Last modified: Thu Apr 15 16:55:12 BST 2004
Updated by Kirill Degtyarenko
Last modified: Thu Apr 15 16:55:12 BST 2004
For a list of corresponding EC numbers, click here.
P450 enzymes constitute a superfamily of haem-thiolate proteins, widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds. Usually, they act as terminal oxidases in multicomponent electron transfer chains, called here P450-containing monooxygenase systems.
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
CYP3A1 rat A22631 P04800 M10161 X62086 D13912 1107256A
S39797 D29967 L24207 2002214A
Q64580 X64401
Q64590 M28452
CYP3A2 rat A25222 P05183 M13646 X62087 M74443 1208360A
U09725 U09726 U09727 U09728
U09729 U09730 U09731 U09732
U09733 U09734 X79319 X79320
CYP3A1 or 3A2 B26997 A26997 M86850
C26997
CYP3A3 hum A25170 A29410 P05184 D00003 M13785 X12387 1208395A
2108280A
CYP3A4 hum A25517 A29815 P08684 M14096 M18907 X12387 D11131 1212387A
A32199 S16900 Q16757 J04449 1404264A
S03851
CYP3A5 hum S06491 A34101 P20815 J04813 L35912 1510260A
1602106A
CYP3A5P hum L26985
CYP3A6 rab A29487 A34236 P11707 M19139 U40569 1403281A
Q29506 J05034 1515287A
CYP3A7 hum S04983 S02152 P24462 D00408 1504252A
JX0062
CYP3A8 mon S28168 P33268 S53047 1905232C
S04509 P25231
CYP3A9 rat P51538 U60085
Q64557 U46118
CYP3A10 ham A40843 M73992 S79317
Cyp3a-11 mou S22334 Q64459 X60452 D28565 1813172A
CYP3A12 dog S14275 P24463 X54915 1707145A
Cyp3a-13 mou S18155 Q64464 X63023 2105184A
CYP3A14 gpi Q64417 D16363
Q64407 D49731
CYP3A15 gpi Q64406 D26487
Cyp3a-16 mou Q64481 D26137 2104197A
CYP3A17 gpi Q64409 D28515
CYP3A18 rat S47471 Q64581 X79991 2106148A
CYP3A19 got P79152 X76503
CYP3A23 rat JX0334 Q06884 X96721 2015293A
CYP3A24 she A60728 Q29496 U59378
CYP3A25 mou O09158 Y11995
CYP3A29 pig P79401 Z93099
CYP3A pig Q29598 F14604
CYP3A rat PX0033
CYP3A bab S21176 P80056
CYP3A bov P79102 Y10214
CYP4A1 rat S01336 B32965 P08516 M14972 M33937 M57718 X07259 1516169A
CYP4A2 rat A32965 P20816 M33938 M57719 1516169B
CYP4A3 rat A27700 A32966 P20817 M33936 1516170A
CYP4A2 or 4A3 A26380 S09074
CYP4A4 rab A29368 P10611 J02818 1908184A
Q02927 L04758
CYP4A5 rab A34260 S14761 P14579 M28655 X57209 1709201A
CYP4A6 rab B34260 A34160 P14580 M28656 M29531 L04755 1602211A
CYP4A7 rab C34260 B34160 P14581 J05150 M29530 M28657 1602211B
CYP4A8 rat A36304 P24464 M37828 1701272A
CYP4A9 hum
Cyp4a-10 mou S35608 Q06772 X69296 X71478 2017209A
CYP4A11 hum S29845 S35609 Q02928 L04751 S67580 D26481 1908216A
Q16802 D13705 S67581 2003235A
Q06766 X71480
Cyp4a-12 mou S35610 Q06767 X71479
CYP4A13 gpi S32714 S35611 Q06768 X71481
Cyp4a-14 mou Y11638 Y11639 Y11640 Y11641
Y11642
CYP4A rab PQ0048
CYP4A cat O02845 U91787
Cyp4a mou Y10221 Y10222
CYP4B1 hum S07765 P13584 J02871 X16699 1515193A
1605167A
rat PQ0092 B40164 P15129 M29853 1509332B
rab A40164 P15128 M29852 1509332A
Cyp4b-1 mou D50834 2119162A
CYP4C1 Bld A39381 P29981 M63798 1711468A
CYP4C2 Aal PC2257 Q16903 L38678 2102220A
CYP4C3 Dme Q24121 U34323
CYP4C8 Mda P91762 U77126
CYP4C? Cel Z74043
CYP4D1 Dme S25707 P33269 X67645 1814309A
CYP4D2 Dme S41192 S34291 Q27588 Z23005 2015216A
Q27589 X75955
CYP4D5 Aal PC2270 Q16904 L38679
CYP4D6 Aal PC2271 Q16905 L38680
CYP4D7 Aal PC2272 Q16906 L38681
CYP4D8 Dme Q24127 U34329
CYP4E1 Dme K00045
CYP4E2 Dme Q27606 U56957
Q24291 X86076
Q24130 U34332
CYP4E3 Dme Q24128 U34330
CYP4E4 Dme Q24129 U34331
CYP4F1 rat S29723 P33274 M94548 S53039 1907136A
CYP4F2 hum Q16677 U02388
P78329 D26480
CYP4F3 hum A46661 Q08477 D12620 D12621 S63604 1914182A
