Accession numbers for FAD-dependent pyridine nucleotide oxidoreductases

Compiled by Kirill N. Degtyarenko (kirill@icgeb.trieste.it)

last modified:

Glutathione reductases
Mercuric reductases
Dihydrolipoamide dehydrogenases
Acetoin dehydrogenases
Trypanothione reductases
Thioredoxin reductases
Alkyl hydroperoxide reductases
NADH:dehydrogenase
Hydrogen peroxide-forming NADH oxidases
(P450-specific) ferredoxin:NADH reductases
Bacterial dioxygenase system ferredoxin:NAD+ reductase component
Rubredoxin:NAD+ reductases
NADH oxidases
NADH peroxidases
NAD(P)H:nitrite reductases
NADH:monodehydroascorbate reductases
Ferric leghaemoglobin reductase
NADPH:dihydropyrimidine dehydrogenase
NADPH:glutamate synthase (NADPH-GOGAT)
NADH:glutamate synthase (NADH-GOGAT)
L-aspartate oxidase
Fumarate reductase (succinate dehydrogenase) flavoprotein subunit
Rotenone-insensitive NADH:ubiquinone oxidoreductase
NADH:flavin oxidoreductase
NADPH:flavin oxidoreductase
NAD(P)H:flavin oxidoreductase
Unknown dehydrogenase A
Heterodisulphide reductase
Flavocytochrome c sulphide dehydrogenase

Species abbreviations

The family referred here to as FAD-dependent pyridine nucleotide reductases (FADPNR) includes FAD flavoproteins belonging to the family of pyridine nucleotide-disulphide oxidoreductases (glutathione reductase, trypanothione reductase, lipoamide dehydrogenase, mercuric reductase, thioredoxin reductase, alkyl hydroperoxide reductase), iron-sulphur protein reductases involved in oxidative metabolism of a variety of hydrocarbons (rubredoxin reductase, putidaredoxin reductase, terpredoxin reductase, ferredoxin:NAD+ reductase components of benzene 1,2-dioxygenase, toluene 1,2-dioxygenase, chlorobenzene dioxygenase, biphenyl dioxygenase), NADH oxidase, NADH peroxidase, and number of other flavoproteins.


A. Pyridine nucleotide-disulphide oxidoreductases class I.


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

Glutathione reductases (EC 1.6.4.2)

GSR       hum  A00404  S08979  P00390  X15722  X54507                  0802147A
               S10730
          hum                          X91247
          mou  S39494                  X76341
          rat                          U73174
ZK637.10  Cel  S15798          P30635  Z11115
                                       Z50859

TrxR      Pfa                          X83603  X87095  U31953  U31954
                                       X93462

gor       Ath                          D14049  U37697                  2005376A
          Gma                          L11632                          2009406A
gor       Nta  S38908                  X76293  X76455  X76533
          Osa                          D78136
          pea  S18973          P27456  X60373  X90996
          Sol                          D37870
gor       Sce  S47931          P41921  L35342  D37871                  2110284A

gor       Ana                          X89712
gor       Eco  A24409  S47720  P06715  M13141  U00039                  1206219A
                                                                       2016464BL
gor       Hin                  P43783  U20229  U32702
gor       Pae  S15236          P23189  X54201                          1818355A
          Pce                          U19883
          Spi  PX0017
gor       Sth  S41386                  Z29494  L27672

Mercuric reductases (EC 1.16.1.1)

merA      Aca                          L04303
merA      Bac  E32227          P16171  M22708                          1504224A
merA      Pae  A00406          P00392  Z00027                          0909192A
merA      Pfl                          X73112                          2018208E
merA      Pse                          K00031
merA      Sau  E29504          P08663  N00048
merA      Sma  A29010          P08662  M15049  M24940
merA      Sfl  A22799          P08332  J01730  K03089                  1106182A
merA      Sli  S30168          P30341  X65467                          1906326E
merA      Tfe  JQ0153          P17239  M32353                          1604207A
merA      Xan                          L40585

Dihydrolipoamide dehydrogenases (EC 1.8.1.4)

