Accession numbers for animal P450 sequences. Family CYP2

Compiled by David R. Nelson [Nelson et al. (1996) Pharmacogenetics 6, 1-42]

Updated by Kirill Degtyarenko

Last modified: Thu Apr 15 16:54:23 BST 2004

For a list of corresponding EC numbers, click here.


Species abbreviations

P450 enzymes constitute a superfamily of haem-thiolate proteins, widely distributed in bacteria, fungi, plants and animals. The enzymes are involved in metabolism of a plethora of both exogenous and endogenous compounds. Usually, they act as terminal oxidases in multicomponent electron transfer chains, called here P450-containing monooxygenase systems.

 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   
CYP2A1    rat  A29560  A34272  P11711  J02669  M33312                  1604168A
CYP2A2    rat  A31887  S03982  P15149  J04187  M33313  M33325  M34392  1604168B
CYP2A3    rat  S15056  A32030  P20812  M33190  J02852                  1507164A
Cyp2a-4   mou  A33531  S16067  P15392  M25146  M25147  M26202  M26203  1405272A
               S16068  S03979          M26205  M26206  M26207  M26208 
                                       J03549  M19319                 
Cyp2a-5   mou  B33531          P20852  M26204  M25205  M25206  M25207 
                                       M25208  M25209  M25210  M25211 
CYP2A6    hum  A00190  S05946  P11509  K03192  M33316  M33318  X06401  1604167A
               A34271  B34271  Q16803  X13929  X13897  X13930          1609083A
               S04698                                                  1511124A
CYP2A6v2  hum                  Q13120  U22027
CYP2A7    hum  C34271          P20853  M33317                          1604167B
                               Q13121  U22029
CYP2A7P   hum                          U22030
CYP2A8    ham  S13884  A33293  P24454  M27906  M34446  M34447  M63788  1511056A
               PX0037                                                  1705176A
CYP2A9    ham                  P24455  M34448  M63789                  1705176B
CYP2A10   rab                  Q05555  L10236                          1920322A
CYP2A11   rab                  Q05556  L10237                          1920322B
Cyp2a-12  mou  S32491                  L06463                          1912175A
CYP2A13   hum                  Q16696  U22028
CYP2A     bov  A35704          P22779                                 
CYP2A     mon                                                          1905232B
CYP2B1    rat  A00176  S03854  P00176  M11251  L00313  L00314  L00315  0805305A
               A22363  S19172          L00316  L00317  L00318  L00319  0904267A
                                       L00320  D00250  M19972  M21412  0904321A
                                       M26854  M26855  M37134          1108237A
                                       J00719  J00720  J00721  J00722 
                                       J00723  J00724  J00725  J00726 
                                       J00727  J00728 
CYP2B2    rat  A00177  A21872  P04167  J00720  J00721  J00722  J00723  0907261A
               S15589  B00176          J00724  J00725  J00726  J00727  0910215A
               S03855  A32736          J00728  K00996  K01626  S51970  1002217A
               A21162                  K01721  K02427  K02428  M13234 
                                       M15947  M19972  M27076 
                                       Y00410  M21403  M13650
                               Q64579  M34452
                               Q03738  M26853
CYP2B1 or 2B2  A34259                                                
CYP2B3    rat  A25459  A29818  P13107  M20406  M19973  U16209  U16210  1407136A
                                       U16211  U16212  U16213  U16214 
CYP2B4    rab  A00178  A00179  P00178  M20856  M20857                  0911310A
               B27717  C27717                                          0905212A
               E27717                                                  0901269A
                               Q29532  S64259
                               Q29515  L10912
CYP2B5    rab  D27717  A27717  P12789  M20855                 
                               Q29516  M18820
CYP2B6    hum  S04578  A32969  P20813  J02864  M29874  X06399  X06400  1601463A
               S07598  S04579          X13494                          1515189A
                               Q14096  X16864
CYP2B7P   hum                  Q14097  M29873  J02864 
CYP2B8    rat                          J04808                         
Cyp2b-9   mou  A31047          P12790  M21855                         
Cyp2b-10  mou  B31047          P12791  M21856
                               Q62397  U48732
 + CPR                                 X99715

