Cytochrome P450 Family


This entry is part of a Gene Family Database , a prototype database of gene families in the human and mouse that contains both community curated information and hypertext links to various biological databases. Please contact Amy Voltz ( avoltz@gdb.org) to comment or contribute.
Gene Family Description
Gene family | Introduction | Function | Evolution

Gene Identity and Location
Genome location | Nucleotide sequence | Gene organization and transcripts

Protein products
Sequences and alignments | Structures | Expression

Biology
Clinical phenotypes | Model organisms

Gene Family

The cytochrome P-450 family is a group of heme-thioloate monooxygenases (EC 1.14.14.1) that function in the oxidative metabolism of steroids, drugs, carcinogens and mutagens.


Function
  1. subfamily 1A

  2. subfamily 2A

  3. subfamily 2B

  4. subfamily 2C

  5. subfamily 2D

  6. subfamily 2E

  7. subfamily 2F

  8. subfamily 3A

  9. subfamily 4A

  10. subfamily 11A

  11. subfamily 11B

  12. subfamily 17

  13. subfamily 19

  14. subfamily 21

  15. subfamily 51


Genome Location

Human

  1. subfamily 1A

  2. subfamily 1B

  3. subfamily 2A

  4. subfamily 2B

  5. subfamily 2C

  6. subfamily 2D

  7. subfamily 2E

  8. subfamily 2F

  9. subfamily 3A

  10. subfamily 4A

  11. subfamily 4B

  12. subfamily 4D

  13. subfamily 7

  14. subfamily 11A

  15. subfamily 11B

  16. subfamily 17

  17. subfamily 19

  18. subfamily 21

  19. subfamily 24

  20. subfamily 27

  21. subfamily 51

  22. pseudogenes

Mouse

  1. subfamily 1

  2. subfamily 2A

  3. subfamily 2B

  4. subfamily 2C

  5. subfamily 2D

  6. subfamily 2E

  7. subfamily 2F

  8. subfamily 3A

  9. subfamily 4A

  10. subfamily 11A

  11. subfamily 11B

  12. subfamily 11D

  13. subfamily 17

  14. subfamily 19

  15. subfamily 21

  16. subfamily 24

  17. subfamily 27

Nucleotide Sequences (obtained from Nelson et al. (1993) and Nelson Web Server , which contains P450 data on many other organisms)

  1. subfamily 1A

  2. subfamily 1B

  3. subfamily 2A

  4. subfamily 2B

  5. subfamily 2C

  6. subfamily 2D

  7. subfamily 2E

  8. subfamily 2F

  9. subfamily 3A

  10. subfamily 4A

  11. subfamily 4B

  12. subfamily 4F

  13. subfamily 5

  14. subfamily 7

  15. subfamily 8

  16. subfamily 11A

  17. subfamily 11B

  18. subfamily17

  19. subfamily 19

  20. subfamily 21A

  21. subfamily 24

  22. subfamily 27

  23. subfamily 51


Gene organization (from On-Line Directory of P450-containing Systems)

  1. subfamily 1A

  2. subfamily 2A

  3. subfamily 2B

  4. subfamily 2C

  5. subfamily 2D

  6. subfamily 2E

  7. subfamily 4B

  8. subfamily 5

  9. subfamily 7

  10. subfamily 11A

  11. subfamily 11B

  12. subfamily 17A

  13. subfamily 19

  14. subfamily 21


Protein Sequences

  1. subfamily 1A

  2. subfamily 2A

  3. subfamily 2B

  4. subfamily 2C

  5. subfamily 2D

  6. subfamily 2E

  7. subfamily 2F

  8. subfamily 3A

  9. subfamily 4B

  10. subfamily 4F

  11. subfamily 5

  12. subfamily 7

  13. subfamily 11A

  14. subfamily 11B

  15. subfamily 17

  16. subfamily 19

  17. subfamily 21

  18. subfamily 27

Alignments


Protein Structures

  1. Ribbon Diagrams

  2. 3-D Space Filling Models


Clinical Phenotypes

  1. subfamily 1A

  2. subfamily 2A

  3. subfamily 2C

  4. subfamily 2D

  5. subfamily 5

  6. subfamily 11B

  7. subfamily 17

  8. subfamily 19

  9. subfamily 21


Model Organisms

Mouse (associated loci)

  1. Ahr aromatic hydrocarbon responsiveness
  2. Rip regulation of phenobarbitol-inducible P450
  3. Ripr repression of phenobarbitol-inducible P450

Please send comments and questions regarding this document to Amy Voltz at avoltz@gdb.org Thank you

Return to Gene Family Database