LAD       hum  A92622          P09622  J03490  J03620  M99384          1404415A 
                                       L13748  L13749  L13750  L13751
                                       L13752  L13753  L13754  L13755
                                       L13756  L13757  L13758  L13759
                                       L13760  L13761
lad       pig  A28448  A21524  P09623  J03489
          rat  S13883
          dog                  P49819  U19872
lpd1      Sce  A30151          P09624  J03645  M20880  D44596          1404425A
          Sce                          U36624
lpd       pea  S22384  A42494  P31023  X63464  X62995                  1807160A

lpd       Azv  S00360          P18925  M37307
          Ccy  A35156
          Csp  B35156
          Eac  D35156
lpd       Eco  A00405  S45195  P00391  V01498  D26562                  2012359P
          Pgl  C35156 
lpdA      Hin                          L45865
lpd       Hvo                  Q04829  L09733                          1902192A
lpd       Pfl  A45796          P14218  M28356
lpdV      Psp  S02139          P09063  X13004
lpdG      Psp  A39406          P31052  M80189
lpd3      Psp  S19685  S15569  P31046  X55704                          1910225A
          Tbb  S30057          Q04933  X70646
          Tcr  S13863

pdhL      Aeu                          U09865                          2015283C
pdhD      Ala  D42653          P35484  M81753
pdhD      Bst  A28514  S13839  P11959  X53560
               S14231
pdhD      Bsu  E36718          P21880  M57435
pdhD      Mge                          U39706
pdhD      Sau  S19723                  X58434

Acetoin dehydrogenases (EC 1.1.1.5)

acoL      Clm                          L31844                          2014293F
acoL      Pca  A39138                  U01100  L24124                  2004329E
acoD      Kpn                          U10552

Trypanothione reductases (EC 1.6.4.8)

tpr       Cfa  S28002          P39040  Z12618  M73323  M73324  M73325  1812327A
                                                                       1904349A 
tpr       Ldo  S34376          P39050  Z23135                          2019398A
tpr       Tbb  S28003          P39051  X63188                          1904349B
tpr       Tco  A27727          P13110  M21122                          1410175A
tpr       Tcr  S30204  S24243  P28593  M38051  Z13958  M97953          1709323A

Pfam family: PF00070


B. Pyridine nucleotide-disulphide oxidoreductases class II.


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

Thioredoxin reductases (EC 1.6.4.5)

cys9      Ncr                          D45049
trxB      Pcr                  P43496  X76119                          2006317A
          Sce  S47907  A55468          U10274  U28372                  
          Spo                          U63713
          Ath  S44026  S50882          Z23108  Z23109                  2005346A
          Han                          L36129

trxB      Cbu  S43131          P39916  X75627
trxB      Cli                          U24268
trxB      Eac  S38988                  L04500                          1923264A
trxB      Eco  A28074          P09625  J03762  L21749                  1409298A
trxB      Scl                  Q05741  Z21946                          1919295A
trxB      Sco                          X92105
trxB      Hin  G64186          P43788  U32795    
trxB      Mge                  P47348  U39689
trx       Mtu                          X95798
tr/trx    Mle                  P46843  X87899  L39923                  2117405A

MIPS protein superfamily: 0123.0

Alkyl hydroperoxide reductases (EC 1.6.4.-)

ahpF      Sty  B35441          P19480  J05478                          1611316B
ahpF      Eco                  P35340  D13187

NADH:dehydrogenase (EC 1.6.99.3)

ndh       Bac  JX0166          P26829  D10701                          1712238A
ndh       Bsu                  P42974  D78193
ndh       Eco  A00461          P00393  V00306                          0706228A

Hydrogen peroxide-forming NADH oxidases (EC 1.6.-.-)

fap       Axy  A49911                  D13563                          2002285A
nox-1     Smu  JC2311                  D21803                          2020275A

MIPS protein superfamily: 0134.0

Miscellaneous

orfA      Clp  S29117          P23160  M60116

gEh-34    Enh                          X79603                          2115369A

YHR106w   Sce  S48948          P38816  U00059

C. (P450-specific) ferredoxin:NADH reductases (EC 1.18.1.-)


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

camA      Psp  JX0078          P16640  J05406  D00528  M12546          1603298A
                                                                       1603298B
                                                                       1607265A

terpA     Pse  S27654  D42971  P33009  M91440                          

forA      Ser                          L38646

thcD      Rho                  P43494  U17130

To the reductase component of three component-type P450-containing systems page ( ).