CYP4F4 rat P51869 U39206 2205230A
CYP4F5 rat P51870 U39207 2205230B
CYP4F6 rat P51871 U39208 2205230C
CYP4G1 Dme Q24126 U34328
CYP4H1 Aal PC2261 Q16907 L38682
CYP4H2 Aal PC2262 Q16908 L38683
CYP4H3 Aal PC2263 Q16909 L38684
CYP4H4 Aal PC2264 Q16910 L38685
CYP4H5 Aal PC2265 Q16911 L38686
CYP4H6 Aal PC2266 Q16912 L38687
CYP4H7 Aal PC2267 Q16913 L38688
CYP4H8 Aal PC2268 Q16914 L38689
CYP4H9 Aal PC2269 Q16915 L38690
CYP4J1 Aal PC2258 Q16916 L38691
CYP4J2 Aal PC2259 Q16917 L38692
CYP4J3 Aal PC2260 Q16918 L38693
CYP4K1 Aal PC2273 Q16919 L38694
CYP4L1 Mse Q25505 L38668 2119160A
CYP4L2 Mse Q25506 L38669 2119160B
CYP4M1 Mse Q25507 L38670 2119160C
CYP4M2 Mse Q25508 L38671
CYP4M3 Mse Q25509 L38672
CYP4P1 Dme Q24125 U34327
CYP4T1 tro P79835 U82983
CYP4(EST) Cel M89401
CYP4(EST) Cel M80176
CYP5A1 hum A41766 S10750 P24557 M74055 M80646 M80647 S60133 1715147A
Q16844 D34613 D34614 D34615 D34616 1805282A
D34617 D34618 D34619 D34620 1805282B
D34621 D34622 D34623 D34624 2019278A
D34625 S51388 U88978
rat S42404 P49430 D28773 S69335 2007255A
pig P47787 L13128 2008200A
Cyp5a-1 mou JN0683 P36423 L18868 1919229A
U41326 U41327 U41328 U41329
U41330 U41331 U41332 U41333
U41334 U41335 U41336 U41337
U41397
CYP6A1 Mdo A32157 P13527 M25367 1505396A
Q27703 L27241 L27242 2019323A
CYP6A2 Dme A45378 A47198 P33270 M88009 S51248 S81983 1812334A
P91669 U78088
CYP6A3 Mdo Q27691 U09231
CYP6A4 Mdo Q27692 U09232
CYP6A5 Mdo Q27694 U09343
CYP6A6 Mdo Q27695 U09344
CYP6A Dme Q27592 L46858
CYP6A8 Dme Q27593 L46859
CYP6A9 Dme Q27594 L46860
Dgr O01648 U87164
CYP6A? Cca P90730 U78795
CYP6B1v1 Ppx A46367 Q04552 M80828 1902339A
2011165A
CYP6B1v2 Ppx Q04552 M83117 2011165B
CYP6B1v3 Ppx Q27878 Z29624 U05037 2018305A
CYP6B2 Har Q27664 U18085 2202248A
CYP6B3v1 Ppx Q27756 U25819
CYP6B3v2 Ppx Q95038 U65488
CYP6B4v1 Ptg Q27902 U47059
CYP6B4v2 Ptg Q95035 U65489
CYP6B5v1 Ptg Q95036 U65490
CYP6B Har Q95031 U64800
CYP6C1 Mdo Q27693 U09233
CYP6C2 Mdo Q27696 U09345
CYP6D1 Mdo Q27697 U15168 2111312A
Q27698 U22362
Q27699 U22366
Q27700 U22367
We use combined listing of GenBank, EMBL and DDBJ accession numbers because they use common numbering.
Some sequences can be identified from N-terminal sequences as belonging to a subfamily. These have been included in the listing of the subfamily even though it is premature to assign a specific number to these sequences.
Aal = Anopheles albimanus (mosquito) bab = baboon (Papio species) Bld = Blaberus discoidalis (cockroach) bov = bovine cat = cat (Felis catus) Cca = Ceratitis capitata (Mediterranean fruit fly) Cel = Caenorhabditis elegans (nematode worm) Chc = Chaetodon capistratus chi = chicken Dgr = Drosophila grimshawi (Hawaiian picture-winged Drosophila) Dme = Drosophila melanogaster (fruit fly) dog = dog fro = bullfrog (Rana catesbeiana) gol = goldfish got = goat gpi = guinea pig ham = hamster Har = Helicoverpa armigera hor = horse hum = human Hvi = Heliothis virescens Ipu = Ictalurus punctatus (channel catfish) jqu = japanese quail Lst = Lymnaea stagnalis (pond snail) Mda = Mastotermes darwiniensis (Australian termite) Mdo = Musca domestica (house fly) mon = monkey mou = mouse Mse = Manduca sexta (tobacco hornworm) Mto = Microgadus tomcod Ota = Opsanus tau (toadfish) pig = pig pla = Pleuronectes platessa (plaice) Ppx = Papilio polyxenes (black swallowtail butterfly) Ptg = Pterourus glaucus rab = rabbit rat = rat Rcu = Romanomermis culicivorax (nematode) Sch = Stenotomus chrysops (scup) she = sheep tro = trout
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