CYP2B11   dog  S11305          P24460  M33575  M92447                  1614241A
CYP2B12   rat  S27160          P33272  X63545  S48369  X63545          1901199A
Cyp2b-13  mou                          K02409                         
CYP2B14P  rat                          U33540                         
CYP2B15   rat                  Q63140  D17343                          2004298A
                               Q62802  D17344
                               Q64583  D17345  D17346  D17347  D17348 
CYP2B16P  rat                          U33541  U33542  U33543  U33544
                                       U33545  U33546
CYP2B     gpi  A36154  S15135                                        
CYP2C1    rab  A00181  A34257  P00180  K01522  M76597                  1002188A
                               Q00172  M74199
                               Q29509  D26152
CYP2C2    rab  A00182  A27718  P00181  K01521  M14955  M19137  M76596  1002188B
               S15587                                                  1403251A
CYP2C3    rab  A00183  A22606  Q29525  M31245  M31246  M31247  M31248  1002188C
               A34534                  M31249  M31250  M31251  M31252  1106190A
                                       M31253  M31254 
                               P00182  K01523  J02901
CYP2C4    rab  A26731  B34257  P11371  M74200  M74201  M74202  M74203  1306327A
CYP2C5    rab  A00180  A37828  P00179  J05575  M11299                  1111272A
               S20227                  M74204  M74205  M74206          1614312A
                               Q29507  M17026
                               Q29511  M55664
CYP2C6    rat  A25954  B25585  P05178  J04466  K03501  M13711  M18336  1209242A
               A28516  S00955  Q64614  M24237  M24238  M24239          1302146B
                                       M36848  X06712  M14776         
CYP2C7    rat  B28516          P05179  M14775  M18774  M31031  M18335  1209242B
CYP2C8    hum  A29782  S06306  P10632  J03472  M17397  M17398  M21941  1314226A
               E28951  C28951          X51535  X54807  M21942          1412182A
               S12688  S21423                                          1412182B
                               Q16743  X65962
CYP2C9    hum  A28530  S06863  P11712  J05326  M21940                  1819194A
               C38462  B38462          M61855  M61857                  1313295A
               A28951  B28951          L16877  L16878  L16879  L16880  1402324A
                                       L16881  L16882  L16883          1709170A
                               Q16872  S46963
                               Q16756  D00173
CYP2C10   hum  D28951  A27541  P11713  J02832  M15331  M21939          1304180A
CYP2C11   rat  A26685          P08683  J02657  X79081                  1402198A
                                       M18356  M18357  M18358  M18359  1303289A
                                       M18360  M18361  M18362  M18363 
CYP2C12   rat  A32140          P11510  J03786                          1409383A
                               Q64648  M33544  M33545  M33546  M33547  1605163A
                                       M33548  M33549  M33656  M33550 
CYP2C13   rat  A32470  A36122  P20814  J02861  J05352  M32277  M33994  1511061A
               S15586          Q64587  M82846  M82848  M82849  M82850  1604157A
                                       M82851  M82852  M82853  M82854 
                                       M82855  M81311  X79810         
CYP2C14   rab  A26921          P17666  D00190  D00191                  1306317A
CYP2C15   rab  B27718          P11372  M19234                         
CYP2C16   rab  S12765  A27479  P15123  M18376  M29968  M29661         
CYP2C17   hum  G38462          P33259  M61858  L07093
CYP2C18   hum  D38462  E38462  P33260  M61853                          1801333A
                               Q16751  M61856
                               Q16703  L16869  L16870  L16871  L16872 
                                       L16873  L16874  L16875  L16876 
                                       S63421  S63424  S63426  X54808 
CYP2C19   hum  F38462          P33261  M61854  L31506  L31507         
CYP2C20   mon  S28166          P33262  S53046                          1905232A
CYP2C21   dog  A37222                                                  1703408A
CYP2C22   rat  A39257  S11160  P19225  M58041  X53477                  1703477A
CYP2C23   rat  S13101          P24470  X55446                          1704329A
                               Q64534  U04733
                               P97716  S80125
CYP2C24   rat  JH0451          P33273  M86677  M86678                  1718168A
                               Q63853  S59652  S59647
                               Q63854  S59652
                               Q63855  S59652
CYP2C25   ham                  Q08078  X63022                          2009386A
CYP2C26   ham                  P33263  D11435                         
CYP2C27   ham                  P33264  D11436                         
CYP2C28   ham                  P33265  D11437                          2112203A
Cyp2c-29  mou                  Q64458  D17674                          2009209A
CYP2C30   rab                  Q29510  D26153
CYP2C31   got  JC2199          Q29478  X76502                          2010191A
CYP2C32   pig                  Q28971  U35733
CYP2C33v1 pig                  Q28972  U35837                          2117161A
CYP2C33v2 pig                  Q28973  U35838
CYP2C33v3 pig                  Q28974  U35839
CYP2C34v1 pig                  Q28975  U35840                          2117161B
CYP2C34v2 pig                  Q28976  U35841
CYP2C34v3 pig                  Q28977  U35842
CYP2C34v4 pig                  Q28978  U35843
CYP2C35   pig                  Q28979  U35844
CYP2C36   pig                  Q28980  U35845
CYP2C42   pig                  P79402  Z93098
CYP2C42P1 pig                          Z93100
CYP2C     hum                  Q16750  X56452
CYP2C     pig                  Q29565  F14781
CYP2C     rat  B60822
CYP2C     dog  A60465
CYP2C     hor  PN0659
Cyp2c     mou  A23739