D. Bacterial dioxygenase system ferredoxin:NAD+ reductase component (EC 1.18.1.3)


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

bedA      Psp  JN0810          Q07946  L04642                          1922249D
bnzD      Psp  D29830          P08087  M17904
todA      Psp  D36516          P13452  J04996                          1513341D
tcbAd     Pse                          U15298  M61114                  

bphG      Cte                          U47638
bphG      Eco                          D90884  D90885 
bphG      Pse  F41858          P37337  M86348                          1810348F
bphG      Pps  E42409

bphA4     Pse                          D16831                          2007331B
bphA4     Rho                          D32142
bphA4     Rgl  S51760                  X80041  U27591                  2110271D

ntdAa     Pse                          U49504  U62430

cmtAa     Psp                          U24215

cumA4     Pfl                          D37828

mopA      Pce                          U29532

MIPS protein superfamily: 0189.0


E. Rubredoxin:NAD+ reductases (EC 1.18.1.1)

alkT      Pol  S09114          P17052  X52935                          1607289B
          Aca  S49922          P42454  Z46863                          2117372B
alkA      Stm                          U40234

F. NADH (per)oxidases


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

NADH oxidases (EC 1.6.-.-)

nox       Efa  S26965  A34491  P37061  X68847                          1901326A
nox       Seh                          U19610
nox       Taq  S23449  S29785          X60110                          1812226A
          Tbr  S25102  S35706  P32382  X67220                          1920210A
               S35707
nox       Mge  D64230                  U39706
          Mja  A64381                  U67512
nox-2     Smu  JC4541                  D49951
naox      Myc                          U62057

NADH peroxidases (EC 1.11.1.1)

npr       Efa  S18332  A34320  P37062  X62755                          1803417A
          Ehi  A36440

G. NAD(P)H:nitrite reductases (EC 1.6.6.4) and homologous components of nitrate-nitrite assimilatory system

nasB      Bsu                  P42433  D30689
nasB      Kpn  A49847          Q06458  L06800                          1911291B

nirB      Bsu                  P42435  D30689
nirB      Eco  S00529  S10791  P08201  X14202                          1615169A
               S04349
niiA      Eni  JH0181          P22944  M58289                          1615178A

nit-6     Ncr  A49848          P38681  L07391                          1911292A

nasA      Azv  S34993

nasC      Kpn                          L27431

H. Other flavoenzymes


 Gene   Species      PIR     SwissProt       GenBank/EMBL/DDBJ            PRF   

NADH:monodehydroascorbate reductases (EC 1.6.5.4)

          cuc  JU0182                  D26392
          Les                          L41345                          2113407A
          pea  A55333                  U06461                          2103235A

Ferric leghaemoglobin reductase (EC 1.6.2.6)

FLbR      Gma                          S70187                          2008310A

NADP+:dihydropyrimidine dehydrogenase (EC 1.3.1.2)

          bov                          U20981
          hum  A54718                  U09178  U20938                  2022262B
          pig  B54718                  U09179                          2022262A

NADPH:glutamate synthase (NADPH-GOGAT) (EC 1.4.1.13), ß-subunit

gltD      Eco  B29617          P09832  M18747 
gltD?                          P37127  L34011
gltD      Abr  A46602          Q05756  L04300
gltD      Tfe                          U36427

NADH:glutamate synthase (NADH-GOGAT) (EC 1.4.1.14)

          Msa  JQ1977          Q03460  L01660
          Cel                          Z49889


L-aspartate oxidase (EC 1.4.3.16)

nadB      Bsu  C47071          P38032  M98822
nadB      Eco  S09000          P10902  X12714  D13169
          Mle                          U00010
nadB      Pae                          U17232
nadB      Rru                          U20508

Fumarate reductase (succinate dehydrogenase) flavoprotein subunit (EC 1.3.99.1)

frdA      Eco  A00376          P00363  J01611  U14003                  0804230A
frdA      Pvu  S00107          P20922  X06144                          1312280A
          Spu  B44238          Q02469  L04283                          1905224B
          Wsu  B44954  S10165  P17412  X51509

sdhA      Bsu  A27763                                                  1304238A
sdhA      Eco  C28836                                                  1010157A
sdhA      Rpr  S33969  JN0895  P31038  M88696  U02603                  1924255A

          bov  A42792          P31039  M60879                          1812273A
sdh       hum  S21302          P31040  X53943  L21936                  2010206A
sdh1      Sce  S34793          Q00711  M86746  M86909  M94874  Z28148  1810371A
                                       Z26877                          1817254A
                                                                       1817424A
osm1      Sce  S46591  JH0106  P21375  M37696  L26347


Rotenone-insensitive NADH:ubiquinone oxidoreductase (EC 1.6.5.3)

ndi1      Sce  S26704          P32340  X61590                          1806213A
          Sce                  P40215  Z47071    

