398  D83399  D83400
                                       D83401  U88977
          rat                  Q62969  U53855

CYP9A1    Hvi                          U23506

CYP9B1    Dme                  Q24122  U34324
CYP9B2    Dme                  Q24123  U34325

CYP9C1    Dme                  Q24124  U34326

CYP10     Lst  JX0225          P48416  S46130                          1817288A

CYP11A1   hum  A25922  S08081  P05108  D00161  D00162  D00163  D00164  1204185A
               S16716                  D00165  D00166  D00167  D00168  1305284A
                                       D00169  M14565  M60421          1301351A
                                       X05367  X05368  X05369  X05370 
                                       X05371  X05372  X05373  X05374 
                               Q16805  M28253
                               Q15081  X14257
          rat  A27321  A34164  P14137  M63125  M63126  M63127  M63128  1313255A
               A23688                  M63129  M63130  M63131  M63132  1602215A
                                       M63133  J05156  M22615          1703304A
          rab  A49189          Q28827  S59219                         
          bov  A00189  S04947  P00189  K02130  M25920  M25921          1009264A
                               Q28152  J05245
          pig  S03188  PN0018  P10612  X13768                         
          she                  P79202  D50057  S65754
          got                  P79153  D50058
          chi  S11144                                                  1616432A
                               O13254  D49803
          tro  S32197          Q07217  S57305                          1912185A
          Dam                  Q92045  U63299
Cyp11a-1  mou                          J05511                         

CYP11B1   hum  A34181  S11338  P15538  M24667  X55764  X55765          1602198A
                                       M32863  M32878  M32879  D10169  1614284A
                                       D16153  D16154  D16155         
          bab                  Q29527  U52081  U52082  U52083  U52084
          rat  B34281          P15393  X15431  S58858  D10107  S63899  1515238A
                                       D14086  D14087  D14088  D14089  1909237A
                                       D14090  D14091                  1909237B
          gpi                  Q64408  Z69785
          bov  A28415  B28860  P15150  D00185  D00186  D00361          1311298A
               JX0050  JX0071  Q29457  D00449  D00450  D00451  D00452  1508213A
               S15805  A38819          D00453  D00454  D00455  D00456  1705242A
                                       D00457                          1414286A
                                       M17843  M17844  M36535         
          ham                  P97720  S82228
          pig                  Q29552  D38590
          she                  P51663  L34337  L47569                  2105192A
Cyp11b-1  mou  B41552          P15539  J04451                         

CYP11B2   hum  JX0151  B34181  P19099  X54741  M32864  M32880  M32881  1602198B
               A37088                  S78399  S78400  D10170          1702153A
                               Q16726  D13752
          rat  A35342  B35342  P30099  D00567  S58859  S64136          1918169A
               S09736                  D14092  D14093  D14094  D14095  1609125A
                                       D14096  D14097                 
          ham                  Q64658  S73810  U71280
          fro                  Q92104  D10984                          2110250A
Cyp11b-2  mou  A41552          Q64661  S85260

CYP11B3   rat  A34281  S09736  P30100  D14098  D14099  D14100  D14101 
               B35342  JX0253          D14102  D14103  D00568  X52766 
                               Q64546  U17082                          2105269A
                                       U14907                          2202323A
CYP11B4   bov  cf.CYP11B1, different flanking regions                 

CYP11B5P  bov                                                   
CYP11B6P  bov                                                   
CYP11B7P  bov                          D00458  D00459                 
CYP11B8P  rat                          D14104  D14105  D14106  D14107

CYP13A1   Cel                  Q27520  Z48717
CYP13A2   Cel                  Q27518  Z48717
CYP13A3   Cel                  Q27517  Z48717
CYP13A4   Cel                  Q27513  Z48717
CYP13A5   Cel                  Q27514  Z48717
CYP13A6   Cel                  Q27515  Z48717
CYP13A7   Cel                  Q27519  Z48717
CYP13A8   Cel                  Q27516  Z48717
CYP13A9P  Cel                          Z48717
CYP13A10  Cel                  Q09653  Z46934

CYP14A1   Cel                  Q27506  Z50742
CYP14A2   Cel                  Q27505  Z50742
CYP14A3   Cel                  Q27507  Z50742
CYP14A4   Cel                  Q27510  Z70212
CYP14A?   Cel                  Q27508  Z50742
CYP14A?   Cel                  Q27531  U64847
CYP14?    Cel                          Z83121
CYP14?    Cel                  O02627  U97008
CYP14?    Cel                  O02628  U97008
CYP14?    Cel                  O02651  Z81127