CYP2D1    rat  A31579  A26822  P10633  J02867  M16654  M22328          1306261A
CYP2D2    rat  C31579  B26822  P10634  M16655  M22330  X52027  X52455  1306261B
               S16871                                                  1414200B
CYP2D3    rat  E32970  S16872  P12938  J02868  X52028  X52456          1701403B
CYP2D4    rat  D31579  S16873  P13108  M22331  X52029  X52457          1414200D
CYP2D5    rat  B31579  S09611  P12939  J02869  M22329  M25143  X52030  1414200C
               S16874                  X52458                          1701403D
CYP2D6    hum  A30335  S01199  P10635  M19697  M20403                  1506410A
               A33629                  X07618  X07619  X07620  X08006 
                                       X16865  X16866  X16867  Y00300 
                               Q16752  M33388
                               Q16804  M24499
                               Q16753  M33189
CYP2D7P   hum                          M33387  X58467                 
CYP2D8P   hum                          M33387  X58468                 
Cyp2d-9   mou  A27384  B27384  P11714  M23998  M23997  M24262  M24267  1403249A
               S15806          Q64529  U20087  U26265                  2116358B
                               Q64489  M27168                          2116358C
Cyp2d-10  mou  A30247  S19168  P24456  M24263                          1509206A
                               Q64530  U20088
                               Q64490  M27167
Cyp2d-11  mou  S19169          P24457  M24264
Cyp2d-12  mou                                                         
Cyp2d-13  mou                                                         
CYP2D14   bov  S29295  S37284  Q01361  X68013  S45538                  1819257A
                               Q29454  X68481
CYP2D15   dog                          D17397                          2114248A
CYP2D16   gpi                  Q64403  U21486                          2111231A
CYP2D17   mon                  Q29488  U38218
CYP2D18   rat                  Q64680  U48219  U48220                  2110198A
CYP2D     rat  A28702

CYP2E1    hum  A31949          P05181  D10014  J02625  J02843  M77918  1301294B
                               Q16868  S77873
          mon  S28167          P33266  S55205                         
          rat  A28145  A25341  P05182  J02627  M20131  S48325          1301294A
               S09072                                                  1911515A
          rab  A26579  A27750  P08682  M15061  M18770  M19235          1303357A
          ham  S27176          P51581  D17449                          2007232A
          pig                  P79383
Cyp2e-1   mou  S18037  S19657  Q05421  X62595  L11650                  1919337A
CYP2E2    rab  B27750  B27680          M18771                          1407213A
                                       M21351  M21349  M21350  M21358 
                                       M21359  M21360  M21361  M21362 
                               Q29508  M21364  M21365  M21366  M21367 
                                       M21368  M21369  M21370  M21371 

CYP2F1    hum  A36036  B36036  P24903  J02906                          1611209A
Cyp2f-2   mou  A39302          P33267  M77497                          1802218A

CYP2G1    rat  A35551          P10610  M31923  M31924  M31925  M31926  1604337A
                                       M31927  M31928  M31929  M31930  1507263A
                                       M31931  M33296  M34444         
          rab  S13907  B31944  P24461                                  1706166A

CYP2H1    chi  A24814          P05180  M13454                          1208339A
CYP2H2    chi  A31418  S10683  P20678  M25469                         

CYP2J1    rab  A40938          P52786  D90405                          1717296A
CYP2J2    hum                  P51589  U37143
CYP2J3    rat                  P51590  U39943
CYP2J3P1  rat                          U40000
CYP2J3P2  rat                          U40004
CYP2J     pig                  P79316  Z84061

CYP2K1    tro  S45644                  L11528                          2015199A

CYP2L1    Paa                  Q27712  U44826

CYP2M1    tro                          U16657

CYP2Q     Xla                          D50560

CYP2(EST) Cel                          M89049                         

We use combined listing of GenBank, EMBL and DDBJ accession numbers because they use common numbering.

Some sequences can be identified from N-terminal sequences as belonging to a subfamily. These have been included in the listing of the subfamily even though it is premature to assign a specific number to these sequences.

Pfam family: PF00067

Species abbreviations

Aal = Anopheles albimanus (mosquito)
bab = baboon (Papio species)
Bld = Blaberus discoidalis (cockroach)
bov = bovine
Cel = Caenorhabditis elegans (nematode worm)
Chc = Chaetodon capistratus
chi = chicken
Dme = Drosophila melanogaster (fruit fly)
dog = dog
fro = bullfrog (Rana catesbeiana)
gol = goldfish
got = goat
gpi = guinea pig
ham = hamster
Har = Helicoverpa armigera
hor = horse
hum = human
Hvi = Heliothis virescens
Ipu = Ictalurus punctatus (channel catfish)
jqu = japanese quail
Lst = Lymnaea stagnalis (pond snail)
Mdo = Musca domestica (house fly)
mon = monkey
mou = mouse
Mse = Manduca sexta (tobacco hornworm)
Mto = Microgadus tomcod
Ota = Opsanus tau (toadfish)
Paa = Panulirus argus (spiny lobster)
pig = pig
pla = Pleuronectes platessa (plaice)
Ppx = Papilio polyxenes (black swallowtail butterfly)
rab = rabbit
rat = rat
Rcu = Romanomermis culicivorax (nematode)
Sch = Stenotomus chrysops (scup)
she = sheep
tro = trout
Xla = Xenopus laevis (african clawed frog)

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