NADH:flavin oxidoreductase (EC 1.-.-.-)

baiH      Eub  C36912          P32370  L11069                          1913359B

NADPH:flavin oxidoreductase (EC 1.-.-.-)

frp       Vha                          U08996                          2014289A

NAD(P)H:flavin oxidoreductase (EC 1.-.-.-)

          Hin                          U32807
          Vfi                          D17743                          2014287A

Unknown dehydrogenase A (EC 1.-.-.-)

udhA      Eco  S21563          P27306  U00006  X66026  X16531

Heterodisulphide reductase

hdrA      Mth  S48720                  X81134                          2020300A

Flavocytochrome c sulphide dehydrogenase

fccB      Cvi  B39859          Q06530  L13419                          1918325D


Species abbreviations

Abr = Azospirillum brasilense
Aca = Acinetobacter calcoaceticus
Aeu = Alcaligenes eutrophus
Ala = Acholeplasma laidlawii
Ana = Anabaena species
Ath = Arabidopsis thaliana
Axy = Amphibacillus xylanus
Azv = Azotobacter vinelandii
bov = bovine
Bac = Bacillus species
Bst = Bacillus stearothermophilus
Bsu = Bacillus subtilis
Cbu = Coxiella burnetii
Ccy = Clostridium cylindrosporum
Cel = Caenorhabditis elegans
Cfa = Crithidia fasciculata
Cli = Clostridium litorale
Clm = Clostridium magnum
Clp = Clostridium pasteurianum
Csp = Clostridium sporogenes
Cte = Comamonas testosteroni
cuc = cucumber (Cucumis sativus)
Cvi = Chromatium vinosum
dog = dog
Eac = Eubacterium acidaminophilum
Eco = Escherichia coli
Efa = Enterococcus faecalis
Ehi = Enterococcus hirae
Enh = Entamoeba histolytica
Eni = Emericella nidulans (syn. Aspergillus nidulans)
Eub = Eubacterium species
Gma = Glycine max (soybean)
Han = Helianthus annuus
Hin = Haemophilus influenzae
hum = human
Hvo = Haloferax volcanii (syn. Halobacterium volcanii)
Kpn = Klebsiella pneumoniae
Ldo = Leishmania donovani
Les = Lycopersicon esculentum (tomato)
Mge = Mycoplasma genitalium
Mja = Methanococcus jannaschii
Mle = Mycobacterium leprae
mou = mouse
Msa = Medicago sativa (alfalfa)
Mth = Methanobacterium thermoautotrophicum
Mtu = Mycobacterium tuberculosis
Myc = Mycoplasma capricolum
Ncr = Neurospora crassa
Nta = Nicotiana tabacum (tobacco)
Osa = Oryza sativa (rice)
Pae = Pseudomonas aeruginosa
Pca = Pelobacter carbinolicus
Pce = Pseudomonas cepacia (Burkholderia cepacia)
Pcr = Penicillium chrysogenum
pea = garden pea (Pisum sativum)
Pgl = Peptostreptococcus glycinophilus
Pfa = Plasmodium falciparum
Pfl = Pseudomonas fluorescens
pig = pig
Pol = Pseudomonas oleovorans
Pps = Pseudomonas pseudoalcaligenes
Pse = Pseudomonas species
Psp = Pseudomonas putida
Pvu = Proteus vulgaris
rat = rat
Rgl = Rhodococcus globerulus
Rho = Rhodococcus species
Rpr = Rickettsia prowazekii
Rru = Rhodospirillum rubrum
Sau = Staphylococcus aureus
Sce = Saccharomyces cerevisiae (baker's yeast)
Scl = Streptomyces clavuligerus
Sco = Streptomyces coelicolor
Seh = Serpulina hyodysenteriae
Ser = Saccharopolyspora erythraea
Sfl = Shigella flexneri
Sli = Streptomyces lividans
Sma = Serratia marcescens
Smu = Streptococcus mutans
Sol = Spinacia oleracea (spinach)
Spi = Spirulina species
Spo = Schizosaccharomyces pombe
Spu = Shewanella putrefaciens
Sth = Streptococcus thermophilus
Stm = Stenotrophomonas maltophilia
Sty = Salmonella typhimurium
Taq = Thermus aquaticus
Tbb = Trypanosoma brucei brucei
Tbr = Thermoanaerobacter brockii
Tco = Trypanosoma congolense
Tcr = Trypanosoma cruzi
Tfe = Thiobacillus ferrooxidans
Vfi = Vibrio fischeri
Vha = Vibrio harveyi
Wsu = Wolinella succinogenes
Xan = Xanthomonas species


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