CYP16A1   Cel                  Q27491  Z54269

CYP17A1   hum  A29587  A26366  P05093  M14564  M19489  M63871          1302320A
               A40908  A40921          M31146  M31147  M31148  M31149  1313220A
                                       M31150  M31151  M31152  M31153 
                                       Z19875  Z20209  S85459  S51705 
          rat  A27659  A30828  P11715  M21208  M22204  M27282  M31681  1502195A
               A33980  S16719          X14086  Z11902  S40343          1409199A
          ham                  P70687  U66494
          gpi  D28860          Q64410  X82878  S75277                  2104182A
          bov  S04346  A26289  P05185  M12547                          1203301A
          hor                  Q95328  D88184
                               Q29483  D30688
          she                  Q29497  L40335
          tro  S21125          P30437  X65800                          1809207A
          Ola                  P70085  D87121
                               P70086  D87122
          pig  B26366  S22339  P19100  M63507  Z11854  Z11855  Z11856  1809168A
                                       S40340  S40341  S40342          1816175A
                                       U41519  U41520  U41521  U41522
                                       U41523  U41524  U41525
          chi  JT0318          P12394  M21406                          1409257A
          Sqa                  Q92113  S77384                          2118305A

Cyp17a-1  mou  A39072          P27786  M64863  S41708                  1711346A
CYP17A2   bov                          X59613                         

CYP18     Dme                  Q95078  U44753
                               Q27767  S66112

CYP19     bov                  P46194  S66248  Z32741 e18447           1924225A
          hum  S03962  A31255  P11511  J04127  J05105  M28420  S52034  1310327A
               A31580  A29480          M30795  M30796  M30797  M30798  1501399A
               A23546  A34451          M30799  M30800  M30801  M30802  1507200A
               A24344  D24344          M30803  M30804  M74714  X55983  1516307A
               B24344  E24344          Y07508  M18856  X13589  S52789  1922320A
               C24344  S22908          S52793  S52794  D14473          1922320B
               A40142                  D29757  D21240  D21241  D13391  1922320C
                                       L21982  S58866  S67203  S67206  1922320D
                                       S67207  S67210  S67214  S85075  1922320E
                                       S96437  S41951  M32245  S71536
                               Q16731  M22246
                               Q16449  S85356
          rab                  Q29605  Z68271 
                               Q28684  Z70302
          rat  A36121  S16901  P22443  M33986  Z11815  S59505
          hor                  Q28373  U37313
          pig                  Q29624  L15471                          2122348A
                                       U37309  U37310  U37311  U37312  2122348B
                               P79286  U52141                          2210279A

                                       U57511  U57512  U57513  U57514 
                                       U57515  U57516  U57510
                               P79430  U57517  U57518  U57519  U52142

                               P79304  U57522  U57520  U57521

                               O02847  U92245  U92246

          chi  A31916          P19098  J04047                          1414320A
                               Q03737  M73277  M73278  M73279  M73280 
                                       M73281  M73282  M73283  M73284 
                                       M73286  M73287  M73288  M73289 
                                       M73290  M73291  M73292  M73293 
                                       M73295  M73296  M73297  M73298 
                                       M73299  M73300  M73301  M73302 
          jqu                  Q92150  S46949 
                               P79699  D50336
          Pog                  Q92112  S75898                         
          tro                                                          1806325A
          Ipu                  Q92111  S75715                          2017254A
          Ola                  Q92087  D82968  D82969 
          Tni                  P70091  U72071
          gol                  P79690  U18974

Cyp19     mou  S13912          P28649  D00659                          1707124A

CYP19P    bov                          Z32813

CYP21A1   bov  A00192  A24101  P00191  K01333  M11267  M12918  M13461  1207187A
               A27555  A21181          M13545                          1207312A
               C28860                                                  1204233A
          pig  A32525          P15540  M83939                          1306214A
          she  A43349                  M92836  M92837                  1818301A
Cyp21a-1  mou  A00193  A26660  P03940  K03234  M64933  M73820  M15009  1108302A
CYP21A1P  hum  A21889  A25446  P08686  M12793  M12792  M26857          1513491A
               A27865  A32715          M25813  M13936  S38953         
                               Q16746  X58898
                               Q16747  X58899
                               Q16874  X58900  X58902  X58901  X58903 
                               Q16748  X58904
                                       X58905  X58906 
                               Q93071  X58907 
                               Q16755  X58908 

CYP21A2   hum  A00191          P04033  K02771  M25813 
                               Q16806  M17252 
                               Q01204  M26856 
                                       X54940  S38953  M19711 
                                       X58901  X58902  X58904  X58905 
                                       X58906  X58907  X58908         
Cyp21a-2p mou                          K03234  M15008

CYP21A3   pig                  Q02390  M83939                         

CYP21B    hum                  Q16741  M31022  M23224  M21544  M21545
                                       M21546  M23225  M21547  M21548
                                       M21549  M21550
                               Q16742  M28548

CYP22A1   Cel                  Q27523  U39648

CYP23A1   Cel                  Q27465  U39472

CYP24     hum  A47436          Q07973  L13286  S67623
          rat  A45228          Q09128  L04608  L04609  L04610  L04611 
                                       L04612  L04613  L04614  L04615 
                                       L04616  L04617  L04618  L04619 
                                       X59506  Z28351  D17792  U03112 
Cyp24     mou                  Q64441  D49438

CYP25A1   Cel                  Q27476  Z66495
CYP25A2   Cel                  Q27477  Z66495
CYP25A3   Cel                  Q27478  Z66495
CYP25A4   Cel                  Q27479  Z66495

CYP25?    Cel                  Q21262  U50072

CYP27     hum  A39740          Q02318  M62401  S62709  X59812 
          rat  A36239  S09198  P17178  M38566  Y07534                  1702186A
               A33406                  U17363  U17369  U17370  U17371
                                       U17372  U17373  U17374  U17375
          rab  A30293  A33813  P17177  J04717                          1508224A

CYP29A1   Cel                  Q27480  Z69787
CYP29A2   Cel                          Z74040

CYP30     Mem                         

CYP31A1   Cel                  Q27466  Z68213
CYP31A2   Cel                          Z68336

CYP32     Cel                  Q27472  U53148

CYP33A1   Cel                  Q27470  U55365

CYP33B1   Cel                  Q27471  U50311

CYP33E1   Cel                  Q27482  U61945
CYP33E2   Cel                  Q27499  U61952
CYP33E3P  Cel                  Q20315  U61952

CYP33?    Cel                  O02641  AF003385

CYP35C1   Cel                          Z77652

CYP35D1   Cel                          Z83105

CYP36A1   Cel                  O02645  Z83220

CYP51     hum                  Q16784  U23942  D55653
                               Q99868  U51684  U51685  U51686  U51687
                                       U51688  U51689  U51690  U51691
          rat  JC2334          Q64654  D55681  U17697

CYP51P1   hum                          U36926
CYP51P2   hum                          U40053
CYP51P    rat                          D78370  D87997

Unidentified sequences

 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   
          hum  S14367                                                
          hum  S08282 (2C like or 2A like)                           
          rat  S09073                                                
CYP2?P    rab                          M12280  M12281  M12282  M12283 
                                       M12284  M12285  M12286  M12287 
          pig  S11471                                                
          pig  S15850                                                
          Cel                          M88882                         
          Cel                  Q09660  U21321
          chi  S10680                                                
          chi  S10681  S13263                                        
          chi  S10682                                                
          Dre                          U68234

We use combined listing of GenBank, EMBL and DDBJ accession numbers because they use common numbering.

Some sequences can be identified from N-terminal sequences as belonging to a subfamily. These have been included in the listing of the subfamily even though it is premature to assign a specific number to these sequences.

Pfam family: PF00067

Species abbreviations

Aal = Anopheles albimanus (mosquito)
bab = baboon (Papio species)
Bld = Blaberus discoidalis (cockroach)
bov = bovine
Cel = Caenorhabditis elegans (nematode worm)
Chc = Chaetodon capistratus
chi = chicken
Dam = Dasyatis americana (southern stingray)
Dme = Drosophila melanogaster (fruit fly)
dog = dog
Dre = Danio rerio (zebrafish)
fro = bullfrog (Rana catesbeiana)
gol = goldfish
got = goat
gpi = guinea pig
ham = hamster
Har = Helicoverpa armigera
hor = horse
hum = human
Hvi = Heliothis virescens
Ipu = Ictalurus punctatus (channel catfish)
jqu = japanese quail
Lst = Lymnaea stagnalis (pond snail)
Mdo = Musca domestica (house fly)
Mem = Mercenaria mercenaria (northern quahog)
mon = monkey
mou = mouse
Mse = Manduca sexta (tobacco hornworm)
Mto = Microgadus tomcod
Ola = Oryzias latipes (medaka), teleost fish
Ota = Opsanus tau (toadfish)
pig = pig
pla = Pleuronectes platessa (plaice)
Pog = Poephila guttata (zebra finch)
Ppx = Papilio polyxenes (black swallowtail butterfly)
rab = rabbit
rat = rat
Rcu = Romanomermis culicivorax (nematode)
Sch = Stenotomus chrysops (scup)
she = sheep
Sqa = Squalus acanthias (spiny dogfish shark)
Tni = Tilapia nilotica
tro = trout

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